‘Molecular Imprinting in Water’ For Target-Specific Drug Designing- Science Behind Homeopathic Potentization

 ‘Drug designing’ is an advanced branch of modern pharmaceutical chemistry, which is involved with the process of developing new medicinal substances appropriate to the specific  biological targets in the organism. Such a ‘designer drug’ is most commonly a small organic molecule which can inhibit or activate the functioning of a target biomolecule such as a protein, thereby resulting in a therapeutic process in the organism. Essentially, ‘drug designing’ involves the development of small molecules that are complementary in ‘shape’ and ‘charge’ to the biomolecular target to which they interact and therefore will bind to it. Modern drug designing protocols utilize computer modeling techniques also. This type of modeling is known as ‘computer-aided drug design’. Actually, ‘drug design’ is involved with ‘ligand’ design. Prediction of binding affinity of molecules to be designed is the first step in a successful modeling technique.  Many other properties such as bioavailability, metabolic half life, lack of side effects, also should be optimized before a designed ‘ligand’ can become a safe and efficacious drug. Most of these ‘other’ characteristics are often very difficult to optimize using presently available drug design techniques.

Selection of drug target is most important in “drug designing”. A drug target is typically a key molecule involved in a particular metabolic or signaling pathway that is specific to a disease condition or pathology, or to the infectivity or survival of a microbial pathogen. Most of the therapeutic inteventions aim to inhibit the functioning of the ‘pathologic’ pathway in the diseased state by causing a key molecule to stop functioning. Drug molecules may be designed that bind to the active region and inhibit this key molecule. Some other therapeutic interventions  actually enhance the ‘normal’ biochemical pathway by promoting specific molecules in the ‘normal’ pathways that may have been affected in the diseased state. Main challenge in all ‘drug therapies’ including ‘designer drugs’ is that  these drug molecules should not affect any other important “off-target” molecules or ‘antitargets’ that may be similar in appearance to the target molecule, since drug interactions with off-target molecules may lead to undesirable side effects.

Designer drugs are small organic molecules produced through chemical synthesis, but biopolymer-based drugs (also known as biologics) produced through biological processes are becoming increasingly more common in modern drug designing.

‘Ligand-based drug design’ and ‘structure-based drug design’ are two major technologies now utilized in drug designing technologies.

Ligand-based drug design is based on the knowledge of other molecules that can bind to the biological target of interest. These other molecules may be used to derive a ‘pharmacophore’ which defines the minimum necessary structural characteristics a molecule must possess in order to bind to the target. In other words, a model of the biological target may be built based on the knowledge of what binds to it and this model in turn may be used to design new molecular entities that interact with the target.

Structure-based drug design is based on the knowledge of the three dimensional structure of the biological target obtained through methods such as x-ray crystallography or NMR spectroscopy. Using the structure of the biological target, candidate drugs that are predicted to bind with high affinity and selectivity to the target may be designed using interactive graphics.

Main draw back of ‘designer drugs’ is that  there is a chance for these drug molecules affecting “off-target” molecules or ‘antitargets’ having similarity to the target molecules. Such interactions with off-target molecules may lead to grave consequences. Optimizing of various factors such as bioavailability, metabolic half life, and lack of side effects are the real challenges facing “drug designing” technology.

Molecular Imprinting in Polymers:

  ‘Molecular imprinting in polymers’ is a fast grownig research area that may be interesting to people engaged in developing “drug designing” techniques. A lot of research is currently going on over this subject the world over. This technology involves the imprinting of synthetic polymer substances using enzymes or such macromolecules as ‘guest’molecules. As a result of imprinting, nano cavities with 3-d spacial configurations complementary to the ‘guest’ molecules will be created in the interaction surfaces of the polymers. These imprinted polymers, by virtue of the nanocavities they contain can be used to bind molecules with configurational similarity to ‘guest’ molecules. They are at present widely used in various laboratory assays as powerful adsorption surfaces. MIPs are also found to be of much practical use in various areas of science  and technology .

Molecular imprinted polymers of today cannot be used as therapeutic agents, since they are totally foreign substances to the organism. More over, native enzymes can not degrade the polymers even if they can play a therapeutic role in the organism.

Molecular imprinting may become part of future drug designing techniques, only if the search for safer substances and methods for molecular imprinting happens to be successful.

Molecular Imprinted Proteins:

 Biopolymer-based drugs (also known as biologics) produced through biological processes are becoming increasingly more common in modern drug designing. But the revolutionary concept of molecular imprinting in proteins is only in its emerging stage, which may have implications in drug designing techniques. It has already been acknowledged that the biological molecules presently classified as antibodies are nothing but native globulin proteins subjected to natural molecular imprinting process with foreign pathologic proteins acting as ‘guest’ molecules. Scientists have already realized the fact that the much discussed pathologic molecules known as ‘prions’ are nothing but disfigured protein molecules subjected to molecular imprinting. Protiens, being polymers with complex and flexible tertiary structures,  are expected to be a very good medium for molecular imprinting. Different types of protein based substances, subjected to artificial molecular imprinting, may  evolve in the future as effective therapeutic agents and laboratory reagents.

Apart from protein molecules,  different types of biopolymers such as polysaccharides and nucleic acids also may be experimented as medium for molecular imprinting.

Native proteins extracted from the patients could be subjected to molecular imprinting with appropriate ligands or other pathologic molecules acting as ‘guest’ molecules and used as target oriented therapeutic agents.  But the problem remains that such imprinted proteins can be used only in the individual whose proteins are used for imprinting. Otherwise it may result in grave anaphylactic reactions. Moreover these imprinted proteins may remain in the organism for very long periods, without undergoing degradation, and cause ever new pathological molecular blocks. Such issues have to be addressed properly.

Molecular Imprinting in Water:

 Our protracted search for a safe and reliable universal medium for molecular imprinted drug designing finally takes us to the study of wonderful physico-chemical properties of the most abundant substance on earth called water. But the concept and technology of molecular imprinting in water still remains in very infantile stage. The author is of the opinion that with its strange polymer-like behaviours, capable of forming hydrogen-bonded supra-molecular structures, water can be the ideal candidate for molecular imprinted drug designing in future.

Though in a slighly lesser level, Ethyl Alcohol and Lactose are also capable of forming polymer-like supra-molecular formations through hydrogen bonding, and hence may be onsidered as  candidates for molecular imprinting experiments. Possibilities of these substances in combination with water also have to be explored.

Water(H2O) is a wonderful substance with strange physico–chemical properties arising from its peculiar supra-molecular structure. Water is a solvent with higher polarity than similar liquids. H–O–H bond angle is 105 degrees. That means, water molecule is a dipole. Because of this peculiarity, water molecules can exist like a supra-molecular network through hydrogen bonding.  A minimum number of five water molecules will be contained in this network. Such supra-molecular formations are called pentamers. Most of the wonderful properties of water arise from this peculiar capacity of hydrogen bonding and resultant supra-molecular formations. Water molecules (H2O) are symmetric (point group C2ν) with two mirror planes of symmetry and a 2-fold rotation axis. The hydrogen atoms may possess parallel or antiparallel nuclear spin. The water molecule consists of two light atoms (H) and a relatively heavy atom (O). The approximately 16-fold difference in mass gives rise to its ease of rotation and the significant relative movements of the hydrogen nuclei, which are in constant and significant relative movement.

Although not often perceived as such, water is a very reactive molecule available at a high concentration. This reactivity, however, is greatly moderated at ambient temperatures due to the extensive hydrogen bonding. Each water molecules possess a strongly nucleophilic oxygen atom that enables many of life‘s reactions, as well as ionizing to produce reactive hydrogen and hydroxide ions. Reduction of the hydrogen bonding at high temperatures or due to electromagnetic fields results in greater reactivity of the water molecules.

As liquid water is so common-place in our everyday lives, it is often regarded as a ‘typical’ liquid. In reality, water is most atypical as a liquid, behaving as a quite different material at low temperatures to that when it is hot. It has often been stated that life depends on these anomalous properties of water. In particular, the high cohesion between molecules gives it a high freezing and melting point, such that we and our planet are bathed in liquid water. The large heat capacity, high thermal conductivity and high water content in organisms contribute to thermal regulation and prevent local temperature fluctuations, thus allowing us to more easily control our body temperature. The high latent heat of evaporation gives resistance to dehydration and considerable evaporative cooling. Water is an excellent solvent due to its polarity, high dielectric constant and small size, particularly for polar and ionic compounds and salts. It has unique hydration properties towards biological macromolecules (particularly proteins and nucleic acids) that determine their three-dimensional structures, and hence their functions, in solution. Hydration of biological molecules results in formation of gels that can reversibly undergo the gel-sol phase transitions that underlie many cellular mechanisms. Water ionize and allows easy proton exchange between molecules, thus contributing to the richness of the ionic interactions in living organisms.

In reality, hydrogen bonding is a special type of dipole force. It is a force of attraction formed between partial electro negative atom which is part of another molecule. The reason for strength is the partial positive charge attained by hydrogen. Hydrogen is capable of establishing similar bonds with the atoms of nitrogen, fluorine and oxygen. That is to say that the basis of hydrogen bonding is the attraction between one hydrogen atom which is part of a molecule which is attached to oxygen or nitrogen and  oxygen or nitrogen which remains part of another molecule. This force is less powerful than the co–valent bonds which keeps the atoms inside molecule bound together. But these less powerful bonds are responsible for the wonderful bio–chemical qualities of water.

In the ordinary liquid state, in spite of 80% of the electrons being concerned with bonding, the three atoms in water do not stay together, as the hydrogen atoms are constantly exchanging between water molecules due to protonation/deprotonation processes. Both acids and bases catalyze this exchange and even when at its slowest (at pH 7), the average time for the atoms in an H2O molecule to stay together is only about a millisecond. As this brief period is, however, much longer than the timescales encountered during investigations into water’s hydrogen bonding or hydration properties, water is usually treated as a permanent structure.

The presence of ethyl alcohol in water is considered to be a factor reducing the rate of protonation/deprotonation processes, thereby enhancing the stability of hydration shells.

Hydrogen bond strength can be affected by electromagnetic and magnetic effects.

Any factors, such as polarization, that reduces the hydrogen bond length, is expected to increase its covalency. There is still some dispute over the size of this covalency, however any covalency will increase the network stability relative to purely electrostatic effects. As hydrogen bond strength depends almost linearly on its length (shorter length giving stronger hydrogen bonding), it also depends almost linearly (outside extreme values) on the temperature and pressure .

Hydrogen bonded chains (that is, O-H····O-H····O) are cooperative; the breakage of the first bond is the hardest, then the next one is weakened, and so on. Thus unzipping may occur with complex macromolecules held together by hydrogen bonding, for example, nucleic acids. Such cooperativity is a fundamental property of liquid water where hydrogen bonds are up to 250% stronger than the single hydrogen bond in the dimer. A strong base at the end of a chain may strengthen the bonding further.

Water-Ethyl Alcohol Mixture :

 At this stage we have to understand a few facts about Ethyl Alcohol(CH3- CH2 – OH ). The molecules of alcohol also have the dipole structure as water molecules. It is possible for them to establish mutual connection through hydrogen bonding. The molecular weight of alcohol molecul is 46. The molecular weight of water(H2O) is 18. That means that the number of water molecules contained in 18 gram of water and the number of alcohol molecules contained in 46 gram of ethyl alcohol are equal. When alcohol and water are thoroughly mixed alcohol molecules network with water molecules through hydration bonds, The mobility of water molecules is restricted by the bonds established with alcohol molecules. Hence, hydration shells formed in alcohol–water mixture are comparatively more stable. The count of alcohol molecules and the count of water molecules contained in their mixture in 73:27 ratio will be equal. (73% w/w. alcohol and 27% w/w water) This mixturei is known as (40 power   spirit).

Ideal medium for molecular imprining is supposed to contains 87% w/w of alcohol and 13% w/w of water. In this ratio, the number of alcohol molecules will be about more than that of of water molecules. Such a ratio will be very suitable for the production of stable hydration shells. More over, the presence of ethyl alcohol in water is considered as a factor reducing the rate of protonation/deprotonation processes, thereby enhancing the stability of hydration shells

We know that water is a good solvent. Let us see what happens when some foreign molecules are made to dissolve in water. If a foreign(called ‘guest’) molecule, ion,  or colloidal particle happens to enter the matrix of 3-dimensional dynamic network of water molecules, they are entrapped inside this network. Water molecules arrange themselves around the ‘guest’ molecule in a peculiar way by the formation of hydrogen bonding. These formations of water molecules around the ‘guest’ molecules is known as hydration shells. These hydration shells exist in a dynamic state, and are more or less unstable. The ‘guest’ molecules dissolved in water exist in a state of being entrapped inside these hydration shells. This phenomenon can be seen both in ionic solutions and colloidal solutions. Obviously, hydration shells assume an internal spacial arrangement exactly fitting to the 3-dimensional spacial configuration of the ‘guest’ molecule entrapped in them. If we could devise some technique to remove the entrapped ‘guest’ molecules from these hydration shells, without disturbing the hydrogen bonds between the constituent water molecules, these hydration shells can retain the molecular memory of the molecular configurations of the removed ‘guest’ molecules. This rarely studied phenomenon underlies the much debated controversial ‘molecular memory of water’. Actual mechanism and forces underlying this phenomenon have to be investigated minutely by physical scientists. Minute changes occuring in the electron clouds of atoms of water molecules during the formation of hydration shells may be one factor responsible for this phenomenon. It has been well proven that these hydration shells later show a peculiar capability to differentially recognize the original ‘guest’ molecules which were  responsible for their formation. This may be due to the existence of some imprinted memory of those host molecules retained in the hydration shells. This imprinting of memory may be compared to formation of finger prints. As in the case of finger prints, configuration of these molecular imprints also will be a complementary negative of ‘guest’  molecules.  These empty hydration shells, or supra-molecular formations of water subjected to molecular imprinting, may be called ‘hydrosomes’, which means, minute ‘cavities of water’.

Homeopathic process of potentization may be a crude method of preparing hydrosomes, imprinted with various drug molecules(‘guest’), for utilizing as therapeutic agents.  It should be specially noted that the medium used for homeopathic potentisation is not pure water, but it is mixed with ethyl alcohol in a particular ratio. It may be  inferred that the presence of camparatively heavy ethyl alcohol molecules in this mixture may be contributing to stabilize the hydrosomes, preventing their easy dissociation.  The convergent forces of rotational movements to which the mixture is subjected as part of homeopathic potentization, may also be a contributing factor in stabilizing the empty hydration shells.

This peculiar 3-d configuration of ‘hydrosomes’ are destroyed only when the energy level of water molecules are disturbed by the effect of heat,  electricity, magnetism and other electro magnetic radiations. As stated earlier the hydration shells formed in pure water are comparatively unstable. Here lies the importance of the fact that homeopathic potencies are made using alcohol- water mixture.

Information we recently receive from various research institutions, regarding the wonderful  supra-molecular structures of various materials and their hitherto unknown peculiar properties, may greatly contribute in our  efforts to devise a protocol for molecular imprinted drug designing using water. Studies on  ‘water clusters’, ‘crystalline structure of water’, ‘shape memory property’, ‘molecular imprinting’,  ‘nano technology’,  ‘clathrate formations’ and other diverse phenomena are offering promising indications in this direction. We have to utilize all these new revealations in our scientific study regarding the possibility of developing a technology of drug designing by molecular imprinting in water.

We all know that water exists as ice crystals in its solid form. But it has been recently observed that water can exist even in its liquid form in crystals. In reality, water formed by melting of ice is in a state of liquid crystals. The lattice structure which is formed through hydration bonds is responsible for this phenomenon. Molecular imprinting in water is much interested in this area of research pertaining to this peculiar crystalline nature of water. It is believed that in the process of molecular imprinting of water using ‘guest’ molecules,  this crystalline structure of water plays a crucial role. It is likely that more advanced studies about dynamics of crystallization of water may help us to evolve a perfect technology for molecular imprinting in water.

The studies about Clathrate Compounds or host-guest compounds in supra-molecular chemistry is an area in which we should have sincere interest. Clathrates are the molecular networks which are formed when gases dissolve  in water under high pressure. They exist in a peculiar host–guest relationship. The studies about this phenomenon are still in their infancy. Clathrates have a crystalline nature,  existing as molecular networks,  formed by a process of water molecules arranging around the guest molecules. The studies about the dynamics of clathrate formation are also likely to help in evolving a perfect protocol for molecular imprinting in water. Even if  the host molecules are removed from clathrates, the network of water molecules have been found to remain intact. More over, the existing clathrates can induce the formation of similar clathrates. It will be very useful to consider these above discoveries connecting them with the phenomenon of molecular imprinting.

A lot of studies has been so far published regarding shape memory materials.  Several alloys having  crystalline structure have been observed to possess shape memory property. Such materials are known as SMART materials. This phenomenon also has to be understood well while trying to evolve a molecular imprinting technique of drug designing.

It is in the phenomenon of ‘molecular memory of water’ itself that we naturally land on when we attempt to develop molecular imprinted drugs. We have already seen that the alcohol–water molecules contained in the medium used for imprinting  arrange themselves around the ‘guest’ molecules, and form hydration shells. We should develop a way to systematically remove the ‘guest’  molecules entrapped in the hydration shells, so that empty hydration shells or ‘hydrosomes’ remain. These ‘hydrosomes’ will be imprinted with the three-dimensional ‘finger print’ of ‘guest’ molecules used for imprinting.

When molecular imprinted water is  introduced into the organism by any route, is carried by the body fluids, and transported to different parts of body. When molecular imprints come in the vicinity of ligands or active groups of pathological foreign molecules having similarity to the original ‘guest’ molecules, these molecular imprints selectively bind to those pathological molecules. By this process, pathological foreign molecules are prevented from binding with biological molecules, thereby relieving the biological molecules from pathological molecular blocks. This can be described as some sort of ‘molecular scavenging’ or entrapping of pathological molecules, by ‘hydrosomes’ or “molecular imrints”.

Drugs designed through molecular imprinting in water will be the safest of all therapeutic agents so far used in the history medical science. Though there is a chance for these molecular imprints affecting “off-target” molecules or ‘antitargets’ having similarity to the target molecules, such interactions will be of very transient nature, since these molecular imprints will be easily degraded into constituent water-ethyl alcohol molecules. Such temporary interactions with off-target molecules may not lead to any dangerous consequences. Factors such as bioavailability, metabolic half life, and lack of side effects also will be obviously remain in favorable range.

Using various ligands and pathological molecules involved in each disease process as ‘guest’  molecules, we can develop most appropriate specifc designer drugs against almost any disease. Instead of original pathological molecules or ligands, drug molecules having configurational similarity to them also can be used as “guest” molecules in the molecular imprinting protocol. Homeopathic potentization utilizes this strategy, which is the real essence of “similia similibus curentur”. I  hereby appeal to the government and scientific community to take up this task with urgent priority, so that a whole new range of safe and effective designer drugs could be developed though this novel process of molecular imprinting in water.

IDEA OF PROVING ‘COMBINATIONS OF POST-AVOGADRO DILUTED DRUGS’ IS SIMPLY RIDICULOUS!

When I talk about “combinations of post-avogadro diluted drugs”, some “classical” friends come with the quesion whether these combinations are “proved”? One of them declared: “If the the symptoms of combination drugs are same as single drug in provings, then only we can accept this theory.. Without clinical proving of combination drugs how we can accept this theory sir.”

First of all, I am not bothered whether anybody “accepts” my suggestions or not. No compulsions at all. I have already explained my rationale regarding “combinations of post-avogadro diluted drugs”. If you are capable of understanding my rationale, and convinced about the the scientific wisdom underlying it, you can accept.

Asking for “proving” of “combinations of post-avogadro diluted drugs” by itself shows that they have not seen or understood my explanations regarding drug proving.

A drug substance could be “proved” only if it can act upon biological molecules and inhibit their normal interactions. Only then it can produce a state of “drug pathology” as well as “drug symptoms”. Inorder to act upon biological molecules and change their actions, drug substance should contain some “chemical” molecules. Most of the drug substances contain diverse types of chemical molecules having their own individual chemical properties. During drug proving, a drug substance interact with our biological molecules not as a singular entity, but the individual drug molecules contained in the drug substance act upon various biological targets by their individual chemical properties, and produce molecular inhibitions that are expressed through diverse groups of symptoms that we compile in our materia medica.

Dear friends, please understand, durg substances potentized above avogadro limit or 12c will not contain even a single drug molecule, if they were genuinely potentized.

Your idea of “proving” post avogadro diluted drugs actually originated from this lack of scientific understanding regarding how drug substances act upon the body and produce symptoms. If you are talking about some mysterious “dynamic energy” that works upon a spiritual “vital force”, sorry sir, I am not interested in discussing that nonsense again and again. I have already done it more than enough earlier.

According to my view, potentization involves a process of MOLECULAR IMPRINTING. Spacial conformations of drug molecules are imprinted as three dimensional nanocavities in the water-alcohol supramolecular matrices. Each individual chemical molecule contained in the drug substance undergoes molecular imprinting as an individual unit. As such, drugs potentized above 12c or avogadro limit will contain diverse types of molecular imprints representing the diverse types of chemical molecules contained in the original drug substance. These individual molecular Imprints are the ACTIVE PRINCIPLES of post avogadro diluted drugs we use in homeopathy. Molecular Imprints act as ARTIFICIAL BINDING POCKETS for pathogenic molecules by their conformtional affinities, deactivate them, and remove the Molecular inhibitions they have produced in the biological molecules. This is the biological mechanism of Homeopathic cure. Molecular imprints cannot interfere in the normal interactions between biological molecules and their natural ligands, and hence, cannot produce any molecular errors in normal vital processes. That is why I say post avogadro diluted drugs cannot produce any pathological conditions or produce any drug symptom. Obviously, idea of conducting drug proving using drugs potentized above post avogadro limit is simply RIDICULOUS!

When we combine post avogadro diluted drugs, we are actually adding more MOLECULAR IMPRINTS together. Since Molecular Imprints cannot interact each other, there is no harm in combining any number of potentized drugs. Individual Molecular Imprints will remain as such, and act only upon specific pathogenic molecules having conformational affinity when introduced into the body as therapeutic agents.

My scientific explanations of Homeopathy may not agree with your “classical” beliefs that evolved in the 200 year old primitive knowledge environment. Sorry for that. Either you update yourselves, or reject my ideas and remain eternally blind! It is your choice!

AN MIT STUDY OF ARSENIC, AND ITS POTENTIAL USE IN MOLECULAR IMPRINTS FORMS FOR PREVENTION OF COMPLICATIONS AND MORTALITY IN CURRENT PANDEMIC

Arsenic Album or Arsenic Trioxide is a chemical substance that can inhibit more than 200 essential enzymes in our body involved in diverse types of biomolecular processes related with genetic transcription, metabolism, energy conversions etc etc. This is due to the ability of Arsenic ions to bind to the cysteine radicals which are part of active sites all enzymes. Almost every biochemical pathways in the living body are deranged by the action of arsenic. This is the reason why the homeopathic materia medica of arsenic album is so rich with symptoms associated with almost all organs and systems of the body.

Arsenic content may be high in people due to living in certain areas, consuming arsenic rich ground water, cigarette smoking, eating unpolished rice, prawns and crabs, exposure to arsenic containing environments, etc etc. Arsenic may enter the body through contaminated liquors, Chinese, Ayurvedic, unani or Herbal preparations, industrial exposures, chemically treated wooden furniture etc also. Arsenic content will naturally be high in aged people, as it has a tendency to accumulated in the body over years through exposures.

It is an already established fact that during viral infections, persons having high levels of arsenic in their body are prone to develop serious complications such as respiratory failure, acute myocardial degeneration, renal failures, liver failures, multiple organ failures etc faster than those having low arsenic levels.

Researchers working upon arsenic toxicity problems in certain arsenic affected countries have already proved that ARSENIC ALBUM 30 can antidote and reverse the chronic effects of arsenic toxicity, and remove the symptoms.

My suggestion to the experts involved in current pandemic research is that determination of arsenic levels in the body of covid patients should be made mandatory, so that high risk people could be identified and better care provided.

Arsenic Album 30 contains MOLECULAR IMPRINTS of arsenic trioxide molecules. Molecular imprints are three dimensional nanocavities formed in water-alcohol supra-molecular matrix through a host-guest interactions between templates and diluent medium during the process of homeopathic POTENTIZATION. Molecular imprints of arsenic trioxide contained in Arsenicum Album 30 can act as artificial binding pockets for arsenic ions and deactivate them, thereby removing the molecular inhibitions they have produced in the enzyme systems of the body.

By using Arsenicum Album 30 in sufficient quantities and frequencies to provide molecular imprints in optimum levels, it will be possible to prevent dangerous complications and multiple organ failures in patients affected with current pandemic, so as to prevent the chances of morbidities due to the disease. Complications and mortality rates could be definitely lowered by use of Arsenic Alb 30.

I don’t know how to get this very important message reach the right persons in right time, or how to convince the scientific basis of this approach described above.

A word to homeopaths : It is a nonsense idea that Arsenic album 30 will “boost immunity”. Arsenic Alb 30 will not contain any chemical molecules that can act as antigens to initiate production of antibodies and boost immune system. But it will surely prevent complications even if you get infected, if molecular imprints of arsenic is available in the body during the time of virus infection.

Homeopaths currently involved in distribution of Arsenicum Album 30 should realize the hard truth that the dosage you are giving now is actually of no use. 4 or 5 medicated sugar pills for 3-4 days you give now cannot provide the sufficient quantity of molecular imprints required to produce desired biological effects. To ensure optimum availability of molecular imprints, medicine should be used in drop doses at least twice a day until the epidemic threat is over. Please understand, it is not any mysterious “dynamic energy” or “vibrations” that work in our potentized drugs. It is “material” MOLECULAR IMPRINTS, that act as “artificial binding pockets” for pathogenic molecules, and deactivate them. As such, dosage and repetition should be appropriate to ensure this availability. I would suggest minimum 1 or 2 drops direct on tongue bds until epidemic is over.

REALIZE THE TRUTH BEHIND THE HYPE OVER ASPIDOSPERMA AND VANADIUM

There is a wild propaganda going on, claiming that homeopathy medicine ASPIDOSPERMA is the GENUS EPIDEMICUS of current pandemic, and people are desperately running from store to store to get a bottle of this “miracle drug” to save their dear ones gasping for oxygen. They also recommend the use of Vanadium as an “oxygen supplier”.

It is claimed that a few drops of “mother tincture” of aspidosperma given twice or thrice for a few days will relieve the breathlessness, and will be helpful in curing the disease.

Problem underlying this claim as well as the propaganda is that homeopaths fail to understand  the difference between MOLECULAR forms and MOLECULAR IMPRINTS forms of drugs.

They also fail to remember the primary lesson that if a drug is found to  be GENUS EPIDEMIC for a disease, it will be administered only in potencies above 12c, and it is NEVER used in mother tincture form.

Crude drugs, mother Tinctures, Potencies below 12c and biochemic TRITURATIONS are MOLECULAR forms of drugs, since they contain molecules of drug substances.

Potencies above 12c or Post-avogadro dilutions do not contain drug molecules, but MOLECULAR IMPRINTS only.

We must not forget the fact that drug symptoms provided in our materia medica actually constitute the list of symptoms that are generated in healthy persons by the use of these drugs in crude form.  Indiscriminate long-term use of mother tinctures containing plant enzymes, poisonous alkaloids, glycosides and various other phyto-chemical ingredients is an  unpardonable  crime even if it is done in the name of homeopathy. The chemical molecules contained in these tinctures might give temporary relief  by nutritional supplementation, or by competitive relationship towards pathological  molecules due to their  conformational similarity. But it is evident from their symptomatologies  that those chemical molecules are capable of creating dangerous pathological molecular inhibitions in various bio-chemic channels in the organism.

We should never forget that the subjective and objective symptoms provided in our materia medica were createdby the molecular errors happened in healthy individuals during drug proving.

Regarding ASPIDOSPERMA, even though homeopaths enthusiastically quote “It stimulates the respiratory centers and increases the oxygen in the blood” from Boericke materia Medica, they conveniently ignore the following statement in Clarke’s materia Medica: “Hale says ASPIDOSPERMA produces in animals respiratory paralysis, slowed heart, and paralysis of extremities.”

Even though it is said in materia Medica that VANADIUM is an “oxygen carrier”, please understand, it is only a chemical property of Vanadium in its molecular form. Vanadium potentized above 12c will not contain any single molecule of Vanadium, and hence, it is totally irrational to expect Vanadium in potentized form to act as an “oxygen supplier”. The widely quoted statement from materia Medica “it increases amount of hemoglobin, also combines its oxygen with toxines and destroys their virulence” is actually applicable to molecular forms of Vanadium only. Vanadium 30 will not contain even a single molecule of Vanadium, and hence, this property cannot be attributed to vanadium 30.

Same time, vanadium in Molecular form is highly toxic, and it is not at all safe to use Vanadium in 3x or potencies below 12c. It is now well known that molecular forms of VANADIUM is a competitive inhibitor of various enzymes such as ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases, and hence, very dangerous if given in Molecular form.

Molecular forms of drugs act by the chemical properties of constituent molecules, whereas MOLECULAR IMPRINTS forms of drugs act by the conformational properties of Molecular imprints.

Since Molecular imprints cannot interfere in the normal interactions between biological molecules and their natural ligands, Molecular imprints forms of drugs cannot produce any short term or long term adverse effects.

On the other hand, Molecular forms of drugs can interact with biological molecules and produce inhibitions, and may cause harmful adverse effects. Even though mother Tinctures are considered Homeopathy drugs, they are no way different from allopathy drugs, when considered in terms of their active principles as well as biological mechanism of actions.

We know, many homeopathic practioners prescribe plenty of mother tinctures, low potency preparations and biochemic TRITURATIONS. They consider it genuine homeopathy, as they manufactured by homeopathy drug companies, and bear the label Homeopathic Medicines. They ignore the fact that mother Tinctures are never prescribed according to similia principles, or on the basis of totality of symptoms.

Mother tinctures and other Molecular forms of drugs may relieve some of the symptoms, due to their allopathic actions. But they are not only un-homeopathic in actions, but chances of emerging new pathological conditions due to them is a reality.

Homeopaths should understand, it is ideal to treat patients using potencies above  12c, which do not contain any trace of the drug molecules of the original drug. If our selection of drug is correct, there is no any chance of failure in such a protocol.

Actually, mother tinctures will have to be considered as identical to Ayurveda, Allopathy or Herbal treatment. Those homeopaths who indulge in excessive use of mother tinctures, without bothering  about their constituent drug  molecules and their adverse long term impacts on the organism, are more hazardous to human health than our allopathic counterparts. I humbly request them to think over.

For example, from our materia medica works, it may be understoodthat most of  those people who had participated in proving of  Hydrastis Canadensis developed symptoms of gastric ulcer and hyperacidity along with many other deep seated pathological conditions. Doctors who administer large doses of Hydrastis Tincture to relive gastric symptoms as part of homoeopathic treatment should note this point . Of course, we may get temporary relief, by the way of competitive relationships with pathological molecules, due to conformational similarity of drug molecules and pathogenic molecules. Prolonged use of Hydrastis Tincture not only produce the symptoms mentioned in the materia medica,  but may even induce very serious genetic errors to happen. If  hydrastis is the similimum for the patient, it will be effective in high potencies. This is real homeopathy.

Please do not be provoked when I say that those who give Vanadium 3x for supplying oxygen,  Passiflora for inducing sleep, Rauwolfia for lowering blood pressure and Syzijium for high blood sugar in their tincture form, are not practicing ideal Homeopathy even if they may be well known homeopaths.

No homeopath with some common sense, who had carefully read the material medica of Alfalfa will dare to prescribe it as tonics to improve the appetite and general health of innocent children. It is evident from its symptomatology that Alfalfais capable of producing diabetes, bulimia, and upsetting the normal functioning of kidneys.

We should remember that there was no exact knowledge regarding the long term evil effects of many drugs, when many of them were proved and their materia medica prepared. There was least knowledge about the genetic disorders they were likely to produce. It is found in Boecricke Materiamedica that Arsenic Bromide Mother Tincture is indicated for Diebetes. No physician with scientific awareness will even think of prescribing it today. Who will now dare to prescribe Ars iod 3x, Iodum 3x, Sulphur Q, or various compounds of Mercury and Lead only because they are found in our text books of Materia Medica?

We know a lot of homeopaths who make their patients consume for prolonged periods, the mother tinctures of several drugs, including various patented combinations flooding the market in the name of Homeopathy. How can Homeopaths prescribe them without any prick of conscience? Those who love homoeopathy should take urgent initiative to prevent such tendencies either through awareness programs and campaigns, or through stringent legislational procedures.

Since crude drugs and mother tinctures contain drug molecules that can act upon biological molecules, they can also bind to various biological targets in the organism. Obviously, there is always chance for creation of new molecular inhibitions and drug-induced pathologies when we use crude drugs and mother tinctures. That is the draw back of using mother tinctures even if they are similimum.

Advantage of drugs potentized above 12c, also known as post-avogadro Dilutions,   is that they do not contain any drug molecule, but only molecular imprints, which are only supra-molecular clusters of water and alcohol molecules. They can act upon pathogenic molecules only, not upon biological molecules. As such, potentized drugs cannot do any further harm to organism.

That is why MIT says use of mother Tinctures and other Molecular forms of drugs cannot be considered genuine Homeopathy. To be genuinely homeopathic regarding active principles as well as biological mechanism of action, we should use only post-avogadro diluted drugs.

AN MIT STUDY OF VANADIUM AND ITS THERAPEUTIC USE IN POST-AVOGADRO DILUTED FORMS

Many homeopaths recently suggest VANADIUM 30 as a remedy for oxygen deficiency in blood during the current Covid 19 pandemic. This suggestion is based on the statements in some homeopathic materia Medica works regarding the “oxygen carrier” capacity of vanadium.

First of all, let us see what is said in Boericke Materia Medica about Vanadium:

“Its action is that of an oxygen carrier and a catalyzer, hence its use in wasting diseases.  Increases amount of hemoglobin, also combines its oxygen with toxines and destroys their virulence. Also increases and stimulates phagocytes. A remedy in degenerative conditions of the liver and arteries.

Anorexia and symptoms of gastro intestinal irritation; albumen, casts and blood in urine. Tremors; vertigo; hysteria and melancholia; neuro-retinitis and blindness. Anaemia, emaciation. Cough dry, irritating and paroxysmal, sometimes with haemorrhages. Irritation of nose, eyes and throat. Tuberculosis, chronic rheumatism, diabetes.

Acts as a tonic to digestive function and in early tuberculosis. Arterio-sclerosis, sensation as if heart was compressed, as if blood had no room in the aorta. Anxious pressure on whole chest. Fatty heart. Degenerative states, has brain softening.  Atheroma of arteries of brain and liver.

Dose:  6-12 potency. The best form is Vanadiate of Soda, 2 mg daily, by mouth.”

Clarke’s Dictionary of Materia Medica says about Vanadium as follows : 

“Addison’s disease. Atheroma. Fatty degeneration. Innutrition.
Burnett  tells how he came to use Vanadium through reading the result of some experiments on animals in which the Salts of Vanadium produced “true cell destruction, the pigment escaping, the liver being hit hardest.”  Burnett had at the time a case of “fatty liver, atheroma of the arteries, much pain corresponding to the course of the basilar artery, large, deeply pigmented patches on forehead, profound adynamia.” Vanadium restored the patient, who was seventy, and at eighty he was “hale and hearty.” Marc Jousset tells of experiments with salts of Vanadium, chiefly the meta-vanadate of sodium, by Lyonnet and others.  Animals poisoned by intravenous injections rapidly develop Cheyne-Stokes respiration; with little or no action on circulation or blood. These observers gave Vanadates to two hundred patients suffering from tuberculosis, chlorosis, chronic rheumatism, neurasthenia etc, and produced in nearly all cases increased appetite, strength, and weight. The amount of urea was also increased. They regard Vanadium as “an energetic excitant of nutrition,” and probably an oxydent stimulating organic combustion. The dose was 2-5 mgr. in twenty-four hours, and only on three separate days in the week.”

Obviously, Boericke and Clarke were saying about the use of “2-5 mg of Sodium Vanadate daily”. Not Vanadium 30! It makes a big difference.

Sodium vanadate is the inorganic compound  with the chemical formula  Na3VO4·2H2O (sodium orthovanadate dihydrate). It is a colorless, water-soluble solid.

Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of PHOSPHATES. By this mimicking, it acts as a COMPETITIVE INHIBITOR of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases. By this competitive relationship VANADIUM acts as a SIMILIMUM for many disease conditions involving inhibitions of ATPases by various endogenous or exogenous pathogenic molecules having phosphate functional groups or moieties. 

ATPases  adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, adenosine 5′-triphosphatase, ATP hydrolase, complex V (mitochondrial electron transport), (Ca2+ + Mg2+)-ATPase, HCO3−-ATPase, adenosine triphosphatase) etc are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion or the inverse reaction. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur. This process is widely used in all known forms of life

Transmembrane ATPases import many of the metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes.

All the symptoms described by Boericke and Clarke are actually due to this inhibitory actions of vanadites  upon the various enzymes listed above, which lead to blocking of all biological pathways associated with involvement of PHOSPHATES. 

Please understand, Vanadium potentized above 12c used in homeopathy will not contain even a single molecule or atom of Vanadium. It contains only MOLECULAR IMPRINTS of vanadium, and hence, will act just opposite to the actions of Molecular or crude forms of Vanadium.  These Molecular imprints actually act by removing the molecular inhibitions caused in the various enzymes by Vanadium or any other pathogenic molecules having functional groups similar to vanadites or phosphates.

 Obviously, Vanadium 30 will not supply oxygen to the tissues as some homeopaths wrongly believe, but may be useful in deactivating harmful reactive oxygen species or ROS generated in the body during the disease processes. 

Even though Boericke and Clarke talks about use of “Vanadium Vanadate 2-5 mg daily” for therapeutic purposes, as per advanced scientific knowledge, vanadium is not a safe substance for human consumption.

Vanadium excess can be toxic and detrimental to human health like any other metal. For instance, occupational inhalation exposure to vanadium was found to induce acute respiratory symptoms, DNA damage in blood cells of workers from a vanadium pentoxide factory, and altered neurobehavioral functions. In turn, environmental overexposures to vanadium oxides attached to fine particulate matter were associated with increased risk of respiratory symptoms in children, and a higher risk of cardiovascular and respiratory hospitalizations of older people. ilRecently, urinary vanadium concentrations during pregnancy were positively associated with impaired fetal growth and preterm or early-term delivery. Association between the high level of trace elements including vanadium in the drinking water and the increased thyroid cancer incidence was suggested. A suicidal death after ingestion of an undetermined amount of ammonium vanadate has also been reported. In addition, laboratory-based studies conducted in animal models or cell cultures found that vanadium exposure can induce a variety of toxic effects such as cardiovascular effects, vascular endothelial dysfunction and arterial hypertension, immune toxicity, damage to the spleen and thymus, neurotoxicity, hippocampal alterations and memory loss, developmental disturbances, increased embryolethality and skeletal defects, and pulmonary toxicity. It should be added that, besides the dose of vanadium and the route of vanadium exposure, many other factors such as the form of vanadium (inorganic versus organic forms) and interactions with other elements such as selenium or magnesium can also influence vanadium toxicity.

Along with the studies of the toxic effects of vanadium, many investigators have been focused on the examination of potential medical applications of this mineral. These include antidiabetic or insulin-mimetic actions, antiviral effects, and anticarcinogenic activity. Among these effects, the antidiabetic action of vanadium complexes with organic ligands has been very intensively studied, which entered into stage II clinical trials. However, due to kidney problems in some patients, this study as an antidiabetic agent could not progress to the next phase of research. Indeed, the risks associated with vanadium intoxication such as vanadium-induced reactive oxygen species generation, adverse effects on the immune system, and a risk of mutagenesis are listed among the arguments against the antidiabetic application of vanadium. Reviews of the results of past and recent human studies on vanadium in diabetes have concluded that the use of vanadium compounds in oral diabetes therapy is misplaced.

Vanadium occurs as a natural component of the earth crust in various minerals, coal, and crude oil, and is released to the environment mainly due to human activities. The unique chemical and physical features of vanadium compounds make it an indispensable material in many industries. Its compounds are frequently used in the production of steel and titanium-aluminum alloys, as catalysts in the sulfuric acid manufacture, and in the production of pigments, inks, and varnishes. The latest use of vanadium involves green technologies and the production of vanadium-based redox flow batteries, which can store electricity produced from renewable sources such as wind or sun.  The industrial use of vanadium is on the increase and so is the release of vanadium to the environment.  Vanadium is one of the elements listed on the second drinking water contaminant candidate list that was announced by the United States Environmental Protection Agency in 2005. This is a list of contaminants that are known or anticipated to occur in public water systems and may require future regulations. Vanadium was reported to contribute to soil pollution.  Heavy oil combustion contributes to the release of vanadium as a component adhering to fine particulate matter observed in large urban and industrial agglomerations. High groundwater concentrations of vanadium of natural geological sources have been noted in volcanic areas.  Vanadium excess can be toxic and detrimental to human health like any other metal. For instance, occupational inhalation exposure to vanadium was found to induce acute respiratory symptoms, DNA damage in blood cells of workers from a vanadium pentoxide factory, and altered neurobehavioral functions. In turn, environmental overexposures to vanadium oxides attached to fine particulate matter were associated with increased risk of respiratory symptoms in children, and a higher risk of cardiovascular and respiratory hospitalizations of older people. Recently, urinary vanadium concentrations during pregnancy were positively associated with impaired fetal growth and preterm or early-term delivery. Association between the high level of trace elements including vanadium in the drinking water and the increased thyroid cancer incidence was suggested. A suicidal death after ingestion of an undetermined amount of ammonium vanadate has also been reported. In addition, laboratory-based studies conducted in animal models or cell cultures found that vanadium exposure can induce a variety of toxic effects such as cardiovascular effects, vascular endothelial dysfunction and arterial hypertension, immune toxicity, damage to the spleen and thymus, neurotoxicity, hippocampal alterations and memory loss, developmental disturbances, increased embryolethality and skeletal defects, and pulmonary toxicity. It should be added that, besides the dose of vanadium and the route of vanadium exposure, many other factors such as the form of vanadium (inorganic versus organic forms) and interactions with other elements such as selenium or magnesium can also influence vanadium toxicity.

Along with the studies of the toxic effects of vanadium, many investigators have been focused on the examination of potential medical applications of this mineral. These include antidiabetic or insulin-mimetic actions, antiviral effects, and anticarcinogenic activity. Among these effects, the antidiabetic action of vanadium complexes with organic ligands has been very intensively studied, which entered into stage II clinical trials. However, due to kidney problems in some patients, this study as an antidiabetic agent could not progress to the next phase of research. Indeed, the risks associated with vanadium intoxication such as vanadium-induced reactive oxygen species generation, adverse effects on the immune system, and a risk of mutagenesis are listed among the arguments against the antidiabetic application of vanadium. Reviews of the results of past and recent human studies on vanadium in diabetes have concluded that the use of vanadium compounds in oral diabetes therapy is misplaced. Vanadium compounds have attracted interest of researchers as potential antitumor agents. Vanadium as vanadyl sulfate has been used by weight training athletes as a nutritional supplement that can increase muscle mass. The role of vanadium in muscle development has been emphasized to be associated with its insulin-mimetic properties and anabolic effects. So far, however, human studies have failed to demonstrate significant effects of vanadium on the body composition and performance enhancement, and the use of vanadium as a sport nutrition supplement is not recommended. Vanadium is also a well-known constituent of the most commercialized titanium alloy named Ti-6Al-4V, which has been widely used in the manufacture of biomedical implants such as artificial hip joints, knee joints, and dental implants due to its excellent physical and mechanical properties. Again, however, the potential cytotoxicity of vanadium limits the medical value of the Ti-6Al-4V alloy. Recently, for example, a case of systemic allergic dermatitis to vanadium has been reported in a patient following placement of a titanium alloy plate in the left foot. Summing up, due to the intensive use of vanadium in industry and the vanadium environmental pollution often related with it as well as the popularity of vanadium-based dietary supplements and medicinal applications of vanadium compounds, increasing numbers of humans are likely to experience the exposure to vanadium compounds in the near future.

Vanadium enters the human body via the gastrointestinal tract or respiratory system. In the bloodstream, transferrin is the major serum protein of vanadium transport from blood into tissues.  Other serum proteins, i.e., albumin, hemoglobin, and immunoglobulin, and low-molecular ligands, e.g., lactate and citrate, can be involved in the blood transport of vanadium as well. From the blood, vanadium is transferred to different tissues such as the liver, kidney, heart, spleen, brain, and bones. Final excretion of absorbed vanadium occurs through urine. In the human body, vanadium can exist in oxidation state +5 (vanadate ions) or +4 (vanadyl cations). Cellular uptake of vanadium species proceeds via receptor-mediated endocytosis of vanadium-laden proteins (transferrin, albumin), phosphate or sulfate ion channels, or membrane citrate transporters. Reductants, e.g., glutathione, ascorbic acid, or NADH, convert pentavalent vanadium to a tetravalent state, the latter being regarded as a predominant oxidation state of vanadium within the cell. Simultaneously, oxidants such as NAD+, O2, and O22- can oxidize vanadyl back to vanadate.

Metabolic detoxification of vanadium possibly involves reduction of vanadate to vanadyl by cellular reductants, and  complexation reactions during which vanadyl interacts with cellular agents such as reduced glutathione (GSH), an oxidized form of glutathione (GSSG), L-cysteine, and cystine forming stable, nonharmful complexes. In addition, vanadium accumulates in bones by replacing bone phosphate in apatite Ca5(PO4)OH with vanadate. The storage of vanadium in bones is also recognized as a potent detoxification mechanism of vanadium in animals.

In contrast to the aforementioned chelating compounds, ascorbic acid was suggested to be a very effective and safe pharmacologic agent for the treatment of vanadium toxicity in humans. Detoxification of vanadium by ascorbic acid mainly relies on ascorbic acid-mediated reduction of vanadate to vanadyl and its high capacity to scavenge reactive oxygen species. Furthermore, vanadyl was found to interact with oxidation products of ascorbic acid forming stable complexes, which may allow excretion of vanadium from the organism. In addition, the results of studies have shown that pyruvic acid could be another potential antidote for the treatment of vanadium toxicity. The studies showed that this alpha-keto acid protected against vanadium-induced oxidative stress and cytotoxicity in a cell culture model. The mechanism of protection probably involves antioxidative effects of pyruvate, especially its ability to neutralize hydrogen peroxide, but still more research is required to elucidate this issue. 

It is well known that many edible plants are the main source of natural compounds acting as exogenous antioxidants. Exogenous antioxidants cannot be produced in the body and therefore must be provided through daily nutrition. They reinforce our intrinsic antioxidant system in the protection of the organism against reactive oxygen species-mediated injuries. As shown below in this review, research studies indicate that vanadium toxicity, which is strongly associated with prooxidant mechanisms, can be efficiently reduced or alleviated by dietary and plant-derived antioxidants. 

Very early studies already explored the efficiency of vitamin C (ascorbic acid, ascorbate) in the prevention and treatment of vanadm toxicity, and found that vitamin C was effective against acute vanadate and vanadyl intoxication. 

Some studies focused on the role of vitamin E (α-tocopherol) in the treatment of vanadium toxicity, which provided in vivo evidence that vitamin E acetate decreased sodium metavanadate-induced oxidative stress and histopathological changes in the testes of rats. Furthermore, vitamin E was demonstrated to exhibit protective activity against sodium metavanadate-mediated neurotoxicity in rat pups. In this study, vitamin E increased performance in neurobehavioral tests,  and decreased reactive astrogliosis in brain tissue of vanadium-treated animals. Both vitamins C and E exhibited protective activity against vanadium pentoxide-induced genotoxicity measured using a micronucleus assay in mouse polychromatic erythrocytes.

In addition, polyphenolic compounds (and other phytochemicals) may prove beneficial for the treatment of vanadium toxicity. 
In conclusion, although the investigations cited in this review show that supplementation with dietary antioxidants has beneficial effects on vanadium poisoning.


First of all, let us see what is said in Boericke Materia Medica about Vanadium:


“Its action is that of an oxygen carrier and a catalyzer, hence its use in wasting diseases. 

Increases amount of hemoglobin, also combines its oxygen with toxines and destroys their virulence. Also increases and stimulates phagocytes. A remedy in degenerative conditions of the liver and arteries.


Anorexia and symptoms of gastro intestinal irritation; albumen, casts and blood in urine. Tremors; vertigo; hysteria and melancholia; neuro-retinitis and blindness. Anaemia, emaciation. Cough dry, irritating and paroxysmal, sometimes with haemorrhages. Irritation of nose, eyes and throat. Tuberculosis, chronic rheumatism, diabetes.
Acts as a tonic to digestive function and in early tuberculosis. Arterio-sclerosis, sensation as if heart was compressed, as if blood had no room in the aorta. Anxious pressure on whole chest. Fatty heart. Degenerative states, has brain softening.  Atheroma of arteries of brain and liver.


Dose:  6-12 potency. The best form is Vanadiate of Soda, 2 mg daily, by mouth.”


Clarke’s Dictionary of Materia Medica says about Vanadium as follows : 


“Addison’s disease. Atheroma. Fatty degeneration.

Innutrition.Burnett  tells how he came to use Vanadium through reading the result of some experiments on animals in which the Salts of Vanadium produced “true cell destruction, the pigment escaping, the liver being hit hardest.”  Burnett had at the time a case of “fatty liver, atheroma of the arteries, much pain corresponding to the course of the basilar artery, large, deeply pigmented patches on forehead, profound adynamia.” Vanadium restored the patient, who was seventy, and at eighty he was “hale and hearty.” Marc Jousset tells of experiments with salts of Vanadium, chiefly the meta-vanadate of sodium, by Lyonnet and others.  Animals poisoned by intravenous injections rapidly develop Cheyne-Stokes respiration; with little or no action on circulation or blood. These observers gave Vanadates to two hundred patients suffering from tuberculosis, chlorosis, chronic rheumatism, neurasthenia etc, and produced in nearly all cases increased appetite, strength, and weight. The amount of urea was also increased. They regard Vanadium as “an energetic excitant of nutrition,” and probably an oxydent stimulating organic combustion. The dose was 2-5 mgr. in twenty-four hours, and only on three separate days in the week.”


Obviously, Boericke and Clarke were saying about the use of “2-5 mg of Sodium Vanadate daily”. Not Vanadium 30! It makes a big difference.


Sodium vanadate is the inorganic compound  with the chemical formula  Na3VO4·2H2O (sodium orthovanadate dihydrate). It is a colorless, water-soluble solid.


Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of PHOSPHATES. By this mimicking, it acts as a COMPETITIVE INHIBITOR of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases. 


All the disease conditions described by Boericke and Clarke are actually due to this inhibitory actions of vanadites upon the various enzymes listed above, which lead to blocking of all biological pathways associated with PHOSPHATES. 


Please understand, Vanadium potentized above 12c used in homeopathy will not contain even a single molecule or atom of Vanadium. It contains only MOLECULAR IMPRINTS of vanadium, and hence, will act just opposite to the actions of Molecular or crude forms of Vanadium.  These Molecular imprints actually act by removing the molecular inhibitions caused in the various enzymes by Vanadium or any other pathogenic molecules having functional groups similar to vanadites or phosphates. Obviously, Vanadium 30 will not supply oxygen to the tissues as some homeopaths wrongly believe, but may be useful in deactivating harmful reactive oxygen species or ROS generated in the body during the disease processes. 


Even though Boericke and Clarke talks about use of “Vanadium Vanadate 2-5 mg daily” for therapeutic purposes, as per advanced scientific knowledge, vanadium is not a safe substance for human consumption.


Vanadium excess can be toxic and detrimental to human health like any other metal. For instance, occupational inhalation exposure to vanadium was found to induce acute respiratory symptoms, DNA damage in blood cells of workers from a vanadium pentoxide factory, and altered neurobehavioral functions. In turn, environmental overexposures to vanadium oxides attached to fine particulate matter were associated with increased risk of respiratory symptoms in children, and a higher risk of cardiovascular and respiratory hospitalizations of older people. ilRecently, urinary vanadium concentrations during pregnancy were positively associated with impaired fetal growth and preterm or early-term delivery.

Association between the high level of trace elements including vanadium in the drinking water and the increased thyroid cancer incidence was suggested. A suicidal death after ingestion of an undetermined amount of ammonium vanadate has also been reported. In addition, laboratory-based studies conducted in animal models or cell cultures found that vanadium exposure can induce a variety of toxic effects such as cardiovascular effects, vascular endothelial dysfunction and arterial hypertension, immune toxicity, damage to the spleen and thymus, neurotoxicity, hippocampal alterations and memory loss, developmental disturbances, increased embryolethality and skeletal defects, and pulmonary toxicity. It should be added that, besides the dose of vanadium and the route of vanadium exposure, many other factors such as the form of vanadium (inorganic versus organic forms) and interactions with other elements such as selenium or magnesium can also influence vanadium toxicity.


Along with the studies of the toxic effects of vanadium, many investigators have been focused on the examination of potential medical applications of this mineral. These include antidiabetic or insulin-mimetic actions, antiviral effects, and anticarcinogenic activity. Among these effects, the antidiabetic action of vanadium complexes with organic ligands has been very intensively studied, which entered into stage II clinical trials. However, due to kidney problems in some patients, this study as an antidiabetic agent could not progress to the next phase of research. Indeed, the risks associated with vanadium intoxication such as vanadium-induced reactive oxygen species generation, adverse effects on the immune system, and a risk of mutagenesis are listed among the arguments against the antidiabetic application of vanadium. Reviews of the results of past and recent human studies on vanadium in diabetes have concluded that the use of vanadium compounds in oral diabetes therapy is misplaced.

USE OF CORTISOL 30 IN MANAGING THE CONDITIONS ASSOCIATED WITH METABOLIC SYNDROME

Homeopathic drug CORTISOL 30 contains Molecular imprints of the hormone cortisol. CORTISOL 30 is a great remedy for many ailments that are associated with Metabolic Syndrome.

Cortisol, also known as “stress hormone”, is a very important hormone produced mainly by the zona fasciculata of the adrenal cortex in the adrenal gland. It is produced in other tissues also in smaller quantities. It is released with a diurnal cycle and its release is increased in response to stress and low blood-glucose concentration. It functions to increase blood sugar through gluconeogenesis, to suppress the immune system, and to aid in the metabolism of fat, protein, and carbohydrates. It also decreases bone formation.

In general, cortisol stimulates the synthesis of ‘new’ glucose from non-carbohydrate sources. This is known as gluconeogenesis, mainly in the liver, and also in the kidneys and small intestine under certain circumstances. The net effect of cortisol is an increase in the concentration of glucose in the blood, further complemented by a decrease in the sensitivity of peripheral tissue to insulin, thus preventing this tissue from taking the glucose from the blood. Moreover, cortisol has a permissive effect on the actions of hormones that increase glucose production, such as glucagon and adrenaline.

Cortisol also plays an important, but indirect, role in liver and muscle glycogenolysis, the breaking down of glycogen to glucose.

Elevated levels of cortisol, if prolonged, can lead to proteolysis or breakdown of proteins, and muscle wasting. The reason for proteolysis is to provide the relevant tissue with ‘building blocks’ for gluconeogenesis. The effects of cortisol on lipid metabolism are more complicated since lipogenesis is observed in patients with chronic, raised circulating cortisol levels, although an acute increase in circulating cortisol promotes lipolysis. The usual explanation to account for this apparent discrepancy is that the raised blood glucose concentration through the action of cortisol will stimulate insulin release. Insulin stimulates lipogenesis, so this is an indirect consequence of the raised cortisol concentration in the blood but it will only occur over a longer time scale.

Metabolic syndrome or MetS is a cluster of common abnormalities arising from persistent high levels of cortisol in the blood. This Syndrome includes hyperglycemia, abdominal obesity, reduced high-density lipoprotein cholesterol levels, and elevated triglyceride and blood pressure. The common characteristics of MetS and hypercortisolemic conditions such as Cushing’s syndrome suggest that the pathogenesis of MetS and central obesity might involve prolonged and excessive exposure to cortisol.

Metabolic Syndrome was originally described as “insulin resistance syndrome”. The components of Metabolic Syndrome are associated with endothelial dysfunction and atherosclerosis and increase the risk for type 2 diabetes mellitus as well as vascular morbidity and mortality. It is estimated that about one fourth of the world’s adult population has Metabolic Syndrome.

Despite the increasing prevalence of MetS worldwide, there is still a lack of uniformly accepted diagnostic criteria, and there is controversy regarding the pathogenesis of MetS. Different organizations have provided their own definitions of MetS. MetS is diagnosed when three or more of the following parameters are present: waist circumference greater than 102 cm in men and greater than 88 cm in women, TG of at least 150 mg/dl (≥1.7 mmol/liter), HDL-C less than 40 mg/dl (<1.04 mmol/liter) in men and less than 50 mg/dl (<1.29 mmol/liter) in women, BP of at least 130/85 mm Hg, and fasting glucose of at least 110 mg/dl (≥6.1 mmol/liter).

It is unclear whether a single primary abnormality triggers a cascade of diverse events that lead to the manifestation of the components of MetS. Because the diagnostic features of MetS are shared by Cushing’s syndrome (CS), which results from endogenous or exogenous hypercortisolism, it was proposed that cortisol contributes to the pathogenesis of both states although only mild hypercortisolism occurs in MetS in contrast with CS. It was also suggested that inhibiting cortisol action could provide a novel therapeutic approach for MetS. Indeed, preliminary data suggest that circulating cortisol concentrations are higher in patients with MetS compared with healthy subjects, both in basal conditions and during dynamic stimulation. This difference is more evident in patients with MetS and hypertension or impaired glucose tolerance. Furthermore, weight loss normalizes cortisol levels and improves insulin resistance. Despite the fact that cortisol levels are within the normal range, there is evidence of increased activity of cortisol in the periphery and dysregulation of the hypothalamic-pituitary-adrenal axis. Differences between CS and MetS also need to be emphasized; in CS, once the tumor is removed, symptoms improve; in the MetS, weight loss reverses both hypercortisolism and phenotypic abnormalities.

Cortisol appears to play a role in adiposity in Metabolic Syndrome. Elevated serum uric acid levels are shared by MetS and CS Syndome. Increased exposure to cortisol contributes to increased fat accumulation in visceral deposits of fat. Increased cortisol serum overnight levels are also associated with insulin resistance.

Some studies showed elevated cortisol levels in situations such as work stress and unemployment. Others reported that chronic life stress results in subtle hyperactivity of HPA axis leading to intraabdominal adiposity and development of Metabolic Syndrome. Patients with Metabolic Syndrome appear to have higher urinary excretion of cortisol metabolites compared with healthy subjects. In vitro, cortisol appears to increase lipoprotein lipase or fat-storing enzyme levels in adipose tissue and particularly in visceral fat.

Experimental studies with cortisol inhibitors further support the role cortisol in the pathogenesis of Metabolic Syndrome, and might provide novel therapeutic approaches in patients with metabolic syndrome or obesity.

The components of Metabolic Syndrome are associated with endothelial dysfunction and atherosclerosis, and increase the risk for type 2 diabetes mellitus as well as vascular morbidity and mortality.

It was also suggested that inhibiting cortisol action could provide a novel therapeutic approach for Metabolic Syndrome. Indeed, preliminary data suggest that circulating cortisol concentrations are higher in patients with Metabolic Syndrome compared with healthy subjects, both in basal conditions and during dynamic stimulation. It was also proved that
reduction of body weight normalizes cortisol levels and improves insulin resistance.

Emerging data suggest that patients with MetS show hyperactivity of the hypothalamic-pituitary-adrenal axis, which leads to a state of “functional hypercortisolism.” The cause for this activation of the HPA axis remains uncertain but may be associated with chronic stress, which is associated with increased circulating cortisol levels and greater responsiveness of the HPA axis. Increased exposure to cortisol contributes to increased fat accumulation in visceral depots. Increased enzyme activity in adipose tissue and liver might contribute to the development of several features of the MetS.

Central abdominal obesity is one of the main components of the MetS. Cortisol appears to play a role in adiposity in MetS. Increased urinary cortisone/cortisol ratio in women with increased abdominal fat compared with those with peripheral fat distribution was observed by researchers, suggesting an increase in the peripheral metabolism of cortisol. Interestingly, cortisol clearance seems to be inversely correlated with insulin sensitivity, and this correlation is independent of body fat. It is also well documented that glucocorticoids promote the differentiation and proliferation of human adipocytes and that their receptors are more abundant in visceral than in subcutaneous adipose tissue. They also redistribute adiposity from peripheral to central depots, increase the size and number of fat cells, and activate lipolysis and the release of free fatty acids into the circulation.

Increased cortisol levels are also associated with insulin resistance. Higher cortisol concentrations were related to a reduced insulin secretion.

Hypertension is one of the most distinguishing features of Metabolic Syndrome as well as hypercortisolism. Many studies reported an association between cortisol and systolic and diastolic BP levels. This correlation might be attributed to the effect of stress, which is associated with the activation of the HPA axis and sympathetic nervous system. Indeed, patients with Metabolic Syndrome and hypertension appear to have higher urine levels of both cortisol and catecholamine metabolites than healthy individuals. A possible mechanism by which cortisol elevate BP seems to be an increased responsiveness to vasoconstrictors along with a decreased vasodilator production.

Obesity , a common finding in both CS and MetS, is also associated with hypertension. The possible underlying mechanisms include volume expansion, increased cardiac output and systemic vascular resistance, increased sodium reabsorption, increased activity of the sympathetic nervous system and the renin-angiotensin-aldosterone system, high leptin levels and concurrent leptin resistance.

Patients with Metabolic Syndrome as well as hypercortisolism frequently have elevated blood glucose levels. In patients with MetS, serum cortisol levels are significantly associated with fasting glucose concentration. The relationship between fasting hyperglycemia and cortisol is due to the glucocorticoid effects on hepatic gluconeogenesis and insulin secretion.

Metabolic Syndrome is associated with endothelial dysfunction that significantly predisposes to an increased risk for cardiovascular diseases. Endothelial dysfunction is also observed in patients with hypercortisolism. Hypercoagulability of blood is also present in MetS. Indeed, elevated fibrinogen and homocysteine concentrations have been observed in MetS patients compared with healthy controls. Hyperfibrinogenemia and homocysteinemia seem to be independent risk factors for cardiovascular diseases and venous thrombosis.

Elevated serum uric acid levels are seen both in Metabolic Syndrome and Hypercortisolism. High uric acid levels are regarded as a predictor of cardiac and overall mortality in patients with cardiovascular diseases or stroke. Elevated uric acid is also associated with higher risk of stroke in patients with or without cardiovascular disease. It was demonstrated that statin atorvastatin therapy is associated with a reduction in uric acid levels, along with an increase in estimated glomerular filtration rate in CKD patients with MetS. This effect on renal function is perhaps due to an amelioration of endothelial function and renal blood flow. On the other hand, patients with CS may have higher SUA and urinary uric acid excretion than healthy subjects.

Adipose tissue is recognized as an important endocrine organ that secretes a variety of bioactive peptides, termed adipokines. These adipokines exert multiple effects and play a key role in glucose and lipid metabolism, insulin sensitivity, BP, and angiogenesis. The major components of this family of adipokines are adiponectin and leptin, which are mainly produced by adipose tissue. Both these proteins exert an insulin-sensitizing effect through fatty-acid oxidation and, in addition, adiponectin is associated with antiatherogenic, antidiabetic, and antiinflammatory properties. In obesity, insulin resistance has been linked to leptin resistance, elevated leptin, and low adiponectin levels, which are associated with higher cardiovascular risk. Resistin is expressed in abdominal fat and is also associated with increased risk of central obesity-related diabetes. However, resistin may not be an “adipokine” because in humans it is mainly produced by monocytes, and its link with central obesity is debated. Excess adiposity leads to dysregulation of adipokine production, which in turn promotes a state of low-level systemic chronic inflammation predisposing to atherosclerosis.

Since molecular imprints of cortisol contained in cortisol 30 can act as artificial binding pockets for cortisol, it can antidote the adverse biological effects of excess cortisol circulated in the body. As such, cortisol 30 will be a powerful ingredient of Homeopathic Prescriptions in the management of all complaints associated with Metabolic Syndrome.

MIT VIDEOS

SIMILIMUM ULTRA SOFTWARE- SALIENT FEATURES AND USERGUIDE

A Complete Clinical Utility Software Package For Homoeopaths

Developed and Marketed by:
Fedarin Mialbs Private Limited,
Sreekandapuram, 670631
Kannur, Kerala, India.
Email: similimum@gmail.com www.fedarinmialbs.com
FOR MORE INFO:

D MUHAMMAD FASIL BHMS

+91 99953 82854

CUSTOMER’S HANDBOOK
Overview of Salient features:
SIMILIMUM ULTRA is a complete, user-friendly and state-of-the art Clinical Utility Software Package for Homoeopathic Practitioners, visibly outstanding by its simplicity and comprehensiveness among those currently available in the market. It is the final glorious outcome of more than 40 years of unrelenting learning and dedication of its author to the cause of Homoeopathy.
SIMILIMUM ULTRA is designed with such a flexibility and richness of contents and tools, that it adapts itself to meet the everyday changing requirements of any Homoeopath to set up and run a fully computerized clinical practice.
SIMILIMUM ULTRA– Sharp-shoot Homoeopathic Software is empowered with following essential practical modules such as :-
# Embedded Patient Management System:
# Most User-friendly Patient Management System– Provides a very simple and relaxed working environment, enabling even those homoepaths with minimum computer skills to use it with ease for their day to day clinical management.
# New Patient Registration is very simple. Only minimum entries required. Start work instantly.
# Unregistered Cases- Cases can also be worked upon without registering the patient, with options for registering later.
# Paitient Register is the functional homepage for clinical work. Unlimited in storage capacity
# Backup and Restore– safe and easily retrievable backups, without any fear of loss of data even if system crashes. Every time you exit the software, you are promptly reminded to make back-ups (optional). In case you re-install the software, all your previous data will be restored by a single mouse-click.
# Search Patients alphabetically, number-wise, diagnosis-wise or using in-built calender tools.
# Case Records- Very user-friendly platform for maintaining patient-wise consultation records, prescriptions and follow-up details.
# Case Taking can be done either in classical schematic format, Key Note Method, Recombinant Method or using scribbling pad.
# Case Taking Forms- Optional for detailed classical schematic case taking. Print options available for case taking forms.
# Record Symptoms, without much typing, by extracting exact repertorial rubrics into the consultation window, simultaneous with interrogation of the patient.
# Case History of a patient may be viewed in a single window, with print options.
# Consultations– Innovative consultation interface, with separate fields for symptoms and prescriptions on same window. Date-wise, and ‘backward-forward’ tools for navigation between different consultations.
# Reference Trays- appended to each case record. All works related with a particular patient, such as repertorisation results, materia medica searches, notes etc can be saved in in this handy tray. Print options.
# Diagnosis– Select and add diagnosis of your patient from list of diseases
# Prescriptions can be created simply by importing drug names and potencies from your drug list. Directions for use also can be added, without any typing
# Print options are available for prscriptions, as chits to pharmacist, or detailed prescriptions in the letter-head of the doctor.
# Drug List- Search and view the drugs and potencies available in your stock, and add to prescriptions. Drug list can be edited and up-dated.
# 4 major Repertories – Kent, Boenninghaussen, Boericke, Boger- empowered with multiple ‘Rubric Search’ tools. Repertories are displayed as exact ‘scroll-and-read’ text pages of original books. Rubrics can be added to rubric basket and case record, book-marked or exported to reference trays. You will be convinced that it is not the number of repertories, but the tools and the ways they are used, that matter in homeopathic practice. As some body have put it correctly, “if you really know how to take case and repertorize, you can even work out any case successfully with only the ‘mind’ and ‘generalities’ of Kent Repertory. If you have not mastered the real art of case taking and repertorization, no bulky bundles of ‘modern’ repertories and sofisticated costly softwares can save you”. Note this point.
# Powefull Rubric Search– Any rubric in any repertory can be located within split-seconds, using single or multiple ‘key-word search’. Search results can be saved into special folders for future use, if desired’.
# Rubric Basket– to collect and display selected rubrics along with their drugs. From here, rubrics can be transferred to Case Record, Work Sheet, or used for QuickPick repertorization. Print options available
# QuickPick– Simple and flexible Expert Tool inked to Rubric Basket, for instant repertorization during busy practice. Eliminate drugs step by step using selected rubrics, and find your similimum at fingertips within seconds .
# 25 Customized Repertories- Clinically important selected rubrics from major repertories are customized into special groups. Can be used as specialized repertories.
# Work Sheet– An innovative platform for for pre-repertorization preparation such as combining and grading and re-arranging of rubrics, for ensuring better output.
# Combine Similar Rubrics- Advanced options for selecting similar rubrics, even from different repertories and combining to form a single rubric, thereby incorporating all probable drugs, same time avoiding the chances of repitition and over representation. An important tool to minimize errors in repertorization.
# Combine with Upper Level Rubrics– Lower level particular rubrics can be combined with their upper level general rubrics, and converted into single rubric, while extracting from repertories, to ensure correct repertorization resuts, by avoiding undue over-representation of same drug.
# Grade Rubrics– Innovative tool for detailed classical grading of rubrics into uncommon, common, generals, mentals, physicals, particulars and so on, to ensure perfect repertorization results. Weightage marks automatically assigned according to the grades of rubrics.
# Innovative Repertorisation Methods: SIMILIMUM ULTRA offers a very rich and flexible repertorization tool box, containing diverse repertorization strategies and protocols. User can select any or multiples of the following repartorization methods, most appropriate to his taste and the peculiarities of the case in hand.
# Totality Method: Find similimum by classical totality method, using any of the protocols such as Using all Symptoms, Using Selected Symptoms, Using Uncommon Symptoms, Using Uncommon Mentals, Using Uncommon Physical Generals Etc. Options for adding weightage marks assigned according to grades of symptoms. Result can be displayed and saved as charts, and summary could be exported to Reference Tray of the patient.
# Elimination Method: Elimination method also can be done using any of the protocols such as Using all Symptoms, Using Selected Symptoms, Using Uncommon Symptoms, Using Uncommon Mentals, Using Uncommon Physical Generals Etc. The most efficient way of reaching a single remedy, through step-by-step elimination of drugs using the selected symptoms.
# Combined Method: This is a revolutionary innovation from similimum team. Hailed by prominent masters of repertorization. Totality Method and Elimination method are combined into a single strategy, thereby effectively avoiding the inherent weaknesses of both methods. The result will be exact similimum. The art of repertorization is finally evolving into perfection!
# Compartmental Method: For those who use multiple drugs for their patients. Makes their way of prescribing more systematic and rational. Symptoms can be compartmentalized into different groups, and repertorized that way. Let us have a try!
# Shoot-out Method: From a comprehensive list of drugs, shoot-out step-by-step, using selected rubrics, until a single drug remain alive. A funny way of finding similimum. Repertorization becomes a real, intelligent game!
# Punch Card Method: Here is the user-friendly digital version of the time-tested PunchCard repertorization. Select the rubrics, instantly prepare punch cards, and repertorize. See the difference!
# Brick Column Method: Rubrics are represented by bricks, colored according to grades. Build columns of bricks against each drug, and the most towering column will represent the similimum. Very beautiful graphic interface and handy tools.
# Reverse Gear Method: A platform for analyzing and comparing the results of different methods of repertorization, for final selection of similimum.
# Re-combinant Method: Digital version of Bonninhausen’s method of case-taking and repertorization. This platform is by itself, of more worth than this whole software!
# Repertorisation results can be saved or extracted to Reference Trays. Can be printed as charts.
# Multiple Repertorisation Protocols- Optional Protocols for all methods of repertorizations
# Re-combinant strategy- of case taking and finding similimum based on Boenninghaussen’s principles.
# Materia Medica– 20 important Materia Medica works in full text, in easily readable interfaces, with key word search and bookmarking options. Options to extract selected text into NoteBooks or Reference Trays. (Hahnemann, Kent, Boericke, Boger, Nash, Clarke, H.C.Allen, T.F.Allen, Guernsy, Lippe, Anshutz, Hering, Cowperthwaite Etc., Etc).
# Synthetic Materia Medica: A wonderful, imaginative and authoritative materia medica study material, synthesized through drug-wise and chapter-wise re-arranging of rubrics of Kent Repartory. This monumental work by itself constitutes more than 20000 thousand printable pages. Tools for comparative study of drugs and rubrics also provided.
# Book Shelf- Containing a huge bundle of clinically important philosophical and therapeutic Reference Books, with key-word search and book-marking tools. Options to extract selected text into NoteBooks or Reference Trays. (Major works of T.F. Allen, C.M. Boger, John Patterson, J.H. Clarke, D.M. Borland, S. Hahnemann, J.T. Kent, W. A. Dewey, H.R. Arndt, Margerette Tylor, E. B. Nash, H. A. Roberts, Karl Robinson, Stuart M. Close, Hutchison, P. F. Curie, Talcott, T. L. Bradford, G.I. Bidwel Etc.Etc.)
# Clinical Utilities– Highly helpful in successful day to day clinical work. Following Clinical Utilities are available. May be customized anytime by users, incorporating new data.
# Normal Clinical values: Normal values of various Body Fluids, Cerebrospinal Fluids, Chemical Constituents of Blood, Function Tests, Metabolic, Endocrine, Renal, Haematologic Values, Stool, Urine, Lipid Profile, Leucocyte Differentials Etc.
# Height-Weight tables: Detailed Height-Weight table of infants, girls, boys, women and men.
# Laboratory Tests: Details of Indications, Test methods, Physiology, Normal Range and Interpretation of various laboratory tests belonging to categories such as Biochemistry, Haematology, Immunology, Microbiology, Hormone Tests, Sputum Tests Etc.
# Clinical Relationships: Table of Clinical Relationships of important homeopathic drugs, such as Complementary, Antagonistic, Durations of action Etc.
# Constitutional Symptoms of Drugs: Constitutional symptom pictures of major drugs, compiled from major materia medica works. Very useful for constitutional analysis and prescriptions.
# Diagnostic Tables: Various Diagnostic tables and charts from Practice of Medicine, containing valuable information helpful in the process of disease diagnosis.
# Prophylactics: Time tested homeopathic prophylactics against various diseases
# Homoeopathic Specifics: A wonderful tool for successful day to day clinical practice. Specific uses of homeopathic drugs with recommended potencies. Collected from works of great masters of homeopathic therapeutics.
#;External Applications: External uses of various homeopathic drugs, with detailed guidelines for preparing and using external applications.
# Mother Tinctures : A reliable practical guide to mother tincture therapeutics in various clinical presentations.
# Stationaries and Registers-
# Stock Register of Drugs: Maintain Stock Register of drugs and potencies available in your pharmacy. Instantly verify the availablity of drugs before making a prescription.
# Purchase Order Forms: Prepare and print purchase orders of drugs with potencies, without typing. Add to purchase list whenever your stock of a particular drug seems to exhaust.
# Medical Certificates: Form for preparing and printing medical certificates to be issued.
# Fitness Certificates: Form for preparing and printing fitness certificates for your patients.
# Letter Pads: Prepare, print or save letters and prescriptions in the user’s letter heads. Select or change fonts and colors of the letters to make them appealing.
# Bills and Vouchers: Prepare and print vouchers and bills related with your daily transactions.
# Personal Organizer– A complete, built-in Personal Organizer, with reminders of appointments, to register and manage various day-to-day appoitments during busy practice. Effectively plan and organize not only your clinical practice, but your whole days and years!
# Analysis of Clinical Performance- Tool for periodically evaluating and comparing patient turn-up in the clinic to identify deficiencies and take remedial actions.
# Ready Reckoners– 31 wonderful clinical compilations from Boericke Materia Medica, highly helpful in making instant prescriptions for various pathologic conditions.
# Note Book- An important platform with versatile utility. Selected portions of texts from Materia Medica, Repertories and Reference Books can be exported to NoteBook, edited and saved in special folders. Articles available from internet or other digital media also may be imported and saved here. Print options available. Handy tool to scribble down anything and everything. Its utility is limited only by the horizons of one’s imagination.
# List of Diseases- Prepare a customized list of diseases. Add diagnosis to each case from this list. Then search and group your patients according to disease category.
# On-screen Tips- An innovative learning tool. Even while sitting idle in front of your computer, you will be in the process of learning. Selected quotes, texts and clinical tips may be added to this platform, and viewed on the desktop as flash text displays. For an imaginative user, this platform offers a wonderful learning experience.

HOW TO USE SIMILIMUM ULTRA

Enter Similimum :
SIMILIMUMULTRA should be installed on your computer first, directions for which are given on the CD cover of the product. To start working, click ‘Similimum’ icon on desktop. Homepage appears. Click ‘Enter Similimum’ button to open ‘PATIENT REGISTER’. This is the functional homepage for your work. List of Patients will be displayed here. Name of Clinic will be shown at the headline of this page. You can navigate to all other modules and open various platforms and tools from window.
Registering New Patient:
Registering a new patient is very simple and less time consuming when compared to ther similar software products. Click ‘New Patient’ icon on the main tool bar. Or, click ‘Show’ on menu bar, and, from the drop-down list, select ‘Patient Registration window’. A Patient Registration window appears. Only ‘Name’ and ‘Age’ are mandatory. Other entries are optional. Patient details can be later edited from ‘Case Record’ window any time. Enter Name, Age, and select ‘Male/Female’. Click ‘OK’. Name of new patient appears displayed at the bottom of ‘Patient List’.
Un-registered cases:
To work up on a case without registering first, click ‘ Unregistered case’ button on the main tool bar. Or, click ‘Show’ on menu bar, and from drop down menu, select ‘Repertory’. A window appears, where all the Repertories are displayed, along with tools. You can Search Rubrics, Repertorise and find your similimum here. When exiting, you will be asked to confirm whether to save the case. If you want to save, opt for it. ‘New patient’ Registration window will appear. Make necessary entries, and click ‘OK’. Your patient will be registered into your ‘Patients Register’. Since many tools may not be available in unregistered cases, it is advised to make a habit of registering the patient first.
Searching Patient Register:
Patients included in the ‘Patients List’ may be located by using search tools provided at the top of this list. Enter Register Number of the patient in the search box and press ‘ENTER’. Patient will be selected. Pressing ‘ENTER’ once again, you can open the ‘Case Record’ of the selected patient. Patient may be located by typing his name in the search box, or using the inbuilt Calender. Patients may be searched Diagnosis-wise, if you have already entered the diagnosis in prescribed way.
Refresh’ or ‘Delete’:
These two buttons are provided at the bottom of ‘Patients List’. To remove the whole records of a particular patient from the ‘Patient Register’, select his name and click ‘Delete’. ‘Refresh’ button can be used to refresh and return to the complete patitent list from the search list.
Case Records:
To open Case Record of a particular patient, first locate and select the patient in the ‘Patient register’. Then double click on the name of the patient, or click ‘Case Record’ icon in the toolbar, or press ‘Enter’ button of the key board. Case record of the selected patient appears instantly.
Name, Register Number and present age of the patient will be displayed on the headline of ‘Case Record’. Please note that the age of the patient is automatically updated periodically.
Over and above the main tool bar on the top of the window, extra tools are provided on the additional tool bar in the middle line of case record window, for various operations like editing patient details, opening case recording form, opening reference tray, opening existing work sheet, opening rubric basket, Quick Pick Tool, Recombinant Method, open Repertories, search Repertories, open drop-down list of consultations, backward-forward navigation buttons, open Case Hisory, open Drug List, Print Options, Save, Delete etc.
The main part of case record window is separate bilateral panels for recording ‘Symptoms’ and ‘Prescriptions’ for consultations and follow-ups.
To return to ‘Patient List’ from case record, click ‘Patient List’ button on toolbar, or, click ‘show’ on menu bar, and from the drop-down list, select ‘Patient List’.
Editing Patient Details:
The peraonal details regarding a particular patient can be edited and modified any time using ‘Edit Personal Details’ button on the case record window. After making necessary entries, save and return to Consultation page.
Case History:
Case history of the selected patient can be viewed in a single window if desired, by clicking ‘Case history’ button on the additional tool bar of case record. A complete printout of case history can be taken from here, if required.
Navigating Consultations:
Navigation buttons, ‘First consultation’, Present consultation’, ‘Backward’, ‘Forward’ etc. are provided to enable navigation thrugh consultation history of the selectd patient. Further, a drop-down list of consultations is provided to enable quick navigation between different consultations.
Carry Forward:
To carry forward text from ‘symptoms’ and ‘prescriptions’ panels from a previous consultations to present consultation, select the text to be carried forward. A button ’Carry Forward’ become actvated. Press. The selected text will be transferred to present consultation. This tool may reduce the need for much typing.
Prescriptions:
Prescriptions may be created by typing down in the field named ‘Prescriptions’, or, simply by selecting ‘Drug names’ and ‘Potencies’ from ‘Drug list’ provided, as described below.
Dispensing Directions:
Customised ‘directions’ for dispensing and using drugs can also be created in the Drug list, and exported when necessary to prescriptions, so as to completely avoid any typing work in prescriptions.
Drug List:
List of drugs can be opened by clicking ‘DrugList’ button on the additional toolbar on the case record window. A list of drugs and various potencies are provided here. Options are available to add or delete drugs or potencies from this list. Drug names and potencies can be selected and exported to prescriptions. Specific directions for dispensing may also be created and added to this drug list
Printing Options:
If a printer is made available in the Pharmacy, prescriptions can be instantly printed there, using ‘print’ button on the additional tool bar. This may reduce much human labour required in the clinic. If ‘Chit’ option is selected, the printout will be a small chit to the pharmacist, containing only the name and register number of the patient, along with body of prescription. If ‘detailed prescription’ option is selected, print-out will be in the letter head of the clinic, with all necessary details. OP cards, Appointment cards, Medical certificates etc. also can be printed using this tool.

Save or Delete Consultations:

Particular onsultation of a patient day can be deleted from his case history, using ‘delete’ button on additioanal tool bar. Use ‘save’ button to save changes while navigating away from the consultation window.
Interpolating Consultaions:
Since the maintaining of case records is linked to in-built computer calender, it may be difficult to interpolate consultations in between previously recorded dates. However, in unavoidable special circumstances, change the computer calender from the task bar to a required previous date, re-start similimum ultra, make necessary entries, save, and again change the computer calender to present date.
Case Taking:
Case taking can be done in different ways using SIMILIMUMULTRA. This flexibility makes it adaptable to any clinical method followed by the practitioners.
Classical Method:
This method is ideal for recording chronic diaseases, especially having large number of complex symptoms involving various regions of the body, and with marked mental and physical generals and modalities. A systematic case recording may be necessary in such cases. If the doctor desires to maintain a case record in the classical schematic model, in patient’s own words, this method will be most suitable. Open ‘Case Recording Form” by clicking the button provided on the ‘CaseRecord’ window. In the ‘Case taking Form’ we can see two panels. Appropriate regions of body can be opened by clicking tabs in the left panel. Type down the Presenting complaints and detailed regional symptoms in patients own words, in this form.
A Printout can be taken if required. The main draw back of this method is that it involves much typing work.
Scribbling Method:
In simple acute cases,where a detailed and systematic case recording and work-out is not essential, we can simply scribble down important symptoms only in the ‘Symptoms’ field provided in the ‘Case Record’ window. In the regular follow ups of existing cases also, this scribbling method is very useful for recording progress reports. Then record your prescriptions on “ prescriptions’ tab.
Search-and-add Rubric’ Method:
This is a very simple and efficient way of case recording, especially for busy practitioners, who have no time and inclination to type down complete case history, but desires a full case taking. Typing work is very nominal in this method. Symptoms are recorded not in patients own words, but as exact repertorial rubrics. Much time and labour is saved, without compromising quality and acuuracy of outcome.
To record cases using this method, open ‘Search Repertory’ tool from ‘Case Record’ window. Select the preferred Repertory from drop-down list. Simultaneous with interrogation of the patient, type down one or more key words that are expected to be part of the repertorial rubric appropriate for the symptom the patient is elaborating. Click ‘Go’ or press ‘Enter’. A list of all rubrics from all chapters of the selected repertory, containing the selected key words will be displayed instantly. Scrolling through this rubric list, select the appropriate rubric for your symptom and click ‘Add to Basket’. Repeat this process for all the important symptoms described by the patient. A fter case taking is over, click “Rubric Basket’ icon above the ‘symptoms’ field to open the ‘Rubric Basket’. A complete list of rubrics already added, along with their drug lists are displayed in the ‘rubric basket’. You can ‘delete’ unwanted rubrics from here. Then click “ Add to Case record’ . All the rubrics are instantly transferred to ‘symptoms’ panel of Case Record.
Case Taking is now complete! You have not even bothered about opening your Repertories, and looking for chapters and Rubrics!
Re-Combinant Strategy:
In this innovative method, case taking and repertorisation are done on an entirely different creative platform called ‘Re-Combinant Method’, available in SIMILIMUMULTRA only. Open ‘Recombinant Method’ by clicking button on the additional tool bar. A new window opens. From this window, go to ‘open repertoy’ or ‘search repertories’, using appropriate buttons on the bottom of this window. Locate the exact rubrics . When adding rubrics, select appropriate categories from the pop-up list. Rubrics will be automatically added to the selected categories under ‘Primary Components’, ‘Secondary Components’ and ‘Tertiary Components’. When a particular ‘symptom complex’ is completely recorded, with its locations, sensations, modalities, concomitants etc, lick ‘Repertorisation’ button. All the added rubrics will be listed for repertorisation. Carefully select the eliminating symptoms one by one from the list, until we get a similimum for that particular symptom complex. Then enter a name for the symptom complex, and click ‘save’. If there is another symptom complex in the same patient to be considered, record the details again in a new window, repertorise and save under an appropriate new name. Later, these different symptom complexes can be opened using the ‘Open’ button, and selecting the name of symptom complex. Remember that we are recording and repertorising the totality of each major symptom complex separately, and we may get more than one similimum. In this innovative method, the cocept of ‘Totality of Symptoms’ means ‘Totality of diverse aspects of Individual Symptom Complexes’, not ‘Totality of all Symptoms’ exhibited by the patient. Try to understand the underlying philosophy and rationale well, before utilising this ‘Recombinant Strategy’.
The concept of symptom complex has to be explained and understood well here. It is a group of inter-related constituent symptoms. For example, a throbbing headache on right forehead, aggravated during menses, aggravated by exposure to sun, ameliorated by vomiting and sleep, accompanied by frequent yawning is a group of constituent symptoms, forming a symptom complex. In order to repertorise, we have to first deconstruct this symptom complex into following individual constituents:- Throbbing pain (Sensation), Forehead (Location), Menses during (Aggravation), Sun exposure to (Aggravation), Vomiting (Amelioration), Sleep (Amelioration), Yawning ( Concomittant) . A drug that covers these constituent symptoms will be the similimum for that particular case of headache.
Deconstructing symptom complexes into constituent symptoms, and then re-combining through repertorisational process to find a similimum- this is the fundamental principle of ReCombinant Strategy. This method is most useful in dealing with acute diseases and wellmarked pathologic conditions.
Key-Note Method:-
May be called ‘Expert Thumb-index Method’ of finding similimum. Fish out a single, charecteristic ‘Key-Note’ or ‘pivotal’ symptom during interogation of the patient, search for an apprpriate rubric for it in your favourite repertory, using multiple keywords on ‘Search Repertory’ window. From the Listof Rubrics thus displayed, locate and select the exact rubric and click ‘Show in Repertory’. The specific part of repertory is opened instantly, and you will see the selected rubric and its drugs displayed there. Select it, right click, and “ Add to Reference Tray”. Close windows, return to case record. Open ‘Reference Tray’. From a small group of drugs for the particular key-note symptom, it will not be difficult for an expereinced and intelligent doctor to select the exact similimum for his case with in seconds, through a comparison and weeding out process. If desired, copy it from ‘reference tray’ and paste in the ‘symptoms’ field of ‘case record’ for easy viewing and future reference. Work is done!
Search Repertory Tool:
‘Search Repertory’ Tool can be used to search appropriate rubrics from repertories using single or multiple key words. This tool can be opened from tool bar on the repertory page, or clicking ‘Search Repertory’ button in the additional tool bar on the ‘case record’ window. A ‘search repertory window’ window pops up, in which there is a drop-down list of repertories. Select the repertory you want to search. In the ‘search’ text box type down key words or parts of key words, expected to be part of rubric you are looking for. When using multiple key words, they should be separated by single space. If search is to be done using any of the key words, tick the ‘select any ‘ selection box. Click ‘GO’ or press ‘ENTER’.
All the rubrics in the selected repertory, containing your keywords will be instantly displayed. You can reduce the size of list by using multiple keywords. If you cannot locate the exact rubric you are looking for, refine your search by changing keywords, or selecting another repertory.
Now locate and select the exact rubric from the displayed list, click ‘add to basket’ button. The selected rubric , along with its list of drugs will be instantly exported to ‘Rubric Basket’, a temporary collection basket for rubrics. This basket may be viewed by clicking the ‘rubric basket’ button on the additional tool bar, or repertory window.
If you want to view the rubric and its drugs in the repertory itself, click ‘show in repertory’ button. The specfic chapter of the repertory containing selected rubric opens instantly. You can add rubrics to ‘rubric basket’ from this window also. You can save the search results if desired into a separate folder, using ‘save results’ button for using later. Use ‘open’ button to read these saved files.
Using Repertories:
Kent, Boericke, Boenninghaussen and Boger are the repertories included in this package. Repertories are given as the exact printed text pages of books. Repertories may be opened from ‘unregistered’ button for unregistered cases, or using ‘open repertory’ button in the additional tool bar of idividual case records. Another way is from menu bar > show > repertory.
Repertories main window contains a menu bar and a tool bar. Individual repertories and chapters may be opened by clicking appropriate icons on the tool bar, and selecting required chapters from the drop-down list. Chapters are listed in alphabetical order for easy selection.
Selected chapter of repertory is opened. Repertory pages are displayed in two panels. Left panel contains list of main rubrics in the chapter. ‘plus’ sign indicates a tree structure, from which we can go to the sub rubrics. When any rubric in left panel is selected, its drug list appears on right panel, and is automatically selected. Using ‘add to basket’ button on the lower right corner, the selected rubric and its drug list can be exported to ‘rubric basket’.
To make locating the appropriate rubrics fast and easy, there is also an additional text box selection tool for ‘main rubric’ and its ‘subrubrics’. While typing text in this text boxes, rubrics will be appearing as drop-down list, from which we can select the rubrics.
You can see two optional buttons on the bottom of repertory page: ‘add’- ‘selected rubric only’/ ‘rubric with upper level rubrics’. We can use either of the options. If ‘selected rubric only’ option is selected, the selected rubric and its drugs will be exported to ‘rubric basket’. If ‘add with upper levl rubrics’ option is selected, the selected rubric will be combined with its upper level rubrics and converted into a single rubric, while adding to the rubric basket. Remember, this simple tool has a very important role in ensuring a correct repertorisation results. It avoids the chances of over representation of same drug , that may happen if we add both upper and lower level rubrics separately.
Select a particular portion of text in the repertory, and right-click over it. Using the dropdown options, we can copy the text to a ‘note book’, ‘add to the reference tray’ attached to the case record of particular patient, or ‘book mark’.
There is button ‘drug list’ on the tool bar of repertory window. It can be used to clear any confusion regarding the real name of drugs, because only abbreviations are provided in the repertories.
Customized Repertories:
There are 25 customized repertories in this package, which may be used to locate rubrics belonging to specific groups. These may be opened from menu bar on the repertory window, or using icon on the tool bar. Rubrics can be located and added to referene tray, or rubric basket as required. Using ‘locate in repertory’ button, we can view the selected rubric directly in the repertory page.
Use the ‘case record’ button on the tool bar to return to ‘case record’, or, ‘show > case record’ from menu bar.
Rubric Basket:
Rubric basket is a very important platform for clinical work. It is a temporary collection box, in which selected rubrics and drug lists are stored temporarily. To view rubric basket, click ‘rubric basket’ button on additional tool bar in the ‘case record’ window, or in the main tool bar of ‘Repertory’ window.
Rubric basket appears as a small pop-up window, with buttons for various important tools. Rubrics already added to it will be listed numberwise, with their drug lists.
Unwanted rubrics an be selected and deleted from the list using ‘delete’ button. All the contents may be removed using ‘ clear’ button. A printout of the rubric basket can be taken using ‘print’ button.‘Hide’ button can be used to temporarily hide rubric basket to the background.
Rubrics listed in the rubric basket can be exported to the ‘symptoms’ field of ‘case record’ by clicking ‘ add to case record’ button. This tool is very useful for avoiding typing of symptoms in the case record. It saves much time and labour.
Use ‘add to work sheet’ button to export the rubrics to a pre-repertorisation preparatory platform. Especaially for cases requiring classical mode of repertorisations, this step is very important. Work sheet appears instantly, which may be closed if you are not repertorising right now. It can be opened later by using ‘ worksheet’ button on the additional tool bar of case record window. This button will be activated only if the work sheet contains some rubrics.
There is a quick pick button on the rubric basket window. This button will open a very important platform useful in day to day practice. Quick pick tool can be opened from case record window using ‘quick pick button’ provided there.
Quick Pick:
Quick Pick is a very useful expert tool to find similimum instantly by elimination method, during busy clinical practice
Click ‘Quick Pick’ button from ‘rubric basket’ or ‘case record’. A new window pops-up. All the rubrics added to the rubric basket are listed selection boxes in the upper panel with of the new window. Select the most important eliminating rubric first. List of drugs covered by that rubric is displayed in the lower panel. Then select the second eliminating symptom. Now, only the drugs covered by both rubrics are displayed. In this way, eliminate systematically, until we reach a single drug , covered by all eliminating rubrics. This will be the similimum for the case. Utmost care should be employed in the selection of eliminating rubrics and their sequences, to ensure correct output. Never do it mechanically.
When elimination has given a satisfactory output, click ‘add to reference tray’ button. The result of quick pick method will be saved into the reference tray attached to the case record of the particular patient.
We can return to ‘Rubric basket’ by clicking ‘view basket’ button whenever necessary.
Work Sheet:
Open Work sheet using ‘Worksheet’ button on the additional tool bar of ‘Case record’, or from the tool bar on the repertory window.
All the rubrics exported to worksheet from rubric basket will be listed in the upper panel of this window.
Pre-repertorisation preparatory works are done here. Now you can delete any unwanted rubric from the list by selecting it and using ‘delete’ button. If it is felt that a few more additional rubrics are required, go to repertory window using the ‘repertory’ button and add new rubrics through rubric basket.
Combining Similar Rubrics:
Combining rubrics is a very important tool that may help to ensure correct repertorisation output. Similar rubrics can be combined into a single rubric using this tool. We can take any number of similar rubrics from same repertory , or different repertories, and combine them. This will help to incorporate maximum number of probable drugs for repertorisation, same time avoiding the possibility of over-representation of same drug. This wil be a major contribution in the process of finding correct similimum.
Click ‘combine rubric’ button on the tool bar. A new window pops-up, with all rubrics listed with selection boxes. Select the rubrics to be combined and click ‘combine’ . The selected rubrics are combined into a single rubric. If desired, it can be split into original form by clicking ‘split’.
Then click ‘OK’ to close and return to ‘worksheet’.
Grading Rubric:
This is a highly appreciated innovation of SIMILIMUMULTRA. Instead of the subjective assigning of marks or selecting intensity of rubrics seen in other similar softwares, we provide a very scientific, principled and objective method of grading rubrics.
Select a rubric from the list, click ‘Grade Rubric’ button. A pop-up window appears. Then select whether it is an ‘Uncommon’ symptom or ‘Common symptom’. Then select whether it is a ‘’General’ symptom or ‘Particular’ symptom. If it is a ‘General’ symptom, select whether ‘Mental’ or Physical.’ Grading further downline is optional. Click ‘OK’ . The graded rubric is transferred to the lower panel. Repeat the process with each rubric, until all rubrics are transferred to lower panel. We can modify the grading later, if required.
After grading is over, click ‘Re-arrange’ button. Now the rubrics will be re-arranged in such a way that uncommon mentals comes at the topmost position, and common particulars comes at the lowest position. Computer assigns weightage marks for each rubric , according to the grade we have selected.
These Weightage marks can be added to the Repartorisation marks at the time of repertorisation.
Repertorisation Methods:
When the grading of rubrics is completed, and rubrics rearranged accordingly, we are ready for repertorisation. Click ‘Repertorise’ button. Repertorisation window appears.
Tool bar of this window provides tools for various innovative methods of repertorisation.
Select Protocol:
When opening various Repertorisation methods, you will see a ‘Select Protocol’ window pop up. This tool provides options to use the particular repertorisation method with different priorities. A Homoeopath can use this tool with great imagination and creative flexibility, to find an exact similimum for his case. Try same repertorisation method with different protocol options and see the difference in output.
Totality Method:
Click ‘Totality’ button to repertorise in the classical ‘Totality Method’. Protocol selection window pops up. Select an appropriate protocol from the list. Select ‘ Weightage marks’ option if desired. Click OK. The result appears as a chart. Use ‘Save’ button on the tool bar to save the chart. Abstract of result can be saved in the ‘Reference Tray’. Protocol for repertorisation may be changed using ‘Protocol’ button. In order to use ‘Totality Method’ with maximum flexibility and creativity, it will be ideal to select ‘ With selected Symptoms’ Protocol.
Elimination Method:
Click ‘Elimination Method’ button on tool bar. Protocol selection window appears. Select ‘Selected symptoms’ protocol. A window appears with all the selected rubrics displayed in it. Decide the first eliminating rubric and tick inside its check box . List of drugs covered by that rubric will appear. Then tick next eliminating rubric. Repeat this proces until similimum is obtained.
Remember, if the grading of rubrics was correct, we can safely eliminate in the same order of rubrics showen in the list. Save, and export the abstract into ‘Reference Tray’. Elimination may be tried using other protocols also.
Combined Method:
‘Combined method’ is an innovation of SIMILIMUMULTRA. This method was designed to overcome the deficiencies of ‘Totality Method’ and ‘Elimination Method’. In the Totality method, if the number of coommon symptoms and particulars are high, the result may not be reliable.
Whereas in the Elimination method, there is no way to verify whether the drug resulting after elimination covers the remaining symptoms also.
In the ‘Combined Method’, both elimination and totality are done simultaneously in the same window. Hence we can verify rhe totality picture of drugs remaining after elimination. ‘Combined Method’ has been already hailed by the experts in repertorisation as the most scientific and reliable method.
Compartmental Method:
Compartmental Method is a novel repertorisation tool introduced by SIMILIMUMULTRA. We are conscious about the chances of being labelled it as a deviation from classical homoeopathy. It is a platform expected to be useful for those who prescribe multiple drugs for their patients. Here, we compartmentalise symptoms into various groups before repertorisation. Each group is repertorised separately, probably leading to different similimum for each group.
For example, Constitutional Symptoms may be grouped into one group, Head symptoms into another group, and abdominal symptoms into yet another group, thereby prescribing different drugs for each group. The philosophical validity of this method can be questioned, but it may be useful to at least some homoeopaths.
Click ‘Compartmental’ button on tool bar. A new window popus up, with all rubrics listed in the upper panel. Decide the groups to be made, and which symptoms are to be inctluded in each group. Select a symptom to be included in the first group, and click ‘add’ button. The selected rubric now appears in lower panel. Then click each symptom one by one and add to this group. When all the symptoms belonging to first group ared added, click ‘Save”. Assign a name to this group and click ‘OK’. Then click ‘New’ to create second group. Add rubrics as before, and save. Repeat this process until all groups are created. Now open the drop-down list of groups you have created by clicking on downward the arrow on ‘Compartments’. From this drop-down list, select the group for repertorisation and click ‘OK’. Repertorisation results will appear as a chart. If you want, a ‘Totality Method using selected rubrics’ repertorisation also can be done here. Add the absract to ‘Reference Tray’. Click ‘Compartments’ button to return to ‘Compartments’ page. Select next group, and repertorise. In this way repertorise all groups. Close and return to ‘Case Record’. Consult Reference Tray, and decide the prescription.
Shoot out Method:
This method is a reverse variant of ‘Elimination Method’. To open, click ‘Shoot out’ button on tool bar. It will be ideal to select ‘Selected symptoms’ as protocol. Click ‘OK’. A new window opens, with all rubrics in upper panel, and list of probable drugs in lower panel. Then ticking the check box of each rubric, you can shoot out drugs progressively, until a similimum remains. Export to ‘Reference tray’
Punch Card Method:
In fact, this is a digital translation of old ‘Punch Card Repertorisation’. To open, click ‘Punch card Method’ button on tool bar. A new window appears, with all rubrics listed. Select ‘all symptoms’ option and click ‘OK’. ‘Select Card’ window opens. Click ‘Selected Symptoms’ option, and select the cards you want to use, by ticking the check boxes. Click ‘Show Punch Cards’. All the selected cards appears, arranged one over other, with holes representing drugs on each card. Each card will have a numbered tag. There is a card holder, into which you can drag cards. You can replace cards by right cilicking the card in the card holder, and dragging over the cards. Names of drugs covering all selected symptoms willl be seen as a bright hole. You can select similimum, exactly the same way you did it using real punch cards.
Brick Column Method:
This is another graphic method of repertorisation. Click the appropriate button and select protocol. ‘Selected Symptoms’ protocol will be more ideal, since it provides freedom to experiment. A new window opens, with rubrics listed with serial numbers in the lower panel. ‘Show Grading’ can be used to the grades of each rubric. Now, select the rubrics you want to use for repertorisation, by ticking check boxes. A row of columns of colored and numbered bicks will build up in the upper panel. Each brick represents a particular rubric. Each brick is numbered with the serial number of the rubric it represents. Color of brick shows shows the mark assigned for each drug in the repertories. Red color represents 3 marks, blue color 2 morks, and black color 1 mark. Total marks obtained for each drug will be shown below the name of drug. This platform can be used to experiment with repertorisation process and find a similimum. Save results to ‘Reference Tray’ and ‘Close’.
Reverse Gear Verification:
In real sense of word, this not an independent repertorisation method, but a tool to compare and evaluate results obtained by other methods of repertorisation. Hence, this should be done only after other methods are done and results saved.
Click ‘Reverse gear’ icon on the tool bar of repertorisation window. A new window opens. Select the ‘Repertorisation Method’ you want to analyse result. The list of drugs obtained from repertorisation will be listed there. Select the name of drug from this list. The list of rubrics covered by that drug will be shown in upper panel, and not covered in the lower panel. This will help for a final comaritive study, before deciding the final choice.
To return from ‘Repertorisation window’ to ‘Case Record’ window, click ‘WorkSheet’ icon on tool bar, and then click ‘Case Record’ icon. Case record window appears.
Reference Tray
We haved saved the abstracts of all repertorisation results to ‘Reference Tray’. To view this platform, click ‘Referece Tray’ tab on the ‘Case Record’ window. ‘Reference tray’ opens. All data we have saved regarding this particular patient can be viewed here. Options are available for editing these data. Print option also available.
We can export any selected text from Repertories, Reference books or Matera Medica to Reference Tray. This helps build up a complete collection of information we have collected during the case study of the patient, which may be grately useful as a quick reference base during future consultaions, saving much time and labour in clinical work.
Materia Medica:
20 Materia Medica works are included in this packagefor clinical refence of drugs. To open Materia Medica, click the downward arrow of ‘Materia Medica’ icon on main tool bar, and select from drop-down list of books. If clicked on directly on the icon, a list o Materia Medica works will appear. Materia Medica may be opened from main menu also.
Materia Medica opens in a new window, with list of drugs in left panel, and materia medica text in the right panel. There is also a drop-down list of drugs to select from. Selecting the name of drug in left panel, its materia medica may be viewd in right panel.
Search Materia Medica:
To search in the materia medica, click ‘search’ tool on tool bar, and type appropriate key words in the text box. Click ’OK”.
In Boericke Materia Medica, which is widely used by homoeopaths during consultations, search tool is more powerfull. Multiple key words can be used here. The result of search is displayed as list of drugs along with the rubric containing the key words. To read the materia medica, select the rubric and click’ show’ button. The specific part of materia medica, containing that selected rubric will open instantly.
Bookmark, Create notes, add to reference tray:
Right click selected portion of text in the materia medica. Using the dropdown menu, we can Bookmark the selected ortion, export it a the Reference tray, or send to the Notebook to make notes and save. These tools highly enhances the utility of materia medica in SIMILIMUMULTRA.
Synthetic Materia Medica:
This is a much appreciated innovation incorporated in SIMILIMUMULTRA. It can be opened from list of Materia Medica’ works.
This is a special kind of Materia Medica prepared by SIMILIMUM team. Contents of Kent Repertory is here re-arranged in a reverse order, converting that great repertory into a powerful materia medica work. Thus we get a very usefull materia medica for day-to-day work, with main rubrics listed in alphabetical order, and sub-rubrics in tree structure, under each chapter, for each drug. More over, rubrics having three marks in Kent repertory are coloured here in red, two marks in blue, and one mark in black.
Utility value of this work is further enhanced by providing a special tool for comparison of drugs. After selecting a rubric and viewing its drugs in the main panel, click ‘Compare’ button.
Instantly, a full list of dugs covered by that rubric appears in right panel.
Book Shelf:
‘Book Shelf’ is a library of reference books. Books that are presumed to be necessary on consultation table of a homoeopath are included. We can read, search, bookmark, create notes, and add to reference tray from these reference books.
To open, click ‘BookShelf’ icon on main tool bar. Or, from ‘Show > reference Books’ from Main Menu.
Clinical Values:
Normal laboratory values for clinical tests are given. Open using ‘Clinical Utilities icon on main tool bar, or from the drop-down list on main menu bar.Clinical Values window opens. Select the name of test in left panel, and read the normal values on rught panel. It may also be viewed by scrolling down. Search may be done by typing keywords in the search tool. Tools for exporting selected portions of text to Reference tray, Note books, or book marking are available.
New tests and values can be added at any time, using ‘Customize’ tool given at the lower part of the left panel.
Height weight tables:
Height-weight tables are given in the same window, below clinical values. Tools for exporting selected portions of text to Reference tray, Note books, or book marking are available here also.
Laboratory Tests:
To open, click ‘Clinical Tests’ icon on the tool bar of ‘Clinical Utilities’ window. Detais of clinially important laboratory tests under various categories such as Biochemistry, Haematology, Immunology, Microbiology, Endocrinology, DNA tests, Sputum Tests etc. are given in this module. All aspects of Indications, Physilogy, Test Method, Normal values and Interpretations of tests are provided. Search option is also available. Practitioner can further enrich this platform by constantly upgrading with new information available time to time, using ‘Customize’ tool. Tools for exporting selected portions of text to Reference tray, Note books, or book marking are available here also.
Drug Relationships:
Clinical relationship of Homoeopathic drugs are provided here. Open from main menu > Clinical Utilities > relationships . Or, main toolbar > Clinical Utilities > Relationships. Search tool is also provided on ‘Rlationships’ window. Tools for exporting selected portions of text to Reference tray, Note books, or book marking are available.
Diagnostic Tables:
A few important diagnostic tables and information are given here. May be useful in differential diagnosis of cliniacl cases. May be also used as a learning tool for beginers. To open, go to main toolbar > Clinical Utilities > Diagnostics. Or, main menu > Clinical Utilities > Diagnostics. You can add new tables using ‘Customize’ tool. ‘Serch‘ option also given. Tools for exporting selected portions of text to Reference tray, Note books, or book marking are available here also.
Constitutionals:
Constitutional Symptoms of all major drugs are given here. May be usefull as a learning tool. It may be also used to select prescriptions based on constitutional make up of the patient. To open, go to main toolbar > Clinical Utilities > Constitutional Symptoms. Or, from main menu > Clinical Utilities > Constitutional Symptoms. Search tool is available. Text may be selected and exported to refeence tray, Note books, or book marked.
Specifics:
This is a very much appreciated and usefull part of SIMILIMUMULTRA package. Homoeopathic Specific treatment is seen by many as a less time consuming practical way of successful day-today clinical management. Specific indications of dugs proven recorded by great masters in the field of homoeopathy are compiled here. Tools for exporting selected portions of text to reference tray, Note books, or book marking are available here also. ‘Customization’ tool also available. To open, go to Main toolbar > Clinical Utilities > Specifics. Or, from Main menu > Clinical Utilities > Specifics.
Prophylactics:
This platform contains Homoeopathic Preventive medicines. Tools for exporting selected portions of text to reference tray, Note books, or book marking are available here also. To open, go to Main toolbar > Clinical Utilities > Prophylactics. Or, from Main menu > Clinical Utilities > Prophylactics. ‘Customize’ and Search tools available.
External Applications:
Clinically well-proven external uses of Homoeopathic drugs, with mode preparation and use are provided here, compiled from clinical records of eminent prescribers of yesterdays. Tools for exporting selected portions of text to reference tray, Note books, or book marking are available here also. ‘Customise’ and ‘search’ tools alao provided. To open, go to Main toolbar > Clinical Utilities > Externals. Or, from Main menu > Clinical Utilities > Externals.
Mother Tinctures:
Information regarding use of mother tinctures in diverse clinical conditions are given here. Tools for exporting selected portions of text to Reference tray, Note books, or book marking are also available. This section also can be customized and enriched by user by adding new information. Serach is also provided.
Stock Register of Drugs:
Stock Register of Drugs is a very usefull addition to the package, making SIMILIMUM ULTRA a real friend of practitioners. While making a prescription, he can instantly verify the availability if a particular potency of drug in his stock, by a smple mouse-click. Stock Register can be prepared and kept up-dated with out any typing. To open, go to Main menu > Registers > Stock Register. Or, click ‘Registers’ icon on Main Toolbar and select ‘Stock Register’.
Stock Register window opens. It will be a blank page while opening first. Click ‘Add/Edit’ button at the right lower corner. A Drug List with edit options appears. From the list of drugs, select the Name of drug to be added to the stock register. Then tick the check boxes of Potencies of that drug available in your Pharmacy. Then move to select next drug. Instantly, the selected drug and potencies appears listed in the stock register.
If the name of drug or specific potency you want to bring to the stock register is not seen in the default drug list, the drug list and potency list may be revised using ‘Add New Drug/ Potency’ buttons. Even Patent drugs can be listed in this way. Later, to search the availability of a particular drug in your stock register, use the Search tool provided.
Create Purchase Orders:
Purchase orders of drugs can be prepared without typing, using the tool provided. This tool can be opened from the toolbar on stock register, or, directly from Main toolbar > Registers > Purchase List.
Opening first time the window will be an empty table, with columns titled Drugs, Poteny and Quantity. To prepare list, click on the empty cell below Drugs column. A list of drugs will drop down, from which you can select the drug you want to add to the list. Then click on the empty cell under Potency. From the drop-down list, select Potency. Then move to the empty cell under Quantity. Here type the quantity you want to order. In this way you can build up a complete Purchase List, and take Printout. Printout will be in the title of your Clinic and its Address, which can be diectly sent to your drug vendor.
Personal Organizer:
Personal Organizer is a very useful application incorporated into the SIMILIMUM ULTRA package. To open this utility, go to Menu bar > Registers > Appointments. Or, Click ‘Registers’ icon on tool bar and select ‘Appointments’ from drop-down list. Personal Organizer Window with built in calener appears. To record an appointment, select date from calender, select time, and type down details of appointment in ‘appointments’ and ‘descriptions’ columns. Click OK. The appointment appears on the right panel of the window. To view the appointments later, open it and select the date.
More than a clinical tool, Personal Organizer can be used for all personal appointments and reminders of day –to-day activities, as part of your digital life.
Evaluate Clinical Turn-up:
This is a tool to periodically evaluate and compare patient turn-up at your clinic. Total number of new cases registerd, follow up consultations total turn up etc can be evaluated, and viewed on a graphic interface. To open this tool, go to Main Menu > Registers > Analysis of Consultations. Or, click ‘Registers’ on Main toolbar, and select ‘Analysis’ from the drop-down list. In the new window, click ‘options’ button. Select ‘Period’, ‘Performance’ and ‘Chart type’ and click OK. View the displayed result.
Ready Reckoners:
Ready Reckoners, compiled through extensive search from Boericke Materia Medica provides a handy tool to find out instant prescriptions for various disease entities. Open ‘Ready Reckoners’ from the ‘Case Record’ window by clicking the icon on main tool bar, and selecting the disease entity from the drop down list. Or, go to Menu bar > Ready Reckoners > Dropdown list.
Ready Reckoner for a selected disease entity opens in a new window. List of Drugs are given in left panel, and differential indications in right panel. Selected portion may be exported to ‘Reference Tray’, using the button provided.
Note Books:
Note Book is a versatile tool. We can export any selected text from Repertories, Materia Medica, Reference books and various Clinical Utilities to Note Book, and prepare notes. These notes may be edited and saved in special folders for future use. NoteBook also may be used as a Scribbling pad, no note down any thing, like name and phone number of a caller etc. Print outs of notes can be taken instantly. More over, any usefull article you receive from internet or any other digital media can be collected in NoteBook and saved. Thus, we can even build up a large additional library inside SIMILIMUM ULTRA.
Note Book may be opened by clicking icon on main toolbar.
Edit User info:
User Info such as name of clinic, name of owner and address is entered at the time of installing the software itself. In case the customer wants to change or edit the details later, click ‘Options’ button on main toolbar and select ‘Edit User Info’. User Info appears, where you can make required changes.
Create and use Diagnosis List:
To build up a list of diseases to select diagnosis from, click ‘Options’ button on main tool bar and select ‘Diagnosis’. ‘Diagnosis Options’ window pops up. Enter name of diasease in ‘Add’ text box, and click OK. Name of Disease will appear in the list on left panel. Add new names as you like. Close. In this way, slowly build up an exhautive list of known diseases. To select a diagnosis for your patient, open ‘Personal Details’ from Case Record window. Click drop down arrow in the diagnosis tab. The list of diseases you have built in will appear as a drop down list. Name appropriate name of disease for the diagnosis of the patient. ‘Save’ and return to ‘Case Record’.
As already described, there is an option in ‘Patient Register’, to search patients by diagnosis. Click the downward arrow here. You will see your in built list of diseases as a dropdown list. Select the daisease of the patient you are searching for. All the names of patients having that particular diagnosis will appear. You can select your patient from this disease. This tool will help to make comaritive studies of patients with same diagnosis, and thereby evolve a common strategy in such cases.
On-screen Tips:
Essentially, this is a learning tool. Selected texts and quotes from Repertories, Materia Medica and Reference books can be added to this paltform and viewed as flash text displays on desktop. Philosophical Quotes, Clinical Tips, Repertorial Rubrics, Specifics etc. can be learne well in this way.
To customises settings and edit onscreen tips, click ‘TipsBox settings’ from ‘Onscreen Tips’ button on the main tool bar. Settings window appears. To add new Tips, click ‘Add’ button, and Type or paste tips in textbox. Select font size, Font color etc. Click OK. New Tip will appear in List of Tips. Existing Tips can be edited using ‘edit’ button, or deleted using ‘delete’ button. Select the tips to be displayed from the list, select interval, and select display options. Click OK and close settings.
If the display option is set as ‘at start up’, Tips Box will appear the moment SIMILIMUMULTRA opens. Otherwise, click ‘Show Tips box’ from main tool bar. The size and shape of Tips box can be resized, and placed anywhere on desktop. To close tips box, rightclick on tips box, and select ‘ close tips box’.
Medical Certificates, Fitness Certficates, Letters, Vouchers, Bills:
Click on the downward arrow of ‘Stationeries’ button on main tool bar to select forms for Medical Certificates, Fitness Certificates, Vouchers, Letters, Bills etc. Make necessary entries and take printout.
Similimum Online Updates:
A link to our website is provided in SIMILIMUMULTRA. We intend to provide regular online backups and customercare solutions.
Similimum User Guide:
There is in inbuilt Userguide in SIMILIMUMULTRA . Go to help in main menubar and open userguide
Advisory Panel:
Our Advisory Panel consists of eminenet Homoeopaths: Dr S G Biu (Changanassery), Dr. K B Dileepkumar (Thrissur), Dr P K Renjeev (Thaliparamba), Dr. Sanath kumar (Bangalore) and Dr. T G Manojkumar (Kannur). We are deeply indebted to them for overseeing our project and providing guidance and regular advices.
Back-up Options:
To avoid any remote chance of lossing precious clinical data in case of system crashes, we have introduced a very powerful back up tool. You will be asked to create backup every time you exit SIMILIMUMULTRA. If this backup dialogue box does not appear during exit, click ‘options’ button on main tool bar and select ‘Backup Options’ A small popup window appears. Ensure the check box is selected there. ‘Close’. Back up option will be activated during next exit.
Back up, Restore:
Never forget to create regular backups of your data. We strongly advise to do it at least once in a day. While exiting from SIMILIMUM ULTRA, a dialogue box “ Do you want to create a back up of your data?” appears. Click ‘Later’ if you do not want to create backup just now. To create backup, click ‘Yes”. A Back up/ Restore window appears. Select ‘ Back Up ‘ option on top. Click ‘Select All’ under left panel. In the right panel, select a drive on which you want to save the back up. ‘Create a new Folder’ assigning a folder name. Always select this particular folder to create backup. Then click ‘Backup’ button. ‘ Backup created successfully’ dialoge appears. Click OK and Exit.
The contents of your back up folder should be copied and kept secured on a flash drive or rewritable CD at least once a week, preferably daily. Open ‘ My Computer’, select the drive, select your backup folder, and open. Back up files with date and time of back up will be seen there. Copy the latest backup file to your external medium, and keep secured. You can restore your data from this file, any time your system crashes and SIMILIMUMULTRA is re installed. In such an event, after re-installing SIMILIMUMULTRA, open it and exit. Click ‘yes’ when back up dailogue appears. Backup/ Restore window appear. Select ‘Restore’ option at the top. Insert your backup medium, and browse to open the latest backup file you have saved. Click ‘Restore’ . ‘Restored successfully’ dialogue appears. Close and exit. Then re-open SIMILIMUMULTRA. and verify whether the contents of Patient Register is restored.
HOW TO INSTALL SIMILIMUM
Similimum Ultra Sharp shoot Homeopathy Software is compatible with all versions of WINDOWS Operating System.
If you have already installed SIMILIMUM ULTRA on this computer earlier, and it is not working properly, uninstall it FIRST, using “Add-Remove program” tool of Windows.
After completing uninstall, explore your computer directories, and find the SIMILIMUM folder. DELETE it.
INSTALLATION STEPS:
STEP 1: Insert cd 1. Explore the files, double click ‘similimum’. Installation begins. Proceed.
When the ‘select directory’ dialogue appear, type it as ‘c:\users\public\similimum’.
Complete the installation of cd1 as per screen dialogues.
STEP 2:
Then take cd 1 out, and insert cd2.
Open cd2. Copy ‘configure’ folder and paste it on desk top.
Take cd2 out. Insert cd1 again
Open ‘configure’ from desktop
Click ‘keymaker’. Select ‘vista’. Click ‘create’. It will turn ‘complete’. Close.
Then open ‘vista’ folder in the ‘configure’ folder. Open ‘set up’. A popup window appears. Select ‘c’ on left panel. Double click ‘users’ on right panel. Double click ‘public’. Double click ‘similimum’.
If you have done it right, the complete path will be displayed below the popup window as ‘c:\users\public\similimum’. Click ‘ok’. ‘Set up complete’ message appears’. Close all windows.
Then click ‘similimum’ shortcut icon on desktop. Key1 and key 2 will appear. Send those keys without any mistake over WHATSAPP to phone number 9446520252 or similimum@gmail.com.
You will get product key by WHATSAPP MESSAGE You can also use software without key, by clicking ‘register later’. If you follow this steps rightly, everything will be ok.

FOR MORE INFO:

DR MUHAMMAD FASIL BHMS

+91 99953 82854

Two Important Scientific Studies That Validate the Possibility of Molecular Imprinting in Homeopathic Potentization

As per the scientific explanation of homeopathy proposed by MIT or Molecular Imprints Therapeutics, potentized medicines contain MOLECULAR IMPRINTS or hydrogen bonded supra-molecular clusters of water/ethyl alcohol carrying the conformational imprints of drug molecules, which act artificial binding sites for pathogenic molecules and thereby removing the pathological molecular inhibitions.

One of the important predictions put forward to be verified for proving MIT was that supramolecular structure of potentized drugs will be different from that of unpotentized water-alcohol mixture, even though both contain same chemical molecules, which should be proved by tools and techniques of scientific methods.

I think the two remarkable works discussed below, one by Dr Tanmoy Maity, and the other by by Louis Rey, provide crucial support as very strong scientific proofs for this important prediction, thereby validating the MIT explanation of scientific homeopathy.

First study is one done by Tanmoy Maity (Department of Electrical Engineering, Indian School of Mines, Dhanbad, Jharkhand 826004, India), D. Ghosh & C.R. Mahata (Department of Electrical Engineering, Bengal Engineering and Science University, Shibpur, Howrah 711103, West Bengal, India), regarding effect of dielectric dispersion on potentised homeopathic medicines, which indicates a “rearrangement of vehicle molecules” in potentized drugs.

This report is available on
http://www.sciencedirect.com/science/article/pii/S1475491609001258

Second is one conducted by Louis Rey on thermo-luminescence of ultra-high dilutions of lithium chloride and sodium chloride, and published in December 2002, which is available in its full form at: http://www.janscholten.com/janscholten/Evidence_files/Rey.thermoluminescence.pdf E-mail address: ouis.rey@bluewin.ch (L. Rey).

STUDY I:

SCIENTIFIC EVIDENCE FOR RE-ARRANGEMENT OF VEHICLE MOLECULES DURING POTENTIATION :

This paper reports dielectric dispersion occurring in potentised homeopathic medicines subjected to variable frequency electric field using an instrumentation method developed by the authors. Oscillations occur in the direction of electric field, and are usually termed longitudinal/acoustic-mode vibrations.

The test material was lactose soaked with homeopathic medicine. Multiple resonance frequencies, forming a frequency-set, were observed repeatedly for each medicine.

The team reports experimental results for three potencies of Cuprum metallicum (Cuprum met) in the frequency range of 100 kHz–1 MHz. Each exhibits a set of resonance frequencies, which may be termed as its characteristic set. As the frequency-set of each medicine is different from those of others, each medicine may, therefore, be identified by its characteristic frequency-set. This suggests that potentised homeopathic medicines, which are chemically identical with the vehicle, differ from one another in the arrangement of vehicle molecules.

According to them, these “experiments show that potentised homeopathic medicines, which are chemically identical with the vehicle, differ from one another in the arrangement of vehicle molecules”.

“Difference in arrangement of vehicle molecules” strongly indicates the presence of “supra-molecular clusters of water and ethyl alcohol, into which the three-dimensional configuration of drug molecules are imprinted as nanocavities” as proposed by the hypothesis proposed by MIT.

The observation that “the resonance frequencies frequency-set of each medicine is different from those of others” strongly indicates clusters of water-ethyl alcohol molecules specifically rearranged in accordance with the shapes of constituent molecules of drug substance used for potentization.

Such a re-arrangement of vehicle molecules strongly indicates the process of ‘molecular imprinting’ happening during homeopathic potentization. Present work is a decisive step in the scientific understanding of homeopathy proposed by MIT.

STUDY II:

SCIENTIFIC EVIDENCE FOR SUPRAMOLECULAR STRUCTURAL CHANGES IN POTENTIZING MEDIUM HAPPENING BY THE PROCESS OF POTENTIZATION:

As per the reported work, ultra-high dilutions of lithium chloride and sodium chloride (10−30g cm−3) have been irradiated by X- and gamma rays at 77 K, then progressively re-warmed to room temperature. During that phase, their thermo-luminance has been studied and it was found that, despite their dilution beyond the Avogadro number, the emitted light was specific of the original salts dissolved initially.

This wonderful observation that high dilutions of salts very much above avogadro number retains the specific thermo-luminance patterns reminding of of original salts seems to be very crucial. This phenomenon could be well explained only in terms of supramolecular nanostructures of water carrying the imprints of exact ‘conformations’ of ‘individual’ molecules of salts, as explained by MIT concepts.

Thermo-luminance studies have been developed and utilized so far as a “tool to study the structure of solids, mainly ordered crystals”. In the present study, the researchers successfully utilized it in ultra-high aqueous dilutions, which demonstrates the short range ‘crystalline’ character of water as well as high dilution preparations.

Actually, the researchers took up this work to ‘challenge’ the ‘water memory’ theory, but proved it otherwise. They confess in their report: “we thought that it would be of interest to challenge the theory according which preexistent ‘structures’ in the original liquid, developed around some added chemicals, could survive a great number of successive dilutions when done under vigorous mechanical stirring”.

Another important point to be noted is that the researchers did not use ‘commercial samples’ as most ‘researches’ do, but prepared themselves 15c dilutions of lithium chloride and sodium chloride under the guidance of boiron labs. This fact provides more scientific credence to this study.

The study “showed quite clearly that the initial addition of a solute (NaCl and LiCl) in the original D2O leaves a permanent effect even when, by successive dilutions made under strong vibration, all traces of solute have disappeared.” The results were reproduced in several repeated experiments, “beyond any ambiguity”.

Thermally stimulated luminance—often called thermo-luminance—is a well known phenomenon amongst the thermally stimulated processes (thermally stimulated conductivity—thermally stimulated electron emission—thermogravimetry—differential thermal analysis and differential scanning calorimetry, etc.). Its theory and applications have been fully developed inter alia by McKeever, Chen and Visocekas and it proved to be a most interesting tool to study the structure of solids, mainly ordered crystals. To that end, the studied material is “activated” at low-temperature, usually by radiant energy (UV, X-rays, gamma rays, electron beams, or neutrons) which most generally creates electrons–holes pairs which become separately “trapped” at different energy levels. Then, when the irradiated material is warmed up, the heating serves as a trigger to release the initially accumulated energy and the trapped electrons and holes move and recombine. A characteristic glow is emitted most often under the shape of different successive peaks according to the depths of the initial traps. As a general rule this phenomenon is observed in ordered crystals though it can be equally seen in disordered materials such as glasses. In that mechanism, imperfections in the lattice play a major role and are considered to be the place where luminance centres appear. Thus, thermoluminance is a good tool to study these imperfections and understand how they appear in the crystal.

This is exactly along those lines that the researchers carried our first investigations, starting, this time, from liquids which were turned into stable solids by low-temperature cooling.

Working essentially with water—mainly deuterium oxide—they have shown that the thermoluminance glow of irradiated hexagonal ice consisted in two major peak areas—Peak 1 near 120 K and Peak 2 near 166 K having well-defined emission spectra the D2O samples giving a much higher signal than the H2O ones.

In both cases, un-irradiated samples gave no signals whatsoever. For both D2O and H2O it was shown that the relative intensity of the thermoluminance glow was a function of the irradiation dose and, that at least for Peak 2, it did show a maximum between 1 and 10 kGy .

As a first hypothesis on the nature of the emission itself it has been suggested by Teixeira that Peak 2 could be connected to the hydrogen-bond network within the ice which, in turn, could result from the structure of the original liquid sample, whilst Peak 1 looked to be closely related to the molecule. This strengthens the views on the involvement of hydrogen bonds in this mechanism.

To develop this concept further, the researchers did select to study the effect of lithium chloride on the thermoluminescence of irradiated D2O ice since this particular substance is known to suppress hydrogen bonds. The result, indeed, is spectacular and, at the relatively low concentration of 0:1M, Peak 2 is totally erased whereas the basic emission of Peak 1 remains almost unchanged.

At that point the researchers thought that it would be of interest to challenge the theory according which pre-existent “structures” in the original liquid, developed around some added chemicals, could survive a great number of successive dilutions when done under vigorous mechanical stirring.

To that end they prepared, courtesy of the BOIRON LABORATORIES, ultra-high dilutions of lithium chloride and sodium chloride by successive dilutions to the hundredths, all done under vigorous mechanical stirring (initially 1 g in 100 cm3, then 1 cm3 of this solution in 99 cm3 of pure D2O … and so on) until they reached— theoretically—at the 15th dilution, a “concentration” of10−30 g cm−3. A reference sample of D2O alone was also prepared according to this technique, still keeping vigorous agitation (150 strokes=7:5 s at each successive “dilution” step).

They did proceed, then, to the “activation” of these materials by irradiation according the following experimental protocol.

One cubic centimeter of each solution is placed in aluminium test cavities of 20 mm diameter and 2 mm depth and frozen to −20◦C on a cold metallic block. The frozen systems are kept 24 h at −20◦C to achieve stability into their crystallization patternand they are immersed into liquid nitrogen and kept at −196◦C for 24 h.

In a first set of experiments the frozen ice disks are irradiated at 77 K with 100 kV X-rays to achieve a dose of 0:4 kGy (30 min). Previous determinations were done to check that the disks having identical positions in the field did receive the same dose (dosimetry has been done using Harwell, FWT, and alanine dosimeters).

After irradiation, all the “activated” samples are transferred into a liquid nitrogen container and kept, there, for a week-time, to even out whatever small differences could exist between them.

Finally, all samples are placed in the thermoluminance equipment and their respective glow recorded—with both a photo-multiplier and a CCD camera connected to a spectrograph—in the course of rewarming (3=min) between 77 and 13 K, as has been done in our previous published experiments.

Much to their surprise, the experimental results do show—without any ambiguity— that for an X-ray dose of 0:4 kGy the thermoluminescence glows of the three systems were substantially different. These findings did prove to be reproducible in the course of many different identical experiments.

To compare the curves between them the researchers normalized the emitted light readings taking Peak 1 as the reference. In doing so, we obtain for Peak 2 the different curves presented which show quite clearly that the initial addition of a solute (NaCl and LiCl) in the original D2O leaves a permanent effect even when, by successive dilutions made under strong vibration, all traces of solute have disappeared. More remarkable were the fact that, by far, lithium chloride demonstrates a stronger hydrogen bond suppressing “ghost” effect which could be related to the larger size of the lithium ion.

A second set of experiments done with gamma rays (courtesy of CELESTIN Reactor, COGEMA, Marcoule), at a higher dose (19 kGy) did confirm these findings

It appears, therefore, that the structural state of a solution made in D2O can be modified by the addition of selected solutes like LiCl and NaCl. This modification remains even when the initial molecules have disappeared and the effect is the same at different irradiation doses (0.4 –19 kGy) and for different radiant sources (X-rays, gamma rays). As a working hypothesis, the researchers propose that this phenomenon results from a marked structural change in the hydrogen bond network initiated at the onset by the presence of the dissolved ions and maintained in the course of the dilution process, probably thanks to the successive vigorous mechanical stirrings.

Researchers had no any idea of Molecular Imprinting. They proposes the following hypothesis for explaining their observation:

“As a working hypothesis, we propose that this phenomenon results from a marked structural change in the hydrogen bond network initiated at the onset by the presence of the dissolved ions and maintained in the course of the dilution process, probably thanks to the successive vigorous mechanical stirrings.”

See, this hypothesis comes very close to the concept of Molecular Imprinting!

If we fail to explain the observations of this monumental research in terms of Molecular Imprinting, there remains the danger that it will be hijacked by ‘energy medicine’ theoreticians, by interpreting in terms of ‘essence of drugs’, ‘information’, ‘vibrations’ and the like. Actually, Jan Scholten has already done such an exercise, by saying ‘information’ of drugs imprinted in water are the cause of thermoluminance observed by the researchers. Then he very cleverly fits this thermoluminance into his energy medicine frame work of ‘bioluminance’, vibrations, vital force, resonance and other pseudoscientific theories.

To be specific, precise and fitting to modern scientific knowledge system and its accepted paradigms, it is better to say ‘molecular imprints’ of original drug molecules are the cause of similarity of thermoluminance the researchers could observe. Such an explanation will clearly demonstrate that we are talking about the ‘complementary’ shape of drug molecules imprinted into nanostructures of water, which produce therapeutic effects by acting as ‘artificial binding sites’ for pathogenic molecules.

MIT EXPLAINS MIASMS IN CORRECT SCIENTIFIC PERSPECTIVE

While introducing the concept of MIASMS, Hahnemann was actually trying to explain the role of residual effects of acute INFECTIOUS DISEASES in precipitating chronic disease conditions. His main focus was on infectious ITCH/LEPROSY, SYPHILIS and HPV-GONORRHOEA complex, which were most widespread around his place during his time.

Hahnemann, from his practical experience of applying ‘Similia Similibus Curentur’, came to the conclusion that complete cure is not possible using SIMILIMUM only, if such a similimum is selected using totality of currently existing symptoms only, without considering the MIASMS or residual effects of previous acute infectious diseases.

Even though Hahnemann could rightly observe the role of MIASMS or residual effects of infectious diseases in the causation as well as the curative process of chronic diseases, he could not explain the exact biological mechanism by which this phenomenon works. This failure was due to the primitive state scientific knowledge available during his period, which later led to various kinds unscientific and “dynamic” interpretations by his “disciples” and “followers” which continue till the present day.

Using the scientific knowledge already available now, I have been trying to explore the exact molecular mechanism by which residual effects of acute INFECTIOUS diseases contribute to the development of chronic disease conditions, which Hahnemann called MIASMS.

It is common knowledge that ANTIBODIES are generated in our body against infectious agents or proteins that are alien to our genetic codes. Even after infectious disease is over, these antibodies remain in our body for long periods, even for whole life in certain cases.

Since ANTIBODIES are native globulin PROTEINS that have undergone misfolding by interacting with alien proteins or infectious agents, they can themselves behave as aliens in the organism and produce pathological inhibitions by binding to various OFF-TARGET biological molecules. Such molecular inhibitions caused by ANTIBODIES are the real molecular level villains playing behind various chronic diseases such as AUTOIMMUNE DISEASES, PROTEINOPATHIES, AMYLOID DISEASES AND PRION DISEASES.

Hahnemann called these chronic residual effects of ANTIBODIES as MIASMS.

See, how Hahnemann’s concept of CHRONIC DISEASES relating it with INFECTIOUS MIASMS, paves the way for a SCIENTIFIC understanding of a whole class of grave diseases, and developing of a whole new range of therapeutic agents and techniques to combat them.

Hahnemann’s observations of CHRONIC DISEASES, relating it with INFECTIOUS DISEASES, would have been a revolutionary event in medical history, had anybody- be it hahnemann himself, his followers or scientists- taken up the task of explaining it in scientific terms.

Had anybody asked the question how an infectious disease can cause life-long RESIDUAL EFFECTS in the organism even after the infection is over, everything would have been clear. It would have been obvious that infectious agents can produce life-long RESIDUAL EFFECTS in the form of CHRONIC DISEASES only through ANTIBODIES generated in the body against infectious agents.

Such a realization would have helped medical as well as scientific community to view ANTIBODIES from a different perspective- as CAUSATIVE AGENTS of diverse types of CHRONIC DISEASES- over and above their role as DEFENSE molecules.

It was hahnemann, who for the first time proposed that diverse types of CHRONIC DISEASES could be produced in the long run by INFECTIOUS agents, which he called MIASMS.

I have been trying to explain in scientific terms, how CHRONIC DISEASES could be produced by infectious agents, even after the infections are over. This led me into the realization that INFECTIOUS AGENTS can produce life-long chronic disease dispositions only through OFF-TARGET actions of ANTIBODIES generated in the body against them.

MODERN BIOCHEMISTRY AND MIT EXPLANATION OF SCIENTIFIC HOMEOPATHY

By Chandran Nambiar KC
Redefining Homeopathy
Whatsapp 9446520252

Without acquiring a baseline knowledge of CHEMISTRY OF LIFE, you cannot follow the MIT explanation regarding biological mechanism of homeopathic cure.

By the term ‘living organism’, we indicate a highly organized complex material system with a specific quantity, quality, structure and functions of its own, which is capable of self-controlled growth and reproduction of its progeny, through an interaction involving constant exchange of matter and energy with its environment.

The phenomenon we call ‘life’ exists through a continuous chain of highly complex biochemical interactions which control each other known as METABOLIC PATHWAYS, which depend up on each other and are determined by each other.

A ‘living organism’ represents a much higher and advanced level of organized existence of the same elements of matter we meet in the inorganic world, different only in its structural organization and functional complexity. The universal phenomenon of material motion we find as part of primary existence of matter itself, attains the wonderful qualities of life, due to this complex structural organization.

In fact, phenomenon of ‘life’ was the result of a continuous evolutionary process of primary matter in this universe through millions of years, attaining different levels of organizational and functional forms. Primary forces, sub-atomic particles, elementary atoms, simple chemical molecules, complex inorganic molecules, carbon containing organic molecules, bio-molecules, complex bio-polymers, RNA-DNA-Protein structures, organelles, unicellular organisms, multi-cellular organisms, diverse species of plants and animals, and ultimately Homo Sapiens- these are the prominent milestones in the known evolutionary ladder on earth, panning through millions and millions of years. Human beings represent the highest form of this material evolutionary history on earth, as far as it is known to us.

Parallel to this biological evolution, we can perceive a systematic evolution and perfection of the nervous system also. Simple forms of conditioned reflexes that existed in primitive organisms, gradually evolved into nerve cells, neural networks and ultimately into a well organized nervous system in higher animals. In higher forms of life such as humans, this nervous system has attained such a structural and functional perfection that human brain and its diverse faculties have begun playing a decisive role even in the existence and development of that species and even life on earth itself. Of course, collective labor, language and social relations also played a major role in this evolutionary process.

A living organism can exist only through a continuous interaction and material exchange with its environment. There is an unceasing flow of matter and energy in both directions, between internal and external environments of the organism. Metabolism, or ‘life process’ is the term used to describe the sum total of this bidirectional flow. The moment this bi-directional flow of matter and energy ceases, the organism can no longer exist.

A living organism is distinguished from other non-living forms of matter by certain fundamental features such as: high level of structural organization, the ability to convert and utilize energy, continuous material exchange with environment, self regulation of chemical transformations, and, reproduction or transfer of hereditary information. A state of disease may ensue when any of the biochemical pathways governing these fundamental factors of life are disturbed. Obviously, it is impossible to make a scientific study of pathology and therapeutics without an understanding of these subjects.

Complex bio-molecules which participate in the diverse chemical processes of life are broadly classified into four major groups: Proteins, Carbohydrates, Lipids and Nucleic Acids. These are polymers of simple chemical components or sub units, called monomers. The monomers of proteins are amino acids, and those of carbohydrates are monosaccharides. Lipids are polymers of fatty acids. The monomers of Nucleic acids are known as nulcleotides. These bio-molecules are considered to be the building blocks of life on earth, and are never seen in the non-living world. These bio-molecules, with their highly complex structure and organization, interact each other in the organism through hundreds of bio-chemic pathways, collectively called ‘vital processes’.

Scientific explanation of Homeopathy should be based on a proper understanding of the the complex dynamics of bio-molecular interactions involved in vital processes, especially protein biochemistry.

Understanding PROTEIN CHEMISTRY and PROTEIN DYNAMICS is an essential part of understanding LIFE, DISEASE and CURE:

Proteins are a class of highly complex nitrogen-containing bio-molecules, functioning as the primary carriers of all the biochemical processes underlying the phenomenon of life. There exist millions of protein molecules belonging to thousands of protein types in a living organism.

Each protein molecule is formed by the polymerization of monomers called amino acids, in different proportions and sequences. Each protein type has its own specific role in the biochemical interactions in an organism. Most of the amino acids necessary for the synthesis of proteins are themselves synthesized from their molecular precursors inside the body. A few types of amino acids cannot be synthesized inside the body, and have to be made available through food. These are called essential aminoacids.

There are specific protein molecules assigned for each biochemical process that take place in the body. Various proteins play different types of roles, such as biological catalysts or enzymes, receptors, transport molecules, hormones, antibodies etc. Some proteins function as specialized molecular switches, systematically switching on and off of specific biochemical pathways.

Proteins are synthesized from amino acids, in conformity with the neucleotide sequences of concerned genes, with the help of enzymes, which are themselves proteins.

‘Protein synthesis’ and ‘genetic expression’ are very important part of vital process. It may be said that genes are molecular moulds for synthesizing proteins of specific conformations. There are specific genes, bearing appropriate molecular codes of information necessary for synthesizing each type of protein molecule. Even the synthesis of these genes happens with the help of various enzymes, which are protein molecules. There is no any single bio-molecular process in the living organism, which does not require an active participation of a protein molecule of any kind.

The most important factor we have to understand while discussing proteins is the role of their three-dimensional spacial organization evolving from peculiar disulphide bonds and hydrogen bonds. Water plays a vital role in maintaining the three dimensional organization of proteins intact, thereby keeping them efficient to participate in the diverse biochemical processes.

Proteins exhibits different levels of molecular organization: primary, secondary, tertiary and quaternary. It is this peculiar three dimensional structure that decides the specific biochemical role of a given protein molecule. More over, co-enzymes and co-factors such as metal ions and vitamins play an important role in keeping up this three-dimensional structure of protein molecules intact, thereby activating them for their specific functions. Buffering properties of body fluids also are decisive in maintaining the specific conformations of proteins and keeping them reactive.

Whenever any kind of error occurs in the particular three-dimensional structure of a given protein molecule, it obviously fails to interact with other biomolecules to accomplish the specific functions it is intended to play in the concerned biochemical processes. Such a failure leads to further harmful deviations in several biochemical processes in the organism, that require the participation of this particular protein, ultimately resulting in a cascading of multitude of molecular errors. This is the fundamental molecular mechanism of pathology, which we perceive as disease of some or other category.

These deviations in biochemical pathways are expressed as various groups of subjective and objective symptoms of disease. The organic system exhibits a certain degree of ability and flexibility to overcome or self repair such molecular deviations and preserve the state of homeostasis required to maintain life. Anyhow, if these deviations happen in any of the vitally decisive biochemical pathways, or, if these are irreversible, the bio-chemical processes ultimately stop and death happens.

Disease is a state of derangement in biochemical interactions so as to disrupt the normal pathways of vital processes of the organism

Derangement in normal biochemical interactions amounting to a state of disease may happen due to diverse reasons.

1. GENETIC FACTORS: Defects in genetic codes arising from heredity or acquired by mutations result in the absence of certain proteins (enzymes, receptors, antibodies etc) that are essential for normal biochemical interactions.defective genes may also synthesis faulty proteins with wrong conformation, which can act as endogenous pathogenic agents by binding to various biological targets.

2. EPIGENETIC FACTORS: Defects of enzymes involved in genetic expressions and post synthetic translations and modifications of protein molecules act as epigenetic factors of diseases.

3. NUTRITIONAL FACTORS: Nutritional deficiencies of essential building blocks and precursors of biological molecules, such as amino acids and other monomers, vitamins, co-factors, elements, metal ions, minerals etc may disrupt the normal biochemical interactions. Any shortage in the availability of various amino acids and their precursers may lead to non- production of essential proteins in the organism. In some cases, it may also result in the production of defective proteins.

4. ENVIRONMENTAL FACTORS: Biochemical interactions happen only if an appropriate pH level and temperature is maintained in the body fluids. Any physical influence that may derange these physical parameters will act as pathogenic factors by deactivating protein molecules. Temperature, magnetic field, electromagnetic radiations, vibrations and various other physical influences can affect the normal biochemical processes. Physical influences actually act as pathogenic agents by producing derangement in protein conformations, which are deactivated or converted to pathogenic molecules.

5. EXOGENOUS MOLECULAR FACTORS: Chemical molecules released by infectious agents invading the organism, drugs, toxins, food articles, environmental pollutants alien proteins entering the body act as EXOGENOUS factors of disease by binding to various biological molecules such as enzymes and receptors and producing molecular inhibitions.

6. ENDOGENOUS MOLECULAR FACTORS: Antibodies, hormones, neuro-mediators, neurotransmitters, cytokines, growth factors, super-oxides, enzymes and various biological molecules of endogenous origin may cause molecular inhibitions of proteins such as enzymes and receptors, thereby acting as pathogenic agents.

It is obvious that almost all conditions of pathology we normally confront, including those resulting from genetic origin, are involved with some or other errors or absence of some protein molecules that are essential for concerned biochemical processes.

Moreover, most of such molecular errors other than of nutritional deficiencies or genetic origin, arise due to binding of some exogenous or endogenous foreign molecules or ions on the active, binding or allosteric sites of protein molecules, effecting changes in their three-dimensional conformations. A host of diseases originating from viral-bacterial infections, allergies, poisoning, drugs, food articles etc, belong to this category. Chronic diseases caused by antibodies, which are considered in homeopathy as miasmatic diseases and modern medicine as auto-immune diseases, also belong to this class. Diseases caused by emotional factors, hormones, neuro-mediators, neurotransmitters, cytokines, growth factors, super-oxides, enzymes and various biological molecules also include in this group.

KEY-LOCK MECHANISM: The most important factor we have to bear in mind when talking about kinetics of proteins in general, and enzymes in particular is their highly defined, peculiar specificity. Each type of protein molecules, or some times even some part of a single protein molecule, is designed in such a way that it can bind only with a specific class of molecules, and hence participate in a specific type of bio-chemic interaction only. This functional specificity is ensured through the peculiar three-dimensional configuration of the protein molecules, exhibited through their characteristic folding and spacial arrangement. Reactive chemical groups known as active sites, binding sites, and regulatory sites are distributed at specific locations on this three dimensional formations of protein molecules. These chemical groups can interact only with molecules and ions having appropriate spacial configurations that fits to their shape. This phenomenon can be compared with the relationship existing between a lock and its appropriate key. Just as a key with an exactly fitting three dimensional shape alone can enter the key hole of a lock and open it, molecules with exactly fitting three dimensional structure alone can establish contact and indulge in chemical activities with specific protein molecules. This key-lock relationship with substrates defines all biochemical interactions involving proteins, ensuring their optimum specificity. Obviously, any deviation in the three dimensional configuration of either lock or key makes their interaction impossible.

It has been already explained that the primary basis of any state of pathology is some deviations occurring in the biochemical processes at the molecular level. Endogenic or exogenic foreign molecules or ions having any configurational similarity to certain biochemical substrates can mimic as original substrates to attach themselves on the regulatory or the active sites of proteins, effecting changes in their native 3-D configuration, thereby making them unable to discharge their specific biochemical role. This situation is called a molecular inhibition, which leads to pathological molecular errors. It is comparable with the ability of objects having some similarity in shape with that of key, to enter the key hole of a lock and obstructing its function. As a result of this inhibition, the real substrates are prevented from interacting with the appropriate protein molecules, leading to a break in the normal biochemical channels. This type of molecular errors are called competitive inhibitions. It is in this way that many types of drugs, pesticides and poisons interfere in the biochemical processes, creating pathologic situations. Such substances are known as anti-melabolities.