‘Molecular Imprinting in Water’ For Target-Specific Drug Designing- Science Behind Homeopathic Potentization
‘Drug designing’ is an advanced branch of modern pharmaceutical chemistry, which is involved with the process of developing new medicinal substances appropriate to the specific biological targets in the organism. Such a ‘designer drug’ is most commonly a small organic molecule which can inhibit or activate the functioning of a target biomolecule such as a protein, thereby resulting in a therapeutic process in the organism. Essentially, ‘drug designing’ involves the development of small molecules that are complementary in ‘shape’ and ‘charge’ to the biomolecular target to which they interact and therefore will bind to it. Modern drug designing protocols utilize computer modeling techniques also. This type of modeling is known as ‘computer-aided drug design’. Actually, ‘drug design’ is involved with ‘ligand’ design. Prediction of binding affinity of molecules to be designed is the first step in a successful modeling technique. Many other properties such as bioavailability, metabolic half life, lack of side effects, also should be optimized before a designed ‘ligand’ can become a safe and efficacious drug. Most of these ‘other’ characteristics are often very difficult to optimize using presently available drug design techniques.
Selection of drug target is most important in “drug designing”. A drug target is typically a key molecule involved in a particular metabolic or signaling pathway that is specific to a disease condition or pathology, or to the infectivity or survival of a microbial pathogen. Most of the therapeutic inteventions aim to inhibit the functioning of the ‘pathologic’ pathway in the diseased state by causing a key molecule to stop functioning. Drug molecules may be designed that bind to the active region and inhibit this key molecule. Some other therapeutic interventions actually enhance the ‘normal’ biochemical pathway by promoting specific molecules in the ‘normal’ pathways that may have been affected in the diseased state. Main challenge in all ‘drug therapies’ including ‘designer drugs’ is that these drug molecules should not affect any other important “off-target” molecules or ‘antitargets’ that may be similar in appearance to the target molecule, since drug interactions with off-target molecules may lead to undesirable side effects.
Designer drugs are small organic molecules produced through chemical synthesis, but biopolymer-based drugs (also known as biologics) produced through biological processes are becoming increasingly more common in modern drug designing.
‘Ligand-based drug design’ and ‘structure-based drug design’ are two major technologies now utilized in drug designing technologies.
Ligand-based drug design is based on the knowledge of other molecules that can bind to the biological target of interest. These other molecules may be used to derive a ‘pharmacophore’ which defines the minimum necessary structural characteristics a molecule must possess in order to bind to the target. In other words, a model of the biological target may be built based on the knowledge of what binds to it and this model in turn may be used to design new molecular entities that interact with the target.
Structure-based drug design is based on the knowledge of the three dimensional structure of the biological target obtained through methods such as x-ray crystallography or NMR spectroscopy. Using the structure of the biological target, candidate drugs that are predicted to bind with high affinity and selectivity to the target may be designed using interactive graphics.
Main draw back of ‘designer drugs’ is that there is a chance for these drug molecules affecting “off-target” molecules or ‘antitargets’ having similarity to the target molecules. Such interactions with off-target molecules may lead to grave consequences. Optimizing of various factors such as bioavailability, metabolic half life, and lack of side effects are the real challenges facing “drug designing” technology.
Molecular Imprinting in Polymers:
‘Molecular imprinting in polymers’ is a fast grownig research area that may be interesting to people engaged in developing “drug designing” techniques. A lot of research is currently going on over this subject the world over. This technology involves the imprinting of synthetic polymer substances using enzymes or such macromolecules as ‘guest’molecules. As a result of imprinting, nano cavities with 3-d spacial configurations complementary to the ‘guest’ molecules will be created in the interaction surfaces of the polymers. These imprinted polymers, by virtue of the nanocavities they contain can be used to bind molecules with configurational similarity to ‘guest’ molecules. They are at present widely used in various laboratory assays as powerful adsorption surfaces. MIPs are also found to be of much practical use in various areas of science and technology .
Molecular imprinted polymers of today cannot be used as therapeutic agents, since they are totally foreign substances to the organism. More over, native enzymes can not degrade the polymers even if they can play a therapeutic role in the organism.
Molecular imprinting may become part of future drug designing techniques, only if the search for safer substances and methods for molecular imprinting happens to be successful.
Molecular Imprinted Proteins:
Biopolymer-based drugs (also known as biologics) produced through biological processes are becoming increasingly more common in modern drug designing. But the revolutionary concept of molecular imprinting in proteins is only in its emerging stage, which may have implications in drug designing techniques. It has already been acknowledged that the biological molecules presently classified as antibodies are nothing but native globulin proteins subjected to natural molecular imprinting process with foreign pathologic proteins acting as ‘guest’ molecules. Scientists have already realized the fact that the much discussed pathologic molecules known as ‘prions’ are nothing but disfigured protein molecules subjected to molecular imprinting. Protiens, being polymers with complex and flexible tertiary structures, are expected to be a very good medium for molecular imprinting. Different types of protein based substances, subjected to artificial molecular imprinting, may evolve in the future as effective therapeutic agents and laboratory reagents.
Apart from protein molecules, different types of biopolymers such as polysaccharides and nucleic acids also may be experimented as medium for molecular imprinting.
Native proteins extracted from the patients could be subjected to molecular imprinting with appropriate ligands or other pathologic molecules acting as ‘guest’ molecules and used as target oriented therapeutic agents. But the problem remains that such imprinted proteins can be used only in the individual whose proteins are used for imprinting. Otherwise it may result in grave anaphylactic reactions. Moreover these imprinted proteins may remain in the organism for very long periods, without undergoing degradation, and cause ever new pathological molecular blocks. Such issues have to be addressed properly.
Molecular Imprinting in Water:
Our protracted search for a safe and reliable universal medium for molecular imprinted drug designing finally takes us to the study of wonderful physico-chemical properties of the most abundant substance on earth called water. But the concept and technology of molecular imprinting in water still remains in very infantile stage. The author is of the opinion that with its strange polymer-like behaviours, capable of forming hydrogen-bonded supra-molecular structures, water can be the ideal candidate for molecular imprinted drug designing in future.
Though in a slighly lesser level, Ethyl Alcohol and Lactose are also capable of forming polymer-like supra-molecular formations through hydrogen bonding, and hence may be onsidered as candidates for molecular imprinting experiments. Possibilities of these substances in combination with water also have to be explored.
Water(H2O) is a wonderful substance with strange physico–chemical properties arising from its peculiar supra-molecular structure. Water is a solvent with higher polarity than similar liquids. H–O–H bond angle is 105 degrees. That means, water molecule is a dipole. Because of this peculiarity, water molecules can exist like a supra-molecular network through hydrogen bonding. A minimum number of five water molecules will be contained in this network. Such supra-molecular formations are called pentamers. Most of the wonderful properties of water arise from this peculiar capacity of hydrogen bonding and resultant supra-molecular formations. Water molecules (H2O) are symmetric (point group C2ν) with two mirror planes of symmetry and a 2-fold rotation axis. The hydrogen atoms may possess parallel or antiparallel nuclear spin. The water molecule consists of two light atoms (H) and a relatively heavy atom (O). The approximately 16-fold difference in mass gives rise to its ease of rotation and the significant relative movements of the hydrogen nuclei, which are in constant and significant relative movement.
Although not often perceived as such, water is a very reactive molecule available at a high concentration. This reactivity, however, is greatly moderated at ambient temperatures due to the extensive hydrogen bonding. Each water molecules possess a strongly nucleophilic oxygen atom that enables many of life‘s reactions, as well as ionizing to produce reactive hydrogen and hydroxide ions. Reduction of the hydrogen bonding at high temperatures or due to electromagnetic fields results in greater reactivity of the water molecules.
As liquid water is so common-place in our everyday lives, it is often regarded as a ‘typical’ liquid. In reality, water is most atypical as a liquid, behaving as a quite different material at low temperatures to that when it is hot. It has often been stated that life depends on these anomalous properties of water. In particular, the high cohesion between molecules gives it a high freezing and melting point, such that we and our planet are bathed in liquid water. The large heat capacity, high thermal conductivity and high water content in organisms contribute to thermal regulation and prevent local temperature fluctuations, thus allowing us to more easily control our body temperature. The high latent heat of evaporation gives resistance to dehydration and considerable evaporative cooling. Water is an excellent solvent due to its polarity, high dielectric constant and small size, particularly for polar and ionic compounds and salts. It has unique hydration properties towards biological macromolecules (particularly proteins and nucleic acids) that determine their three-dimensional structures, and hence their functions, in solution. Hydration of biological molecules results in formation of gels that can reversibly undergo the gel-sol phase transitions that underlie many cellular mechanisms. Water ionize and allows easy proton exchange between molecules, thus contributing to the richness of the ionic interactions in living organisms.
In reality, hydrogen bonding is a special type of dipole force. It is a force of attraction formed between partial electro negative atom which is part of another molecule. The reason for strength is the partial positive charge attained by hydrogen. Hydrogen is capable of establishing similar bonds with the atoms of nitrogen, fluorine and oxygen. That is to say that the basis of hydrogen bonding is the attraction between one hydrogen atom which is part of a molecule which is attached to oxygen or nitrogen and oxygen or nitrogen which remains part of another molecule. This force is less powerful than the co–valent bonds which keeps the atoms inside molecule bound together. But these less powerful bonds are responsible for the wonderful bio–chemical qualities of water.
In the ordinary liquid state, in spite of 80% of the electrons being concerned with bonding, the three atoms in water do not stay together, as the hydrogen atoms are constantly exchanging between water molecules due to protonation/deprotonation processes. Both acids and bases catalyze this exchange and even when at its slowest (at pH 7), the average time for the atoms in an H2O molecule to stay together is only about a millisecond. As this brief period is, however, much longer than the timescales encountered during investigations into water’s hydrogen bonding or hydration properties, water is usually treated as a permanent structure.
The presence of ethyl alcohol in water is considered to be a factor reducing the rate of protonation/deprotonation processes, thereby enhancing the stability of hydration shells.
Hydrogen bond strength can be affected by electromagnetic and magnetic effects.
Any factors, such as polarization, that reduces the hydrogen bond length, is expected to increase its covalency. There is still some dispute over the size of this covalency, however any covalency will increase the network stability relative to purely electrostatic effects. As hydrogen bond strength depends almost linearly on its length (shorter length giving stronger hydrogen bonding), it also depends almost linearly (outside extreme values) on the temperature and pressure .
Hydrogen bonded chains (that is, O-H····O-H····O) are cooperative; the breakage of the first bond is the hardest, then the next one is weakened, and so on. Thus unzipping may occur with complex macromolecules held together by hydrogen bonding, for example, nucleic acids. Such cooperativity is a fundamental property of liquid water where hydrogen bonds are up to 250% stronger than the single hydrogen bond in the dimer. A strong base at the end of a chain may strengthen the bonding further.
Water-Ethyl Alcohol Mixture :
At this stage we have to understand a few facts about Ethyl Alcohol(CH3- CH2 – OH ). The molecules of alcohol also have the dipole structure as water molecules. It is possible for them to establish mutual connection through hydrogen bonding. The molecular weight of alcohol molecul is 46. The molecular weight of water(H2O) is 18. That means that the number of water molecules contained in 18 gram of water and the number of alcohol molecules contained in 46 gram of ethyl alcohol are equal. When alcohol and water are thoroughly mixed alcohol molecules network with water molecules through hydration bonds, The mobility of water molecules is restricted by the bonds established with alcohol molecules. Hence, hydration shells formed in alcohol–water mixture are comparatively more stable. The count of alcohol molecules and the count of water molecules contained in their mixture in 73:27 ratio will be equal. (73% w/w. alcohol and 27% w/w water) This mixturei is known as (40 power spirit).
Ideal medium for molecular imprining is supposed to contains 87% w/w of alcohol and 13% w/w of water. In this ratio, the number of alcohol molecules will be about more than that of of water molecules. Such a ratio will be very suitable for the production of stable hydration shells. More over, the presence of ethyl alcohol in water is considered as a factor reducing the rate of protonation/deprotonation processes, thereby enhancing the stability of hydration shells
We know that water is a good solvent. Let us see what happens when some foreign molecules are made to dissolve in water. If a foreign(called ‘guest’) molecule, ion, or colloidal particle happens to enter the matrix of 3-dimensional dynamic network of water molecules, they are entrapped inside this network. Water molecules arrange themselves around the ‘guest’ molecule in a peculiar way by the formation of hydrogen bonding. These formations of water molecules around the ‘guest’ molecules is known as hydration shells. These hydration shells exist in a dynamic state, and are more or less unstable. The ‘guest’ molecules dissolved in water exist in a state of being entrapped inside these hydration shells. This phenomenon can be seen both in ionic solutions and colloidal solutions. Obviously, hydration shells assume an internal spacial arrangement exactly fitting to the 3-dimensional spacial configuration of the ‘guest’ molecule entrapped in them. If we could devise some technique to remove the entrapped ‘guest’ molecules from these hydration shells, without disturbing the hydrogen bonds between the constituent water molecules, these hydration shells can retain the molecular memory of the molecular configurations of the removed ‘guest’ molecules. This rarely studied phenomenon underlies the much debated controversial ‘molecular memory of water’. Actual mechanism and forces underlying this phenomenon have to be investigated minutely by physical scientists. Minute changes occuring in the electron clouds of atoms of water molecules during the formation of hydration shells may be one factor responsible for this phenomenon. It has been well proven that these hydration shells later show a peculiar capability to differentially recognize the original ‘guest’ molecules which were responsible for their formation. This may be due to the existence of some imprinted memory of those host molecules retained in the hydration shells. This imprinting of memory may be compared to formation of finger prints. As in the case of finger prints, configuration of these molecular imprints also will be a complementary negative of ‘guest’ molecules. These empty hydration shells, or supra-molecular formations of water subjected to molecular imprinting, may be called ‘hydrosomes’, which means, minute ‘cavities of water’.
Homeopathic process of potentization may be a crude method of preparing hydrosomes, imprinted with various drug molecules(‘guest’), for utilizing as therapeutic agents. It should be specially noted that the medium used for homeopathic potentisation is not pure water, but it is mixed with ethyl alcohol in a particular ratio. It may be inferred that the presence of camparatively heavy ethyl alcohol molecules in this mixture may be contributing to stabilize the hydrosomes, preventing their easy dissociation. The convergent forces of rotational movements to which the mixture is subjected as part of homeopathic potentization, may also be a contributing factor in stabilizing the empty hydration shells.
This peculiar 3-d configuration of ‘hydrosomes’ are destroyed only when the energy level of water molecules are disturbed by the effect of heat, electricity, magnetism and other electro magnetic radiations. As stated earlier the hydration shells formed in pure water are comparatively unstable. Here lies the importance of the fact that homeopathic potencies are made using alcohol- water mixture.
Information we recently receive from various research institutions, regarding the wonderful supra-molecular structures of various materials and their hitherto unknown peculiar properties, may greatly contribute in our efforts to devise a protocol for molecular imprinted drug designing using water. Studies on ‘water clusters’, ‘crystalline structure of water’, ‘shape memory property’, ‘molecular imprinting’, ‘nano technology’, ‘clathrate formations’ and other diverse phenomena are offering promising indications in this direction. We have to utilize all these new revealations in our scientific study regarding the possibility of developing a technology of drug designing by molecular imprinting in water.
We all know that water exists as ice crystals in its solid form. But it has been recently observed that water can exist even in its liquid form in crystals. In reality, water formed by melting of ice is in a state of liquid crystals. The lattice structure which is formed through hydration bonds is responsible for this phenomenon. Molecular imprinting in water is much interested in this area of research pertaining to this peculiar crystalline nature of water. It is believed that in the process of molecular imprinting of water using ‘guest’ molecules, this crystalline structure of water plays a crucial role. It is likely that more advanced studies about dynamics of crystallization of water may help us to evolve a perfect technology for molecular imprinting in water.
The studies about Clathrate Compounds or host-guest compounds in supra-molecular chemistry is an area in which we should have sincere interest. Clathrates are the molecular networks which are formed when gases dissolve in water under high pressure. They exist in a peculiar host–guest relationship. The studies about this phenomenon are still in their infancy. Clathrates have a crystalline nature, existing as molecular networks, formed by a process of water molecules arranging around the guest molecules. The studies about the dynamics of clathrate formation are also likely to help in evolving a perfect protocol for molecular imprinting in water. Even if the host molecules are removed from clathrates, the network of water molecules have been found to remain intact. More over, the existing clathrates can induce the formation of similar clathrates. It will be very useful to consider these above discoveries connecting them with the phenomenon of molecular imprinting.
A lot of studies has been so far published regarding shape memory materials. Several alloys having crystalline structure have been observed to possess shape memory property. Such materials are known as SMART materials. This phenomenon also has to be understood well while trying to evolve a molecular imprinting technique of drug designing.
It is in the phenomenon of ‘molecular memory of water’ itself that we naturally land on when we attempt to develop molecular imprinted drugs. We have already seen that the alcohol–water molecules contained in the medium used for imprinting arrange themselves around the ‘guest’ molecules, and form hydration shells. We should develop a way to systematically remove the ‘guest’ molecules entrapped in the hydration shells, so that empty hydration shells or ‘hydrosomes’ remain. These ‘hydrosomes’ will be imprinted with the three-dimensional ‘finger print’ of ‘guest’ molecules used for imprinting.
When molecular imprinted water is introduced into the organism by any route, is carried by the body fluids, and transported to different parts of body. When molecular imprints come in the vicinity of ligands or active groups of pathological foreign molecules having similarity to the original ‘guest’ molecules, these molecular imprints selectively bind to those pathological molecules. By this process, pathological foreign molecules are prevented from binding with biological molecules, thereby relieving the biological molecules from pathological molecular blocks. This can be described as some sort of ‘molecular scavenging’ or entrapping of pathological molecules, by ‘hydrosomes’ or “molecular imrints”.
Drugs designed through molecular imprinting in water will be the safest of all therapeutic agents so far used in the history medical science. Though there is a chance for these molecular imprints affecting “off-target” molecules or ‘antitargets’ having similarity to the target molecules, such interactions will be of very transient nature, since these molecular imprints will be easily degraded into constituent water-ethyl alcohol molecules. Such temporary interactions with off-target molecules may not lead to any dangerous consequences. Factors such as bioavailability, metabolic half life, and lack of side effects also will be obviously remain in favorable range.
Using various ligands and pathological molecules involved in each disease process as ‘guest’ molecules, we can develop most appropriate specifc designer drugs against almost any disease. Instead of original pathological molecules or ligands, drug molecules having configurational similarity to them also can be used as “guest” molecules in the molecular imprinting protocol. Homeopathic potentization utilizes this strategy, which is the real essence of “similia similibus curentur”. I hereby appeal to the government and scientific community to take up this task with urgent priority, so that a whole new range of safe and effective designer drugs could be developed though this novel process of molecular imprinting in water.
SOME OPEN QUESTIONS TO OUR RESPECTED “HOMEOPATHY RESEARCHERS”
How can you discuss “MODUS OPERANDI” of Arsenic Alb 30 or any other post-avogadro diluted homeopathic drug, without discussing regarding the ACTIVE PRINCIPLES they contain?
Is Water a Polymer?
MIT or MOLECULAR IMPRINTS THERAPEUTICS is a scientific hypothesis trying to explain homeopathy.
As per this hypothesis, potentization involves a process of Molecular Imprinting in water-alcohol supra-molecular matrix using drug molecules as templates, by which nanocavities or molecular imprints bearing the spacial conformations of drug molecules in a negative orientation are produced. Drugs potentized above avogadro limit contain these MOLECULAR IMPRINTS as their active principles, which can act as artificial binding pockets for the pathogenic molecules.
One of the main criticisms against this hypothesis was that molecular imprinting could be done only in POLYMERS, and since water is not a polymer, molecular imprinting could not be done in water-alcohol matrix. Even though I had scientifically explained why water is considered a polymer-like substance, many people were reluctant to accept my explanations. Now comes a great research work that has scientifically proved that “Liquid water is a dynamic polydisperse branched polymer. This work done by a team led by William A. Goddard III and Saber Naserifar is a great breakthrough in water research, which will of course be of course a decisive help in establishing THE concept MOLECULAR IMPRINTING involved in homeopathic potentization as hypothesised by MIT.
According to the researchers, they have proved through quantum mechanics force field molecular simulations that Liquid water is a dynamic polydisperse branched polymer. They have showed that when ice undergoes melting, the number of SHBs (strong hydrogen bonds) drops quickly to two in liquid water. These two SHBs couple into chains containing over 150 water molecules, resembling a branched polymer, where polymer branches evolve dynamically. Authors expect that this dynamics-branched polymer paradigm may explain long-standing puzzles of water, and may explain the observed angular correlations in water.
You can read the research paper on this link: .https://www.pnas.org/content/116/6/1998
A COVID-19 HOMEOPATHY “RESEARCH PAPER” PUBLISHED FROM KERALA
I have before me a research paper titled “covid-19 research Homoeopathy- Efficacy of Arsenicum Alb 30c for upregulating immunological markers among residents of covid-19 related hot spot areas in Pathanamthitta, Kerala”, recently published by Dr M V Thomas and coworkers, including some of the senior homeopaths from kerala.
“NANOPARTICLE THEORY OF HOMEOPATHY” AND AVOGADRO NUMBER
“Dynamic Energy” Reflects the Limitations of Scientific Knowledge Available to Hahnemann!
HAHNEMANN UTILIZED THE CONCEPT OF “DYNAMIC ENERGY” DUE TO HIS “INABILITY” TO EXPLAIN CERTAIN PHENOMENA HE OBSERVED “BY ANY OTHER MANNER”!
Read Hahnemann saying in Organon : Aphorism 11 : Sixth Edition: Foot Note:
“Is it then so utterly impossible for our age celebrated for its wealth in clear thinkers to think of dynamic energy as something non-corporeal, since we see daily phenomena which cannot be explained in any other manner?”
It obviously means, he would not have thought about the concept of ‘dynamic energy’, if it was possible for him to explain these “daily phenomena” “in any other manner”!
Hahnemann was compelled to ‘think’ about ‘dynamic energy’, only because he saw many daily phenomena which he could not explain in “any other manner”‘. It amounts to a humble confession by the master:
Which were those “daily phenomena” Hahnemann observed, “which cannot be explained in any other manner” that prompted him to think about a “dynamic energy” that is something “non-corporeal”?
Further he gives in the same footnote a list of “daily phenomena” which he could not explain by any other manner other than “dynamic energy” as follows:
“If one looks upon something nauseous and becomes inclined to vomit, did a material emetic come into his stomach which compels him to this anti-peristaltic movement? Was it not solely the dynamic effect of the nauseating aspect upon his imagination?”
“if one raises his arm, does it occur through a material visible instrument? a lever? Is it not solely the conceptual dynamic energy of his will which raises it?”
“Our earth, by virtue of a hidden invisible energy, carries the moon around her in twenty-eight days and several hours, and the moon alternately, in definite fixed hours (deducting certain differences which occur with the full and new moon) raises our northern seas to flood tide and again correspondingly lowers them to ebb. Apparently this takes place not through material agencies, not through mechanical contrivances”
“we see numerous other events about us as results of the action of one substance on another substance without being able to recognize a sensible connection between cause and effect”
“dynamic effect of the sick-making influences upon healthy man, as well as the dynamic energy of the medicines upon the principle of life in the restoration of health is nothing else than infection and so not in any way material, not in any way mechanical”
“Just as the energy of a magnet attracting a piece of iron or steel is not material, not mechanical”
“One sees that the piece of iron is attracted by one pole of the magnet, but how it is done is not seen.”
“This invisible energy of the magnet does not require mechanical (material) auxiliary means, hook or lever, to attract the iron. The magnet draws to itself and this acts upon the piece of iron or upon a steel needle by means of a purely immaterial invisible, conceptual, inherent energy, that is, dynamically, and communicates to the steel needle the magnetic energy equally invisibly (dynamically).”
“The steel needle becomes itself magnetic, even at a distance when the magnet does not touch it, and magnetises other steel needles with the same magnetic property (dynamically) with which it had been endowered previously by the magnetic rod”
“a child with small-pox or measles communicates to a near, untouched healthy child in an invisible manner (dynamically) the small-pox or measles, that is, infects it at a distance without anything material from the infective child going or capable of going to the one to be infected”
“A purely specific conceptual influence communicated to the near child small-pox or measles in the same way as the magnet communicated to the near needle the magnetic property.”
These were the “daily phenomena” which he could not explain by “any other means”, and compelled him to explain using the concepts of “dynamic energy”.
1. Hahnemann could not scientifically explain how limbs are raised at will- and hence, he explained it using dynamic energy.
2. Hahnemann could not scientifically explain why people get nauseated by seeing others vomit- and hence, he explained it using dynamic energy.
3. Hahnemann could not scientifically explain how measles and chicken pox are transmitted- and hence, he explained it using dynamic energy.
4. Hahnemann could not scientifically explain why earth revolves around sun- and hence, he explained it using dynamic energy.
5. Hahnemann could not scientifically explain the phenomena of high and low ebbsl- and hence, he explained it using dynamic energy.
6. Hahnemann could not scientifically explain how a magnet attracts an iron needle- and hence, he explained it using dynamic energy.
7. Hahnemann could not scientifically explain how a steel needle gets magnetized in the vicinity of a magnet – and hence, he explained it using dynamic energy.
8. Hahnemann could not scientifically explain the phenomenon of life – and hence, he explained it using vital force and dynamic energy.
9. Hahnemann could not scientifically explain disease and cure- and hence, he explained it using dynamic energy.
10. Hahnemann could not scientifically explain symptoms and drug proving- and hence, he explained it using dynamic energy.
11. Hahnemann could not scientifically explain how substances get medicinal property- and hence, he explained it using dynamic energy.
12. Hahnemann could not scientifically explain how potentization really worksl- and hence, he explained it using dynamic energy.
13. Hahnemann could not scientifically explain how potentized drugs act- and hence, he explained it using dynamic energy.
“QUANTUM PHYSICS” IN HOMEOPATHY- JUST ANOTHER NONSENSE!
Some homeopaths think that therapeutic actions of post-avogadro diluted homeopathic medicines could be explained using the concepts of QUANTUM PHYSICS.
They should bear in mind that Quantum physics is a branch modern science that deals with the behaviour of matter and light on the atomic and subatomic scale. It attempts to describe and account for the properties of molecules and atoms and their constituents—electrons, protons, neutrons, and other more esoteric particles such as quarks and gluons.
Attempts of explaining homeopathy using QUANTUM PHYSICS comes from the idea that drug substances are converted to SUBATOMIC PARTICLES and ENERGY during the process of homeopathic potentization.
The funny thing is that those who now comes with QUANTUM THEORIES of homeopathy were so far talking about NANOPARTICLE research in homeopathy!
They should understand, NANOPARTICLES has nothing to do with QUANTUM PHYSICS. Science of nanoparticles deas with the study of SUPRA-MOLECULAR and SUPRA-ATOMIC FORMATIONS of matter, where as quantum physics deals with the study of SUB-ATOMIC particles and forces. First of all you have to decide whether it is “subatomic particles” or “nanoparticles” you are talking about.
Anybody with high school level knowledge of science is aware that complex chemical molecules contained in drug substances cannot be converted to subatomic particles or energy particles by the process of potentization. With the minimal mechanical energy involved in “shaking”, you cannot break the very strong covalent bonds that hold atoms together in a chemical molecule.
What a ridiculous nonsense it will be if anybody says he can split a simple water molecule into oxygen and hydrogen atoms by “shaking” it? It is wonderful to see that our homeopathy “scientists” are imagining about converting matter into energy by the simple mechanical process of shaking involved in potentization! To convert drug substance into energy, they have split molecules into atoms, atoms into subatomic particles, and then subatomic particles into energy particles. One have to be an idiot to believe that it is happening during potentization!
Even if somebody could split drug molecules into atoms and subatomic particles, how can those particles retain the medicinal properties of complex drug molecules? Medicinal properties of drug molecules are due to their peculiar structure and chemical properties. How can an individual atom or subatomic particle retain the chemical properties of complex drug molecules?
Once the complex molecules are divided into constituent atoms, their molecular level properties are lost. Once the atoms are split into subatomic particles, their atomic level properties are lost. When matter is converted into energy, it will be ENERGY only. There cannot be a NUX VOMICA energy or SULPHUR energy once they are converted to energy form!
Same way as our SCIENCE-STARVED homeopaths swallowed the nonsense “nanoparticle theory” without asking a single question, they will swallow this QUANTUM PHYSICS THEORY OF HOMEOPATHY also! Especially when BIG scientists are talking it!
Notes on MIT Approach To Homeopathic Prophylaxis and Treatment of COVID 19
I do not agree with the current campaign for mass distribution of Arsenic Alb 30 as “immune booster”, being conducted by a section of homeopaths with the official support of AYUSH authorities. I have sufficient reasons for this disagreement.
Call it HOMEOPATHIC PROPHYLACTIC. It is the appropriate expression.
Post-avogadro homeopathic medicines contain molecular imprints of constituent molecules as their active principles. These molecular imprints act as ARTIFICIAL BINDING POCKETS for pathogenic molecules such as viral glycoproteins. They do not act upon our biological molecules or produce any effect unless pathological molecules having conformational affinity are present. Obviously, our medinces act ONLY if pathogenic molecules are present in our body. Molecular imprints fight viral infections by preventing from binding to our cells, not by enhancing IMMUNITY. That is why I say homeopathy medicines can prevent a viral disease only if taken continuously until epidemic is over.
COVID 19 is spreading very fast, and is almost going out of control in many states. Lives of people are in danger.
Please reconsider your earlier advice of distributing Arsenic Album 30 as preventive. It is not sufficient for mass prevention.
A disease-specific COMBINATION of all indicated homeopathic drugs in 30c potencies is essential to ensure protection on mass scale.
Dosage as well as frequency also have to be reconsidered. My suggestion is drop doses twice daily directly on tongueue until epidemic is over.
is an insult to HOMEOPATHY!
Nobody ever proved or can prove post-avogadro homeopathic medicines could induce production of immune bodies or initiate an immune process.!
Only way the molecular imprints contained in post-avogadro diluted homeopathic medicines act is to bind to the pathogenic molecules, deactivate them, and remove the pathological molecular inhibitions they produced.
In the absence of pathogenic molecules having conformational affinity, molecular imprints have no any action in the body.
Molecular imprints cannot interfere in the normal interactions between biological molecules and their natural ligands.
They cannot produce any positive or negative changes in the body. They cannot make us more healthy or more diseased, when there are no pathological molecules available for binding.
You can realize the folly involved in calling homeopathy medicines as IMMUNE BOOSTERS, only if you understand the biological mechanism by which post-avogadro drugs act.
1. Does that drug in 30c dilution actually contains the original drug ?
2. If “yes”, in what form original drug substance exists in 30c dilution? As molecules, atoms, nanoparticles, electrons, protons, subatomic particles or any other material form? Or does it exists in the form of some “dynamic energy”, “vial force”, “vibrations” or any other “immaterial form?
3. What is the biological mechanism by which the drug in 30c dilution produces immune boosting, prophylactic or therapeutic effects?
4. When answering these questions, please do not forget, 30c is a dilution of 1 in 1 and 60 zeros, much above avogadro limit. Above avogadro limit, there is no any chance for even a single particle of original substance to exist.
5. If you say Arsenic Alb 30 contains NANOPARTICLES of original drug, you will have to explain where from this unlimited supply of nanoparticles come, to be present in each and every split drop of the preparation even in such high dilutions! That will be possible only if new matter particles are generated from nothingness during the process of potentization!
6. Do you think the complex chemical molecules, chemical properties of which decide the medicinal properties of the substance, could be split into elemental atoms during potentization? Do you think the mechanical energy of shaking a few times will generate the huge energy required to break the covalent bonds that hold the atoms together in a molecule? If you think it is possible, can you split a simple water molecule into hydrogen and oxygen by SHAKING?
Dear sir, you cannot evade these important questions by simply quoting the aphorisms of the master, or abusing and ridiculing me for asking these kinds of uncomfortable questions!
1. Does Arsenic Alb 30 actually contains Arsenic Trioxide?
2. If “yes”, in what form Arsenic Trioxide exists in Arsenic Alb 30? As molecules, atoms, nanoparticles, electrons, protons, subatomic particles or any other material form? Or does it exists in the form of some “dynamic energy”, “vial force”, “vibrations” or any other “immaterial form?
3. What is the biological mechanism by which Arsenic Alb 30 produces, immune boosting, prophylactic or therapeutic please?
4. When answering these questions, please do not forget, 30c is a dilution of 1 in 1 and 60 zeros, much above avogadro limit. Above avogadro limit, there is no any chance for even a single particle of original substance to exist.
And of course another sect of them will claim it was sepia 200 two drops spray that did the work! Just like the claim going around that covid 19 is being prevented in some states by drinking cow urine!
Next generation homeopathy students will naturally be taught in colleges that it was homeopathy that defeated COVID 19 outbreak of 2020!
Some people claim they protected thousands by giving “holy ashes” brought from Himalaya! Some others claim they protected people using holy water from Ganges!
Millions are claimed to be protected by drinking cow urine! They might have consumed cow dung also!
One swamiji claims he can prevent corona by pranayama or breathing exercises!
Some people conduct pujas to prevent corona! Clapping hands and ringing bells on roads to eradicate covid were also performed all over the country!
Millions are also claimed to be protected by the mysterious vibrations emanating from homeopathic pills they distributed!
The truth is that spread of covid 19 was contained at least to this level by massive governmental vigilance, quaretines, isolations, lockdowns, social distancing, handwashing, sanitizers, masks etc! And every charlatans are claiming credits for it!
Had the whole world gone crazy by covid fear?
All the infected ones were identified in time, strictly quatentined, their root maps were published, primary and secondary contacts were identified and isolated, a massive “break the chain” campaign was implemented with active cooperation of public, lockdown was brought much before it came at national level, all of which ultimately prevented the spread of covid in the state.
Homeopaths please do not make homeopathy ridiculed and humiliated by making bogus claims!
AS with any other VIRAL DISEASE, homeopathy should be capable of preventing and curing covid-19. I have no least doubt the efficacy of homeopathy. But it should be established not by broadcasting bogus claims propagated by some irresponsible persons. That is my point.
Before raising claims, it should be proved by conducting systematic and well monitored trials, using appropriate prescriptions, appropriate medicines, appropriate potencies, appropriate doses and appropriate frequencies. You cannot prove the efficacy of homeopathy by giving some medicines “along with allopathic medicines” as some people are trying to do now.
You cannot evade from scientific questions by simply abusing the person who raises questions, and raising counter questions about his qualifications for questions. No special qualifications are necessary to question unscientific, superstitious and nonsense ideas that may harm the community. Mind it.
If you have any scientifically viable argument that “fragility and breaking of human genomes due to the disturbance of earth’s electromagnetic field” is the FUNDAMENTAL CAUSE of covid-19, prove it by scientific methods before broadcasting it to the community.
Existing scientific knowledge do not agree with your theory that “viruses do not come from outside, but from inside of individuals”.
Especially in this time global pandemic of covid-19, your arguments have a lot of dangerous implications. Need for lock downs, shutting of flights, isolation, quarantine, handwashes, social distancing, face masks, sanitization, and every preventive measures WHO and Govt have advised and globally practiced to prevent spread of COVID-19 will be irrelevant and unnecessary if your theory is right.
Please understand, you are questioning the rationale of ongoing fight against COVID 19, and you are bound to attract legal actions for violation of provisions of epidemics act currently in force.
In the current grave circumstances, you are not authorised to broadcast all your whims and fancies that may weakn the social preventive measures against COVID.
It will be very dangerous situation for the whole society around him, if someone belonging to the class of your “blind followers” dare to defy the directives of health officials, believing your words that covid is not spread from person to person, but come from his own “inside”.
Please think about the dangerous situation that may be created if people start believing your theory that covid could be cured and prevented by correcting the “vibrations” by applying some sepia 200 on his toes, and putting same medicines around the house!
Dear sir, please understand, by broadcasting this kind of dangerous ideas about corona virus infection in the current circumstances , you have actually done a big crime against humanity as a whole. Kindly withdraw your video and disown it as early as possible, as it is being widely propagated and broadcasted by your foolish followers who failed to realize it’s dangerous social and legal implications.
I know you do not like this kind of questions. And most of you will say those who ask this kind of questions are “enemies” of homeopathy. But for me, these questions arise from my love and concern for homeopathy, and from my desire to make it scientific! I know, your intolerance to scientific questions actually come from your realization that you are incapable of providing answers to them. Whether you like it or not, I will go on asking questions until I get satisfactory answers.
And remember, homeopathy will get recognized as a medical science only when you are capable of answering these questions in a way fitting to the modern scientific knowledge system!
Engaging in inappropriately designed and inaccurately conducted TRIALS based on blind beliefs and overenthusiasm about the “infallibility” of so-called “fundamental principles”, without any scientific idea regarding the active principles and biological mechanism of actions of homeopathic drugs may lead to failures of your trials. Ultimately, it will be doing big damages to the future of homeopathy.
As far as scientific people are concerned, Ars Alb 30 is nothing but a mixture of water and alcohol without any drug molecule in it. We will have to explain a lot
Some “researchers” will say they cured covid with camphor, some others with sepia, some others with Justicia, some others with zincum, some with Ars Alb, some with “multiple drugs”, and some other drug in material medica, depending upon their tastes and fancies!
Since there are no controls or blinding, this kind of trials are not going to be accepted by scientific community as valid proofs for anything.
What will remain at the end will be enough stuff for homeopaths to celebrate, and for skeptics to ridicule homeopathy!
ONE THING IS SURE. IT WILL BE GOING TO INFLICT MORE INJURIES TO THE SCIENTIFIC CREDIBILITY OF HOMEOPATHY!
You are bound to fail, if you think you can convince the skeptics regarding the efficacy of potentized homeopathic drugs by conducting conventional types of ‘clinical trials’ or RCTs as they demand for.
You can never expect ‘individual-based’ homeopathic drugs to be proved using the protocols of testing drugs in ‘disease-based’ modern medicine. Asking to ‘prove’ homeopathic drugs using protocols of allopathic drug trials is like trying to measure ‘length’ using units of ‘mass’.
Allopathic methods of ‘drug trials’ are applicable to ‘molecular forms’ of drugs only. But potentized homeopathic drugs, different from allopathic drugs, contain only ‘molecular imprints’, which can act only up on pathogenic molecules having specific conformational affinity. That means, potentized drugs can act only if indicated by similarity of symptoms.
You cannot ignore this peculiarity of homeopathy in matters of active principles as well as mechanism of drug actions while designing ‘drug trials’ for homeopathy.
In homeopathy, you cannot ‘verify’ action of a particular drug on a particular disease- you have to ‘verify’ action of ‘indicated drugs’ up on indicated individual patients, since different people with same disease may need different drugs.
Same time, disease-specific combinations of post-avogadro dilutions could be subjected to Random Controlled Trials in the same way as allopathic drugs. This is the most effective way to prove that potentized homeopathy drugs are not placebo, fraud, or “mere water”, but they really work.
As far as skeptics as well as homeopaths hesitate to accept this peculiarity of potentized homeopathic drugs and agree to design the ‘trials’ of disease-specific combinations of post-avogadro dilutions, there is no way to convince the scientists that ‘homeopathy’ works’.
I WANT TO REPEAT: WE CAN PROVE THE EFFECTIVENESS OF HOMEOPATHY THROUGH RANDOM CONTROLLED TRIALS ONLY BY USING DISEASE-SPECIFIC COMBINATIONS OF POST-AVOGADRO DILUTIONS.
Some “researchers” will say they cured covid with camphor, some others with sepia, some others with Justicia, some others with zincum, some with Ars Alb, some with “multiple drugs”, and some other drug in material medica, depending upon their tastes and fancies!
Since there are no controls or blinding, this kind of trials are not going to be accepted by scientific community as valid proofs for anything.
What will remain at the end will be enough stuff for homeopaths to celebrate, and for skeptics to ridicule homeopathy!
ONE THING IS SURE. IT WILL BE GOING TO INFLICT MORE INJURIES TO THE SCIENTIFIC CREDIBILITY OF HOMEOPATHY!
You are bound to fail, if you think you can convince the skeptics regarding the efficacy of potentized homeopathic drugs by conducting conventional types of ‘clinical trials’ or RCTs as they demand for.
You can never expect ‘individual-based’ homeopathic drugs to be proved using the protocols of testing drugs in ‘disease-based’ modern medicine. Asking to ‘prove’ homeopathic drugs using protocols of allopathic drug trials is like trying to measure ‘length’ using units of ‘mass’.
Allopathic methods of ‘drug trials’ are applicable to ‘molecular forms’ of drugs only. But potentized homeopathic drugs, different from allopathic drugs, contain only ‘molecular imprints’, which can act only up on pathogenic molecules having specific conformational affinity. That means, potentized drugs can act only if indicated by similarity of symptoms.
You cannot ignore this peculiarity of homeopathy in matters of active principles as well as mechanism of drug actions while designing ‘drug trials’ for homeopathy.
In homeopathy, you cannot ‘verify’ action of a particular drug on a particular disease- you have to ‘verify’ action of ‘indicated drugs’ up on indicated individual patients, since different people with same disease may need different drugs.
Same time, disease-specific combinations of post-avogadro dilutions could be subjected to Random Controlled Trials in the same way as allopathic drugs. This is the most effective way to prove that potentized homeopathy drugs are not placebo, fraud, or “mere water”, but they really work.
As far as skeptics as well as homeopaths hesitate to accept this peculiarity of potentized homeopathic drugs and agree to design the ‘trials’ of disease-specific combinations of post-avogadro dilutions, there is no way to convince the scientists that ‘homeopathy’ works’.
I WANT TO REPEAT: WE CAN PROVE THE EFFECTIVENESS OF HOMEOPATHY THROUGH RANDOM CONTROLLED TRIALS ONLY BY USING DISEASE-SPECIFIC COMBINATIONS OF POST-AVOGADRO DILUTIONS.
At the end, only things remaining for homeopathy will be some bogus unconvincing claims from homeopaths, and lot of ridicules from the other side!
Even a few drops of “holy water” will be enough to make a CLAIM of cure in a disease more than 80% of which is resolved without any medication at all, when you are not expected to explain HOW IT ACTS!
“Scientific Advisory Board considered that the same medicine has been advised for prevention of Influenza like illnesses. As one of the constituents of a formulation , Arsenicum Album has been shown to affect the HT-29 cells and human macrophages”. It reduced the expression of reporter gene GFP in transfect HT 29 cells, and reduced TNF-alfa release in macrophages. Moreover, Arsenic Album is a common prescription in the cases of respiratory infections in day to day practice.”
If we examine the above reasoning, it contains THREE points:
1. ” the same medicine has been advised for prevention of Influenza like illnesses”.
2. “As one of the constituents of a formulation, Arsenicum Album has been shown to affect the HT-29 cells and human macrophages”.
3. It reduced the expression of reporter gene GFP in transfect HT 29 cells, and reduced TNF-alfa release in macrophages.”
4. “Arsenic Album is a common prescription in the cases of respiratory infections in day to day practice.”
Point 1 and 4 are obviously of no relevance as a scientific reasoning, other than quoting hearsays. How could anybody recommend Ars Alb or any other medicine for Covid 19, on the simple reasons that “same medicine has been advised for prevention of Influenza like illnesses”, or “it is a common prescription in the cases of respiratory infections in day to day practice”? It is totally unscientific and illogical.
Coming to POINT 2, See on Wikipedia what is HT-29 cells: “HT-29 is a human colon cancer cell line used extensively in biological and cancer research. HT-29 cells form a tight monolayer while exhibiting similarity to enterocytes from the small intestine. HT-29 cells overproduce the p53 tumor antigen, but have a mutation in the p53 gene at position 273, resulting in a histidine replacing an arginine. The cells proliferate rapidly in media containing suramin, with corresponding high expression of the c-myc oncogene. However, c-myc is deregulated, but may have a relation with the growth factor requirements of HT-29 cells”.
Even if Arsenicum Album has been proved to act upon HT 29 cells, what is its relevance in covid 19 treatment? Has anybody proved that HT 29 cells are anyway involved in pathology of corona? Any argument or any evidence? Nothing!
Another thing is, the paper shown in the reference actually is regarding a study regarding action of MOLECULAR forms of Arsenic Trioxide on HT 29 cells. Does our ARSENIC ALB 30 contain any molecules of Arsenic Trioxide?
Coming to POINT 3, see what WIKIPEDIA says: The green fluorescent protein (GFP) is a protein composed of 238 amino acid residues (26.9 kDa) that exhibits bright green fluorescence when exposed to light in the blue to ultraviolet range. In cell and molecular biology, the GFP gene is frequently used as a reporter of expression.[5] It has been used in modified forms to make biosensors, and many animals have been created that express GFP, which demonstrates a proof of concept that a gene can be expressed throughout a given organism, in selected organs, or in cells of interest. GFP can be introduced into animals or other species through transgenic techniques, and maintained in their genome and that of their offspring. To date, GFP has been expressed in many species, including bacteria, yeasts, fungi, fish and mammals, including in human cells”.
How the “reduced the expression of reporter gene GFP in transfect HT 29 cells” by the action of MOLECULAR forms of Arsenic Trioxide becomes relevant in the treatment of covid 19?
Regarding the reference to “reduced TNF-alfa release in macrophages” by the action of molecular forms of Arsenic Trioxide, somebody has to explain how it justifies the use of ARS ALB 30 in covid 19. It is well known that TNF alfa plays a role in induction of inflammations and antiviral responses. But it is Arsenic Trioxide in MOLECULAR FORM. Our Arsenic alb 30 is a 1/1and 60 zeros dilution of Arsenic Trioxide. Can anybody say Arsenic Trioxide molecules will be retained in a dilution 3 times above Avogadro limit? If not, in what form Arsenic Trioxide will be available in Ars Alb 30, and what will be the biological mechanism by which it acts? Without getting answers to this question, do you expect scientific community to recognize homeopathy as a medical system?
You can never expect ‘individual-based’ homeopathic drugs to be proved using the protocols of testing drugs in ‘disease-based’ modern medicine. Asking to ‘prove’ homeopathic drugs using protocols of allopathic drug trials is like trying to measure ‘length’ using units of ‘mass’.
Allopathic methods of ‘drug trials’ are applicable to ‘molecular forms’ of drugs only. But potentized homeopathic drugs, different from allopathic drugs, contain only ‘molecular imprints’, which can act only up on pathogenic molecules having specific conformational affinity. That means, potentized drugs can act only if indicated by similarity of symptoms.
You cannot ignore this peculiarity of homeopathy in matters of active principles as well as mechanism of drug actions while designing ‘drug trials’ for homeopathy.
In homeopathy, you cannot ‘verify’ action of a particular drug on a particular disease- you have to ‘verify’ action of ‘indicated drugs’ up on indicated individual patients, since different people with same disease may need different drugs.
Same time, disease-specific combinations of post-avogadro dilutions could be subjected to Random Controlled Trials in the same way as allopathic drugs. This is the most effective way to prove that potentized homeopathy drugs are not placebo, fraud, or “mere water”, but they really work.
As far as skeptics as well as homeopaths hesitate to accept this peculiarity of potentized homeopathic drugs and agree to design the ‘trials’ of disease-specific combinations of post-avogadro dilutions, there is no way to convince the scientists that ‘homeopathy’ works’.
I WANT TO REPEAT: WE CAN PROVE THE EFFECTIVENESS OF HOMEOPATHY THROUGH RANDOM CONTROLLED TRIALS ONLY BY USING DISEASE-SPECIFIC COMBINATIONS OF POST-AVOGADRO DILUTIONS.
MIT view is that it is effective as palliatives to use ‘disease-specific’ combinations of ‘molecular imprinted’ forms (potencies above Avogadro limit- 12c and onwards) of two or more homeopathic drugs selected on the basis of common symptoms and biochemical evaluations of specific diseases. But such ‘disease-specific’ combinations will not offer ‘total cure’ for patients, without incorporating drugs selected on the basis of symptoms also. This approach also is very close to the method of ‘banerji protocols’ that makes ‘specific’ prescriptions based on ‘disease diagnosis’ as well as symptomatology..
I am talking on the basis of my concepts of ‘molecular imprinting’ involved in potentization. I perceive all crude drugs as combinations of diverse types of constituent drug molecules. I perceive even the so called potentized ‘single’ drug as combinations of diverse types of individual drug molecules contained in the drug substance used for potentization.
My stand on this issue is based on my understanding of diseases as multitudes of pathological derangement in the organism, caused by diverse of types of molecular inhibitions caused by different types of pathogenic agents, and therapeutics involves the removal of those inhibitions using appropriate molecular imprints.
I am talking on the basis of my understanding of ‘similia similibus curentur’ as: “pathological molecular inhibitions caused by specific pathogenic molecules and expressed through a certain group of subjective and objective symptoms, could be removed by applying ‘molecular imprints’ of drug molecules that could create similar molecular inhibitions and symptoms in a healthy organism when applied in crude form.
That makes the difference between my views and classical homeopathy. I know, homeopaths trained and experienced in classical homeopathy cannot agree with my views on this topic.
MIT or Molecular Imprints Therapeutics refers to a scientific hypothesis that proposes a rational model for biological mechanism of homeopathic therapeutics.
According to MIT hypothesis, potentization involves a process of ‘molecular imprinting’, where in the conformational details of individual drug molecules are ‘imprinted’ or engraved as hydrogen-bonded three dimensional nano-cavities into a supra-molecular matrix of water and ethyl alcohol, through a process of molecular level ‘host-guest’ interactions. These ‘molecular imprints’ or ‘hydrosomes’ are the active principles of post-avogadro dilutions used as homeopathic drugs.
Due to ‘conformational affinity’, molecular imprints can act as ‘artificial key holes’ or ‘ligand binds’ for the specific drug molecules used for imprinting, and for all pathogenic molecules having functional groups ‘similar’ to those drug molecules. When used as therapeutic agents, molecular imprints selectively bind to the pathogenic molecules having conformational affinity and deactivate them, thereby relieving the biological molecules from the inhibitions or blocks caused by pathogenic molecules. According to MIT hypothesis, this is the biological mechanism of high dilution therapeutics involved in homeopathic cure.
According to MIT hypothesis, ‘Similia Similibus Curentur’ means, diseases expressed through a particular group of symptoms could be cured by ‘molecular imprints’ forms of drug substances, which in ‘molecular’ or crude forms could produce ‘similar’ groups of symptoms in healthy individuals. ‘Similarity’ of drug symptoms and diseaes indicates ‘similarity’ of pathological molecular inhibitions caused by drug molecules and pathogenic molecules, which in turn indicates conformational ‘similarity’ of functional groups of drug molecules and pathogenic molecules. Since molecular imprints of ‘similar’ molecules can bind to ‘similar’ ligand molecules by conformational affinity, they can act as therapeutic agents when applied as indicated by ‘similarity of symptoms’.
No body in the whole history could so far propose a hypothesis about homeopathy as scientific, rational and perfect as MIT, explaining the molecular process involed in potentization, and the biological mechanism involved in ‘similia similibus curentur’, in a way fitting well to modern scientific knowledge system.
Arsenic Album or Arsenic Trioxide is a chemical substance that can inhibit more than 200 essential enzymes in our body involved in diverse types of biomolecular processes related with genetic transcription, metabolism, energy conversions etc etc. This is due to the ability of Arsenic ions to bind to the cysteine radicals which are part of active sites all enzymes. Almost every biochemical pathways in the living body are deranged by the action of arsenic. This is the reason why the homeopathic materia medica of arsenic album is so rich with symptoms associated with almost all organs and systems of the body.
It is an already established fact that during viral infections, persons having high levels of arsenic in their body are prone to develop serious complications such as respiratory failure, acute myocardial degeneration, renal failures, liver failures, multiple organ failures etc faster than those having low arsenic levels. My suggestion to the experts involved in covid 19 research is that determination of arsenic levels in the body of covid patients should be made mandatory, so that high risk people could be identified and better care provided.
Arsenic content may be high in people due to living in certain areas, consuming arsenic rich ground water, cigarette smoking, eating unpolished rice, prawns and crabs, exposure to arsenic containing environments, etc etc. Arsenic may enter the body through contaminated liquors, Chinese, Ayurvedic, unani or Herbal preparations, industrial exposures, chemically treated wooden furniture etc also. Arsenic content will naturally be high in aged people, as it has a tendency to accumulated in the body over years through exposures.
Researchers working upon arsenic toxicity problems in certain arsenic affected countries have already proved that ARSENIC ALBUM 30 can antidote and reverse the chronic effects of arsenic toxicity, and remove the symptoms.
Arsenic Album 30 contains MOLECULAR IMPRINTS of arsenic trioxide molecules. Molecular imprints are three dimensional nanocavities formed in water-alcohol supra-molecular matrix through a host-guest interactions between templates and diluent medium during the process of homeopathic POTENTIZATION. Molecular imprints of arsenic trioxide contained in Arsenicum Album 30 can act as artificial binding pockets for arsenic ions and deactivate them, thereby removing the molecular inhibitions they have produced in the enzyme systems of the body.
By using Arsenicum Album 30 in sufficient quantities and frequencies to provide molecular imprints in optimum levels, it will be possible to prevent dangerous complications and multiple organ failures in covid 19 patients, so as to prevent the chances of morbidities due to the disease. Covid 19 deaths could prevented by use of Arsenic Alb 30.
I don’t know how to get this vey important message reach the right persons in right time, or how to convince the scientific basis of this approach described above.
A word to homeopaths : Homeopaths currently involved in distribution of Arsenicum Album 30 should realize the hard truth that the dosage you are giving now is actually of no use. 4 or 5 medicated sugar pills you give now cannot provide the sufficient quantity of molecular imprints required to produce desired biological effects. To ensure optimum protection, medicine should be used in drop doses at least twice a day until the epidemic threat is over.
Please understand, it is not any mysterious “dynamic energy” or “vibrations” that work in our potentized drugs. It is MOLECULAR IMPRINTS, that act as “artificial binding pockets” for pathogenic molecules, and deactivate them.
I am not sure whether Arsenic album 30 will prevent or not covid. Be sure it will surely prevent complications even if you get infected. But dosage should be reconsidered. I would suggest minimum 1 or 2 drops direct on tongue bds until epidemic is over.
My Social Media Notes On Homoeopathic Prophylaxis
Call it HOMEOPATHIC PROPHYLACTIC. It is the appropriate expression.
Post-avogadro homeopathic medicines contain molecular imprints of constituent molecules as their active principles. These molecular imprints act as ARTIFICIAL BINDING POCKETS for pathogenic molecules such as viral glycoproteins. They do not act upon our biological molecules or produce any effect unless pathological molecules having conformational affinity are present. Obviously, our medinces act ONLY if pathogenic molecules are present in our body. Molecular imprints fight viral infections by preventing from binding to our cells, not by enhancing IMMUNITY. That is why I say homeopathy medicines can prevent a viral disease only if taken continuously until epidemic is over.
COVID 19 is spreading very fast, and is almost going out of control in many states. Lives of people are in danger.
Please reconsider your earlier advice of distributing Arsenic Album 30 as preventive. It is not sufficient for mass prevention.
A disease-specific COMBINATION of all indicated homeopathic drugs in 30c potencies is essential to ensure protection on mass scale.
Dosage as well as frequency also have to be reconsidered. My suggestion is drop doses twice daily directly on tongueue until epidemic is over.
is an insult to HOMEOPATHY!
Nobody ever proved or can prove post-avogadro homeopathic medicines could induce production of immune bodies or initiate an immune process.!
Only way the molecular imprints contained in post-avogadro diluted homeopathic medicines act is to bind to the pathogenic molecules, deactivate them, and remove the pathological molecular inhibitions they produced.
In the absence of pathogenic molecules having conformational affinity, molecular imprints have no any action in the body.
Molecular imprints cannot interfere in the normal interactions between biological molecules and their natural ligands.
They cannot produce any positive or negative changes in the body. They cannot make us more healthy or more diseased, when there are no pathological molecules available for binding.
You can realize the folly involved in calling homeopathy medicines as IMMUNE BOOSTERS, only if you understand the biological mechanism by which post-avogadro drugs act.
1. Does that drug in 30c dilution actually contains the original drug ?
2. If “yes”, in what form original drug substance exists in 30c dilution? As molecules, atoms, nanoparticles, electrons, protons, subatomic particles or any other material form? Or does it exists in the form of some “dynamic energy”, “vial force”, “vibrations” or any other “immaterial form?
3. What is the biological mechanism by which the drug in 30c dilution produces immune boosting, prophylactic or therapeutic effects?
4. When answering these questions, please do not forget, 30c is a dilution of 1 in 1 and 60 zeros, much above avogadro limit. Above avogadro limit, there is no any chance for even a single particle of original substance to exist.
5. If you say Arsenic Alb 30 contains NANOPARTICLES of original drug, you will have to explain where from this unlimited supply of nanoparticles come, to be present in each and every split drop of the preparation even in such high dilutions! That will be possible only if new matter particles are generated from nothingness during the process of potentization!
6. Do you think the complex chemical molecules, chemical properties of which decide the medicinal properties of the substance, could be split into elemental atoms during potentization? Do you think the mechanical energy of shaking a few times will generate the huge energy required to break the covalent bonds that hold the atoms together in a molecule? If you think it is possible, can you split a simple water molecule into hydrogen and oxygen by SHAKING?
Dear sir, you cannot evade these important questions by simply quoting the aphorisms of the master, or abusing and ridiculing me for asking these kinds of uncomfortable questions!
1. Does Arsenic Alb 30 actually contains Arsenic Trioxide?
2. If “yes”, in what form Arsenic Trioxide exists in Arsenic Alb 30? As molecules, atoms, nanoparticles, electrons, protons, subatomic particles or any other material form? Or does it exists in the form of some “dynamic energy”, “vial force”, “vibrations” or any other “immaterial form?
3. What is the biological mechanism by which Arsenic Alb 30 produces, immune boosting, prophylactic or therapeutic please?
4. When answering these questions, please do not forget, 30c is a dilution of 1 in 1 and 60 zeros, much above avogadro limit. Above avogadro limit, there is no any chance for even a single particle of original substance to exist.
And of course another sect of them will claim it was sepia 200 two drops spray that did the work! Just like the claim going around that covid 19 is being prevented in some states by drinking cow urine!
Next generation homeopathy students will naturally be taught in colleges that it was homeopathy that defeated COVID 19 outbreak of 2020!
Some people claim they protected thousands by giving “holy ashes” brought from Himalaya! Some others claim they protected people using holy water from Ganges!
Millions are claimed to be protected by drinking cow urine! They might have consumed cow dung also!
One swamiji claims he can prevent corona by pranayama or breathing exercises!
Some people conduct pujas to prevent corona! Clapping hands and ringing bells on roads to eradicate covid were also performed all over the country!
Millions are also claimed to be protected by the mysterious vibrations emanating from homeopathic pills they distributed!
The truth is that spread of covid 19 was contained at least to this level by massive governmental vigilance, quaretines, isolations, lockdowns, social distancing, handwashing, sanitizers, masks etc! And every charlatans are claiming credits for it!
Had the whole world gone crazy by covid fear?
All the infected ones were identified in time, strictly quatentined, their root maps were published, primary and secondary contacts were identified and isolated, a massive “break the chain” campaign was implemented with active cooperation of public, lockdown was brought much before it came at national level, all of which ultimately prevented the spread of covid in the state.
Homeopaths please do not make homeopathy ridiculed and humiliated by making bogus claims!
AS with any other VIRAL DISEASE, homeopathy should be capable of preventing and curing covid-19. I have no least doubt the efficacy of homeopathy. But it should be established not by broadcasting bogus claims propagated by some irresponsible persons. That is my point.
Before raising claims, it should be proved by conducting systematic and well monitored trials, using appropriate prescriptions, appropriate medicines, appropriate potencies, appropriate doses and appropriate frequencies. You cannot prove the efficacy of homeopathy by giving some medicines “along with allopathic medicines” as some people are trying to do now.
You cannot evade from scientific questions by simply abusing the person who raises questions, and raising counter questions about his qualifications for questions. No special qualifications are necessary to question unscientific, superstitious and nonsense ideas that may harm the community. Mind it.
If you have any scientifically viable argument that “fragility and breaking of human genomes due to the disturbance of earth’s electromagnetic field” is the FUNDAMENTAL CAUSE of covid-19, prove it by scientific methods before broadcasting it to the community.
Existing scientific knowledge do not agree with your theory that “viruses do not come from outside, but from inside of individuals”.
Especially in this time global pandemic of covid-19, your arguments have a lot of dangerous implications. Need for lock downs, shutting of flights, isolation, quarantine, handwashes, social distancing, face masks, sanitization, and every preventive measures WHO and Govt have advised and globally practiced to prevent spread of COVID-19 will be irrelevant and unnecessary if your theory is right.
Please understand, you are questioning the rationale of ongoing fight against COVID 19, and you are bound to attract legal actions for violation of provisions of epidemics act currently in force.
In the current grave circumstances, you are not authorised to broadcast all your whims and fancies that may weakn the social preventive measures against COVID.
It will be very dangerous situation for the whole society around him, if someone belonging to the class of your “blind followers” dare to defy the directives of health officials, believing your words that covid is not spread from person to person, but come from his own “inside”.
Please think about the dangerous situation that may be created if people start believing your theory that covid could be cured and prevented by correcting the “vibrations” by applying some sepia 200 on his toes, and putting same medicines around the house!
Dear sir, please understand, by broadcasting this kind of dangerous ideas about corona virus infection in the current circumstances , you have actually done a big crime against humanity as a whole. Kindly withdraw your video and disown it as early as possible, as it is being widely propagated and broadcasted by your foolish followers who failed to realize it’s dangerous social and legal implications.
I know you do not like this kind of questions. And most of you will say those who ask this kind of questions are “enemies” of homeopathy. But for me, these questions arise from my love and concern for homeopathy, and from my desire to make it scientific! I know, your intolerance to scientific questions actually come from your realization that you are incapable of providing answers to them. Whether you like it or not, I will go on asking questions until I get satisfactory answers.
And remember, homeopathy will get recognized as a medical science only when you are capable of answering these questions in a way fitting to the modern scientific knowledge system!
Engaging in inappropriately designed and inaccurately conducted TRIALS based on blind beliefs and overenthusiasm about the “infallibility” of so-called “fundamental principles”, without any scientific idea regarding the active principles and biological mechanism of actions of homeopathic drugs may lead to failures of your trials. Ultimately, it will be doing big damages to the future of homeopathy.
As far as scientific people are concerned, Ars Alb 30 is nothing but a mixture of water and alcohol without any drug molecule in it. We will have to explain a lot!
Some “researchers” will say they cured covid with camphor, some others with sepia, some others with Justicia, some others with zincum, some with Ars Alb, some with “multiple drugs”, and some other drug in material medica, depending upon their tastes and fancies!
Since there are no controls or blinding, this kind of trials are not going to be accepted by scientific community as valid proofs for anything.
What will remain at the end will be enough stuff for homeopaths to celebrate, and for skeptics to ridicule homeopathy!
ONE THING IS SURE. IT WILL BE GOING TO INFLICT MORE INJURIES TO THE SCIENTIFIC CREDIBILITY OF HOMEOPATHY!
You are bound to fail, if you think you can convince the skeptics regarding the efficacy of potentized homeopathic drugs by conducting conventional types of ‘clinical trials’ or RCTs as they demand for.
You can never expect ‘individual-based’ homeopathic drugs to be proved using the protocols of testing drugs in ‘disease-based’ modern medicine. Asking to ‘prove’ homeopathic drugs using protocols of allopathic drug trials is like trying to measure ‘length’ using units of ‘mass’.
Allopathic methods of ‘drug trials’ are applicable to ‘molecular forms’ of drugs only. But potentized homeopathic drugs, different from allopathic drugs, contain only ‘molecular imprints’, which can act only up on pathogenic molecules having specific conformational affinity. That means, potentized drugs can act only if indicated by similarity of symptoms.
You cannot ignore this peculiarity of homeopathy in matters of active principles as well as mechanism of drug actions while designing ‘drug trials’ for homeopathy.
In homeopathy, you cannot ‘verify’ action of a particular drug on a particular disease- you have to ‘verify’ action of ‘indicated drugs’ up on indicated individual patients, since different people with same disease may need different drugs.
Same time, disease-specific combinations of post-avogadro dilutions could be subjected to Random Controlled Trials in the same way as allopathic drugs. This is the most effective way to prove that potentized homeopathy drugs are not placebo, fraud, or “mere water”, but they really work.
As far as skeptics as well as homeopaths hesitate to accept this peculiarity of potentized homeopathic drugs and agree to design the ‘trials’ of disease-specific combinations of post-avogadro dilutions, there is no way to convince the scientists that ‘homeopathy’ works’.
I WANT TO REPEAT: WE CAN PROVE THE EFFECTIVENESS OF HOMEOPATHY THROUGH RANDOM CONTROLLED TRIALS ONLY BY USING DISEASE-SPECIFIC COMBINATIONS OF POST-AVOGADRO DILUTIONS.
Some “researchers” will say they cured covid with camphor, some others with sepia, some others with Justicia, some others with zincum, some with Ars Alb, some with “multiple drugs”, and some other drug in material medica, depending upon their tastes and fancies!
Since there are no controls or blinding, this kind of trials are not going to be accepted by scientific community as valid proofs for anything.
What will remain at the end will be enough stuff for homeopaths to celebrate, and for skeptics to ridicule homeopathy!
ONE THING IS SURE. IT WILL BE GOING TO INFLICT MORE INJURIES TO THE SCIENTIFIC CREDIBILITY OF HOMEOPATHY!
You are bound to fail, if you think you can convince the skeptics regarding the efficacy of potentized homeopathic drugs by conducting conventional types of ‘clinical trials’ or RCTs as they demand for.
You can never expect ‘individual-based’ homeopathic drugs to be proved using the protocols of testing drugs in ‘disease-based’ modern medicine. Asking to ‘prove’ homeopathic drugs using protocols of allopathic drug trials is like trying to measure ‘length’ using units of ‘mass’.
Allopathic methods of ‘drug trials’ are applicable to ‘molecular forms’ of drugs only. But potentized homeopathic drugs, different from allopathic drugs, contain only ‘molecular imprints’, which can act only up on pathogenic molecules having specific conformational affinity. That means, potentized drugs can act only if indicated by similarity of symptoms.
You cannot ignore this peculiarity of homeopathy in matters of active principles as well as mechanism of drug actions while designing ‘drug trials’ for homeopathy.
In homeopathy, you cannot ‘verify’ action of a particular drug on a particular disease- you have to ‘verify’ action of ‘indicated drugs’ up on indicated individual patients, since different people with same disease may need different drugs.
Same time, disease-specific combinations of post-avogadro dilutions could be subjected to Random Controlled Trials in the same way as allopathic drugs. This is the most effective way to prove that potentized homeopathy drugs are not placebo, fraud, or “mere water”, but they really work.
As far as skeptics as well as homeopaths hesitate to accept this peculiarity of potentized homeopathic drugs and agree to design the ‘trials’ of disease-specific combinations of post-avogadro dilutions, there is no way to convince the scientists that ‘homeopathy’ works’.
I WANT TO REPEAT: WE CAN PROVE THE EFFECTIVENESS OF HOMEOPATHY THROUGH RANDOM CONTROLLED TRIALS ONLY BY USING DISEASE-SPECIFIC COMBINATIONS OF POST-AVOGADRO DILUTIONS.
At the end, only things remaining for homeopathy will be some bogus unconvincing claims from homeopaths, and lot of ridicules from the other side!
Even a few drops of “holy water” will be enough to make a CLAIM of cure in a disease more than 80% of which is resolved without any medication at all, when you are not expected to explain HOW IT ACTS!
“Scientific Advisory Board considered that the same medicine has been advised for prevention of Influenza like illnesses. As one of the constituents of a formulation , Arsenicum Album has been shown to affect the HT-29 cells and human macrophages”. It reduced the expression of reporter gene GFP in transfect HT 29 cells, and reduced TNF-alfa release in macrophages. Moreover, Arsenic Album is a common prescription in the cases of respiratory infections in day to day practice.”
If we examine the above reasoning, it contains THREE points:
1. ” the same medicine has been advised for prevention of Influenza like illnesses”.
2. “As one of the constituents of a formulation, Arsenicum Album has been shown to affect the HT-29 cells and human macrophages”.
3. It reduced the expression of reporter gene GFP in transfect HT 29 cells, and reduced TNF-alfa release in macrophages.”
4. “Arsenic Album is a common prescription in the cases of respiratory infections in day to day practice.”
Point 1 and 4 are obviously of no relevance as a scientific reasoning, other than quoting hearsays. How could anybody recommend Ars Alb or any other medicine for Covid 19, on the simple reasons that “same medicine has been advised for prevention of Influenza like illnesses”, or “it is a common prescription in the cases of respiratory infections in day to day practice”? It is totally unscientific and illogical.
Coming to POINT 2, See on Wikipedia what is HT-29 cells: “HT-29 is a human colon cancer cell line used extensively in biological and cancer research. HT-29 cells form a tight monolayer while exhibiting similarity to enterocytes from the small intestine. HT-29 cells overproduce the p53 tumor antigen, but have a mutation in the p53 gene at position 273, resulting in a histidine replacing an arginine. The cells proliferate rapidly in media containing suramin, with corresponding high expression of the c-myc oncogene. However, c-myc is deregulated, but may have a relation with the growth factor requirements of HT-29 cells”.
Even if Arsenicum Album has been proved to act upon HT 29 cells, what is its relevance in covid 19 treatment? Has anybody proved that HT 29 cells are anyway involved in pathology of corona? Any argument or any evidence? Nothing!
Another thing is, the paper shown in the reference actually is regarding a study regarding action of MOLECULAR forms of Arsenic Trioxide on HT 29 cells. Does our ARSENIC ALB 30 contain any molecules of Arsenic Trioxide?
Coming to POINT 3, see what WIKIPEDIA says: The green fluorescent protein (GFP) is a protein composed of 238 amino acid residues (26.9 kDa) that exhibits bright green fluorescence when exposed to light in the blue to ultraviolet range. In cell and molecular biology, the GFP gene is frequently used as a reporter of expression.[5] It has been used in modified forms to make biosensors, and many animals have been created that express GFP, which demonstrates a proof of concept that a gene can be expressed throughout a given organism, in selected organs, or in cells of interest. GFP can be introduced into animals or other species through transgenic techniques, and maintained in their genome and that of their offspring. To date, GFP has been expressed in many species, including bacteria, yeasts, fungi, fish and mammals, including in human cells”.
How the “reduced the expression of reporter gene GFP in transfect HT 29 cells” by the action of MOLECULAR forms of Arsenic Trioxide becomes relevant in the treatment of covid 19?
Regarding the reference to “reduced TNF-alfa release in macrophages” by the action of molecular forms of Arsenic Trioxide, somebody has to explain how it justifies the use of ARS ALB 30 in covid 19. It is well known that TNF alfa plays a role in induction of inflammations and antiviral responses. But it is Arsenic Trioxide in MOLECULAR FORM. Our Arsenic alb 30 is a 1/1and 60 zeros dilution of Arsenic Trioxide. Can anybody say Arsenic Trioxide molecules will be retained in a dilution 3 times above Avogadro limit? If not, in what form Arsenic Trioxide will be available in Ars Alb 30, and what will be the biological mechanism by which it acts? Without getting answers to this question, do you expect scientific community to recognize homeopathy as a medical system?
You can never expect ‘individual-based’ homeopathic drugs to be proved using the protocols of testing drugs in ‘disease-based’ modern medicine. Asking to ‘prove’ homeopathic drugs using protocols of allopathic drug trials is like trying to measure ‘length’ using units of ‘mass’.
Allopathic methods of ‘drug trials’ are applicable to ‘molecular forms’ of drugs only. But potentized homeopathic drugs, different from allopathic drugs, contain only ‘molecular imprints’, which can act only up on pathogenic molecules having specific conformational affinity. That means, potentized drugs can act only if indicated by similarity of symptoms.
You cannot ignore this peculiarity of homeopathy in matters of active principles as well as mechanism of drug actions while designing ‘drug trials’ for homeopathy.
In homeopathy, you cannot ‘verify’ action of a particular drug on a particular disease- you have to ‘verify’ action of ‘indicated drugs’ up on indicated individual patients, since different people with same disease may need different drugs.
Same time, disease-specific combinations of post-avogadro dilutions could be subjected to Random Controlled Trials in the same way as allopathic drugs. This is the most effective way to prove that potentized homeopathy drugs are not placebo, fraud, or “mere water”, but they really work.
As far as skeptics as well as homeopaths hesitate to accept this peculiarity of potentized homeopathic drugs and agree to design the ‘trials’ of disease-specific combinations of post-avogadro dilutions, there is no way to convince the scientists that ‘homeopathy’ works’.
I WANT TO REPEAT: WE CAN PROVE THE EFFECTIVENESS OF HOMEOPATHY THROUGH RANDOM CONTROLLED TRIALS ONLY BY USING DISEASE-SPECIFIC COMBINATIONS OF POST-AVOGADRO DILUTIONS.
MIT view is that it is effective as palliatives to use ‘disease-specific’ combinations of ‘molecular imprinted’ forms (potencies above Avogadro limit- 12c and onwards) of two or more homeopathic drugs selected on the basis of common symptoms and biochemical evaluations of specific diseases. But such ‘disease-specific’ combinations will not offer ‘total cure’ for patients, without incorporating drugs selected on the basis of symptoms also. This approach also is very close to the method of ‘banerji protocols’ that makes ‘specific’ prescriptions based on ‘disease diagnosis’ as well as symptomatology..
I am talking on the basis of my concepts of ‘molecular imprinting’ involved in potentization. I perceive all crude drugs as combinations of diverse types of constituent drug molecules. I perceive even the so called potentized ‘single’ drug as combinations of diverse types of individual drug molecules contained in the drug substance used for potentization.
My stand on this issue is based on my understanding of diseases as multitudes of pathological derangement in the organism, caused by diverse of types of molecular inhibitions caused by different types of pathogenic agents, and therapeutics involves the removal of those inhibitions using appropriate molecular imprints.
I am talking on the basis of my understanding of ‘similia similibus curentur’ as: “pathological molecular inhibitions caused by specific pathogenic molecules and expressed through a certain group of subjective and objective symptoms, could be removed by applying ‘molecular imprints’ of drug molecules that could create similar molecular inhibitions and symptoms in a healthy organism when applied in crude form.
That makes the difference between my views and classical homeopathy. I know, homeopaths trained and experienced in classical homeopathy cannot agree with my views on this topic.
MIT or Molecular Imprints Therapeutics refers to a scientific hypothesis that proposes a rational model for biological mechanism of homeopathic therapeutics.
According to MIT hypothesis, potentization involves a process of ‘molecular imprinting’, where in the conformational details of individual drug molecules are ‘imprinted’ or engraved as hydrogen-bonded three dimensional nano-cavities into a supra-molecular matrix of water and ethyl alcohol, through a process of molecular level ‘host-guest’ interactions. These ‘molecular imprints’ or ‘hydrosomes’ are the active principles of post-avogadro dilutions used as homeopathic drugs.
Due to ‘conformational affinity’, molecular imprints can act as ‘artificial key holes’ or ‘ligand binds’ for the specific drug molecules used for imprinting, and for all pathogenic molecules having functional groups ‘similar’ to those drug molecules. When used as therapeutic agents, molecular imprints selectively bind to the pathogenic molecules having conformational affinity and deactivate them, thereby relieving the biological molecules from the inhibitions or blocks caused by pathogenic molecules. According to MIT hypothesis, this is the biological mechanism of high dilution therapeutics involved in homeopathic cure.
According to MIT hypothesis, ‘Similia Similibus Curentur’ means, diseases expressed through a particular group of symptoms could be cured by ‘molecular imprints’ forms of drug substances, which in ‘molecular’ or crude forms could produce ‘similar’ groups of symptoms in healthy individuals. ‘Similarity’ of drug symptoms and diseaes indicates ‘similarity’ of pathological molecular inhibitions caused by drug molecules and pathogenic molecules, which in turn indicates conformational ‘similarity’ of functional groups of drug molecules and pathogenic molecules. Since molecular imprints of ‘similar’ molecules can bind to ‘similar’ ligand molecules by conformational affinity, they can act as therapeutic agents when applied as indicated by ‘similarity of symptoms’.
No body in the whole history could so far propose a hypothesis about homeopathy as scientific, rational and perfect as MIT, explaining the molecular process involed in potentization, and the biological mechanism involved in ‘similia similibus curentur’, in a way fitting well to modern scientific knowledge system.
Arsenic Album or Arsenic Trioxide is a chemical substance that can inhibit more than 200 essential enzymes in our body involved in diverse types of biomolecular processes related with genetic transcription, metabolism, energy conversions etc etc. This is due to the ability of Arsenic ions to bind to the cysteine radicals which are part of active sites all enzymes. Almost every biochemical pathways in the living body are deranged by the action of arsenic. This is the reason why the homeopathic materia medica of arsenic album is so rich with symptoms associated with almost all organs and systems of the body.
It is an already established fact that during viral infections, persons having high levels of arsenic in their body are prone to develop serious complications such as respiratory failure, acute myocardial degeneration, renal failures, liver failures, multiple organ failures etc faster than those having low arsenic levels. My suggestion to the experts involved in covid 19 research is that determination of arsenic levels in the body of covid patients should be made mandatory, so that high risk people could be identified and better care provided.
Arsenic content may be high in people due to living in certain areas, consuming arsenic rich ground water, cigarette smoking, eating unpolished rice, prawns and crabs, exposure to arsenic containing environments, etc etc. Arsenic may enter the body through contaminated liquors, Chinese, Ayurvedic, unani or Herbal preparations, industrial exposures, chemically treated wooden furniture etc also. Arsenic content will naturally be high in aged people, as it has a tendency to accumulated in the body over years through exposures.
Researchers working upon arsenic toxicity problems in certain arsenic affected countries have already proved that ARSENIC ALBUM 30 can antidote and reverse the chronic effects of arsenic toxicity, and remove the symptoms.
Arsenic Album 30 contains MOLECULAR IMPRINTS of arsenic trioxide molecules. Molecular imprints are three dimensional nanocavities formed in water-alcohol supra-molecular matrix through a host-guest interactions between templates and diluent medium during the process of homeopathic POTENTIZATION. Molecular imprints of arsenic trioxide contained in Arsenicum Album 30 can act as artificial binding pockets for arsenic ions and deactivate them, thereby removing the molecular inhibitions they have produced in the enzyme systems of the body.
By using Arsenicum Album 30 in sufficient quantities and frequencies to provide molecular imprints in optimum levels, it will be possible to prevent dangerous complications and multiple organ failures in covid 19 patients, so as to prevent the chances of morbidities due to the disease. Covid 19 deaths could prevented by use of Arsenic Alb 30.
I don’t know how to get this vey important message reach the right persons in right time, or how to convince the scientific basis of this approach described above.
A word to homeopaths : Homeopaths currently involved in distribution of Arsenicum Album 30 should realize the hard truth that the dosage you are giving now is actually of no use. 4 or 5 medicated sugar pills you give now cannot provide the sufficient quantity of molecular imprints required to produce desired biological effects. To ensure optimum protection, medicine should be used in drop doses at least twice a day until the epidemic threat is over. Please understand, it is not any mysterious “dynamic energy” or “vibrations” that work in our potentized drugs. It is MOLECULAR IMPRINTS, that act as “artificial binding pockets” for pathogenic molecules, and deactivate them.
I am not sure whether Arsenic album 30 will prevent or not covid. Be sure it will surely prevent complications even if you get infected. But dosage should be reconsidered. I would suggest minimum 1 or 2 drops direct on tongue bds until epidemic is over.
ARSENIC ALB 30 IN COVID 19 TREATMENT – AN INNOVATIVE SCIENTIFIC APPROACH
Arsenic Album or Arsenic Trioxide is a chemical substance that can inhibit more than 200 essential enzymes in our body involved in diverse types of biomolecular processes related with genetic transcription, metabolism, energy conversions etc etc.
This is due to the ability of Arsenic ions to bind to the cysteine radicals which are part of active sites all enzymes. Almost every biochemical pathways in the living body are deranged by the action of arsenic. This is the reason why the homeopathic materia medica of arsenic album is so rich with symptoms associated with almost all organs and systems of the body.
It is an already established fact that during viral infections, persons having high levels of arsenic in their body are prone to develop serious complications such as respiratory failure, acute myocardial degeneration, renal failures, liver failures, multiple organ failures etc faster than those having low arsenic levels.
My suggestion to the experts involved in covid 19 research is that determination of arsenic levels in the body of covid patients should be made mandatory, so that high risk people could be identified and better care provided.
Arsenic content may be high in people due to living in certain areas, consuming arsenic rich ground water, cigarette smoking, eating unpolished rice, prawns and crabs, exposure to arsenic containing environments, etc etc. Arsenic may enter the body through contaminated liquors, Chinese, Ayurvedic, unani or Herbal preparations, industrial exposures, chemically treated wooden furniture etc also. Arsenic content will naturally be high in aged people, as it has a tendency to accumulated in the body over years through exposures.
Researchers working upon arsenic toxicity problems in certain arsenic affected countries have already proved that ARSENIC ALBUM 30 can antidote and reverse the chronic effects of arsenic toxicity, and remove the symptoms.
Arsenic Album 30 contains MOLECULAR IMPRINTS of arsenic trioxide molecules. Molecular imprints are three dimensional nanocavities formed in water-alcohol supra-molecular matrix through a host-guest interactions between templates and diluent medium during the process of homeopathic POTENTIZATION.
Molecular imprints of arsenic trioxide contained in Arsenicum Album 30 can act as artificial binding pockets for arsenic ions and deactivate them, thereby removing the molecular inhibitions they have produced in the enzyme systems of the body.
By using Arsenicum Album 30 in sufficient quantities and frequencies to provide molecular imprints in optimum levels, it will be possible to prevent dangerous complications and multiple organ failures in covid 19 patients, so as to prevent the chances of morbidities due to the disease. Covid 19 deaths could prevented by use of Arsenic Alb 30.
I don’t know how to get this vey important message reach the right persons in right time, or how to convince the scientific basis of this approach described above.
A word to homeopaths : Homeopaths currently involved in distribution of Arsenicum Album 30 should realize the hard truth that the dosage you are giving now is actually of no use. 4 or 5 medicated sugar pills you give now cannot provide the sufficient quantity of molecular imprints required to produce desired biological effects. To ensure optimum protection, medicine should be used in drop doses at least twice a day until the epidemic threat is over.
Please understand, it is not any mysterious “dynamic energy” or “vibrations” that work in our potentized drugs. It is MOLECULAR IMPRINTS, that act as “artificial binding pockets” for pathogenic molecules, and deactivate them.
How Scientific Studies are Misused for Justifying Pseudo-scientific Explanations of Homeopathy
Many homeopaths refer to a link as the most scientific and authoritative reference for research evidences in favor of homeopathy. This article titled “Beyond Substance” by Norman Allan, Ph.D.is about the much discussed findings regarding the so-called “ghost-DNA” molecules in ultra-diluted aqueous solutions of viral DNA. This work was referred to the name of Professor Mounir AbouHaidar and his colleagues, Dr. Mohammed Eweida and Michael Dobbs. Exactly, this ghost DNA concept is same as that of Luc Montagnier. If you read the article carefully, you will understand how clever our ‘pseudoscientists’ are in hijacking scientific studies and misuse them for pseudoscientific explanations of homeopathy. Hence, I think it is worth analyzing the observations and conclusions of this article in detail. http://www.normanallan.com/Sci/bs.html.
I find this article is a classical example of how scientific studies are misused for pseudo-scientific explanations of homeopathy.
“The team found that a solution of viral DNA, diluted beyond substance in the manner of homeopathy, can physically bind its substantial, molecular, complementary strand. This implies that the water “remembers” the substance that was in it. It behaves as though the DNA – even though diluted beyond substance – were still there. The ramifications of this phenomenon deeply effects ours understanding of physics, medicine, and of psychology, and as I hope to explain may prove to be a key to our understanding consciousness”.
“In Prof. AbouHaidar’s viral assay a solution of DNA, the genetic ribbon – even after it has been serially diluted until there was no substance left – binds its labeled complementary strand. This means water can be patterned; can carry a signal, and in this sense “remembers”. Water prefers to be ordered, to be patterned, prefers this to our usual conception of liquid as random. Water is stressed by, rather than enjoying amorphous chaos. It prefers to be organized, to behave like a crystal. So water takes whatever substance we put in it, be that salt, or sulphur, or viral DNA, as a seed from which to organize a pattern”.
Based on this research finding, the author tries to explain the homeopathic potentization according to his speculative theorizations.
He expects that if the observed “phenomenon can be replicated, we have a scientific revolution, a paradigm shift, possibly as vast as the discovery of electricity some two hundred and fifty years ago: vast because, as with electricity, it shows us whole new dimensions of order underpinning the phenomenal world, and there is no predicting where all of this may lead”.
The author, himself a physical scientist, explains how he was attracted to this work:
“Jacque Benveniste was a prominent French immunologist, chief immunologist at the government’s research institute, INSERM. When two of his research assistants asked him if they might conduct an experiment into homeopathy, believing a happy coworker is a good coworker, Benveniste said they might. They showed the results to Benveniste, and he became curious.
If you take an antigen, and dilute it homeopathically – again, diluted until there is no substance – it will still generate an immunological response in certain white blood cells. In this case Benveniste, and his colleagues, were looking at basophils.
Benveniste took these findings to the most prestigious scientific journal, Nature. Because of Benveniste’s prominence Maddox, the editor of Nature, said he would publish the work if Benveniste could find three reputable laboratories that could replicate his findings. “That should get rid of him,” thought Maddox.
Bruce Pomeranz, of the University of Toronto, was one of the researchers that “replicated” the work, along with labs in Milan and Tel Aviv.
In June 1988 the journal Nature, the gatekeeper of scientific orthodoxy, published Benveniste’s ultradilution (homeopathy) paper. The implications of this work are revolutionary, a paradigm shift it there ever was one. There are a lot of people who would rather fight than shift. Nature, the journal, as part of their publishing arrangement with Benveniste, sent a team to investigate his lab. The team included Randy the Magician, to look for sleight of hand, Walter Stewart, a biologist and statistician who had made his reputation as a figure crunching fraud-detector, and the editor, Maddox himself, who had a background in physics. It did not, however, include a cell biologist who might understand the nuances of Benveniste’s experiment. The team had already made up their minds (as Walter Stewart wrote in “Omni”). They knew there had to be a problem with the experiment because in their view the experiment was impossible. In the lab, Beneviniste and his team demonstrated the phenomenon to them three times, but the Nature team had determined before hand that it was an impossible experiment, and not knowing what else to doubt they decided that they couldn’t trust Beneveniste”blind”. The visiting team therefore insisted on adding their own “blind” to the procedure. To do this they introduced an extra manipulation of the samples (they moved the samples into new tubes). Of course this added procedure might or might not effect the outcome of an already delicate experiment. The investigating team sealed their extra code in an envelope, wrapped that up in silver foil (to foil X-ray eyes), and stuck it on to the ceiling of the lab with a video camera trained on it.! When, in this one trial, this new variation of the experiment no longer worked, Maddox announced that the whole affair was a delusion, or a fraud. Such is the stature of the journal, Nature, that the “expert’s” pronouncement was treated with gravity. “In our view, ultradilution should not work. Therefore it does not. Trust us. We’ve looked. We’ve tried it.” (I paraphrase.) This was all every unscientific, yet here the matter rests. (Work by Professor M Roberfroid, Madeleine Ennis, and colleagues, has since vindicated Beneviniste’s work and homeopath.)
Now our name was on this controversial Benveniste ultradilution paper, and we’re a very respectable laboratory, so there was a large section of the world, at least here in Canada, that looked to us to see what we’d finally have to say on the matter. “We have promising preliminary results,” was all the Professor could say. That, and “No comment.” So when Prof. AbouHaidar’s team stumbled on the incredible that DNA diluted (one part in ten) eighteen or twenty five times (diluted beyond substance) still binds its complementary strand – they came to see us”.
This was how by Norman Allan, Ph.D, author of present article became involved in this work.
The work was done as follows:
“Prof. AbouHaidar is a virologist; a Professor with tenure at the University of Toronto. Professor AbouHaidar was working on a viral assay. You’d take a plant from a field – he was working with potatoes – grind it up, run it through the Professor’s assay, and it would tell you whether there was any of a particular virus present in those potatoes. It works like this: you take a virus, which in this case was a DNA virus, and you “digest it”, splitting each bit of viral DNA into two single complementary strands. Then you divide this digest into two parts. At this point the two parts are (statistically) identical. Take one half of this now single stranded DNA and call it the “target”. Take the other half and call it the “probe”.
The target is spotted out on a filter paper – that is to say, you put a drop of it on a microfilter to make a spot. Then you dilute what’s left one part in ten, and put a drop of the dilute solution at a second spot. Then dilute again one part in ten, and spot it out again. Keep diluting and spotting out the successive dilutions. This is to test how sensitive the assay is. After all, we may be looking for a little bit of virus in a whole field of potatoes. We need a sensitive assay.
Having spotted out all these successive dilutions, we take the filter paper and bake it at 80 degrees centigrade. After baking, the target won’t wash off. Next let us consider the probe. The probe, remember, in this explanation, the probe is made up of the same single stranded viral DNA fragments. These we’re going to label so we can see them. We mix them with avidin-biotin. The avidin binds to the DNA, and the biotin will bind to a stain, so we’ll get a dark spot where our DNA-avidin-biotin binds the stain.
Now we take our probe and wash it over the targeted filter paper. Where the DNA in the probe finds its complementary strand in the target it binds to it. Next we wash the probe and target, and only where the probe has bound to its complementary strand will there be any of the probe be left. The rest is washed away. Then we ‘develop’ the probe/target filterpaper with our stain. Only where the labeled probe has bound to the target will we see any stain. In the test as set it up, the stain gets lighter and lighter with each dilution. It’s dark, almost black, in the first couple of dilutions, but fades out of sight at about the seventh dilution.
That’s the assay AbouHaidar was refining. (Actually, it’s Dr. Southern’s dot-blot test, so it’s called “Southern blot”, though Dr. Western’s “Western dot-blot” predates it and is more widely used.). Mohammed Eweida was a postdoc working in Prof. AbouHaidar’s lab with this Southern blot assay. Mohammed Ewieda wasn’t very happy about his situation. I don’t know why, but he was out of there: he was off to the Karolinska Institute in Stockholm in the summer: and so, perhaps to kill time, he spotted out the dilutions eighteen times, even though the staining was lost to sight at the seventh, and and he got a dark spot at the eighteenth dilution!
“Look at that,” said Dr. Eweida to Michael Dobbs, a postgraduate student working in the lab. Some months before Mike Dobbs had been to Jacque Benveniste’s lecture on ultradilution. (In Homeopathy substances are diluted beyond the infinitesimal till there’s no substance left, which is what is meant by “ultradilution”.) So, when Mohammed showed Michael his anomalous result with an unexpected spot at the eighteenth dilution Michael thought, incredulously, “ultradilution”. “Eh, Mohammed,” he said. “Do that again.” Dr. Eweida repeated the viral assay, this time taking it out to the fiftieth decimal (one in ten) dilution. (That’s 10-50 where ten to the minus 30 is like a drop in the ocean, and 10-37 is like a drop in a million oceans. At 10-26 we pass “Avagadro’s number [which relates to the number of molecules in a “gram molecule”] and would no longer expect to find a single molecule in a gram.) Again there was a dark spot that shouldn’t be there at the eighteenth dilution, and now there were also stained spots at the 19th dilution, and the 25th and 26th, and the 38th, and 43rd dilution, but not at the dilutions in between. At the 25th and 26th dilutions there is certainly no substance left in the solution. We have passed Avagadro’s number. There is no DNA left in the target. And yet the undiluted complementary strands in the probe (labeled with avidin-biotin) binds to the target! They can not be binding to a substance, not to molecular DNA. They may be binding to a signal, an electrical signal imprinted into the nitrocellulose. They are binding to something!
At first sight, to some, this has seemed to contradict classical science. “How can water, with nothing in it, remember what was there formerly, but is no longer there?” But here were Prof. AbouHaidar and Dr. Eweida, here they were with these filterpapers, dozens of them, with dark spots at the 18th and 19th dilution, and the 25th and 26th. Sometimes the pattern moved a little: sometimes only the 18th turned dark, once it was the 17th.
Well, Prof. AbouHaidar when he first saw it, suspected a joke. And when Dr. Eweida repeated it yet again, Menir AbouHaidar suspected a hoax. So he tried it himself, and there it was. No hoax.
What to do next? One of the next things that Prof. AbouHaidar did was to come and see us, Dr. Pomeranz and his research team. From here on in I’m going to call Dr. Pomeranz, the Professor. The Professor’s lab (where I had worked for seven years) was one of the labs that replicated Benveniste’s work with ultradilute antigens. The Professor’s name was on Benveniste’s controversial paper, so Prof. AbouHaidar came to talk to us, in confidence, to hear what we could tell them. “Do it again,” we said. And they did.
What does all this mean? It suggests a multitude of things. First let’s look at the patterning of water. If you put, say, one part salt in a hundred parts of water, it seems that the salt will pattern the water – the water mirrors the salt’s “vibration”. Certainly with Prof. AbouHaidar’s DNA we seem to see an electrical patterning that comes back into register with the original space/charge patterning at the 18th dilution.”
Based on these observations, the author tries to explain homeopathy as follows:
“Now if homeopathic [ultradilute, potentiated] remedies are having effects on organisms – they cured my cat – one of the implications, it seems, is that the body has vibrational fields, patterned energy fields, on which these (vibrational, patterned) remedies can work. Many people, particularly those on the fringe of science, and beyond, have been saying this for years. But no one has demonstrated it in any convincing or replicable manner. This is where Prof. AbouHaidar’s discovery is so special. Finally we have a handle into this realm of vibration.”
Obviously, the author is caught in the “theory of vibrations” in his interpretations. This is a clear example of how a scientist slips and falls into “pseudoscience”. He understands he is moving into the realm of ‘fringe science’ and ‘beyond science’. And now he is trying to utilize “AbouHaidar’s discovery” to rationalize the speculations of ‘fringe science’ and ‘beyond science’, which “have been saying this for years”. He tries to utilize this unexplained phenomenon as a “handle into this realm of vibration”. The intention of the author is clear now. This shows how science can be used to rationalize ‘unscientific’ theories.
How does homeopathy work in practice? As a scientist, we would expect from the author an explanation that would fit to the existing scientific knowledge system available to modern biochemistry, molecular biology and medical science. But to our total dismay, he comes with totally unscientific and irrational concepts and arguments. He says:
“How does homeopathy work in practice? At its simplest level, let’s say you’re in an accident, traumatized, the body goes into a particular pattern of vibration, in this case a kind of ‘shock’, Often people seem to get stuck in these patterns. Tinctures made from the plant Arnica have a vibratory pattern that (we may imagine) closely resembles this vibratory pattern associated with traumatic shock. Empirically it has been observed, again and again, that the potentised remedy prepared from Arnica helps physically traumatised people to heal. So, it may be that the body becomes locked in a particular oscillatory pattern, and the remedy, the “similar”, helps to jog it free, to loosen that pattern’s hold on the body so the body can stop repetitively singing that song”
How is it? Is he talking science? Do these words reflect a scientific mind? We had many times heard this pseudo-scientific ‘theory of vibrations’ from so-called vitalists, classical homeopaths and metaphysical theoreticians. But it is a real pity to hear this from a reputed scientist. As a scientist, we would expect him to talk about the bio-chemical derangements caused by traumas, and how the constituent molecules of arnica tincture rectify these bio-molecular errors. How could the author reach such unscientific conclusions from the reported research findings? The researchers only observed the presence of some sort of ‘memory’ of DNA molecules in ultra-dilutions in water. They said nothing about the mechanism of this ‘memory’. Obviously, the author utilizes these findings to rationalize his ‘fringe science’ speculations. This is unfair and unethical as far as a scientist is concerned.
He continues his imaginative speculations further:
”A further implication of homeopathy is seen in the fact that the personality, the emotional make-up, the thought patterns, of patients are the most important guiding feature in deciding which remedy to use. The “mentals” are given more weight then the physical symptoms. The implication of this is that mind, that thought and emotion, are patterns”.
We expect to hear a scientist explain “thought and emotions” on the basis of neurochemistry, where as this ‘scientist’ is talking about ‘patterns’. Wonderful!.
His interpretation of ‘patterns’ in water formed by adding salt shows his total ignorance regarding the process of ‘hydration’ in aqueous solutions. Every science student knows that so-called patterning is nothing but supra-molecular clustering of water molecules through hydrogen bonding. I think he uses the terms like ‘patterns’ and vibrations’ to take this phenomenon into the realm of ‘fringe science’ which seems to be a subject very dear to him.
Instead of speculating over ‘patterns’ and ‘vibrations’, and discussing ‘fringe science’ and ‘beyond science’, this phenomenon could have been scientifically explained on the basis of “Molecular Imprinting”. Such an explanation would fit in to the existing scientific knowledge-system perfectly. More over, based on this concept, we can provide scientific explanation to the molecular mechanism of therapeutic action of potentized homeopathic medicines, fitting to modern biochemistry and molecular biology. Homeopathy could be dealt with not as a ‘fringe science” or “beyond science”. but as real science!
Let us listen to what the author says further on this subject:
“Come back to the one part salt in a hundred parts water. If we take this salt water and dissolve it again one part in a hundred in clear water, and shake it, it again patterns the water, but this time with some changes. Remember it’s at the 18th and 19th dilution that AbouHaidar’s target bound the probe (at least, that was the case in the first sample that MAME showed us). At the 15th, 16th, there was nothing. This suggests that we are seeing something similar to the interference phenomenon that occurs with harmonic overlays. This is a fairly well known phenomenon (e.g. “Poincare’s recurrence”, see below). However here because it’s a dilution procedure, the harmonics are going to include lower frequency multiples, “subharmonics”, of the original signal as well as the more usual higher frequency harmonics.
It is very funny to see how hastily the author jumps to his pre-determined conclusions such as ‘interference’ phenomenon and ‘frequency harmonics’, based simply on the observed phenomenon of ‘patterning’ of water in salt solutions. Before that he should have applied some thought regarding ‘hydrogen bonding’, hydration’ and ‘supra-molecular clustering’, and also the probability of ‘molecular imprinting’.
“Imagine a conjurer’s rope. Take a segment out of that magician’s rope – say one foot out of ten – and hold it taut between your hands, and twang it. Now (by magic) put it back in the original rope. The note, the vibration, in the small piece will pattern and inform the longer piece. The longer piece will now carry that information, but it will also, during the process, generate harmonics, multiples of that original note. But note, in the dilution process (which the homeopaths have traditionally called “potentiation”) it becomes intuitively apparent that we will be generating both harmonics andsubharmonics of the original pattern. And this explains one of the mysteries of homeopathy”
How can see declare that “this explains one of the mysteries of homeopathy”?
Obviously, he is overtly trying to ‘prove’ his concepts of ‘vibration theory’ in homeopathy utilizing the unexplained phenomenon observed by the research team..
“It is part of the traditional homeopathic wisdom that the higher potencies, the higher dilutions, are stronger and deeper acting than the lower potencies: that the mother tincture and the low potencies act superficially, at a surface level, at skin level, and at the physical level, while the high potencies act deeper and begin to effect emotions, thoughts, personality – and they are also, the high potencies, much stronger.”
Author tries to utilize the “traditional wisdom’ of homeopathy to rationalize his speculations. As a scientist, we expect from him rational explanations for those “traditional wisdom” on the basis of “scientific wisdom”. Not the other way.
“If I were going to treat you, say, with salt, sodium chloride (in Homeopathy we latinize it and call it Nat mur, short for Natrium muraticum). Now why would I treat you with Nat mur. Nat mur is one of the polycrests, which is to say it has power over an extremely broad range of symptoms, and with Nat mur, for sure, I would be guided in large part by personality and etiology (causation). Nat mur is seen in problems caused by grief where the person internalises. With that internalizing there’s a withholding and a holding. The person is likely to brood. “Attachment” is a key word with nat mur, and yet they don’t like to be consoled. Consolation will irritate them. The substance, salt, will cause (this pattern, this disposition) these problems, and it will also cure them. That’s why we call this type of medicine homeopathy: we treat like with like. This thought, that “like cures like” was Hahnemann’s great “law”. Now this, to me, is not intuitively apparent. But it is a piece of empiricism that was first recorded by Hippocrates, was reiterated by Paracelsus, and explored and developed into a fine art and science by Hahnemann at the end of the eighteenth and the beginning of the nineteenth century. Hahnemann experimented on himself. His first experiment was to take quinine. Quinine gave him ague-like fevers!”
As per the author this is the “scientific” explanation for the mechanism of homeopathic therapeutics. The wonder is that this ‘explanation’ comes from a “scientist”. According to him, “internalized grief” creates them “changes in pattern” in the “emotions” of an individual. “The substance, salt, will cause (this pattern, this disposition) these problems, and it will also cure them”. “That’s why we call this type of medicine homeopathy: we treat like with like”. How would this “explain the mysteries of homeopathy” as the author claim? To become a scientific explanation, he would have told us how “grief” creates the pathological disturbances in an individual, and what are the neuro-chemical errors happening at molecular level in various related biological pathways. We would also expect him to explain how sodium chloride creates similar biochemical changes individuals. If he wants to “explain the mysteries of homeopathy”, he should also explain what is the active principles in potentized sodium chloride, and how these active principles interact with the biochemical molecules and relieve the organism from the molecular errors caused by “grief”. That is the way a real scientist would talk about a science of therapeutics. Instead, the author talks about “patterns” created by “grief” and “patterns” created by “sodium chloride”. This is not the language of a scientist. We had already had this type of pseudoscientific “explanations’ ad nauseum fro the “gurus” and “masters” of “classical homeopathy”.
After making all these big noises about “explaining the mysteries” of homeopathy on the basis of concepts like “fringe science”, “beyond science”, “beyond substance”, “harmonics”, “resonance”, “vibrations” etc., it is quite wonderful how the author concludes”
“How do I know all this is what is going on? I don’t. I do know that homeopathy cured my cat. I know that MAME’s ultradilute DNA bound molecular DNA And then we have the well conducted clinical trials of Reilly published in Lancet that demonstrate beyond reasonable doubt that a phenomenon exists. Homeopathic remedies are reproducibly significantly more effective than placebo controls (Reilly 94). We know the phenomenon exists. What I’ve written here is my groping for an explanation.”
See his confession: “What i’ve written here is my groping for an explanation.”. That means, all through this article we were “groping” along with him!
Kindly read further:
“In May 1989 MAME submitted a paper on this ultradilute DNA phenomena to Nature. And Maddox, the editor, sat on it. In the summer of 1989 the University of Toronto opened a new botany building, and Prof. AbouHaidar moved his lab out of its old quarters. After the move and some initial difficulties for a short while the ultradilute experiment ran as before, though the pattern (18, 19, 25, 26) became more chaotic. But then shortly after the move, they lost the phenomenon! It no longer worked. They tried it a few times, and moved back to their mainstream work, genetic engineering, with the world not even ruffled.”
“It was not my impression that procedures, protocols, were clearly and precisely defined in AbouHaidar’s lab. (Elizabeth once characterized their work as “bucket chemistry”.) Nonetheless the phenomenon seemed to be robust up to the move, and for a short while after the move. As far as I am aware, apart from Elizabeth and my follow up in 1992/93, there has been no further work done with the phenomenon”
”The fact that when MAME moved labs the phenomenon vanished is itself fascinating”.
“So I urge anyone who has the opportunity to look for ultradilute activity, whether in dot-blots or in other assays, to do so. We stand on the threshold of a new science, a level of patterning in the natural world hitherto overlooked, and who can say where this knowledge might lead”
Dear friends, is this not the same proverbial situation we say “the mountain delivering a mouse”! The whole verbosity has finally faded into nothing!
According to Luc Montaigner, the ‘nanostructures’ formed in high dilutions are ‘mimics’ of original molecules. Scientifically, ‘molecular imprints’ are 3d structures with configurations just complementary to original molecules. If we consider original molecules as ‘keys’, montaigner consider ‘nanostructures’ as duplicate keys. According to my concept, ‘molecular imprints’ are ‘artificial key holes’ that could act as ‘artificial binding sites’ for original keys or keys similar to them. Molecular imprints bind to the pathogenic molecules due to complementary configuration, exactly like a key hole binds to a key. Molecular imprinting produces artificial key-holes, not duplicate keys. Once we understand this difference in perceptions, it would be easy for us to understand ‘similia similibus curentur’ scientifically.
Concept of ‘Molecular imprinting in Water’ involved in homeopathic potentization could have many unpredictable and unforeseen implications in the field of genetic engineering and gene therapy. Molecular imprints of genes or ‘DNA fragments’ could be utilized as templates for preparing ‘designer genes’ as per requirement in laboratories, that could be utilized for ‘genetic repairing’ protocols.
Extract the required genes or DNA fragments from healthy genomes and potentize them according to homeopathic procedures. These potencies would obviously contain ‘molecular imprints’ of DNA fragments used for potentization.
Add these potentized ‘DNA’ to a mixture of neucleotide primers and DNA polymerase enzymes involved in the biochemical process of DNA synthesis. ‘Molecular imprints’ can act as templates and selectively bind and hold the neucleotide primers in correct positions and sequences exactly similar to original DNA fragments used for imprinting. Polymerase enzymes will then link the individual neucleotides together to form DNA fragments exactly similar to original ones in terms of neucleotide structure and sequence.
This is a possibility I foresee when thinking about ‘molecular imprints’. Interested scientists are free to work upon this idea.
Since Luc Montaigner could not understand the scientific concept of ‘molecular imprinting’, he tried to explain the observed phenomenon using the concepts of ’emr resonance’. That only shows the limitation of his understanding.
Each and every particle in this universe are ‘vibrating’, or exist in constant motion. This ‘motion’ is the primary form of existence of matter. When we subject any object for any form of spectroscopic studies, there will be specific pattern of light rays, depending up on absorption, reflection and refraction which indicates molecular level organization. When we subject potentized drugs for spectrosopy, the light patterns are found to be different from those of unpotentized water-alcohol mixture. That only indicates the presence of ‘supramolecular clusters’ formed by potentization. DNA will have specific spectum, molecular imprints of DNA will also have spectific spectrum. We can utilize spectroscopic studies of potentized drugs to sturdy the presence of molecular imprints in our potentized drugs.
‘Supra molecular nanostructures’ is an important topic of study with implications in in areas of nanotechnology, supramolecular chemistry, molecular imprinting in polymers etc. I was trying to explain homeopathic potentization from this perspective.
Polymer-like supramolecular behavior of water and its capacity to form ‘supramolecular nanostructures’ through hydrogen bonding make water an appropriate medium for molecular imprinting. Through the process of molecular imprinting involved in potentization, three dimensional configuration of individual drug molecules are imprinted into these supramolecular nanostructures of water as ‘nanocavities’, which can act as ‘artificial key-holes’ or ‘binding sites’ for the drug molecules as well as pathogenic molecules having simialar functional groups. This is the scientific explanation I provide for homeopathic potentization.
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