What are exactly the active principles of potentized drugs? What is the molecular mechanism by which these active principles interact with organism and produce a therapeutic effect?
I think these are the fundamental question to be addressed while trying to make homeopathy a scientific medical system. The answer we provide should be capable of explaining the time-proven experiences of homeopathic practice, same time fitting to the existing scientific knowledge system. Most importantly, it should be provable with scientific methods.
I was trying to explain homeopathic potentization on the basis of modern technology of ‘molecular imprinting’, and ‘similia similibus curentur’ on the basis scientific understanding regarding molecular mechanism of resolving pathologic molecular inhibitions involved in therapeutics.
According to my concept, potentization involves a process of molecular imprinting in water, exactly similar to ‘molecular imprinting in polymers’. During this process, constituent drug molecules contained in drug substances are ‘imprinted’ into the supra-molecular matrix of water-ethyl alcohol mixture, generating three-dimensional nanocavities that can act as artificial ‘targets’ for pathological ligands that have configurations similar to the drug molecules used for imprinting. These ‘molecular imprints’, when introduced into the organism can selectively bid to the pathological molecules having complementary conformational affinity, thereby relieving the biological molecules from pathological molecular inhibitions. This is the most rational and logical explanation of molecular dynamics of homeopathic therapeutics.
I use the term ‘molecular imprints’ in its most scientific meaning. But those who are not familiar with the technology of ‘molecular imprinted polymers’, fail to conceive this concept in its real meaning. The real problem is that people talking about pseudo-scientific theories regarding homeopathy misuse this term. They say ‘molecular imprints’ in the meaning of ‘water memory’. Some people even talk about ‘molecular imprints’ of drug energy, molecular imprints of ‘vibrations’ etc. I read an article on net where the author was discussing about transferring of ‘molecular imprints’ of ‘medicinal vibrations’ into mp3 files!
All this has created confusions about the real meaning of ‘molecular imprints’. Many people misunderstand my concepts with the pseudoscientific theories going around. Actually, in its scientific sense, molecular imprints are three-dimensional nanocavities in a polymer matrix generated through the process of ‘molecular imprinting’. Once it is misunderstood, all my explanations on the basis of this concept get misunderstood.
Hence, I think I have to use a more specific and meaningful term while explaining ‘molecular imprints’ in my explanations of homeopathy. I have coined a term ‘MIALBs’ or Molecular Imprinted Artificial Ligand Binds, which seems to be more specific.
According to my concept, ‘MIALBs’ are defined as ‘supra-molecular clusters of water and ethyl alcohol, into which the three-dimensional configuration of drug molecules are imprinted as nanocavities, which can act as artificial binding sites for pathogenic molecules having configuration similar to the drug molecules used for imprinting.
Put in a different way, ‘molecular imprints’ or MIALBs are what remains when ‘guest’ molecules are removed from a ‘guest-host’ complex or ‘clathrate-like’ supra-molecular formation of water. Potentization involves a process of formation of ‘guest-host’ complexes followed by removal of ‘guest’ molecules, thereby preparing hollow ‘host’ formations.
Actually, ‘molecular imprints’ are ‘inter-molecular spaces’ in water-alcohol matrix, into which the 3-dimensional configuration of drug molecules are imprinted as negative spacial images.
Hereafter I propose to use the term ‘MIALBs’ to describe molecular imprints. It should be understood as ‘nanovaities of water’. I hope this would resolve the confusions.
‘MIALBs’ are actually ‘hydration shells’ formed around drug molecules used as ‘guest’ molecules in imprinting protocol. Water already exists as a ‘supra-molecular net work’ by peculiar type of ‘hydrogen bonding’ between hydrogen atom being part of one water molecule and oxygen atom being part of another water molecule. As such, there are ‘nanocavities’ in between water molecules. When a foreign molecule is introduced into water, the water molecules re-arranges around the foreign molecules and forms a ‘hydration shell’ through hydrogen bonding. Even though these hydration bonds and hydration shells are very much temporary in ordinary conditions, by the process of potentization serial dilution and shaking, these hydration shells are freed from foreing molecules and preserved as ‘MIALBs’. Presence comparatively heavier ethyl alcohol molecules in the medium play a role in strengthening the hydrogen bonds.
Without understanding ‘MIALBs’ or ‘molecular imprints’ in its scientific meaning of ‘nanovaities of supra-molecular clusters’, one cannot follow my explanations of homeopathy.