REDEFINING HOMEOPATHY

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SCIENCE BEHIND HOMEOPATHY

HOMEOPATHY will become a real medical science only when we are capable of scientifically explaining and proving the biological mechanism involved in SIMILIA SIMILIBUS CURENTUR, as well as the exact molecular level process happening during POTENTIZATION, by which the medicinal properties of drug substances are transmitted to a medium without any drug molecule remaining in it.

So far as we do not know what actually happens during potentization, what are the active principles of highly diluted homeopathic drugs we use, and what is the exact biological mechanism by which they work, everything we talk about mode of application, dosage, repetitions, durations of actions, side effects, single-multiple drugs, medicinal aggravations, suppressions, high potency proving, drug relationships, antidoting and so on are mere speculations without any scientific validity. Only thing we are really sure about is that it works!

A knowledge could be considered SCIENTIFIC if it is in the form of explanations and predictions about any phenomenon of the universe that is testable using SCIENTIFIC METHOD. Scientific method involves making hypothetical explanations about phenomena using existing knowledge, deriving predictions from the hypotheses as logical consequences, and then carrying out experiments or empirical observations based on those predictions, so as to prove or disprove the hypotheses.

For homeopathy to survive in this new era of scientific awareness and advancement, it is inevitable that modern biochemistry should be made the foundation of homeopathy education. But our respected decision makers cannot understand its importance, as they are still immersed themselves in the two centuries old superstitious beliefs of “immaterial vital force” and “dynamic medicinal energy”!

SIMILIA SIMILIBUS CURENTUR

If symptoms expressed in a particular disease condition as well as symptoms produced in a healthy individual by a particular drug substance were similar, it means the disease-causing molecules and the drug molecules could bind to same biological targets and produce similar molecular errors, which in turn means both of them have similar functional groups or molecular conformations. This phenomenon of competitive relationship between similar chemical molecules in binding to similar biological targets scientifically explains the fundamental homeopathic principle SIMILIA SIMILIBUS CURENTUR.

DISEASE AND CURE

Normal biomolecular interactions essential for vital processes happen through selective binding between biological target molecules and their natural ligands. A state of disease emerges when some endogenous or exogenous molecules having conformational similarity to natural ligands prevent this binding between biological targets and their legitimate ligands by competing with natural ligands by a sort of molecular mimicry and binding themselves to the target molecules. Molecular imprints of ligands, or of any drug molecule having conformations similar to them, can bind to the exogenous or endogenous pathogenic molecules, deactivate them, and facilitate the normal interactions between biological ligands and their natural targets. THIS IS THE BIOLOGICAL MECHANISM OF HOMEOPATHIC CURE.

MOLECULAR IMPRINTING INVOLVED IN HOMEOPATHIC POTENTIZATION

Only way the medicinal properties of a drug substance could be transmitted to a medium during homeopathic POTENTIZATION without any single drug molecule remaining in it is by preserving its conformational details by a process of MOLECULAR IMPRINTING, since conformational properties of molecules play a decisive role in biomolecular interactions.

During trituration, substances are converted into fine nano particles, their intermolecular bonds get broken and made free, molecules become more reactive and soluble, so that even insoluble substances can form colloidal solutions in water.

When added to water-ethanol mixture, these drug molecules get surrounded by water-ethanol molecules, leading to the formation of hydrogen bonded host-guest complexes, in which drug molecules act as guests and water-ethanol hydration shells as hosts.

During the process of succussion, due to the high mechanical energy involved, the solution is subjected to a process of cavitation and nanobubble formation, whereby the drug molecules are detatched from host-guest complexes, adsorbed to the fine membranes of nanobubbles, and raised to the top layers of the solution, leaving the empty hydration shells free, which are actually supra-molecular nanocavities formed in water-ethanol matrix into which the conformational details of drug molecules are imprinted. We call these empty supramolecular cavities formed of water and ethanol molecules as MOLECULAR IMPRINTS.

Even though hydrogen bonds in water are normally known to be very weak and transient, due to the strong and unbreakable hydrogen bonding between water and ethanol molecules characteristic of their peculiar AZEOTROPIC mixtures used in homeopathic potentization, molecular imprints formed in homeopathic potentized drugs remain highly stable and active for very long periods.

“SIMILIMUM” IS NOT THAT MUCH “UNSCIENTIFIC” AS OUR LEARNED SKEPTICS WRONGLY THINK!

When a homeopath searches for a SIMILIMUM for a patient by matching his totality of symptoms with the DRUG symptoms given in the materia medica, he is actually trying to identify a drug substance that contains some chemical molecules that have conformations similar to those of the particular chemical molecules that are involved in the disease process, so that the drug molecules and disease-causing molecules will have a COMPETITIVE relationship in binding to SIMILAR biological targets.

Since MOLECULAR IMPRINTS of drug molecules contained in potentized forms of drug substance can act as ARTIFICIAL LIGAND BINDS (MIALBS) for the disease-causing molecules having competitive relationship due to the CONFORMATIONAL affinity in between them, and can remove the pathological molecular inhibitions, post-avogadro dilutions of SIMILIMUM drug could be used as a therapeutic agent as per the principle SIMILIA SIMILIBUS CURENTUR.

If you are not yet convinced regarding what I said about SIMILIMUM above, kindly find some time to read your old biochemistry texts, and try to understand the molecular mechanism involved in the phenomenon known as COMPETITIVE RELATIONSHIP of similar chemical molecules in binding to biological targets, also known as MOLECULAR MIMICRY!

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‘Molecular Imprinting in Water’ For Target-Specific Drug Designing- Science Behind Homeopathic Potentization

 ‘Drug designing’ is an advanced branch of modern pharmaceutical chemistry, which is involved with the process of developing new medicinal substances appropriate to the specific  biological targets in the organism. Such a ‘designer drug’ is most commonly a small organic molecule which can inhibit or activate the functioning of a target biomolecule such as a protein, thereby resulting in a therapeutic process in the organism. Essentially, ‘drug designing’ involves the development of small molecules that are complementary in ‘shape’ and ‘charge’ to the biomolecular target to which they interact and therefore will bind to it. Modern drug designing protocols utilize computer modeling techniques also. This type of modeling is known as ‘computer-aided drug design’. Actually, ‘drug design’ is involved with ‘ligand’ design. Prediction of binding affinity of molecules to be designed is the first step in a successful modeling technique.  Many other properties such as bioavailability, metabolic half life, lack of side effects, also should be optimized before a designed ‘ligand’ can become a safe and efficacious drug. Most of these ‘other’ characteristics are often very difficult to optimize using presently available drug design techniques.

Selection of drug target is most important in “drug designing”. A drug target is typically a key molecule involved in a particular metabolic or signaling pathway that is specific to a disease condition or pathology, or to the infectivity or survival of a microbial pathogen. Most of the therapeutic inteventions aim to inhibit the functioning of the ‘pathologic’ pathway in the diseased state by causing a key molecule to stop functioning. Drug molecules may be designed that bind to the active region and inhibit this key molecule. Some other therapeutic interventions  actually enhance the ‘normal’ biochemical pathway by promoting specific molecules in the ‘normal’ pathways that may have been affected in the diseased state. Main challenge in all ‘drug therapies’ including ‘designer drugs’ is that  these drug molecules should not affect any other important “off-target” molecules or ‘antitargets’ that may be similar in appearance to the target molecule, since drug interactions with off-target molecules may lead to undesirable side effects.

Designer drugs are small organic molecules produced through chemical synthesis, but biopolymer-based drugs (also known as biologics) produced through biological processes are becoming increasingly more common in modern drug designing.

‘Ligand-based drug design’ and ‘structure-based drug design’ are two major technologies now utilized in drug designing technologies.

Ligand-based drug design is based on the knowledge of other molecules that can bind to the biological target of interest. These other molecules may be used to derive a ‘pharmacophore’ which defines the minimum necessary structural characteristics a molecule must possess in order to bind to the target. In other words, a model of the biological target may be built based on the knowledge of what binds to it and this model in turn may be used to design new molecular entities that interact with the target.

Structure-based drug design is based on the knowledge of the three dimensional structure of the biological target obtained through methods such as x-ray crystallography or NMR spectroscopy. Using the structure of the biological target, candidate drugs that are predicted to bind with high affinity and selectivity to the target may be designed using interactive graphics.

Main draw back of ‘designer drugs’ is that  there is a chance for these drug molecules affecting “off-target” molecules or ‘antitargets’ having similarity to the target molecules. Such interactions with off-target molecules may lead to grave consequences. Optimizing of various factors such as bioavailability, metabolic half life, and lack of side effects are the real challenges facing “drug designing” technology.

Molecular Imprinting in Polymers:

  ‘Molecular imprinting in polymers’ is a fast grownig research area that may be interesting to people engaged in developing “drug designing” techniques. A lot of research is currently going on over this subject the world over. This technology involves the imprinting of synthetic polymer substances using enzymes or such macromolecules as ‘guest’molecules. As a result of imprinting, nano cavities with 3-d spacial configurations complementary to the ‘guest’ molecules will be created in the interaction surfaces of the polymers. These imprinted polymers, by virtue of the nanocavities they contain can be used to bind molecules with configurational similarity to ‘guest’ molecules. They are at present widely used in various laboratory assays as powerful adsorption surfaces. MIPs are also found to be of much practical use in various areas of science  and technology .

Molecular imprinted polymers of today cannot be used as therapeutic agents, since they are totally foreign substances to the organism. More over, native enzymes can not degrade the polymers even if they can play a therapeutic role in the organism.

Molecular imprinting may become part of future drug designing techniques, only if the search for safer substances and methods for molecular imprinting happens to be successful.

Molecular Imprinted Proteins:

 Biopolymer-based drugs (also known as biologics) produced through biological processes are becoming increasingly more common in modern drug designing. But the revolutionary concept of molecular imprinting in proteins is only in its emerging stage, which may have implications in drug designing techniques. It has already been acknowledged that the biological molecules presently classified as antibodies are nothing but native globulin proteins subjected to natural molecular imprinting process with foreign pathologic proteins acting as ‘guest’ molecules. Scientists have already realized the fact that the much discussed pathologic molecules known as ‘prions’ are nothing but disfigured protein molecules subjected to molecular imprinting. Protiens, being polymers with complex and flexible tertiary structures,  are expected to be a very good medium for molecular imprinting. Different types of protein based substances, subjected to artificial molecular imprinting, may  evolve in the future as effective therapeutic agents and laboratory reagents.

Apart from protein molecules,  different types of biopolymers such as polysaccharides and nucleic acids also may be experimented as medium for molecular imprinting.

Native proteins extracted from the patients could be subjected to molecular imprinting with appropriate ligands or other pathologic molecules acting as ‘guest’ molecules and used as target oriented therapeutic agents.  But the problem remains that such imprinted proteins can be used only in the individual whose proteins are used for imprinting. Otherwise it may result in grave anaphylactic reactions. Moreover these imprinted proteins may remain in the organism for very long periods, without undergoing degradation, and cause ever new pathological molecular blocks. Such issues have to be addressed properly.

Molecular Imprinting in Water:

 Our protracted search for a safe and reliable universal medium for molecular imprinted drug designing finally takes us to the study of wonderful physico-chemical properties of the most abundant substance on earth called water. But the concept and technology of molecular imprinting in water still remains in very infantile stage. The author is of the opinion that with its strange polymer-like behaviours, capable of forming hydrogen-bonded supra-molecular structures, water can be the ideal candidate for molecular imprinted drug designing in future.

Though in a slighly lesser level, Ethyl Alcohol and Lactose are also capable of forming polymer-like supra-molecular formations through hydrogen bonding, and hence may be onsidered as  candidates for molecular imprinting experiments. Possibilities of these substances in combination with water also have to be explored.

Water(H2O) is a wonderful substance with strange physico–chemical properties arising from its peculiar supra-molecular structure. Water is a solvent with higher polarity than similar liquids. H–O–H bond angle is 105 degrees. That means, water molecule is a dipole. Because of this peculiarity, water molecules can exist like a supra-molecular network through hydrogen bonding.  A minimum number of five water molecules will be contained in this network. Such supra-molecular formations are called pentamers. Most of the wonderful properties of water arise from this peculiar capacity of hydrogen bonding and resultant supra-molecular formations. Water molecules (H2O) are symmetric (point group C2ν) with two mirror planes of symmetry and a 2-fold rotation axis. The hydrogen atoms may possess parallel or antiparallel nuclear spin. The water molecule consists of two light atoms (H) and a relatively heavy atom (O). The approximately 16-fold difference in mass gives rise to its ease of rotation and the significant relative movements of the hydrogen nuclei, which are in constant and significant relative movement.

Although not often perceived as such, water is a very reactive molecule available at a high concentration. This reactivity, however, is greatly moderated at ambient temperatures due to the extensive hydrogen bonding. Each water molecules possess a strongly nucleophilic oxygen atom that enables many of life‘s reactions, as well as ionizing to produce reactive hydrogen and hydroxide ions. Reduction of the hydrogen bonding at high temperatures or due to electromagnetic fields results in greater reactivity of the water molecules.

As liquid water is so common-place in our everyday lives, it is often regarded as a ‘typical’ liquid. In reality, water is most atypical as a liquid, behaving as a quite different material at low temperatures to that when it is hot. It has often been stated that life depends on these anomalous properties of water. In particular, the high cohesion between molecules gives it a high freezing and melting point, such that we and our planet are bathed in liquid water. The large heat capacity, high thermal conductivity and high water content in organisms contribute to thermal regulation and prevent local temperature fluctuations, thus allowing us to more easily control our body temperature. The high latent heat of evaporation gives resistance to dehydration and considerable evaporative cooling. Water is an excellent solvent due to its polarity, high dielectric constant and small size, particularly for polar and ionic compounds and salts. It has unique hydration properties towards biological macromolecules (particularly proteins and nucleic acids) that determine their three-dimensional structures, and hence their functions, in solution. Hydration of biological molecules results in formation of gels that can reversibly undergo the gel-sol phase transitions that underlie many cellular mechanisms. Water ionize and allows easy proton exchange between molecules, thus contributing to the richness of the ionic interactions in living organisms.

In reality, hydrogen bonding is a special type of dipole force. It is a force of attraction formed between partial electro negative atom which is part of another molecule. The reason for strength is the partial positive charge attained by hydrogen. Hydrogen is capable of establishing similar bonds with the atoms of nitrogen, fluorine and oxygen. That is to say that the basis of hydrogen bonding is the attraction between one hydrogen atom which is part of a molecule which is attached to oxygen or nitrogen and  oxygen or nitrogen which remains part of another molecule. This force is less powerful than the co–valent bonds which keeps the atoms inside molecule bound together. But these less powerful bonds are responsible for the wonderful bio–chemical qualities of water.

In the ordinary liquid state, in spite of 80% of the electrons being concerned with bonding, the three atoms in water do not stay together, as the hydrogen atoms are constantly exchanging between water molecules due to protonation/deprotonation processes. Both acids and bases catalyze this exchange and even when at its slowest (at pH 7), the average time for the atoms in an H2O molecule to stay together is only about a millisecond. As this brief period is, however, much longer than the timescales encountered during investigations into water’s hydrogen bonding or hydration properties, water is usually treated as a permanent structure.

The presence of ethyl alcohol in water is considered to be a factor reducing the rate of protonation/deprotonation processes, thereby enhancing the stability of hydration shells.

Hydrogen bond strength can be affected by electromagnetic and magnetic effects.

Any factors, such as polarization, that reduces the hydrogen bond length, is expected to increase its covalency. There is still some dispute over the size of this covalency, however any covalency will increase the network stability relative to purely electrostatic effects. As hydrogen bond strength depends almost linearly on its length (shorter length giving stronger hydrogen bonding), it also depends almost linearly (outside extreme values) on the temperature and pressure .

Hydrogen bonded chains (that is, O-H····O-H····O) are cooperative; the breakage of the first bond is the hardest, then the next one is weakened, and so on. Thus unzipping may occur with complex macromolecules held together by hydrogen bonding, for example, nucleic acids. Such cooperativity is a fundamental property of liquid water where hydrogen bonds are up to 250% stronger than the single hydrogen bond in the dimer. A strong base at the end of a chain may strengthen the bonding further.

Water-Ethyl Alcohol Mixture :

 At this stage we have to understand a few facts about Ethyl Alcohol(CH3- CH2 – OH ). The molecules of alcohol also have the dipole structure as water molecules. It is possible for them to establish mutual connection through hydrogen bonding. The molecular weight of alcohol molecul is 46. The molecular weight of water(H2O) is 18. That means that the number of water molecules contained in 18 gram of water and the number of alcohol molecules contained in 46 gram of ethyl alcohol are equal. When alcohol and water are thoroughly mixed alcohol molecules network with water molecules through hydration bonds, The mobility of water molecules is restricted by the bonds established with alcohol molecules. Hence, hydration shells formed in alcohol–water mixture are comparatively more stable. The count of alcohol molecules and the count of water molecules contained in their mixture in 73:27 ratio will be equal. (73% w/w. alcohol and 27% w/w water) This mixturei is known as (40 power   spirit).

Ideal medium for molecular imprining is supposed to contains 87% w/w of alcohol and 13% w/w of water. In this ratio, the number of alcohol molecules will be about more than that of of water molecules. Such a ratio will be very suitable for the production of stable hydration shells. More over, the presence of ethyl alcohol in water is considered as a factor reducing the rate of protonation/deprotonation processes, thereby enhancing the stability of hydration shells

We know that water is a good solvent. Let us see what happens when some foreign molecules are made to dissolve in water. If a foreign(called ‘guest’) molecule, ion,  or colloidal particle happens to enter the matrix of 3-dimensional dynamic network of water molecules, they are entrapped inside this network. Water molecules arrange themselves around the ‘guest’ molecule in a peculiar way by the formation of hydrogen bonding. These formations of water molecules around the ‘guest’ molecules is known as hydration shells. These hydration shells exist in a dynamic state, and are more or less unstable. The ‘guest’ molecules dissolved in water exist in a state of being entrapped inside these hydration shells. This phenomenon can be seen both in ionic solutions and colloidal solutions. Obviously, hydration shells assume an internal spacial arrangement exactly fitting to the 3-dimensional spacial configuration of the ‘guest’ molecule entrapped in them. If we could devise some technique to remove the entrapped ‘guest’ molecules from these hydration shells, without disturbing the hydrogen bonds between the constituent water molecules, these hydration shells can retain the molecular memory of the molecular configurations of the removed ‘guest’ molecules. This rarely studied phenomenon underlies the much debated controversial ‘molecular memory of water’. Actual mechanism and forces underlying this phenomenon have to be investigated minutely by physical scientists. Minute changes occuring in the electron clouds of atoms of water molecules during the formation of hydration shells may be one factor responsible for this phenomenon. It has been well proven that these hydration shells later show a peculiar capability to differentially recognize the original ‘guest’ molecules which were  responsible for their formation. This may be due to the existence of some imprinted memory of those host molecules retained in the hydration shells. This imprinting of memory may be compared to formation of finger prints. As in the case of finger prints, configuration of these molecular imprints also will be a complementary negative of ‘guest’  molecules.  These empty hydration shells, or supra-molecular formations of water subjected to molecular imprinting, may be called ‘hydrosomes’, which means, minute ‘cavities of water’.

Homeopathic process of potentization may be a crude method of preparing hydrosomes, imprinted with various drug molecules(‘guest’), for utilizing as therapeutic agents.  It should be specially noted that the medium used for homeopathic potentisation is not pure water, but it is mixed with ethyl alcohol in a particular ratio. It may be  inferred that the presence of camparatively heavy ethyl alcohol molecules in this mixture may be contributing to stabilize the hydrosomes, preventing their easy dissociation.  The convergent forces of rotational movements to which the mixture is subjected as part of homeopathic potentization, may also be a contributing factor in stabilizing the empty hydration shells.

This peculiar 3-d configuration of ‘hydrosomes’ are destroyed only when the energy level of water molecules are disturbed by the effect of heat,  electricity, magnetism and other electro magnetic radiations. As stated earlier the hydration shells formed in pure water are comparatively unstable. Here lies the importance of the fact that homeopathic potencies are made using alcohol- water mixture.

Information we recently receive from various research institutions, regarding the wonderful  supra-molecular structures of various materials and their hitherto unknown peculiar properties, may greatly contribute in our  efforts to devise a protocol for molecular imprinted drug designing using water. Studies on  ‘water clusters’, ‘crystalline structure of water’, ‘shape memory property’, ‘molecular imprinting’,  ‘nano technology’,  ‘clathrate formations’ and other diverse phenomena are offering promising indications in this direction. We have to utilize all these new revealations in our scientific study regarding the possibility of developing a technology of drug designing by molecular imprinting in water.

We all know that water exists as ice crystals in its solid form. But it has been recently observed that water can exist even in its liquid form in crystals. In reality, water formed by melting of ice is in a state of liquid crystals. The lattice structure which is formed through hydration bonds is responsible for this phenomenon. Molecular imprinting in water is much interested in this area of research pertaining to this peculiar crystalline nature of water. It is believed that in the process of molecular imprinting of water using ‘guest’ molecules,  this crystalline structure of water plays a crucial role. It is likely that more advanced studies about dynamics of crystallization of water may help us to evolve a perfect technology for molecular imprinting in water.

The studies about Clathrate Compounds or host-guest compounds in supra-molecular chemistry is an area in which we should have sincere interest. Clathrates are the molecular networks which are formed when gases dissolve  in water under high pressure. They exist in a peculiar host–guest relationship. The studies about this phenomenon are still in their infancy. Clathrates have a crystalline nature,  existing as molecular networks,  formed by a process of water molecules arranging around the guest molecules. The studies about the dynamics of clathrate formation are also likely to help in evolving a perfect protocol for molecular imprinting in water. Even if  the host molecules are removed from clathrates, the network of water molecules have been found to remain intact. More over, the existing clathrates can induce the formation of similar clathrates. It will be very useful to consider these above discoveries connecting them with the phenomenon of molecular imprinting.

A lot of studies has been so far published regarding shape memory materials.  Several alloys having  crystalline structure have been observed to possess shape memory property. Such materials are known as SMART materials. This phenomenon also has to be understood well while trying to evolve a molecular imprinting technique of drug designing.

It is in the phenomenon of ‘molecular memory of water’ itself that we naturally land on when we attempt to develop molecular imprinted drugs. We have already seen that the alcohol–water molecules contained in the medium used for imprinting  arrange themselves around the ‘guest’ molecules, and form hydration shells. We should develop a way to systematically remove the ‘guest’  molecules entrapped in the hydration shells, so that empty hydration shells or ‘hydrosomes’ remain. These ‘hydrosomes’ will be imprinted with the three-dimensional ‘finger print’ of ‘guest’ molecules used for imprinting.

When molecular imprinted water is  introduced into the organism by any route, is carried by the body fluids, and transported to different parts of body. When molecular imprints come in the vicinity of ligands or active groups of pathological foreign molecules having similarity to the original ‘guest’ molecules, these molecular imprints selectively bind to those pathological molecules. By this process, pathological foreign molecules are prevented from binding with biological molecules, thereby relieving the biological molecules from pathological molecular blocks. This can be described as some sort of ‘molecular scavenging’ or entrapping of pathological molecules, by ‘hydrosomes’ or “molecular imrints”.

Drugs designed through molecular imprinting in water will be the safest of all therapeutic agents so far used in the history medical science. Though there is a chance for these molecular imprints affecting “off-target” molecules or ‘antitargets’ having similarity to the target molecules, such interactions will be of very transient nature, since these molecular imprints will be easily degraded into constituent water-ethyl alcohol molecules. Such temporary interactions with off-target molecules may not lead to any dangerous consequences. Factors such as bioavailability, metabolic half life, and lack of side effects also will be obviously remain in favorable range.

Using various ligands and pathological molecules involved in each disease process as ‘guest’  molecules, we can develop most appropriate specifc designer drugs against almost any disease. Instead of original pathological molecules or ligands, drug molecules having configurational similarity to them also can be used as “guest” molecules in the molecular imprinting protocol. Homeopathic potentization utilizes this strategy, which is the real essence of “similia similibus curentur”. I  hereby appeal to the government and scientific community to take up this task with urgent priority, so that a whole new range of safe and effective designer drugs could be developed though this novel process of molecular imprinting in water.

IS HOMEOPATHY AN “ANCILLARY” OF MODERN MEDICINE?

Thanks to the compulsions of corona epidemic, the term Homeopathic PROPHYLAXIS is now displaced by a new term IMMUNE BOOSTER in the vocabulary of of homeopaths. Homeopaths themselves have already accepted the new term very enthusiastically, as if they consider it gives to a new higher STATUS to homeopathy! They are not much bothered about the meaning of “immune boosting”, what is the biological mechanism of immune boosting, or HOW homeopathic medicines boost immunity. It is a nice and appealing term, that is enough for them to rejoice!

Now comes another term and another STATUS for homeopathy – ANCILLARY MEDICINE. Homeopathy is now raised to a NEW status of ANCILLARY MEDICINE, instead of the erstwhile status of ALTERNATIVE MEDICINE! This new status is the contribution of OUR HOMEOPATHIC CORONA RESEARCHERS.

The title given to a “homeopathic drug trial” conducted by a team of leading homeopaths was
“Effectiveness of Homeopathy as an ancillary mode of treatment and management in combating corona virus infection”.

Going to the details of that “RESEARCH” it is found that homeopathic medicines were used along with “drugs of modern medicine according to standard treatment protocol”!

In modern medicine, the word ANCILLARY is clearly defined.

Ancillary services in modern medicine is classified into three categories:
diagnostic
therapeutic
custodial
Diagnostic services include laboratory tests, radiology, genetic testing, diagnostic imaging, and more.

Therapeutic services range from rehabilitation to physical and occupational therapy, as well as massage, chiropractic services, and speech therapy.

Custodial services include everything from hospice care and long-term acute care to nursing facilities and urgent care.

Ancillary services are medical services or supplies that are not provided by acute care hospitals, doctors or health care professionals. Examples of ancillary services include:
Ambulance services
Ambulatory surgery center (ASC) services
Audiology services
Behavioral health services (inpatient and outpatient)
Cardiac monitoring
Dialysis services
Durable medical equipment (DME)
Hearing services
Home health care services
Home infusion therapy services
Hospice care services
Laboratory services
Medical day care (adult and pediatric)
Mobile diagnostic services
Orthotics and prosthetics
Personal care assistant services
Private duty nursing
Radiology/diagnostic imaging
Rehabilitation services (inpatient and outpatient)
Skilled nursing services
Sleep laboratory services
Speech services
Substance-abuse services (inpatient and outpatient)
Ventilator services
Wound-care services

By earning a status that is ANCILLARY to modern medicine, what advancement we have to expect for homeopathy? By REDEFINING HOMEOPATHY as Molecular Imprints Therapeutics, we were trying to establish that homeopathy is actually a scientifically more advanced stage of modern medicine. Using the corona researchers, modern medicine has very successfully pulled down homeopathy to the status of their ANCILLARY system, even from the current status of ALTERNATIVE MEDICINE ! Do homeopaths think ANCILLARY status is more desirable and prestigious that ALTERNATIVE status? Why do you fail to think about at least a PARALLEL status?

Why should homeopaths do research to establish homeopathy as an ANCILLARY of modern medicine? What you are actually trying to prove by giving homeopathy medicines along with “drugs of modern medicine according to standard treatment protocol”! Is it not the real MIXOPATHY or MIXING OF MEDICAL SYSTEMS you are so MUCH abhorrent about? Even if our medicines acted in such cases, do you expect scientific will accept your research as a proof for effectiveness of homeopathy?

Homeopaths are averse to give TWO medicines together in potentized form, as it is against the “words of maser”! But they have no aversion to give homeopathic medicines ALONG WITH allopathic medicines to same patient, if it is given by another doctor! Is it not ridiculous? Where did master permit you to use potentized homeopathic medicines to a patient along with allopathic medicines?

ON HOMEOPATHIC ‘DIAGNOSIS’

One of the accusations we hear against homeopathy from its critics is that homeopathy treat only symptoms, without diagnosing the disease. This criticism comes from the idea that diagnosis means fitting the sufferings of the patient into a ‘disease name’ given in the textbooks.

It is wrong to say “homeopathy treats symptoms”.

Actually, homeopathy uses “totality of symptoms” as an indirect means for identifying the biomolecular errors underlyning the disease conditions, as symptoms are nothing but subjective and objective expressions of underlying molecular level pathology.

Homeopathy uses ‘similarity of disease symptoms and drug symptoms’ as a means to identify the appropriate therapeutic agent, based on the knowledge of biochemistry that molecules with ‘similar’ functional groups can bind to ‘similar’ biological targets and produce ‘similar’ molecular inhibitions that are expressed through ‘similar’ trains of symptoms, and that ‘similar’ molecules will compete each other for binding to same biological targets, leading to the removal of molecular inhibitions. This is the basis of therapeutic principle ‘similia similibus curentur’.

If we could identify the drug molecules that are ‘similar’ to particular disease-causing molecules, molecular imprints of those drug molecules can act as artificial binding pockets for those disease-causing molecules by their conformational affinity and deactivate them, thereby removing the pathological molecular inhibitions they had produced in the organism. This is the molecular mechanism of high dilution therapeutics involved in homeopathy.

When a homeopath selects a particular drug or a combination of drugs as ‘similimum’ for a particular patient on the basis of ‘totality’ of subjective and objective symptoms, he is actually making a ‘diagnosis’- a diagnosis that is more comprehensive, more minute, more deep, more subtle and more specific than what is commonly known as ‘diagnosis’ according to the paradigms of modern medicine.

Homeopathic diagnosis of identifying a ‘similimum’ actually goes much deeper level into the identification of exact ‘molecular level’ errors existing in the individual. These molecular level errors could not be accurately identified with any modern sophisticated techniques or bio-chemical studies with such a perfection, other than by the observation of subjective and objective symptoms expressed by the individual. Disease diagnosis of modern medicine is only a very superfluous part of this molecular level ‘total diagnosis’ done by homeopathy. That is why modern medicine find it difficult to treat without proper ‘disease diagnosis’, where as homeopathy can treat any complex case by it ‘symptom diagnosis’ methodology.

Derangement in a particular biochemical pathway resulting from a molecular level inhibition produces a specific train of subjective and objective symptoms in the organism. In other words, each specific group of symptoms exhibited by the organism indicates a particular error occurred in the molecular level.

Homeopathy actually chases these trains of symptoms to their minutest level, from periphery to interior, in order to identify the exact molecular errors underlying any particular state of pathology.Then, those pathological molecular inhibitions are removed by applying appropriate therapeutic agents, selected on the basis of ‘law of similars’ or ‘Similia Similibus Curentur’.

The subjective and objective symptoms presented by the organism are the only reliable indicators to help us correctly understand the minute molecular deviations underlying a state of pathology. Each group or trains of symptoms represent a specific molecular error that had occurred in a particular biochemical pathway. These symptoms invariably indicate the specific type and character of the endogenous or exogenous foreign molecules or ions responsible for the causation of particular molecular inhibition. By studying the train of symptoms carefully and systematically, homeopaths are actually observing these exact molecular inhibitions.

This symptom-based analytical method of diagnosing done in homeopathy is far more exact and superior to the multitude of expensive complex laboratory chemical tests and imaging technologies we consider to be ‘scientific’. Identifying the exact molecular errors in the organism of the patient by observing the expressed symptoms, and identifying the most appropriate therapeutic agents from the similarity of symptoms those drugs could produce in healthy organism- this is the scientific essence of “similia similibus curentur”.

This fundamental strategy underlying the homeopathic system of therapeutics evidently surpasses even the most ‘scientific’ methods of modern molecular medicine. It is high time that the modern medicine realize and recognize this great truth, and incorporate this wonderful tool of homeopathy into their armamentarium. Obviously, “similia similibus curentur” is the most effective technique of identifying and removing the pathological molecular inhibitions in the organism.

Why Biological Properties of Molecular Forms and Molecular Imprinted Forms of A Drug Substance Appear Mutually Opposite?

Homeopathy or Similia Similibus Curentur is actually a therapeutic method that utilise the mutually OPPOSITE actions of crude forms and potentized forms of drug substances. It is the fundamental of homeopathy. If a drug substance can produce a group of symptoms in a healthy individual that are similar to the symptoms of a disease, that disease can be cured by applying the potentized forms of that drug substance. Producing symptoms actually means producing certain molecular errors in the body. Similarity of symptoms indicates similarity of molecular errors. If a drug substance in its crude forms can produce certain molecular errors in the body, its potentized forms can remove that molecular errors.

In our everyday clinical practice, we have a lot of experiences with this OPPOSITE actions of crude drugs and their potentized forms. Many times we apply this knowledge also. Using APIS MEL 30 for bee stings, anacardium 30 for antidoting anacardium poisoning, tabaccum 30 for removing bad effects of tobacco, cannabis 30 for cannabis addiction – there are actually hundreds of such empirical uses which very successful.

Tautopathy is the use of potentized forms of allopathic drugs to remove the short-term or long-term bad effects of allopathic drugging. Potentized forms of almost all allopathic drugs are available in market. Many nosodes are successfully used by homeopaths on the basis of this knowledge of OPPOSITE actions of crude forms and potentized forms. The researches referred above regarding the use of Arsenic Alb 30 in arsenic toxicity, cadmium sulph 30 in cadmium toxicity etc also ratify the correctness of this observation.

When trying to find an answer to the question “what are the active principles of post-avogadro potentized drugs, it is very important that these ACTIVE PRINCIPLES should be something that can remove the molecular inhibitions caused by the molecular forms of that drug.

We have already found in earlier discussions that post-avogadro dilutions do not contain any molecule of original drug substance, and that they contain nothing but alcohol and water, along with some particles coming through contaminations. We have also found that chemical properties of post-avogadro dilutions and unpotentized water-alcohol mixture are similar. But all of us know, and it is well established that these post-avogadro dilutions without any drug molecule contained in them have specific biological actions and disease curing properties. It was also observed and proved through spectroscopic studies mentioned earlier that post-avogadro dilutions have some supra-molecular arrangements that make them different from the plain water-alcohol mixture. It is now obvious that the ACTIVE PRINCIPLES should be some supra-molecular water-ethyl alcohol structures formed during the process of potentization. And it is very much evident that these supra-molecular structures are not MIMICS of drug molecules, but something that can produce biological effects that are exactly OPPOSITE to those produced by original drug molecules.

Our inquiry for ACTIVE PRINCIPLES of post-avogadro diluted homeopathic drugs has now arrived at a very decisive point. Now we are very much sure that these active principles are some sort of supramolecular structures formed by water and alcohol, and these structures have retained the medicinal properties of original drug molecules in a REVERSE order.

It is already known to us that chemical molecules produce errors in biological processes by binding to and inhibiting biological molecules such as enzymes, receptors, transport molecules etc. Chemical molecules having some functional groups or moieties SIMILAR to those of natural ligands can compete with the natural ligands in binding to the biological targets. When a chemical molecule succeed in this competition, the biological molecules get inhibited, and the interactions between biological molecules and their natural ligands are blocked. This is the molecular mechanism involved in disease processes. Drug molecules as well as various pathogenic molecules can inhibit the actions of biological molecules by this mechanism, which result in diverse kinds of pathological conditions.

CURE involves removal of pathological inhibitions happened in biological molecules. If the post-avogadro diluted drugs can cure disease conditions produced by their molecular forms , it means, they contain some supra-molecular structures that can bind to those molecules, deactivate them, and remove the molecular inhibitions they produced. In order to bind to the chemical molecules, these supra-molecular structures should have some conformational properties that are just opposite to the concerned chemical molecules.

Now our answer for the question “what are ACTIVE PRINCIPLES of post-avogadro potentized drugs” is very much near to us. We can say, the ACTIVE PRINCIPLES are some “supra-molecular structures formed in water-ethyl alcohol medium during the process of potentization, which can act as artificial binding sites for pathogenic molecules having some sort of opposite conformations”.

Next question we have to answer is, HOW these “supra-molecular structures” are formed during the process of potentization. This question could be answered only if we study the supramolecular properties of water-ethyl alcohol mixture, phenomena of hydrogen bonding, formation of host-guest complexes, cavitation and a lot of such things, and also the molecular processes involved in the technology of MOLECULAR IMPRINTING.

”ശാസ്ത്രീയ ഹോമിയോപ്പതിയുടെ ശക്തി സ്വയം അനുഭവിച്ചറിയുക”- ഹാനിമാൻ ജന്മവാർഷിക കാംപൈൻ

“ശാസ്ത്രീയമായ ഗവേഷണ പഠനങ്ങൾവഴി നവീകരിക്കപ്പെട്ട ആധുനിക ഹോമിയോ ചികിത്സാരീതിയുടെ ഗുണഫലങ്ങൾ ജനങ്ങളെ പരിചയപ്പെടുത്തുന്നതിനായി ഹാനിമാൻ ജന്മവാർഷികത്തോടനുബന്ധിച്ച് Center for Research in Redefining Homeopathy (CRRH) “ശാസ്ത്രീയഹോമിയോപ്പതി അനുഭവിച്ചറിയുക” എന്ന 6 മാസം നീണ്ടുനിൽക്കുന്ന ഒരു സൗജന്യ ചികിത്സാ പദ്ധതി ആവിഷ്കരിച്ചിരിക്കുകയാണ്. ശ്രീകണ്ഠപുരം എം എം കോംപ്ലക്സിൽ പ്രവർത്തിക്കുന്ന MIT SCIENTIFIC HOMEOPATHY CHAMBER എന്ന സ്ഥാപനം വഴിയാണ് ഈ പദ്ധതി നടപ്പിലാക്കുന്നത്. പഴകിയതോ താൽക്കാലികമോ ആയ എല്ലാവിധ ശാരീരിക-മാനസിക രോഗങ്ങൾക്കും, ജീവിതശൈലീരോഗങ്ങൾക്കും, ലൈംഗിക-വന്ധ്യതാ പ്രശ്നങ്ങൾക്കും, മദ്യ-മയക്കുമരുന്ന്-ലഹരി അടിമത്തത്തിനും പ്രത്യേകം തയാർചെയ്യപ്പെട്ട ഹോമിയോ ഔഷധങ്ങൾ ഉപയോഗിച്ച് വിദഗ്ധ ഡോക്ടർമാർ MIT PROTOCOL അനുസരിച്ചുള്ള ശാസ്ത്രീയ ഹോമിയോപ്പതി ചികിത്സ നൽകുന്നതാണ്. ഈ പദ്ധതി അനുസരിച്ച് കൺസൾട്ടേഷനും ഔഷധങ്ങളും പൂർണമായും സൗജന്യമായിരിക്കും. താൽപര്യമുള്ളവർ ഈ നോട്ടീസോ വാട്ട്സപ്പ് വഴി ലഭിച്ച ഈ മെസേജോ സഹിതം ശ്രീകണ്oപുരം എം എം കോപ്ലക്സിലുള്ള ഞങ്ങളുടെ സ്ഥാപനത്തിന്റെ കൗണ്ടറിൽ വന്ന് പേരും വ്യക്തിവിവരങ്ങളും നൽകിയാൽ സൌജന്യ ചികിത്സക്കായി രജിസ്റ്റർചെയ്ത് കാർഡ് വാങ്ങിക്കാവുന്നതാണ്. നേരിട്ടു വരാതെതന്നെ 9747320252 എന്ന ഫോൺ നമ്പറിൽ വിളിച്ച് പേർ രജിസ്റ്റർ ചെയ്യാവുന്നതുമാണ്.”

I AM TRYING TO EXPLAIN AND PROVE FUNDAMENTALS OF HOMEOPATHY SCIENTIFICALLY – NOT TO DENY OR DEFEAT HOMEOPATHY!

I am not “trying to change fundamental laws of homeopathy” as some of our homeopath friends accuse. I am only trying to “explain fundamentals” of homeopathy in terms of modern science , and to prove them using scientific method. If you take some time to go through my articles on this topic, you would realize that I have “explained” ‘similia similibus curentur’ and ‘potentization’ “as per ‘already proved’ modern science”. I am not proposing any “new theory” or trying to “change fundamental laws”.

Please note, so far there is no any ‘fundamental law’ or any hypothesis in homeopathy which anybody proved or could be proved “as per modern science”. Not even “explained” as per modern science”. But we teach, learn and practice those “unproved” ideas as “fundamental  laws” without any hesitation. You never asked anybody to “prove” those theories before accepting them. 

One friend even asked me to “show molecular imprints present in potentized drugs”, as if he understands molecular imprints as something that could be picked by a forceps and shown to him! Can anybody ‘show’ him supra-molecular formations of water? It should be by indirect methods and ‘understood’, not ‘seen’. Either they did not read what I have written, or failed to follow the concepts due to poor back ground knowledge in the scientific topics I have discussed to ‘prove’ molecular imprints concept. Or, it may be that they do not want to understand on reasons known only to them!

How can I convince you something, if you hesitate to read anything? I regularly post at least one article everyday explaining my concept of ‘molecular imprints’ and their implication in homeopathy. Without reading what I write, you ask me to “prove”! I once again request you to take some time to read at least some of those articles.

How can I prove my scientific concepts of homeopathy to somebody who does not know or is not willing to learn supra-molecular properties of water? How can I prove my concepts to somebody who does not know or is not willing to learn the subject matter of molecular imprinting technology? How can I prove my concepts to somebody who does not know or is not willing to learn the modern biochemistry and molecular biology? How can I prove my concepts to somebody who does not know or is not willing to learn advanced concepts of enzyme kinetics and molecular level pathology?

My request to those who ask for ‘proof for my concepts’ is, kindly update your basic knowledge in the topics I discuss. Then only you can follow these concepts. Then only I can ‘prove’ molecular imprints concepts to you. Once you acquire the background knowledge and then read my articles, you will see that everything I say is simple ‘proved’ science, and only very little remains to be ‘proved’.

If you go through my articles and try to understand the ideas I am proposing, you will realize that I have successfully explained   SIMILIA SIMILIBUS CURENTUR and POTENTIZATION in a way fitting very well to modern biochemistry, molecular pathology,  pharmacodynamics and supramolecular chemistry. Nobody even from scientific community can question my explanation of SIMILIA concept in terms of competitive relationship between similar molecules in binding to biological targets, and the phenomenon of “molecular mimicry” well explained in modern biochemistry. You should understand, my studies of POTENTIZATION as a tecnique of preparing molecular imprints has paved the way for hectic research activities in modern medicine to produce a whole range of target-specific MOLECULAR IMPRINTED DRUGS. It is undeniable that my explanations of MIASMS as “chronic disease dispositions produced by off-target inhibitions of biological molecules caused by antibodies generated against alien proteins and infectious agents” has raised the status of homeopathy to a new level. 

I would like to make it clear that I did not produce any ‘theories’ artificially. All my proposals on various aspects homeopathic practice are logical extensions evolved naturally from the fundamental concept of ‘molecular imprinting’ as the process involved in potentization. Once we accept ‘molecular imprints’ as the active principles of potentizaed drugs, and that they act therapeutically upon the organism by selectively binding to the pathogenic molecules, we cannot perceive or resolve these practical issues from another angle.

How can I ‘modify’ or distort logical and obvious scientific truths to satisfy your erstwhile habits, deep-rooted beliefs and long continued comfortable ways of practicing?

I can understand the discomfort brewing among ‘settled’ homeopaths when hearing my concepts that they fear would ‘change their ‘fundamentals’. “Coming out of comfort zones” is not an easy task, especially for ‘seniors’. It is very difficult to get exposed to a new knowledge environment, which would demand a fundamental re-thinking and modifying of many things they ‘believed’, learned, taught and practiced in their whole life. That would be a very uneasy situation, very hard to cope with.

MANAGING METABOLIC SYNDROME USING COMBINATIONS OF MOLECULAR IMPRINTED DRUGS OF HOMEOPATHY

Metabolic Syndrome has become a major lifestyle related health issue of modern man, probably due to stressful life, lack of exercise and changed food habits. 

Metabolic syndrome or MetS is a cluster of common abnormalities arising from persistent high levels of cortisol in the blood. This Syndrome includes hyperglycemia, abdominal obesity, reduced high-density lipoprotein cholesterol levels, and elevated triglyceride and blood pressure. The common characteristics of MetS and hypercortisolemic conditions such as Cushing’s syndrome suggest that the pathogenesis of MetS and central obesity might involve prolonged and excessive exposure to cortisol.

Metabolic Syndrome was originally described as “insulin resistance syndrome”.

 The components of Metabolic Syndrome are associated with endothelial dysfunction and atherosclerosis and increase the risk for type 2 diabetes mellitus as well as vascular morbidity and mortality. It is estimated that about one fourth of the world’s adult population has Metabolic Syndrome.

Metabolic Syndrome is diagnosed when three or more of the following parameters are present: waist circumference greater than 102 cm in men and greater than 88 cm in women, triglycerides of at least 150 mg/dl, HDL cholesterol less than 40 mg/dl in men and less than 50 mg/dl in women, blood pressure of at least 130/85 mm Hg, and fasting glucose of at least 110 mg/dL.

It is unclear whether a single primary abnormality triggers a cascade of diverse events that lead to the manifestation of the components of MetS. Because the diagnostic features of MetS are shared by Cushing’s syndrome (CS), which results from endogenous or exogenous hypercortisolism, it was proposed that cortisol contributes to the pathogenesis of both states although only mild hypercortisolism occurs in MetS in contrast with CS. It was also suggested that inhibiting cortisol action could provide a novel therapeutic approach for MetS. 

Indeed, preliminary data suggest that circulating cortisol concentrations are higher in patients with MetS compared with healthy subjects, both in basal conditions and during dynamic stimulation. This difference is more evident in patients with MetS and hypertension or impaired glucose tolerance. Furthermore, weight loss normalizes cortisol levels and improves insulin resistance. Despite the fact that cortisol levels are within the normal range, there is evidence of increased activity of cortisol in the periphery and dysregulation of the hypothalamic-pituitary-adrenal axis. 

Differences between CS and MetS also need to be emphasized; in CS, once the tumor is removed, symptoms improve; in the MetS, weight loss reverses both hypercortisolism and phenotypic abnormalities.

Cortisol appears to play a role in adiposity in Metabolic Syndrome. Elevated serum uric acid levels are shared by MetS and CS Syndome. Increased exposure to cortisol contributes to increased fat accumulation in visceral deposits of fat. Increased cortisol serum overnight levels are also associated with insulin resistance.

Some studies showed elevated cortisol levels in situations such as work stress and unemployment. Others reported that chronic life stress results in subtle hyperactivity of HPA axis leading to intraabdominal adiposity and development of Metabolic Syndrome. Patients with Metabolic Syndrome appear to have higher urinary excretion of cortisol metabolites compared with healthy subjects. In vitro, cortisol appears to increase lipoprotein lipase or fat-storing enzyme levels in adipose tissue and particularly in visceral fat.

Cortisol, also known as “stress hormone”, is a very important hormone produced mainly by the zona fasciculata of the adrenal cortex in the adrenal gland. It is produced in other tissues also in smaller quantities. It is released with a diurnal cycle and its release is increased in response to stress and low blood-glucose concentration. It functions to increase blood sugar through gluconeogenesis, to suppress the immune system, and to aid in the metabolism of fat, protein, and carbohydrates. It also decreases bone formation.

In general, cortisol stimulates the synthesis of ‘new’ glucose from non-carbohydrate sources. This is known as gluconeogenesis, mainly in the liver, and also in the kidneys and small intestine under certain circumstances. The net effect of cortisol is an increase in the concentration of glucose in the blood, further complemented by a decrease in the sensitivity of peripheral tissue to insulin, thus preventing this tissue from taking the glucose from the blood. Moreover, cortisol has a permissive effect on the actions of hormones that increase glucose production, such as glucagon and adrenaline.

Cortisol also plays an important, but indirect, role in liver and muscle glycogenolysis, the breaking down of glycogen to glucose.

Elevated levels of cortisol, if prolonged, can lead to proteolysis or breakdown of proteins, and muscle wasting. The reason for proteolysis is to provide the relevant tissue with ‘building blocks’ for gluconeogenesis. The effects of cortisol on lipid metabolism are more complicated since lipogenesis is observed in patients with chronic, raised circulating cortisol levels, although an acute increase in circulating cortisol promotes lipolysis. The usual explanation to account for this apparent discrepancy is that the raised blood glucose concentration through the action of cortisol will stimulate insulin release. Insulin stimulates lipogenesis, so this is an indirect consequence of the raised cortisol concentration in the blood but it will only occur over a longer time scale.

Experimental studies with cortisol inhibitors further support the role cortisol in the pathogenesis of Metabolic Syndrome, and might provide novel therapeutic approaches in patients with metabolic syndrome or obesity.

The components of Metabolic Syndrome are associated with endothelial dysfunction and atherosclerosis, and increase the risk for type 2 diabetes mellitus as well as vascular morbidity and mortality.

It was also suggested that inhibiting cortisol action could provide a novel therapeutic approach for Metabolic Syndrome. Indeed, preliminary data suggest that circulating cortisol concentrations are higher in patients with Metabolic Syndrome compared with healthy subjects, both in basal conditions and during dynamic stimulation. It was also proved that
reduction of body weight normalizes cortisol levels and improves insulin resistance.

Emerging data suggest that patients with MetS show hyperactivity of the hypothalamic-pituitary-adrenal axis, which leads to a state of “functional hypercortisolism”. The cause for this activation of the HPA axis remains uncertain but may be associated with chronic stress, which is associated with increased circulating cortisol levels and greater responsiveness of the HPA axis. Increased exposure to cortisol contributes to increased fat accumulation in visceral depots. Increased enzyme activity in adipose tissue and liver might contribute to the development of several features of the MetS.

Central abdominal obesity is one of the main components of the MetS. Cortisol appears to play a role in adiposity in MetS. Increased urinary cortisone/cortisol ratio in women with increased abdominal fat compared with those with peripheral fat distribution was observed by researchers, suggesting an increase in the peripheral metabolism of cortisol. Interestingly, cortisol clearance seems to be inversely correlated with insulin sensitivity, and this correlation is independent of body fat. It is also well documented that glucocorticoids promote the differentiation and proliferation of human adipocytes and that their receptors are more abundant in visceral than in subcutaneous adipose tissue. They also redistribute adiposity from peripheral to central depots, increase the size and number of fat cells, and activate lipolysis and the release of free fatty acids into the circulation.

Increased cortisol levels are also associated with insulin resistance. Higher cortisol concentrations were related to a reduced insulin secretion.

Hypertension is one of the most distinguishing features of Metabolic Syndrome as well as hypercortisolism. Many studies reported an association between cortisol and systolic and diastolic BP levels. This correlation might be attributed to the effect of stress, which is associated with the activation of the HPA axis and sympathetic nervous system. Indeed, patients with Metabolic Syndrome and hypertension appear to have higher urine levels of both cortisol and catecholamine metabolites than healthy individuals. A possible mechanism by which cortisol elevate BP seems to be an increased responsiveness to vasoconstrictors along with a decreased vasodilator production.

Obesity , a common finding in both CS and MetS, is also associated with hypertension. The possible underlying mechanisms include volume expansion, increased cardiac output and systemic vascular resistance, increased sodium reabsorption, increased activity of the sympathetic nervous system and the renin-angiotensin-aldosterone system, high leptin levels and concurrent leptin resistance.

Patients with Metabolic Syndrome as well as hypercortisolism frequently have elevated blood glucose levels. In patients with MetS, serum cortisol levels are significantly associated with fasting glucose concentration. The relationship between fasting hyperglycemia and cortisol is due to the glucocorticoid effects on hepatic gluconeogenesis and insulin secretion.

Metabolic Syndrome is associated with endothelial dysfunction that significantly predisposes to an increased risk for cardiovascular diseases. Endothelial dysfunction is also observed in patients with hypercortisolism. Hypercoagulability of blood is also present in MetS. Indeed, elevated fibrinogen and homocysteine concentrations have been observed in MetS patients compared with healthy controls. Hyperfibrinogenemia and homocysteinemia seem to be independent risk factors for cardiovascular diseases and venous thrombosis.

Elevated serum uric acid levels are seen both in Metabolic Syndrome and Hypercortisolism. High uric acid levels are regarded as a predictor of cardiac and overall mortality in patients with cardiovascular diseases or stroke. Elevated uric acid is also associated with higher risk of stroke in patients with or without cardiovascular disease. It was demonstrated that statin atorvastatin therapy is associated with a reduction in uric acid levels, along with an increase in estimated glomerular filtration rate in CKD patients with MetS. This effect on renal function is perhaps due to an amelioration of endothelial function and renal blood flow. 

Adipose tissue is recognized as an important endocrine organ that secretes a variety of bioactive peptides, termed adipokines. These adipokines exert multiple effects and play a key role in glucose and lipid metabolism, insulin sensitivity, BP, and angiogenesis. The major components of this family of adipokines are adiponectin and leptin, which are mainly produced by adipose tissue. Both these proteins exert an insulin-sensitizing effect through fatty-acid oxidation and, in addition, adiponectin is associated with antiatherogenic, antidiabetic, and antiinflammatory properties. In obesity, insulin resistance has been linked to leptin resistance, elevated leptin, and low adiponectin levels, which are associated with higher cardiovascular risk. Resistin is expressed in abdominal fat and is also associated with increased risk of central obesity-related diabetes. However, resistin may not be an “adipokine” because in humans it is mainly produced by monocytes, and its link with central obesity is debated. Excess adiposity leads to dysregulation of adipokine production, which in turn promotes a state of low-level systemic chronic inflammation predisposing to atherosclerosis.

According to MIT approach, since molecular imprints of cortisol can act as artificial binding pockets for cortisol, it can antidote the adverse biological effects of excess cortisol circulated in the body. 

Homeopathic drug CORTISOL 30 contains Molecular imprints of the hormone cortisol. CORTISOL 30 is a great remedy for many ailments that are associated with Metabolic Syndrome. As such, cortisol 30 will be a powerful ingredient of Homeopathic Prescriptions in the management of all complaints associated with Metabolic Syndrome. Incorporation of PITUTRINUM 30 as well as common anti-stress homeopathy remedies such as Arg Nit 30, Gesls 30, Adrenalin 30 also produces beneficial effects in reducing the bad effects of stress and increased cortisol levels, and thereby preventing and curing Metabolic Syndrome and the health risks arising from its complications.

HOW THE KNOWLEDGE OF MOLECULAR PATHOLOGY HELPS IN MAKING SCIENTIFIC HOMEOPATHY PRESCRIPTIONS

According to MIT explanations of homeopathy. SIMILIMUM means a drug substance that can provide all the molecular imprints required to remove all the pathological molecular inhibitions underlying a disease existing in a patient. SIMILIA SIMILIBUS is only a practical way of identifying such a drug substance by observing the symptoms in a patient, and comparing them with the symptoms drug substances are known to have produced earlier in healthy idividuals. This therapeutic technique is actually based on the knowledge that chemical molecules having similar conformations can bind to similar molecular targets, produce similar molecular inhibitions, that are expressed through similar symptoms.

This scientific understanding will obviously lead homeopathy to a shift from symptom based prescriptions to molecular pathology based prescritions. The more we understand the molecular pathology of disease conditions as well as the details of ligands and targets involved in each pathological molecular inhibitions, and the more we study the molecular constitution of drug substances we use, the more we will be able to make perfect homeopathy prescriptions on the basis of that knowledge, and the more we can avoid symptom based approach.

The more we know about the molecular pathology of each disease, and the more we know the molecular constitutions of drug substances, the more homeopathy will shift away from “similarity of symptoms” to “conformational similarity of pathogenic molecules and drug molecules”.

Let us try to demonstrate this idea using the knowledge regarding molecular pathology of HYPERTENSION. Renin or angiotensinogenase, is the key enzyme produced in kidneys that modulates body’s renin-angiotensin-aldosterone system (RAAS) that mediates volume of extracellular fluids such as blood plasma, lymph and interstitial fluid, as well as arterial vasoconstriction. Thus, RENIN regulates the body’s mean arterial blood pressure.

The enzyme renin is secreted by the kidneys from specialized cells called granular cells of the juxtaglomerular apparatus in response to stimuli such as decrease in arterial blood pressure or decrease in blood volume detected by pressure-sensitive cells known as baroceptors, a decrease in sodium chloride levels in the ultrafiltrate of the nephrons, or sympathetic nervous system activity, acting through the beta1 adrenergic receptors.

The renin enzyme produced in kidneys circulates in the blood stream and breaks down angiotensinogen secreted from the liver into angiotensin I.

Angiotensin I is further converted in the lungs by angiotensin-converting enzyme (ACE) into angiotensin II. Angiotensin II is a very potent constrictor of all blood vessels. It acts on the smooth muscle and, therefore, raises the resistance posed by these arteries to the heart. The heart, trying to overcome this increase in its ‘load’, works more vigorously, causing the blood pressure to rise. This is the essential dynamics involved in rise of blood pressure.

Angiotensin II also acts on the adrenal glands and releases Aldosterone, which stimulates the epithelial cells in the nephrotic tubules and collecting ducts of the kidneys to increase re-absorption of sodium and water, leading to raised blood volume and raised blood pressure.

Aldosterone also acts on the CNS to increase water intake by stimulating thirst, as well as conserving blood volume, by reducing urinary loss through the secretion of Vasopressin from the posterior pituitary gland, resulting in increased blood pressure.

In normal physiological conditions, once the reduced blood pressure is raised to the adequate level, production of RENIN in kidneys is stopped by a NEGATIVE FEEDBACK mechanism, where angiotensin II act upon the special ‘angiotensin II receptors’ on the cell membranes of juxtaglomerular apparatus of kidneys. By this process, level of RENIN in blood stream is maintained with in limits, thereby preventing hypertension. 

Same way, production of catecholamines such as adrenalin which also plays a role in inducing production of RENIN and maintaining blood pressure high, is stopped by negative feedback action of adrenalin upon adrenogenic receptors on cells of adrenal cortex.

A pathological state of RENIN-ANGIOTENSIN AXIS happens once the NEGATIVE FEED BACK mechanism controlling the production of RENIN is disturbed by inhibition of angiotensin II receptors and adrenergic receptors involved in FEEDBACK process. Such inhibitions may be caused by binding of some pathogenic molecules of exogenous or endogenous origin, having functional groups similar to angiotensin II or adrenalin, so that they can competitively bind to the receptors. This leads to elevated state of RENIN in the circulation, resulting in ESSENTIAL HYPERTENSION.

Modern allopathic drugs are targeted either to block the conversion of angiotensin I into angiotensin II by inhibiting the angiotensin converting enzymes, or blocking the angiotensin II receptors using potent drug molecules. Since such molecular inhibitions may necessarily lead to molecular errors in different essential biochemical pathways, modern antihypertension drugs are prone to produce harmful side effects.

According to MIT concepts, maintaining the plasma level of RENIN by controlling its production by facilitating unhindered NEGATIVE FEED BACK mechanism is the ideal way of treating hypertension without any harmful side effects. Inhibition of FEEDBACK mechanism should be removed by using MOLECULAR IMPRINTS of angiotensin II, adrenalin, or drug molecules having similar functional groups. Various drug substances such as RAUWOLFIA contains a number of bioactive chemicals like ajmaline, aricine, corynanthine, deserpidine lankanescine rauwolscine, rescinnamine, reserpine, reserpiline, isoreserpine, isoreserpiline, serpentinine, and yohimbine, which can inhibit the angiotensin and adrenogenic receptors. As such, POTENTIZED FORMS of such drugs will contain MOLECULAR IMPRINTS that can act as artificial binding sites for binding to the endogenous and exogenous pathogenic molecules which are the causative factors of HYPERTENSION.

According to MIT approach, potentized or MOLECULAR IMPRINT forms of ANGIOTENSIN II, ADRENALIN, CATECHOLAMINES and various DRUG SUBSTANCES that can produce hypertension in crude form will be ideal drugs for treating hypertension without any side effects.

AN APPEAL TO CCRH FOR EXPLORING THE DESIRABILITY OF USING PROPIONIC ACID-WATER AZEOTROPIC MIXTURE AS AN IDEAL HOMEOPATHIC POTENTIZING MEDIUM

One of the most difficult questions related with scientific understanding of homeopathy was , how the medicinal properties of a drug substance could be transmitted and preserved into a medium without any drug molecule remaining in it. This cardinal question could be rationally answered once it was realised that homeopathic potentization involves a process of MOLECULAR IMPRINTING in water-ethanol azeotropic supramolecular matrix, and that MOLECULAR IMPRINTS of drug molecules are the active principles of post-avogadro diluted homeopathic drugs.

As per this scientific explanation, conformational details of drug molecules or template molecules are imprinted into the water-alcohol medium in the form of three dimensional nanocavities during the pricess of serial dilution and agitation involved in homeopathic potentization. By their conformational properties, these molecular imprints can act as artificial binding sites for pathogenic molecules that are similar to the template molecules, thereby deactivating pathogenic molecules and removing the molecular inhibitions they produced in the living system. Similia Similibus Curentur, the fundamental principle of homeopathy , could be satisfactorily explained by this biological mechanism, which fits very well to the advanced knowledge of biochemistry and pharmacodynamics.

In order to evolve this scientific explanation for potentization as well as similia similibus curentur, we had to delve deep into diverse areas of knowledge such as supramolecular chemistry of water and ethyl alcohol, polymer structure of water, hydrogen bonding, azeotropism, host-guest molecular interactions, cavitation, molecular imprinting in polymers, etc etc.

A mixture of water and ethyl alcohol in an approximate ratio of 10:90 is used as the medium for homeopathic potentization. According to some references, “pure distilled spirit” could also be used for this purpose, but all of us know, what is called “pure distilled spirit” actually contains 5% water and 95% ethanol, since it is impossible to separate water and ethanol beyond that level by fractional distillation, due to a peculiar phenomenon known as AZEOTROPISM. Studying the molecular level mechanism underlying the phenomenon of azeotropism is essential for understanding how molecular imprinting happens during homeopathic potentization.

In chemistry, AZEOTROPE is a mixture of liquids that has a constant boiling point, because the vapour has the same composition as the liquid mixture. The boiling point of an azeotropic mixture may be higher or lower than that of any of its components. The components of azeotropic mixtures of liquids cannot be separated by simple distillation.

An azeotropic mixture is a mixture of substances that has the same concentration at vapour and fluid phases. It is basically a mixture that contains two or more liquids. Azeotropic mixture basically has constant or the same boiling points and the mixtures’ vapour will also have the same composition as the liquid. Normally, we use distillation to isolate materials as the ideal solutions with one part normally more volatile than the other. However, in an azeotropic mixture, since the vapour and fluid concentrations will be the same this approach will prevent their separation.

Boiling a 95% solution of ethanol in water will produce a 95% ethanol vapour. It is not possible to obtain higher ethanol concentrations even by repeated distillations. Alcohol and water are miscible in any ratio, making it possible to combine any quantity of ethanol with any quantity of water to produce a homogeneous solution that could be separated by fractional distillation, but there will finally remain an azeotrope part in it containing 95% ethanol and 5% water that could not be separated by distllation.

I have been searching for a more biofriendly as well as stable substance that could be used as an ideal imprinting medium for preparing molecular imprinted drugs.

In an azeotropic mixture of two liquids, concentration of molecules will be such that each molecule of both compound will be strongly bound to each molecule of other compound, thereby restricting their freedom of movements. This mutual binding of molecules is retained even when they go to vapour phase. This is the reason why two liquids with different boiling points evaporate at a constant boiling point in azeotropic ratio. This unbreakable binding between molecules of constituent liquids in azeotropic mixture imparts peculiar physical and chemical properties to it.

Actually, it is this peculiar AZEOTROPIC properties that make water-ethanol mixture an ideal medium for homeopathic potentization and molecular imprinting. Even though pure water is a dynamic branched polymer, molecular imprints formed in it will be very transient and unstable due to the free movements of water molecules and the protonation-deprotonation process constantly taking place. But when ethanol is added to water in an azeotropic ratio, due to their mutual molecular binding, movements of molecules get restricted and protonation-deprotonation process reduced. Due to this mechanism, molecular imprints formed in an azeotropic mixture of alcohol and water remain stable and long standing. This phenomenon explains the importance of using water-ethanol mixture in a particular ratio as the medium for homeopathic potentization.

It is obvious that molecular imprints are actually formed by formation of hydrogen bonded networks of water molecules aroung drug molecules used as templates. It means, only the 5% water contained in the medium actually undergoes molecular imprining, and the remaining 90% alcohol plays only a preservative effects by stabilizing the molecular imprints formed in water. It means, potentized homeopathic drugs contain only 5% as their active principles. When we take 100 ml of potentized drug, only 5 ml of it actually carries molecular imprints. This is an important draw back of using water-ethanol mixture as potentizing medium, which also indicates the need for developing better alternatives.

Water-ethanol azeotropic mixture boils at 78.2 °C, even though boiling point of water is 100 degrees and that of ethanol is 78.4 degrees. It means potentized homeopathic drugs will evaporate in atmospheric temperature much easier than water or ethanol. It is a major problem encountered in homeopathy pharmacy.

I have been searching for long to find out an alternative imprinting medium for preparing molecular imprinted drugs and homeopathic potentization, that is more stable and more biofriendly than water-ethanol mixture.

After a lot of studies and research on this topic, an AZEOTROPIC mixture of water and propionic acid in the ratio 82.3: 17.7 is finally found to be a comparatively much better candidate as an ideal imprinting medium for preparing MOLECULAR IMPRINTED DRUGS, instead of water-ethanol azeotropic mixture conventionally used in homeopathic POTENTIZATION.

Propionic acid can hold much water than ethanol in an azeotropic mixture, it is a simple native fatty acid being a universal part of metabolic processes in living systems, it is hundred percent non toxic, and far much safer than ethanol.

PROPIONIC ACID is a simple fatty acid with chemical formula CH3CH2CO2H, belonging to the chemical group known as carboxylic acids. It is also known by different names, such as propanoic acid, ethylformic acid, methyacetic acid, carboxyethane, ethanecarboxylic acid, pseudoacetic acid, metacetonic acid etc.

Molecular mass of propionic acid is 74.079. It forms azeotropic mixture with water at a ratio 82.3 % water and 17.7% propionic acid. Boiling point of water-propionic acid azeotrope is 99.98 degree celsius, whereas boiling point of propionic acid is 141.1 degree celsius and boiling point of water is 100 degrees. As such, water-propionic acid azeotropic mixture cannot be separated by fractional distillation. Propionic acid consists of hydrogen bonded pairs of molecules in both the liquid and the vapor.

Propionic acid is a naturally occurring carboxylic acid with chemical formula CH3CH2CO2H. It is a liquid with a pungent and unpleasant smell somewhat resembling body odor.

Propionic acid has physical properties intermediate between those of the smaller carboxylic acids, formic and acetic acids, and the larger fatty acids. It is fairly miscible with water. As with acetic and formic acids, it consists of hydrogen bonded pairs of molecules in both the liquid and the vapor forms.

Propionic acid is a natural part of various biological processes and pathways. Propionic acid is produced biologically as its coenzyme A ester, propionyl-CoA, from the metabolicbreakdown of fatty acids containing odd numbers of carbonatoms, and also from the breakdown of some amino acids. The metabolism of propionic acid begins with its conversion to propionyl coenzyme A, the usual first step in the metabolism of carboxylic acids. Since propionic acid has three carbons, propionyl-CoA cannot directly enter either beta oxidationor the citric acid cycles. In most vertebrates, propionyl-CoA is carboxylated to D-methylmalonyl-CoA, which is isomerisedto L-methylmalonyl-CoA. A vitamin B12-dependent enzyme catalyzes rearrangement of L-methylmalonyl-CoA to succinyl-CoA, which is an intermediate of the citric acid cycle and can be readily incorporated there.
Propionic acid serves as a substrate for hepaticgluconeogenesis via conversion to succinyl-CoA.

Some propionic acid is used widely as a preservative for both animal feed and food for human consumption. Another major application is as a preservative in baked goods. As a food additive, it is approved for use in the EU, USA, Australia and New Zealand.

Designated as generally regarded as safe by the US Food and Drug Administration, propionic acid has shown little toxicity in humans and other organisms.

In the human body, however, propionic acid is generally metabolized with little ill effect and ultimately becomes a chemical intermediate in the citric acid cycle.

Some propionic acid is oxidized to lactic acid during absorption, but most passes to the liver, which removes nearly all of it from the portal blood. Propionic acid represents 20-25% of absorbed volatile fatty acids. Propionic acid is rapidly absorbed through the gastrointestinal tract.

Most absorbed propionic acid is passed to the liver, which removes nearly all of it from the portal blood.

As a compound that is typically found naturally in the body, little to no adverse cumulative health effects have been associated with exposure to propionic acid.

Designated as generally regarded as safe by the US Food and Drug Administration, propionic acid has shown little toxicity in humans and other organisms.

There are no known birth defects associated with the use of propionic acid in animals or humans.

ABOVE ALL, SINCE THE RATIO OF WATER IS VERY HIGH, A GIVEN DOSE OF POTENTIZED DRUG PREPARED USING PROPIONIC ACID-WATER AZEOTROPE WILL PROVIDE SIXTEEN TIMES MORE MOLECULAR IMPRINTS THAN WHAT WE GET FROM SAME MEASURE OF DRUG PREPARED USING WATER-ETHANOL MIXTURE. IT MEANS SIXTEEN TIMES MORE EFFECTIVENESS!

I would request the authorities at CCRH to conduct studies regarding my proposal to use 18% azeotropic solution of propionic acid in water as a better alternative to alcohol water mixture as homeopathic imprinting medium. Since water-propionic acid azeotropic mixture contain 82% water, the resulting homeopathic products will contain very high percentage of active principles or molecular imprints, which is a big advantage over water-ethanol mixture which contain only 5% molecular imprints.

Chandran Nambiar KC
Sci-Homeopathy

DISEASE-SPECIFIC COMBINATIONS OF POST-AVOGADRO DILUTIONS WILL REVOLUTIONIZE HOMEOPATHY PRACTICE!

Homeopathy practice will become more simple, effective and predictable, and homeopaths will become capable of producing better cure rates and gaining more popular acceptance, once the use of disease-specific combinations of post avogadro diluted drugs becomes the norm of applied homeopathy, and taught to students as such. It should be understood and accepted by the homeopathic community as a most scientific and rational method of practice, rather than an unprincipled shortcut of convenience or unwelcome aberration arising from lack of theoretical knowledge as it is presently considered.


Theoretical basis of combining potentized drugs evolves from the understanding that potentization involves a process of ‘molecular imprinting’, and individual constituent molecules of drugs are ‘imprinted’ in their individual capacities during this process.

According to this understanding, even a drug we consider ‘single’ is in fact a mixture of different types of ‘molecular imprints’ of diverse constituent drug molecules, and they exist without interacting with each other. As per this view, even if we mix two or more potentized drugs together, the constituent ‘molecular imprints’ will not interact each other, and will act up on the appropriate molecular targets in their individual capacities.

For the last few years I was experimenting on this idea , and I have found it totally harmless and very effective to combine potentized drugs above 30c, selected on the basis of constitutional as well as particular ‘symptom complexes’.

Hahnemann was talking about SINGLE drug on the basis of scientific knowledge available to him during his period 250 years ago. He had no idea about the molecular level structure of drug substances, or their molecular level interactions with biological molecules. He had no idea about the molecular level pathology and molecular inhibitions undelying diseases. He considered drugs as ‘single’ substance, and diseases as ‘singular’ entities. For him, NUX was a ‘single’ substance, whereas we now know NUX tincture is a mixture of hundreds of types of alkaloids, gycosides and other phytochemicals, which act upon our body on the basis of their molecular structure and chemical properties.

All those noises made by CLASSICAL homeopaths over SINGLE DRUG/ MULTIPLE DRUGS issue actually come from their lack scientific understanding of homeopathy. When a drug substance containing different types of chemical molecules is subjected to potentization, each chemical molecule undergoes molecular imprinting as individual units. As such, any potentized drug will be a combination of diverse types of molecular imprints representing diverse types of constituent chemical molecules, which can act upon the pathogenic molecules as individual units, in capacity of their individual conformational properties.

When we combine two or more potentized drugs together, all the diverse types of individual molecular imprints contained in those different drugs will exist in that combination as individual units, and act up on pathogenic molecules by their individual conformational properties. Obviously, a combination of of different potentized drugs will be no way different from a potentized single drug that contains diverse types of chemical molecules.

Molecular imprints act upon pathogenic molecules as individual units, whether they come from single drug substance or multiple drug substances. All controversies over single drug/ multiple drugs issue become totally irrelevant once you realise this scientific truth. But you can understand this truth only if you have a scientific temper, and you are capable of thinking beyond the lessons you learned from organon and your unscientific teachers!


Once you understand MIT explanations of scientific homeopathy, and start perceiving potentized drugs in terms of diverse types of ‘molecular imprints’ as the ‘active principles’ they contain, you will realize that all controversies over ‘single/multiple’ drug issue become totally irrelevant.

According to MIT view, ‘similimum’ essentially means a drug substance that can provide the specific molecular imprints required to remove the particular molecular errors that caused the particular disease condition in the particular patient. Whatever be the ‘method’ by which the drug is selected, similimum is a similimum if it serves the purpose of curing the patient when administered in potentized form. Since ‘multiple’ molecular errors exist in any patient in a particular point of time, expressed through ‘multiple’ groups of symptoms, he will inevitably need ‘multiple’ molecular imprints to remove them. If potentized form of a ‘single’ medicinal substance can provide all those ‘multiple’ molecular imprints, that ‘single’ drug substance will be enough. If we could not find a ‘single’ drug substance that contain ‘all’ the ‘multiple’ molecular imprints required by the patient as indicated by the ‘symptom groups’, we will have to include ‘multiple’ drug substances in our prescription. It is the constituent molecular imprints contained in our particular prescription that matter.

Important point is, we have to ensure that our prescription supplies all the diverse types of molecular imprints required for deactivating all the diverse types of pathogenic molecules existing in the patient, as indicated by the diverse groups of subjective and objective symptoms expressed by him. If we could find a single drug preparation that could supply all the molecular imprints required by the patient we are dealing with, we can use that single drug preparation only. If we do not find such a single drug, we have to include as many number of drug preparations as required, in order to provide all the molecular imprints needed to remove all the molecular errors in the patient.

‘Single/multiple’ drug controversy never bothers one who understands this scientific approach proposed by MIT, as we start thinking in terms of molecular imprints- not in terms of drug names. Actually, a drug could be called ‘single’, if it contains ‘single’ type of molecular imprints only. IF a drug contains more than one type of molecular imprints, it is a compound drug, even if it is known by a ‘single’ drug name, prepared from a ‘single’ source material, kept in a ‘single’ bottle, consumed as a ‘single’ unit for ‘drug proving’, or considered by ‘masters’ as ‘single’ drug.

When we consume a complex drug substance in crude form, it is absorbed into the blood as various individual chemical molecules contained in it. It is these individual chemical molecules that interact with various biological molecules. Different molecules act up on different biological targets according to the molecular affinities of their functional groups. Biological molecules are inhibited, resulting in errors in the biochemical pathways mediated by those biological molecules. Such molecular level errors in biological processes cascades into a series of molecular errors, which are expressed through various groups of subjective and objective symptoms.

It is obvious that what we consider as the symptoms of that drug substance are actually the sum total of different symptom groups, representing entirely different molecular errors produced in entirely different biological molecules, by the actions of entirely different chemical molecules contained in the crude drug.

We have to remember, there is no such a thing called nux vomica molecule or pulsatilla molecule- only individual chemical molecules contained in nux vomica or pulsatilla tinctures. Each constituent molecule has its own specific chemical structure and properties. They act on different biological targets by their chemical properties. Each individual chemical molecule contained in a complex crude drug substance acts as an individual drug. That means, nux vomica or pulsatilla are not single drugs as we are taught, but compound drugs.


Classical homeopaths may find it difficult to accept this fact, as it contradicts with their beliefs as well as the lessons they are taught. But it is the scientific fact. From scientific point of view of pharmaceutical chemistry, a drug is a biologically active unit contained in a substance used as therapeutic agent. It is the structure and properties of that chemical molecule that decides its medicinal properties and therapeutic actions. if such as substance contains only one type of biologically active unit, it is a single drug. If it contains different types of biologically active units, it is a compound drug. It is obvious that most of the drugs we use in homeopathy – especially drugs of biological origin and complex minerals- contain diverse types of biologically active units, and hence they cannot be considered single drugs.


Molecular imprinting happens as individual molecules, and as such, potentized drugs prepared from a single drug substance will contain diverse types of molecular imprints representing the diverse types of individual constituent molecules contained in the substance. Those molecular imprints also act as individual units when applied in the organism. Hence, potentized drugs prepared by using a complex, seemingly single drug substance is actually a compound drug, containing diverse types of biologically active units, or ‘molecular imprints’.


Once homeopathic community could realize and accept the great truth that disease-specific COMBINATIONS of homeopathic drugs in 30c potencies are many many times more effective and safer than so-called SINGLE drugs, homeopathy will be on the top of all medical systems in this world! There will not be any disease that could not be practically cured by using rationally formulated appropriate combinations.

All homeopaths should be taught the art and science of preparing and using their own formulations. Whether for prophylactic or curative purpose, you cannot expect a so-called SINGLE homeopathic post-avogadro diluted drug to work as a specific for a DISEASE in a community as a whole. To be successful, you need to use a well-formulated disease-specific combination of MULTIPLE drugs in post-avogadro dilutions for that purpose. It is based on this rational idea that I have formulated more than 300 disease-specific post-avogadro MIT FORMULATIONS which are used by homeopaths around the world successfully.

NEED TO INTERPRET THE SPECTROSCOPIC STUDIES OF HOMEOPATHIC DRUGS PROPERLY

It is a great “scientific blunder” happening to energy medicine homeopaths to think that if some “electromagnetic radiations” or “photons” are observed to come out a medicinal substance when it is irradiated and excited, those discharged “photons” are the active principles of those medicinal substances. Then they start constructing all sorts of nonsense psuedoscientific theories about curative process using these “photons”, such as “resonance”, “dynamic energy”, “quantum entanglement”, “biofield vibrations”, “vital force”, etc etc!

They should know, it is natural for any substance to discharge photons when its molecules or atoms are excited by applying external energy and then allowed to return to base level. This happens when the absorbed extra energy is discharged when returning to rest level. By analyzing the patterns of photon emissions, scientists study the structure and arrangement of molecules and atoms in a substance. Various techniques of spectroscopic studies have been developed by scientists for this purpose.

When drugs potentized below 12c or avogadro limit are excited using electromagnetic irradiation and then allowed to return back to rest, the extra photons absorbed by the elemental particles will be naturally emitted. We can study the molecular structure and arrangement of these substances by analyzing the spectra of emitted photons. It is totally absurd to theorize that the medicinal properties of drug substances could be reproduced by these photons, whereas medicinal properties of drug molecues come from the structure and properties of chemical molecules contained in them.

For example, color of a substance is actually the pattern of photons emitting or reflected from the substance once its molecules are excited by electromagnetic irradiations such as sunlight. These colors or emitted photons cannot be utilized to reproduce the chemical or biological properties of the molecules contained in the substance.

Drugs potentized above avogadro limit or 12c will not contain any molecule of original drug substance, but only water and ethanol, along with some natural contaminant particles. When these high dilution drugs are studied using spectroscopic techniques, the patterns of resultant spectra will obviously represent the structure and arrangement of alcohol and water molecules contained in them. We can also utilize these spectra to study the changes happening in their supramolecular arrangements happening during process of potentization. It means, by conducting spectroscopic studies of potentized drugs, and then comparing their spectra with those of unpotentized water-alcohol solutions, we can understand the processes the supramolecular rearrangements happening during potentization. This supramolecular rearrangement actually indicates MOLECULAR IMPRINTING.