WHY POTENTIZED DRUGS ANTIDOTE THE BIOLOGICAL EFFECTS OF CRUDE FORMS OF SAME DRUGS?

It is a clinically experienced and experimentally verified fact that if a particular drug substance in crude or molecular form can produce a specific train of symptoms in healthy persons, potentized form of that drug can cure diseases having similar symptoms. Actually, this observation is the basis of the concept of homeopathic ‘drug proving’ as well as ‘similia similibus curentur’.

In our everyday clinical practice, we have a lot of experiences with this OPPOSITE actions of crude drugs and their potentized forms. Using APIS MEL 30 for bee stings, anacardium 30 for antidoting anacardium poisoning, tabaccum 30 for removing bad effects of tobacco, cannabis 30 for cannabis addiction, use of histamine 30 in allergic complaints, use of pepsinum 30 in gastritis– there are actually hundreds of such empirical uses which are very successful.

Potentized forms of allopathic drugs are clinically used to remove the short-term or long-term bad effects of allopathic drugging. This method is known as tautopathy. Potentized forms of almost all allopathic drugs are available in market.

Many nosodes are successfully used by homeopaths on the basis of this knowledge of OPPOSITE actions of crude forms and potentized forms.

The famous researches conducted by team of Dr Anisur Rahman Khuda-Bukhsh of calcutta regarding the use of Arsenic Alb 30 in reversing arsenic toxicity, cadmium sulph 30 in reversing genotoxic effects of crude cadmium etc also ratify the validity of this observation.

Why a drug substance in ‘potentized’ form act upon living organism in a reverse direction to its action in crude or ‘molecular’ form? What may be the molecular mechanism involved in this ‘reverse’ actions?

Whole riddles of homeopathy will be resolved once we could explain this phenomenon of ‘reverse action’ rationally and scientifically in a way fitting to modern biochemistry and kinetics of biomolecular interactions.

Phenomenon of ‘reverse actions’ of potentized forms and crude forms of same drug substance could be rationally explained only if we perceive potentized drugs in terms of MOLECULAR IMPRINTS of drug molecules, and understand these molecular imprints as three-dimensional nanocavities’ ‘molecular voids’ ‘engraved’ into a water-ethyl alcohol supra-molecular matrix. It is obvious that such molecular imprints can act as artificial binding pockets for molecules having similar conformations.

Homeopathy is actually a therapeutic method that utilises the mutually OPPOSITE actions of crude forms and potentized forms of drug substances. Producing symptoms actually means producing certain molecular errors in the body. Similarity of symptoms indicates similarity of molecular errors. If a drug substance in its crude forms can produce certain molecular errors in the body, its potentized forms can remove that molecular errors.

When trying to find an answer to the question “what are the active principles of post-avogadro potentized drugs, it is very important that these ACTIVE PRINCIPLES should be something that can remove the molecular inhibitions caused by the molecular forms of same drug.

If potentized correctly, post-avogadro dilutions will not contain any molecule of original drug substance, and that they contain nothing but alcohol and water, along with some particles coming through contaminations. Studies have also shown that CHEMICAL properties of post-avogadro dilutions and unpotentized water-alcohol mixture are similar. But all of us know, and it is well established that these post-avogadro dilutions without any drug molecule contained in them have specific biological actions and disease curing properties when used as similimum. It was also observed and proved through spectroscopic studies mentioned earlier that post-avogadro dilutions have some supra-molecular arrangements that make them different from the plain water-alcohol mixture. It is obvious that the ACTIVE PRINCIPLES should be some supra-molecular water-ethyl alcohol structures formed during the process of potentization. And it is very much evident that these supra-molecular structures are not MIMICS of drug molecules, but something that can produce biological effects that are exactly OPPOSITE to those produced by original drug molecules.

Now we are very much sure that active principles of potentized drugs are some sort of supramolecular structures formed by water and alcohol, and these structures have retained the medicinal properties of original drug molecules in a REVERSE order.

It is already known to us that chemical molecules produce errors in biological processes by binding to and inhibiting biological molecules such as enzymes, receptors, transport molecules etc. Chemical molecules having some functional groups or moieties SIMILAR to those of natural ligands can compete with the natural ligands in binding to the biological targets. When a chemical molecule succeed in this competition, the biological molecules get inhibited, and the interactions between biological molecules and their natural ligands are blocked. This is the molecular mechanism involved in disease processes. Drug molecules as well as various pathogenic molecules can inhibit the actions of biological molecules by this mechanism, which result in diverse kinds of pathological conditions.

CURE involves removal of pathological inhibitions happened in biological molecules. If the post-avogadro diluted drugs can cure disease conditions produced by their molecular forms , it means, they contain some supra-molecular structures that can bind to those molecules, deactivate them, and remove the molecular inhibitions they produced. In order to bind to the chemical molecules, these supra-molecular structures should have some conformational properties that are just opposite to the concerned chemical molecules.

Now our answer for the question “what are ACTIVE PRINCIPLES of post-avogadro potentized drugs” is very much near to us. We can say, the ACTIVE PRINCIPLES are some “supra-molecular structures formed in water-ethyl alcohol medium during the process of potentization, which can act as artificial binding sites for pathogenic molecules having some sort of opposite conformations”.

Next question we have to answer is, HOW these “supra-molecular structures” are formed during the process of potentization. This question could be answered only if we study the supramolecular properties of water-ethyl alcohol azeotropic mixture, phenomena of hydrogen bonding, formation of host-guest complexes, cavitation and a lot of such things, and also the molecular processes involved in the technology of MOLECULAR IMPRINTING.