Let us examine what actually happens during potentization.
During trituration of crude drugs, and during early stages of dilution and succussion, individual molecules contained in the drug substance are liberated by breakage of inter-molecular bonds that held them together. By this process,drug molecules get ionized and more reactive, and even insoluble substances thereby become soluble in the water-alcohol medium. Triturations and lower dilutions are biologically more active than crude drugs and mother tinctures, due to these free molecules and and ions they contain.
Drug molecules are subjected to a process of ‘hydration’ when they are dissolved in water-alcohol mixture. Hydration takes place by the water-alcohol molecules arranging themselves around independent drug molecules, and forming a supra-molecular network around them through hydrogen bonding. These supra-molecular networks are called ‘hydration shells’. Hydrogen bonds of water molecules are normally weak, but presence of comparatively heavy ethyl alcohol molecules attached to them make the hydration shells more stable. A clathrate-like supra-molecular ‘host-guest’ complexes are formed, where drug molecules act as ‘guests’ and water-ethyl alcohol molecules as ‘hosts’. This is what happen during early stages of potentization.
During serial process of diluting and violent shaking, ‘guest’ molecules happen to escape from ‘guest-host’ complexes, and empty ‘hydration shells’ remains. Formation of new ‘guest-host’ complexes and generation of empty ‘hydration shells’ continues. Due to serial dilutions, the concentration of drug molecules is reduced by each stage, same time increasing the concentration of empty ‘hydration shells’. By the time potentization crosses 12c or Avogadro’s limit, the medium become totally devoid of all drug molecules, and will be concentrated by only empty ‘hydration shells’ representing diverse types of constituent drug molecules.
It has been reported to have observed that supra-molecular formations of water, being part of ‘clathrate’ complexes can maintain their network structures even after the ‘guest’ molecules are removed from them. More over, ‘clathrates’ are found to have behaving some what like crystals, and existing ‘clathrates’ can induce the formation of similar networks even in the absence of ‘guest’ molecules’. All these complex factors have to be taken into account when studying the molecular processes involved in potentization.
As such, homeopathic potencies above 12c contains only empty ‘hydration’ shells remaining after the removal of drug molecules from the ‘guest-host’ complexes formed during earlier stages of dilutions. These empty ‘hydration shells’ are actually supra-molecular clusters of water-ethyl alcohol molecules, carrying 3-dimensional nanocavities remaining after removal of ‘guest’ drug molecules. Actually, these nanocavities are ‘molecular imprints’ of drug molecules, which can act as artificial binding sites for pathogenic molecules similar to the drug molecules in their molecular configurations. This ‘configurational affinity of ‘molecular imprints’ towards specific pathogenic molecules make them powerful therapeutic agents. Similia Similibus Curentur is logically explained in terms of these molecular imprints.
Since I consider molecular imprints as the active principles of potentized drugs, I do not subscribe to the idea that ‘higher’ potencies are more ‘powerful’, and I see no special benefit by using ‘higher’ potencies.
I think 12c is enough for completing molecular imprinting and removal of all drug molecules from the medium. What happens at molecular level during further potentization is still an open question for me. In supra-molecular chemistry, there is research going on regarding a phenomenon known as ‘induced molecular assembly’. That means, supra-molecular clusters acting as templates and inducing other molecules to form similar clusters. We know, ‘induced molecular assembly’ is involved in crystallization, clathrate formation etc. Even ‘prions’, which are misfolded proteins, multiply by ‘induced misfolding’. Antibodies, which are ‘molecular imprinted proteins’, also multiply by ‘inducing’ other globulin proteins to change configuration. Molecular imprints, which are supra-molecular clusters of water, may also multiply by the process of ‘induced molecular assembly’, where existing ‘molecular imprints’ may act as templates and induce formation of similar molecular imprints. It is only a possibility, which need in-depth study, which may provide us a rational way of resolving the riddle of high potencies. For the time being, I leave it as an open question.
Even though ‘molecular imprints’ may be formed in higher potencies through the process of ‘induced molecular assembling’, by no way that makes higher potencies more ‘powerful’ or ‘potent’. By 12c, all drug molecules will be removed from the medium, and medium gets saturated with ‘molecular imprints’. 12c will be ideal homeopathic. therapeutic agent. I see no special benefits by going ‘higher’. But, diluting medicines while administering by mixing with water may be beneficial, by increase the number of molecular imprints.
Triturations and low potencies containing original drug molecules act as ‘competitive’ factors towards pathogenic molecules in binding to biological molecules. But, ‘molecular imprints’ contained in potencies above 12c act as ‘complementary’ factors, binding directly to specific pathogenic molecules due to their configurational affinity. Obviously, low potencies and high potencies act therapeutically by different molecular mechanisms.