As per MIT, active principles of potentized drugs are MOLECULAR IMPRINTS of drug molecules formed in supramolecular matrix of water and ethyl alcohol. As per this concept, molecular imprints are hydrogen bonded networks of water and ethanol molecules, into which the conforformational properties of drug molecules are imprinted as three dimensional negatives. These molecular imprints work as therapeutic agents by acting by conformational properties as artificial binding pockets for original drug molecules as well as pathogenic molecules having conformations similar to those of original drug molecules. If this idea of MOLECULAR IMPRINTS is correct, potentized drugs should be experimentally proved to be capable of antidoting the biological effects of original drug molecules.
Can potentized drugs antidote or reverse the biological effects of crude forms of same drugs?
This question is of paramount importance when trying to prove the concepts of ‘molecular imprints’ proposed by MIT as part of scientific explanation for the molecular mechanism of homeopathic potentization and therapeutics.
Most homeopaths maintain that medicinal properties of crude drugs are transferred to the medium during potentization. They may call it ‘vibrations’, ‘electromagnetic signals’, ‘medicinal memory’, ‘dynamic power’ or anything like that. But all those theories are based on the concept that potentized medicines can ‘mimic’ the properties of parent drugs.
If potentized medicines were really ‘mimicking’ the medicinal properties of parent drugs, they should be able to produce similar biological effects. But we have before us a monumental work which proves through in vitro experiments that potentized medicines do not act the same way as parent drugs, but as their antidotes on biological molecules.
According to the hypothesis put forward by MIT, potentized medicines contains ‘molecular imprints’ of constituent molecules of parent drugs. As such, these molecular imprints can act as artificial recognition sites for parent molecules, and bind to them, thereby preventing them from interacting with biological targets.
If this concept of ‘molecular imprint’ is correct, potentized medicines should be capable of antidoting or reversing of biological effects of their parent molecules. If we prove this point, it would be a big step in favor of ‘molecular imprinting’ concept put forward by MIT.
Here I am reproducing a report regarding such a successful experiment published in 2001. This historic experiment was conducted by a team consisting of Swapna S Datta, Palash P Mallick and Anisur AR Rahman Khuda-Bukhsh of Cytogenetics Laboratory, Department of Zoology, University of Kalyani, Kalyani-741 235, West Bengal, India and published online on 23 November 2001. Report may be read at this link: http://www.springerlink.com/content/b2t71744t426j5n4/
They proved through strictly controlled experiments that potentized homeopathic drug, Cadmium Sulphoricum, could reduce the genotoxic effects produced by cadmium chloride in mice. They used potentized Cadmium Sulph because they could not get homeopathic potencies of Cadmium Chloride. Since Cadium Sulph and Cadmium Chlor contains Cadmium, and Cadmium is the real genotoxic factor, such an experimental protocol is acceptable.
Through these experiments, the team could prove that both Cad Sulph-30 and 200 were able to combat cadmium induced genotoxic effects in mice. From the results of the reported investigation it is revealed that both Cad Sulph-30 and Cad Sulph-200 showed remarkable potential to reduce genotoxic effects produced by CdCl2. In the study the homeopathic forms of cadmium could protect the structural integrity of chromosomes and sperm antidoting the destructive ability of CdCl2 in causing DNA damage by preventing cadmium molecules from binding to the enzymes involved. Even in the absence of a single original drug molecule both Cad Sulph-30 and 200 elicited spectacular ability of protection/repair to damaged chromosomes and sperm, a fact which would lead one to speculate that the the potentized of drugs must have acted as antidotes to the biological effects of cadmium molecules. This observation validates the idea of MIT.
We have also another relevant study conducted by a team consisting of Philippe Belon, Pathikrit Banerjee, Sandipan Chaki Choudhury, Antara Banerjee,Surjyo Jyoti Biswas, Susanta Roy Karmakar, Surajit Pathak, Bibhas Guha, Sagar Chatterjee, Nandini Bhattacharjee, Jayanta Kumar Das, and Anisur Rahman Khuda-Bukhsh of Boiron Lab, 20 rue de la Libėration, Sainte-Foy-Lės-Lyon, France, and Department of Zoology, University of Kalyani, Kalyani-741235, West Bengal, India , published on December 26, 2005. Complete report is available at this link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1375236/
This team undertook a study to find out whether administration of potentized homeopathic remedy,Arsenicum Album, alter Antinuclear Antibody (ANA) Titer in people living in high-risk arsenic ontaminated areas.
To examine whether elevated antinuclear antibody (ANA) titers reported in random human population of arsenic contaminated villages can be reverted to the normal range by administration of a potentized homeopathic drug, Arsenicum album, randomly selected volunteers in two arsenic contaminated villages and one arsenic-free village in West Bengal (India) were periodically tested for their ANA titer as well as various blood parameters in two types of experiments: ‘placebo-controlled double blind’ experiment for shorter duration and ‘uncontrolled verum fed experiment’ for longer duration. Positive modulation of ANA titer was observed along with changes in certain relevant hematological parameters, namely total count of red blood cells and white blood cells, packed cell volume, hemoglobin content, erythrocyte sedimentation rate and blood sugar level, mostly within 2 months of drug administration.
Thus, potentized Arsenicum album was proved to have great potential for ameliorating arsenic induced elevated ANA titer and other hematological toxicities.
Both these controlled scientific studies have proved beyond doubt that potentized homeopathic medicines can antidote or reverse the biological effects of parent drugs.
In the absence of original drug molecules, how could the homeopathic potencies exhibit such an action? The theory that potentized medicines ‘mimic’ the parent drugs is obviously disproved through these experiments. Only logical explanation we can provide for this phenomenon is the ‘molecular imprints’ of parent drug molecules being the active principles of potentized medicines. ‘Molecular imprints’ can specifically bind to the parent molecules, and thereby antidote or reverse the biological properties of parent molecules.
EVEN THOUGH INDIRECTLY, THESE STUDIES HAVE SUPPLIED ENOUGH DATA WHICH STRONGLY SUPPORT IN PROVING THE “MOLECULAR IMPRINTING” HYPOTHESIS PROPOSED BY MIT REGARDING MOLECULAR MECHANISM OF POTENTIZATION AND HOMEOPATHIC THERAPEUTICS.