As per the scientific understanding of homeopathy proposed by Dialectical Homeopathy, active principles of potentized drugs are ‘molecular imprints’ of constituent molecules contained in the drug substances used for potentization. Exactly, ‘molecular imprints’ are considered as supra-molecular clusters of water-alcohol molecules into which the three-dimensional molecular configuration of guest molecules(drug molecules) are imprinted as nanocavities. These ‘molecular imprints’ will have a specific affinity towards the original drug molecules, as well as other molecules having similar functional moieties, and can bind to them. Potentized homeopathic drugs act as therapeutic agents due to this configurational affinity towards pathogenic molecules having similar functional moieties.
According to this view, crude drug molecules will have an affinity towards their own molecular imprints due to their complementary configuration, and can specifically bind to them. As such, drug molecules should be capable of deactivating their potentized forms by binding to the molecular imprints. Due to this reason, it is commonly advised not to administer mother tinctures and lower potencies of drug substances when the patient is undergoing treatment with higher potencies of same drugs.
A question commonly raised in this connection is, why NATRUM MUR in high potencies are not antidoted by the use of molecular forms of sodium chloride as part of daily diet. If crude molecules of a drug substance could antidote its potentized forms, potentized Nat Mur should be deactivated by sodium chloride we consume. As per our experience, such an antidoting does not happen. If potentized Natrum Mur is used as similimum, it acts well even if the patient consumes sodium chloride as part of his food. Many articles used as spices and culinary during preparation of foods are also used as therapeutic agents in high potencies, and many of them do not deactivate potentized forms, where as some are found to be antidotal to potentized drugs. A logical and scientific answer is required for these reasonable questions.
When administered into the organism as medicinal agents, ‘molecular imprints’ contained in potentized drugs are released into the blood stream, which is a saline aqueous medium. Crude molecules of sodium chloride being consumed as food are also released into the blood stream.
The question to be answered is, how the molecular imprints of sodium chloride can exist in the blood stream without getting bound or antidoted by crude sodium cholide molecules present in blood, in spite of the configurational affinity between them.
To get an answer to this question, we should understand some important factors regarding the behavior of sodium chloride in aqueous medium.
Sodium chloride is an ionic substance, composed of positive charged sodium ions and negative charged chloride ions. In solid state, each ion is surrounded by six ions of the opposite charge as expected on electrostatic grounds. The surrounding ions are located at the vertices of a regular octahedron. In the language of close-packing, the larger chloride ions are arranged in a cubic array whereas the smaller sodium ions fill all the cubic gaps or octahedral voids between them. The attraction between the Na+ and Cl- ions in the solid is so strong that only highly polar solvents like water can dissolve NaCl well.
When dissolved in water, the sodium chloride framework present in solid state disintegrates as the Na+ and Cl- ions, and become surrounded by the polar water molecules. These solutions consist of positively charged metal-aqua complex with the formula [Na(H2O)8], consisting of a sodium ion closely surrounded by eight water molecules. This sodium-water complex by itself acts as positively charged ion. The chloride ions are also strongly solvated, each being surrounded by an average of 6 molecules of water.
Important point to be noted here is that Na+ ions or Cl- ions never exist free in the aqueous medium, but only as surrounded and strongly solvated by water molecules. Since the sodium and chloride moieties are covered with closely packed water molecules, they cannot interact with the molecular imprints contained in potentized Natrum Mur present in the medium. Na and Cl ions have a comparatively greater affinity towards the water molecules around them, than towards molecular imprints. Due to this reason, potentized Nat Mur cannot be easily antidoted by crude sodium chloride molecules consumed as part of regular diet. This is applicable to all drug substances that are ionized and strongly solvated in aqueous medium.
REDEFINING HOMEOPATHY 
Sir, when you say “pathogenic molecule is also a molecular imprint of a disease”, it means you are not using the term ‘molecular imprint’ in its specific scientific meaning. “Molecular imprint’ is only a recognition site imprinted in the medium as three dimensional nanocavities, in a configuration just opposite to that of original molecule. “”pathogenic molecule” cannot be a “Molecular imprint”.
“NaCl can not counter NaCl in its potentised form(Nat mur) as their chemical structures are basically the same and they act in unison” is also not correct. “Molecular imprints’ have no ‘chemical structure’. Molecules and their molecular imprints can bind each other, and antidote each other, since their configurations are complementary, molecules acting as ‘keys’ and ‘molecular imprints acting as ‘locks’.
Correct me if I am wrong, Mr. Nambiar, but my take on potentised remedies vis-a-vis its crude form is as follows.
1. A bio pathogenic molecule is also a molecular imprint of a disease and to inactivate it one needs to counter it with a remedy in its ‘molecular imprint form’ so a fast bonding and inactivation can take place.
MTs and crude remedy forms should be used to correct structural deformities(bone, etc.) that are basically produced by ones internal system or to repair damages eg. Calc carb for bone knitting, etc.
2. A crude form of a remedy can not counter its potentised form. In other words NaCl can not counter NaCl in its potentised form(Nat mur) as their chemical structures are basically the same and they act in unison – otherwise the first dose of Nat mur would be antidoted by a second dose of Nat mur and therefore, a remedy could never be repeated; whereas, in fact and in an acute ailment a remedy is repeated even every 5 minutes for speedy control.
Not only the molecules of sodium even the potassium or calcium or even the minerals such as phosphorus, sulfuric .Zink, copper never inter-fear with the homoeo drugs action. .Rather their physiological presence and chemical structure with combination of various proteins and enzymes related to that particular molecules or mineral with dense aqueous medium and cellulose exist in the body their by provides needed kinetic energy, nutrition and resistance or immunity that maintains the health of the human body. What is their to get doubt and the question of anti doting never arises. A medical person who is accustomed with cell structure never gets such doubts rather he understands the cell mechanism. This particular cell structure made the homeopathic drugs to produce few symptoms when they proved on humans and this particular cell structure prevented various symptoms which were not produced but mentioned in materia medica. Because of presence of cell mechanism which I need not write here as already mentioned in the texts of molecular biology almost all homoeopathic drugs produced only few symptoms when they were proved on humans. The maximum symptoms produced are 7 seven symptoms only by sulphur and Lycopodium (provers symptoms). Rest of the symptoms written in materia medic are verified symptoms which were deemed as unscientific in the present day context. There fore this lack of understanding the basic cell structure and molicular biology making homoeopaths not to understand thair merits as well as thair demerits. But most of the allopathic drugs interfere with cell machanisum and the action of the various drugs will be from sodium, potassium calcium and glucose chains which you know very well.