Do Potentized Drugs Interact With Biological Molecules In The Same Way As Their Parent Drugs?

This question is very important in the scientific understanding of molecular processes involved in homeopathic potentization and therapeutics. There are many homeopaths believing that during potentization, the medicinal properties of drugs are some way or other transferred to the potentizing medium, and hence potentized medicines can interact with human organism in the same way as the original drugs.

On the contrary, DIALECTICAL HOMEOPATHY proposes that potentization involves a process of ‘molecular imprinting’, in which the spacial configuration of drug molecules are imprinted into the medium as 3-D nano cavities, which can act as recognition sites towards original drug molecules or other molecules similar in configuration. As per this view, potentized medicines contain only ‘molecular imprints’ of drug molecules, which are complementary in configuration to the drug molecules. When applied for therapeutic purpose, these molecular imprints bind to the pathogenic molecules, and not to the biological targets.

In order to prove this concept, we have to experimentally prove that potentized medicines can not interact with biological molecules in the same way as original drug molecules used for potentization.

Here I am reproducing a previously published report regarding such an experiment already conducted by a team of eminent scientists in Germany five years back. It is published in “The Journal of Alternative and Complementary Medicine. May 2006, 12(4): 359-365. doi:10.1089/acm.2006.12.359”

The team conducted this experiment to verify whether potentized HgCl2 (Mercurius corrosivus) affect the activity of Diastase and α-Amylase in a way similar to crude form of HgCl2.

Research team consisted of: 1. Claudia M. Witt, M.D. Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany. 2. Michael Bluth, M.D. Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany. 3. Stephan Hinderlich, Ph.D. Institute for Biochemistry and Molecular Biology, Charité University Medical Center, Berlin, Germany. 4. Henning Albrecht, Ph.D. Karl and Veronica Carstens-Foundation, Essen, Germany. 5. Rainer Lüdtke, M.Sc. Karl and Veronica Carstens-Foundation, Essen, Germany. 6. Thorolf E.R. Weisshuhn Institute for Social Medicine, Epidemiology and Health Economics, Charité University  Medical Center, Berlin, Germany. 7. Stefan N. Willich, M.D., M.P.H. Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany.

Their objective was to test for a stimulating or inhibiting effect of high potencies of the homeopathic remedy HgCl2 (Mercurius corrosivus) on two sugar hydrolases- (α-amylase from hog pancreas and diastase extract from winter barley)

High potencies of HgCl2 were produced using stepwise dilution plus shaking. Controls included potentized solvent (aqua bidestillata), equimolar dilutions without shaking, and enzyme-free references. Tested were potencies with dilution factors 1:200 (CC) on diastase extract from winter barley, and 1:100 (C) on α-amylase from hog pancreas. Enzyme activity was colorimetrically determined by Lugol’s iodine-starch reaction.

An inhibiting effect of HgCl2 on enzyme activities was observed only in low potencies and dilutions (which contained molecules of HgCl2). Statistically significant differences between potencies and controls were not found in randomized and blinded experiments.

 This experimental design provided independent reproducible results of cell-free in vitro assays.However, it did not indicate an effect of potentized HgCl2 on hydrolases. The researchers conclusion was that demonstrating potency effects may require additional experimental features.

My Interpretations:

 Reported experiments and the results they obtained may help us in designing and conducting further in vitro experiments to prove the hypothesis put forward by DIALECTICAL HOMEOPATHY regarding potentization.

 HgCl2 is known in  homeopathy as Merc Cor.

Crude HgCl2 is a known inhibitor of glucose hydrolases such as diastase and α-amylase.

Reported experiments show that similar to crude forms, lower dilutions of this compound also inhibits the hydrolyzing activity of those sugar hydrolase enzymes. Obviously, these lower dilutions contain molecules of HgCl2, and hence the inhibitory action on enzymes.

Same time, these experiments clearly showed that higher potencies of HgCl2 have no inhibitory action on those enzymes. That means, highly potentized HgCl2 cannot ‘mimic’ the original compound as expected by some theoreticians.

This finding, though considered by the researchers as a set back to their expectations, has serious implications in proving the concepts of DIALECTICAL HOMEOPATHY regarding potentization.

This experiment proves that through the potentization process, the properties of original drugs are not transferred to the potenizing medium in such a way so as to enable it to ‘mimic’ the original drugs.

We homeopaths know beyond any doubt that potentized HgCl2 or Merc Cor produces expected therapeutic effects when administered on the basis of principle of ‘similia similibus curentur’. That means, potentized HgCl2 contains some active principles having specific biochemical properties. Since the present experiments have shown that potentized HgCl2 cannot ‘mimic’ the biochemical properties of original compound, a logical and scientific explanation regarding the real molecular mechanism involved in potentization as well as therapeutic action becomes very much necessary.

Only possibility is ‘molecular imprinting’, as proposed by DIALECTICAL HOMEOPATHY.

Now, we have to repeat these in vitro experiment to verify whether higher potencies of HgCl2 can reactivate the enzymes already inhibited by lower potencies or crude forms of the same compound.


Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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