As per the scientific understanding of homeopathy proposed by Dialectical Homeopathy, active principles of potentized drugs are ‘molecular imprints’ of constituent molecules contained in the drug substances used for potentization. Exactly, ‘molecular imprints’ are considered as supra-molecular clusters of water-alcohol molecules into which the three-dimensional molecular configuration of guest molecules(drug molecules) are imprinted as nanocavities. These ‘molecular imprints’ will have a specific affinity towards the original drug molecules, as well as other molecules having similar functional moieties, and can bind to them. Potentized homeopathic drugs act as therapeutic agents due to this configurational affinity towards pathogenic molecules having similar functional moieties.
According to this view, crude drug molecules will have an affinity towards their own molecular imprints due to their complementary configuration, and can specifically bind to them. As such, drug molecules should be capable of deactivating their potentized forms by binding to the molecular imprints. Due to this reason, it is commonly advised not to administer mother tinctures and lower potencies of drug substances when the patient is undergoing treatment with higher potencies of same drugs.
A question commonly raised in this connection is, why NATRUM MUR in high potencies are not antidoted by the use of molecular forms of sodium chloride as part of daily diet. If crude molecules of a drug substance could antidote its potentized forms, potentized Nat Mur should be deactivated by sodium chloride we consume. As per our experience, such an antidoting does not happen. If potentized Natrum Mur is used as similimum, it acts well even if the patient consumes sodium chloride as part of his food. Many articles used as spices and culinary during preparation of foods are also used as therapeutic agents in high potencies, and many of them do not deactivate potentized forms, where as some are found to be antidotal to potentized drugs. A logical and scientific answer is required for these reasonable questions.
When administered into the organism as medicinal agents, ‘molecular imprints’ contained in potentized drugs are released into the blood stream, which is a saline aqueous medium. Crude molecules of sodium chloride being consumed as food are also released into the blood stream.
The question to be answered is, how the molecular imprints of sodium chloride can exist in the blood stream without getting bound or antidoted by crude sodium cholide molecules present in blood, in spite of the configurational affinity between them.
To get an answer to this question, we should understand some important factors regarding the behavior of sodium chloride in aqueous medium.
Sodium chloride is an ionic substance, composed of positive charged sodium ions and negative charged chloride ions. In solid state, each ion is surrounded by six ions of the opposite charge as expected on electrostatic grounds. The surrounding ions are located at the vertices of a regular octahedron. In the language of close-packing, the larger chloride ions are arranged in a cubic array whereas the smaller sodium ions fill all the cubic gaps or octahedral voids between them. The attraction between the Na+ and Cl- ions in the solid is so strong that only highly polar solvents like water can dissolve NaCl well.
When dissolved in water, the sodium chloride framework present in solid state disintegrates as the Na+ and Cl- ions, and become surrounded by the polar water molecules. These solutions consist of positively charged metal-aqua complex with the formula [Na(H2O)8], consisting of a sodium ion closely surrounded by eight water molecules. This sodium-water complex by itself acts as positively charged ion. The chloride ions are also strongly solvated, each being surrounded by an average of 6 molecules of water.
Important point to be noted here is that Na+ ions or Cl- ions never exist free in the aqueous medium, but only as surrounded and strongly solvated by water molecules. Since the sodium and chloride moieties are covered with closely packed water molecules, they cannot interact with the molecular imprints contained in potentized Natrum Mur present in the medium. Na and Cl ions have a comparatively greater affinity towards the water molecules around them, than towards molecular imprints. Due to this reason, potentized Nat Mur cannot be easily antidoted by crude sodium chloride molecules consumed as part of regular diet. This is applicable to all drug substances that are ionized and strongly solvated in aqueous medium.