During discussions on my scientific concept of ‘miasms’, many friends raised this question: “What difference it would make in practice, if we understand ‘miasms’ as ‘antibodies’?
I think this question is very much relevant, and I am bound to respond it positively.
First, we have to understand the exact molecular mechanism of ‘pathology’ and ‘therapeutics’ in terms of modern biochemistry and molecular biology.
Antibodies are native globulin proteins ‘imprinted’ with exogenous protein molecules entering into the organism from the environment, as infections, food, drugs, toxins or as part of any interactions with the environment. These exogenous proteins may come from bacterial/viral/fungal/parasitic infections that invade the body, bites and stings of insects and serpents, uncooked food articles, drugs like antibiotics and serum, vaccines, and so on. These exogenous foreign proteins, alien to our genetic constitution, are dangerous to the normal functioning of the organism, and have to be destroyed or eradicated. Body has a well organized defense system for this, which we call immune system. Foreign proteins are called antigens. Body prepares immune bodies or antibodies against these dangerous invaders. Antibodies are specific to each antigen, There are also polyclonal antibodies, which can identify different antigens. Antibodies are exactly native proteins of globulin types, which have peculiar molecular structure with an active group known as ‘paratope’ on its periphery. Active groups of antigen molecules are known as ‘epitopes’. Epitopes of antigens and paratopes of antibodies has a ‘key-lock’ relationship of configuration. They should fit exactly each other in order to happen an immune reaction. Paratopes of antibodies once interacted with epitopes of a particular antigen undergoes a process of ‘molecular imprinting’, by which the ‘memory’ of epitope is imprinted into the paratope of antibody. Even after the antigens are destroyed and eradicated by the immune system, these ‘molecular imprinted’ globulins, or antibodies exist and circulate in the organism, in most cases life long. This is the mechanism by which life long immunity is attained through certan infections and vaccinations. These antibodies, or ‘molecular imprinted proteins’ are very important part of our defense system, playing a vital role in protecting us against infections.
Same time, these ‘molecular imprinted proteins’ or antibodies plays a negative role also, which is what we call ‘miasms’. They can act as pathogenic factors. Whenever these antibodies happen to come in contact with a native biological molecule having a structural group of configuration similar to the ‘epitope’ of its natural antigen, its paratope binds to it and inhibits the biological molecules. This is a ‘molecular error’ amounting to a state of pathology. Diverse types of chronic diseases and dispositions are created by the antibodies in the organism. These pathological conditions caused by ‘off-target’ binding of antibodies or ‘molecular imprinted proteins’ are the real ‘miasms’ hahnemann described as the underlying factors of ‘chronic diseases’.
Obviously, identifying and removal of these ‘off-target’ molecular blocks or ‘miasms’ caused by antibodies or ‘molecular imprinted proteins’ is an important part in the treatment of chronic diseases. Observing and collecting the whole history of infections and intoxications that might have generated antibodies are important in the management of chronic diseases. History of skin infections, venereal infections, stings of poisonous creatures, vaccinations, serum/antibiotic treatments, sensitization with protein foods etc. has to be collected in detail and appropriate ‘anti-miasmatics’ included in the treatment protocols of chronic treatments.
Another important thing we have to remember is that we cannot permanently inactivate ‘antibodies’ using potentized nosodes or anti-miasmatic drugs. Our drugs may act in two ways. If the nosodes are prepared from antibodies themselves, they contain ‘molecular imprints of epitopes of ‘exogenous toxins’ or antigens themselves. These ‘molecular imprints can compete with the paratopes of antibodies in binding to biological molecues, and prevent them from creating ‘off-target’ biological blocks. Since ‘molecular imprints’ cannot successfully compete with the epitopes of antigens in binding with the paratopes of antibodies, our potentized drugs never interferes with the normal immune mechanism of the body. They only prevents antibodies from binding to ‘off-target’ biological molecules, and thus act as ‘antimiasmatics’.
If we are preparing nosodes by potentizing antibodies themselves, our drugs contains ‘molecular imprints’ of paratopes of antibodies. These molecular imprints can bind to the paratopes, thereby preventing them from interacting with ‘off-target’ biological molecules. Same time, they also cannot interfere in the interaction between antibodies and their natural antigens, which have comparatively increased affinity. In any way, potentized nosodes or ‘antimiasmatics’ will not weaken the normal immunological mechanism of the organism.
Since we cannot eradicate or permanently inactivate antibodies or miasms with our potentized drugs, we have to administer antimiasmatic drugs in frequent intervals, probably life long. This is a very important realization evolving from the understanding of ‘miasms’ as ‘antibodies’ or ‘molecular imprinted proteins’.
I think hahnemann included all ‘itch’ producing infections under the carpet of ‘psora’. He mentioned about Leprosy, scarlet fever, scabies and many such ‘infectious’ agents as causative factors of psora. He talked about “three miasms”, only because those three infectious agents were creating havoc in europe during his period. According to me, this classification of psora, syphilis and sycosis is not much relevant if we understand ‘miasms’ in terms of ‘antibodies’.
We should carefully study the whole history of patient to learn his ‘miasms’ or ‘antibodies’. For example, ‘vaccinations’. Each vaccination creates different types of miasms, which we have to antidote with appropriate nosodes . If the patient had history of severe allergy from bee stings, we have to antidote with apis. Same way, history of sanake bites, scabies, TB, everything will have to be considered.
Most of the bacterial toxins has a sulph containg ‘thio’ group on its epitome, and as such, potentized sulph would act as an antidote to almost all types of ‘antibodies’ or ‘miasms’ caused by such bacterial infections. That may be the reason why “sulph” became ‘king of anti-psorics’.
While considering ‘miasms’ of a patient, we should not limit ourselves to inquiries regarding history infectious diseases in his life. Antibodies may form against respiratory allergens such as pollens, fungus, housedust(contain mites), eggs, shell fishes, milk etc., all of which contains proteins exogenous to the body. History of anaphylaxis due to insect bites such as bees and wasps and snakebites should be noticed. History of vaccinations taken, including anti-rabies and anti-venom is also important. All such antibodies may act as chronic ‘miasms’ by attacking off-target biological molecules. We have lot of experiences with cases of kidney failures resulting from anti-rabies vaccinations. Many so-called auto-immune diseases are actually the chronic effects of ‘antibodies’ formed against exogenous proteins acting as ‘miasms’. Even though these ‘miasms’ may laso be part of ‘totality of symptoms’ during a perfect case taking, ‘miasmatic symptoms’ never come top during repertorizations. Hence, in the treatment of chronic diseases, ‘anti-miasmatic drugs’ and ‘nosodes’ should be considered, and applied in frequent intervals along with selected similimum.
NOW WE CAN SEE, THROUGH THE UNDERSTANDING OF ‘MIASMS’ AS ‘ANTIBODIES’, OUR MANAGEMENT OF CHRONIC DISEASES BECOMES MORE SIMPLE AND ACCURATE.
MORE OVER, OUR THEORY AND PRACTICE HAVE NOW BECOME MORE SCIENTIFIC, EXACTLY FITTING TO THE MODERN SCIENTIFIC KNOWLEDGE, ACCEPTABLE TO SCIENTIFIC COMMUNITY.
I THINK THIS IS A GREAT FORWARD STEP IN MAKING HOMEOPATHY A REAL SCIENTIFIC MEDICAL SYSTEM