Study The So-called ‘Auto-immune Diseases’ In The Light Of Our Understanding Of ‘Miasms’ As ‘Antibody-Mediated’ Diseases.

I was trying to explain concept of ‘miasms’ as ‘chronic disease dispositions’ due to the ‘off-target’ molecular inhibitions caused by ‘antibodies’ formed against ‘infectious agents’ and ‘exogenous’ proteins.  As per this view, antibodies are the causative agents of ‘miasms’.

 Many friends now raise the question ‘how would you explain autoimmune diseases?”

 All of us know, so-called ‘autoimmune diseases’ are caused by ‘antibodies’. But, those ‘antibodies’ are considered to be formed not against ‘exogenous antigens’, but ‘endogenous or host antigens’. If we explain ‘miasms’ as ‘antibodies’ formed against ‘exogenous’ proteins, should we exclude ‘autoimmune diseases’ from ‘miasms’, since they are considered to be formed against ‘endogenous antigens’, not ‘exogenous proteins’?

 Here, we have to undertake a serious study of the phenomena of ‘autoimmunity’ and ‘autoimmune diseases.

According to immunologists,  ‘autoimmune diseases’ arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body actually attacks its own cells. The immune system mistakes some part of the body as a pathogen and attacks it. This may be restricted to certain organs (e.g. in autoimmune thyroiditis) or involve a particular tissue in different places (e.g. Goodpasture’s disease which may affect the basement membrane in both the lung and the kidney).

Hundreds of chronic systemic diseases are now classified as ‘autoimmune diseases’. This group include Coeliac disease, diabetes mellitus type 1, systemic lupus erythematosus (SLE), Sjögren’s syndrome, Churg-Strauss Syndrome, Hashimoto’s thyroiditis, Graves’ disease, idiopathic thrombocytopenic purpura, rheumatoid arthritis (RA), lupus and allergies. This group is expanding every day.

Autoimmune diseases are broadly divided into systemic and organ-specific or localised autoimmune disorders, depending on the principal clinico-pathologic features of each disease.

Systemic autoimmune diseases– include SLE, Sjögren’s syndrome, scleroderma, rheumatoid arthritis, and dermatomyositis. These conditions tend to be associated with antibodies to antigens which are not tissue specific. Thus although polymyositis is more or less tissue specific in presentation, it may be included in this group because the autoantigens are often ubiquitous t-RNA synthetases.

Local syndromes which affect a specific organ or tissue:

 Endocrinologic: Diabetes mellitus type 1, Hashimoto’s thyroiditis, Addison’s diseaseGastrointestinal: Coeliac disease, Crohn’s Disease, Pernicious anaemia

Dermatologic: Pemphigus vulgaris, Vitiligo

Haematologic: Autoimmune haemolytic anaemia, Idiopathic thrombocytopenic purpura

Neurological: Myasthenia gravis

Autoimmunity is defined as “the failure of an organism to recognize its own constituent parts as self, which allows an immune response against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease”.

This definition does not answer the question we are interested. Are the antibodies ‘formed against’ native targets, or ‘antibodies formed against’ exogenous antigens mistaking native targets as the ‘exogenous antigens’?

 Actually, are the antibodies considered to be the causative agents of ‘autoimmune diseases’ really formed against ‘host antigens’? Or, are they ‘antibodies’ formed against ‘exogenous proteins’ attacking ‘off-target’ sites in the organism?

 This topic is still a controversial subject in immunology. We should remember that ‘immune’ mechanism is basically a defense mechanism of our organism to identify and destroy ‘exogenous proteins’ which are alien to our genetic blueprint. Several mechanisms are thought to be operative in the pathogenesis of autoimmune diseases, against a backdrop of genetic predisposition and environmental modulation. It is beyond the scope of this article to discuss each of these mechanisms exhaustively, but a summary of some of the important mechanisms suggested by various hypotheses may be examined.

1. T-Cell Bypass – A normal immune system requires the activation of B-cells by T-cells before the former can produce antibodies in large quantities. This requirement of a T-cell can be bypassed in rare instances, such as infection by organisms producing super-antigens, which are capable of initiating polyclonal activation of B-cells, or even of T-cells, by directly binding to the β-subunit of T-cell receptors in a non-specific fashion.

2. Molecular Mimicry – An exogenous antigen may share structural similarities with certain host antigens; thus, any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and amplify the immune response. The idea of molecular mimicry arose in the context of Rheumatic Fever, which follows infection with Group A beta-haemolytic streptococci. Although rheumatic fever has been attributed to molecular mimicry for half a century no antigen has been formally identified (if anything too many have been proposed). Moreover, the complex tissue distribution of the disease (heart, joint, skin, basal ganglia) argues against a cardiac specific antigen. It remains entirely possible that the disease is due to e.g. an unusual interaction between immune complexes, complement components and endothelium.

 3. Idiotype Cross-Reaction – Idiotypes are antigenic epitopes found in the antigen-binding portion (Fab) of the immunoglobulin molecule. Plotz and Oldstone presented evidence that autoimmunity can arise as a result of a cross-reaction between the idiotype on an antiviral antibody and a host cell receptor for the virus in question. In this case, the host-cell receptor is envisioned as an internal image of the virus, and the anti-idiotype antibodies can react with the host cells.

4. Epitope spreading or epitope drift – when the immune reaction changes from targeting the primary epitope to also targeting other epitopes. In contrast to molecular mimicry, the other epitopes need not be structurally similar to the primary one.

If we carefully study the above hypotheses proposed by modern immunology, you will find that all these hypotheses indirectly agree with our contention that so called autoimmune diseases are actually caused by ‘off-target’ inhibitions created by ‘antibodies’ formed against ‘exogenous antigens’

A recent observation regarding relationship of autoimmune diseases and infectious diseases is found to be very important from our ‘miasmatic’ angle. Studies revealed  strong association of certain microbial organisms with autoimmune diseases. For example, Klebsiella pneumoniae and coxsackievirus B have been strongly correlated with ankylosing spondylitis and diabetes mellitus type 1, respectively. This has been explained by the tendency of the infecting organism to produce ‘super-antigens’ that are capable of polyclonal activation of B-lymphocytes, and production of large amounts of antibodies of varying specificities, some of which may be self-reactive.

This ‘polyclonal’ ‘super-antigen’ theory goes very close to our explanation of ‘miasms’ as antibody-mediated.

There is a recent proposal among immunologist that the spectrum of autoimmunity should be viewed along an “immunological disease continuum,” with classical autoimmune diseases at one extreme and diseases driven by the innate immune system at the other extreme. Within this scheme, the full spectrum of autoimmunity can be included. Many common human autoimmune diseases can be seen to have a substantial innate immune mediated immunopathology using this new scheme.

I am appending an exhaustive list of ‘antibody-mediated diseases’, which shows the vastness of topic we are dealing with. Kindly go through this list to realize the real range of ‘anti-body’ mediated diseases or ‘miasmatic’ diseases in our day today medical practice: 

 Acute disseminated encephalomyelitis, Acute hemorrhagic leukoencephalitis, Addison’s Disease, Agammaglobulinemia, Alopecia areata, Amyotrophic Lateral Sclerosis, Ankylosing Spondylitis, Anti-GBM/TBM Nephritis, Antiphospholipid syndrome,  Antisynthetase syndrome, Atopic allergy, Atopic allergy, Atopic dermatitis, Autoimmune aplastic anemia, Autoimmune cardiomyopathy, Autoimmune enteropathy, Autoimmune hemolytic anemia, Autoimmune hepatitis, Autoimmune inner ear disease, Autoimmune lymphoproliferative syndrome, Autoimmune peripheral neuropathy, Autoimmune pancreatitis, Autoimmune polyendocrine syndrome, Autoimmune thrombocytopenic purpura, Autoimmune progesterone dermatitis, Autoimmune urticaria, Autoimmune uveitis, Balo disease/Balo concentric sclerosis,  Bechets Syndrome, Berger’s disease, Bickerstaff’s encephalitis, Blau syndrome, Bullous pemphigoid, Cancer, Celiac disease, Castleman’s disease, Chronic inflammatory demyelinating polyneuropathy, Chronic recurrent multifocal osteomyelitis, Churg-Strauss syndrome,  Cicatricial pemphigoid, Cogan syndrome, Cold agglutinin disease, Complement component 2 deficiency, Cranial arteritis, CREST syndrome, Crohns Disease, Cushing’s Syndrome, Cutaneous leukocytoclastic angiitis, Dego’s disease, Dercum’s disease, Dermatitis herpetiformis, Dermatomyositis, Diabetes mellitus type 1, Discoid lupus erythematosus, Eczema, Erythema nodosum, Diffuse cutaneous systemic sclerosis, Enthesitis-related arthritis,  Epidermolysis bullosa acquisita, Eosinophilic gastroenteritis, Eosinophilic fasciitis, Dressler’s syndrome,  Diffuse cutaneous systemic sclerosis, Essential mixed cryoglobulinemia, Evan’s syndrome, Fibrodysplasia ossificans progressive, Fibrosing aveolitis, Gastritis, Gastrointestinal pemphigoid, Giant cell arteritis, Glomerulonephritis, Goodpasture’s syndrome, Graves’ disease, Henoch-Schonlein purpura, Guillain-Barré syndrome, Hashimoto’s encephalitis, Hashimoto’s thyroiditis, Haemolytic anaemia, Herpes gestationis, Hypogammaglobulinemia, Idiopathic Inflammatory Demyelinating Diseases, Idiopathic pulmonary fibrosis, Idiopathic thrombocytopenic purpura,  IgA nephropathy, Inclusion body myositis, Inflammatory demyelinating polyneuopathy, Interstitial cystitis, Juvenile idiopathic arthritis, Juvenile rheumatoid arthritis, Kawasaki’s Disease, Lambert-Eaton myasthenic syndrome, Leukocytoclastic vasculitis, Lichen planus, Linear IgA disease, Lichen sclerosus, Lou Gehrig’s disease, Lupoid hepatitis, Lupus erythematosus, Majeed syndrome, Ménière’s disease, Microscopic polyangiitis, Miller-Fisher syndrome, Mixed Connective Tissue Disease, Morphea, Mucha-Habermann disease, Multiple sclerosis, Myasthenia gravis, Myositis, Neuromyelitis optica, Neuromyotonia, Occular cicatricial pemphigoid, Opsoclonus myoclonus syndrome, Ord thyroiditis, Palindromic rheumatism, pediatric autoimmune neuropsychiatric disorders associated with streptococcus, Paraneoplastic cerebellar degeneration, Paroxysmal nocturnal hemoglobinuria, Parry Romberg syndrome, Parsonnage-Turner syndrome,  Pars planitis, Pemphigus vulgaris, Pernicious anaemia, Perivenous encephalomyelitis, POEMS syndrome, Polyarteritis nodosa, Rheumatoid fever, Psoriasis, Polymyalgia rheumatica, Polymyositis, Primary biliary cirrhosis, Primary sclerosing cholangitis, Progressive inflammatory neuropathy, Psoriatic arthritis, Pyoderma gangrenosum, Pure red cell aplasia, Rasmussen’s encephalitis, Raynaud phenomenon, Relapsing polychondritis, Reiter’s syndrome, Restless leg syndrome, Retroperitoneal fibrosis, Rheumatoid arthritis, Sarcoidosis, Schmidt syndrome, Schnitzler syndrome, Scleritis, Scleroderma, Sjögren’s syndrome, Spondyloarthropathy, Still’s disease, Undifferentiated spondyloarthropathy, Stiff person syndrome, Subacute bacterial endocarditis, Susac’s syndrome, Sweet’s syndrome, Sydenham chorea, Sympathetic ophthalmia, Takayasu’s arteritis, Temporal arteritis, Tolosa-Hunt syndrome, Transverse myelitis, Ulcerative colitis, Undifferentiated connective tissue disease, Vasculitis, Vitiligo, Wegener’s granulomatosis

Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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