Relevance Of ‘Molecular Pathology’ And ‘Proteomics’ In The Scientific Understanding Of ‘Similia Similibus Curentur’

‘Molecular pathology’ and ‘’proteomics’ are emerging branches of modern science, which provide us valuable insights in the scientific understanding of homeopathy and its therapeutic principle ‘similia similibus curentur’ This understanding enables us to explain homeopathy as an advanced branch of ‘molecular therapeutics’.

‘Molecular pathology’ is an emerging discipline within pathology, and focuses in the study and diagnosis of disease through the examination of ‘molecules’ within organs, tissues or bodily fluids. Molecular pathology shares some aspects of practice with both anatomic pathology and clinical pathology, molecular biology, biochemistry, proteomics and genetics, and is sometimes considered a “crossover” discipline. It is multi-disciplinary in nature and focuses mainly on the sub-microscopic aspects of disease and unknown illnesses with strange causes.

It is a scientific discipline that encompasses the development of molecular and genetic approaches to the diagnosis and classification of various human diseases, the design and validation of predictive biomarkers for treatment response and disease progression, the susceptibility of individuals of different genetic constitution to develop cancer, and the environmental and lifestyle factors implicated in pathogenesis.

Exactly, ‘proteomics’ is the basis of ‘molecular pathology’.

‘Proteomics’ is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term “proteomics” was first coined in 1997 to make an analogy with genomics, the study of the genes. The word “proteome” is a blend of “protein” and “genome“, and was coined by Marc Wilkins in 1994. The proteome is the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or system. This will vary with time and distinct requirements, or stresses, that a cell or organism undergoes. After genomics, proteomics is considered the next step in the study of biological systems. It is much more complicated than genomics mostly because while an organism’s genome is more or less constant, the proteome differs from cell to cell and from time to time. This is because distinct genes are expressed in distinct cell types. This means that even the basic set of proteins which are produced in a cell needs to be determined.

Scientists are very interested in proteomics because it gives a much better understanding of an organism than genomics. First, the level of transcription of a gene gives only a rough estimate of its level of expression into a protein. An mRNA produced in abundance may be degraded rapidly or translated inefficiently, resulting in a small amount of protein. Second, as mentioned above many proteins experience post-translational modifications that profoundly affect their activities; for example some proteins are not active until they become phosphorylated. Methods such as phosphoproteomics and glycoproteomics are used to study post-translational modifications. Third, many transcripts give rise to more than one protein, through alternative splicing or alternative post-translational modifications. Fourth, many proteins form complexes with other proteins or RNA molecules, and only function in the presence of these other molecules. Finally, protein degradation rate plays an important role in protein content

One of the most promising developments to come from the study of human genes and proteins has been the identification of potential new drugs for the treatment of disease. This relies on genome and proteome information to identify proteins associated with a disease, which computer software can then use as targets for new drugs. For example, if a certain protein is implicated in a disease, its 3D structure provides the information to design drugs to interfere with the action of the protein. A molecule that fits the active site of an enzyme, but cannot be released by the enzyme, will inactivate the enzyme. This is the basis of new drug-discovery tools, which aim to find new drugs to inactivate proteins involved in disease. As genetic differences among individuals are found, researchers expect to use these techniques to develop personalized drugs that are more effective for the individual

Understanding the proteome, the structure and function of each protein and the complexities of protein–protein interactions will be critical for developing the most effective diagnostic techniques and disease treatments in the future.

Without a clear understanding of concepts and methods of ‘molecular pathology’ and ‘proteomics’, one cannot follow my discussions of ‘scientific homeopathy. In this article I was trying to prepare the factual ground for understanding scientific discussions about homeopathy. Let us do that first. If any body ask why discuss all these things with homeopathy, I would say your question is like asking an engineer engaged in leveling of ground for constructing a house entrusted to him, that “you were entrusted to build my house, not to level the ground”. Without leveling the ground how can a house could be started constructing?

Proteins are macromolecules with complex structures and functions, and they act as the ‘molecular carriers of life process’. There is not a single biochemic reaction happening without the involvement of proteins in their capacities as enzymes, receptors, immune factors, structural factors and so on.

First we have to understand ‘vital processes’ in terms of protein interactions. We have to understand the complex dynamics of ‘ligand-receptor’, ‘substrate-enzyme’ and ‘antigen-antibody’ interactions. Then we have to study the dynamics of ‘protein molecular inhibitions’, and the role of these inhibitions in the creation of pathological ‘molecular errors’. Only then we can understand the exact mechanism of how the pathogenic agents causes diseases. Then we can study therapeutics in terms of removal of these ‘molecular inhibitions’.

Then I can explain the actual process involved in drug proving in terms of creating ‘molecular inhibitions’ caused by constituent molecules of our drug substances. Then we can understand ‘symptoms’ as expressions’ of ‘molecular errors’. Then my concept of drug potentization as ‘molecular imprinting’ and active principles of potentized drugs as ‘molecular imprints’ could be clearly understood.

Then, i can explain how the ‘molecular imprints’ removes ‘protein inhibitions’ by their complementary configurational affinities to pathogenic molecules. That way we can understand the real molecular dynamics of homeopathic therapeutics involved in ‘similia similibus curentur’. Then you will understand my concepts of ‘miasms’ as ‘antibody mediated’ diseases caused by ‘off-target’ molecular inhibitions created by antibodies formed against exogenous’ proteins.

I HOPE NOW YOU WOULD HAVE GOT A GLIMPSE OF WHAT I MEANT BY THE IMPORTANCE OF STUDYING ‘MOLECULAR PATHOLOGY’ AND ‘PROTEOMICS’ IN THE SCIENTIFIC UNDERSTANDING OF HOMEOPATHY.

Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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