‘Drug Proving With High Potency Drugs’- A ‘Belief’ Never Verified By Well-Organised Experiments

Homeopaths have many deep-rooted ‘beliefs’- most of them very irrational and unscientific. But I am sure, they cannot be convinced by talking logic or science that goes against such beliefs.

Homeopaths ‘believe’ that ‘highly potentized’ drugs can produce symptoms, and can be used for ‘drug proving’. They believe it is dangerous to use potentized drugs without indications.

One homeopath claimed: “I once took a dose of medhorrinum 1M, because I really wanted to know more about Homeopathy, and I got a date of symptoms for some time (a month or less), most corresponded well to the set of symptoms described in materia medica for medhorrinum… So you say that high dilutions is not good for experimentations…. I think it is not correct…”

Pure rubbish. If he wanted to “know more about homeopathy”, this is not the way he should do experiments. Taking oneself ‘single dose’ of a drug and waiting for ‘its symptoms’ to appear! And he got symptoms of that drug for one month! And he considers he has ‘proved’ that “high dilutions are good for experimentation” beyond any doubt!

If he really wanted to ‘prove’ that potentized drugs can produce symptoms, he should conduct the experiments according to scientific method. Person who is subjected to experiment should not know which medicine he is taking. Person conducting the experiment should not know which drug is given to which individual. There should be enough controls also. Then we should try to identify the drugs from comparing the symptoms produced with symptoms in materia medica. Only when we succeed in identifying drugs from symptoms in such a well controlled blinded experiment, we can say we ‘proved’ that high potency drugs could produce symptoms.

Taking a dose of ‘known’ drug oneself, waiting for its symptoms for one month, and ascribing all symptoms you produced during one month to that single drug- it is a joke. After taking that ‘single dose’, he will be ‘taking’ diverse types of exogenous molecules into your body- through food, water, drinks, air and many many other environmental factors. All those molecules can produce symptoms in him. How can he say all symptoms produced for one month ‘after’ a ‘single dose of medorrhinum 1m’ were due that ‘single dose’?

Only homeopaths, blinded by ‘beliefs’ can make such claims. For them, everything that happens ‘after’ their dose is the ‘effect’ of that dose! They never bother to consider the variables involved! I know it is a waste of time arguing to convince them. They cannot be convinced by logic or science. They are ‘believers’.

Homeopathic drugs potentized above avogadro limit (12c) contain only ‘molecular imprints’. Molecular imprints are supramolecular nanostructures formed by hydrogen bonding of ethyl alcohol-water molecules, into which the 3-dimensional configuration of drug molecules are imprinted as nano-cavities. These nano-cavities can act as artificial binding sites for endogenous or exogenous molecules having configurational similarity to the molecules used for imprinting. We can say, molecular imprints are ‘artificial key-holes’ for pathogenic molecular keys.

Biochemical processes involves two aspects: 1.Binding of ligands to targets, which is determined by configurational affinity.2. Chemical transformation, which is determined by charge affinity of ligands and targets. Since ‘molecular imprints’ have only ‘configurational affinity’, without any ‘charge affinity’ towards biological molecules, potentized drugs cannot interfere in normal biological processes.

Molecular imprints contained in the potentized homeopathic preparations bind to ligands or biological molecules merely due to their complementary cofigurations without any charge affinity, whereas natural ligands bind to their biological target molecules in capacity of their appropriate spacial configurations as well as charge affinities. So, the bindings of molecular imprints with biological molecules or their ligands will be very temporary and cannot stay long. Such bindings of molecular imprints cannot replace the natural ligand-target interactions happening as part of vital processes. Molecular imprints can not compete with natural ligands in binding to their natural biological targets. Hence it is obvious that potentized homeopathic preparations cannot interfere in biological ‘ligand-target’ processes such as ‘substrate-enzyme’, ‘antigens-antibodies’, ‘signal-receptor’ etc. As such, chances of potentized homeopathic medicines acting as pathological agents are very rare even if used indiscriminately. Molecular imprints can interfere only in interactions between pathogenic molecules and biological molecules, as well as off-target bindings of ligands with biological molecules, where only configurational affinity is involved. Obviously, molecular imprints can act upon only the molecular blocks created by exogenous or endogenous foreign pathological molecules.

Molecular imprints contained in the potentized homeopathic preparations cannot successfully compete with natural ligands in binding with their biological target molecules, and hence, cannot interfere in the interactions between biological molecules and their natural ligands. Obviously, potentized drugs cannot produce any pathological molecular inhibitions in the organism or produce symptoms.

According to scientific view, ‘Similia Similibus Curentur’ means: ‘diseases caused by specific molecular inhibitions and expressed through specific groups of subjective and objective symptoms can be cured by potentized forms of drugs that could create similar pathologic molecular inhibitions and symptoms in healthy individuals if applied in crude form’. Same can be stated in a different way as: “pathological molecular inhibitions can be rectified using ‘molecular imprints’ of drug molecules that can create similar molecular inhibitions if applied in molecular form”.

Homeopathy utilizes ‘drug proving’ for studying the pathogenic properties of drug substances by observing their capacity to produce various pathological symptoms in healthy organisms. Homeopathy is based on the principle that a substance becomes a medicinal agent only because it has some disease-producing properties. In other words, if we could know what pathological inhibitions and symptoms a drug can create in healthy organism, we can decide in what disease states that drug could be used as a therapeutic agent in potentized form. Drug proving is unique to homeopathy. Whereas modern medicine studies the disease-curing properties of drugs, homeopathy studies the disease-producing properties of drugs. That makes a great difference.

Drug proving is done by administering small quantities of a particular drug to controlled volunteer groups of apparently healthy individuals. The subjective and objective symptoms, representing the diverse molecular deviations caused in the organism by the drug substance are carefully observed and recorded. These symptoms are systematically arranged compiled as materia medica of the substance used.

Let us examine what actually happens at molecular level during drug proving:

First point we have to note is that most drug substances, especially of vegetable or animal origin, are not ‘simple’ substance. Even if we use them as a ‘single’ substance, actually they consist of diverse types of individual molecules. A substance can interact with biological molecules only as individual molecules. If we really want to understand homeopathy and drug proving scientifically, we should first of all learn to perceive drug substance in terms of its diverse constituent molecules. Once we introduce a sample of drug substance into the living organism for ‘proving’, its constituent molecules are instantly subjected to various processes such as disintegration, ionization, hydration and certain chemical transformations.
Individual constituent molecules are carried and conveyed through blood and other internal transport systems into the cells and body fluids in different parts of the body. They can interact with various enzymes, receptors, and other biological molecules inside the organism. Individual drug molecules, in capacities of their molecular affinities, get themselves bound to various bio-molecules which participate in the essential biochemical activities in the organism. These interactions are decided and directed by the specific properties such as configurations and charges of active groups of individual drug molecules, and their specific affinity towards biological target molecules.

The three dimensional structure of the individual drug molecules, and that of the concerned bio-molecules are the decisive factors in this process of formation of molecular binding between them. This peculiarity is called molecular affinity. It is very important to note that drug substances interact with different biological molecules, not as a singular entity, but as individual constituent molecules and ions. These individual drug molecules and ions are capable of competing with natural ligands and substrates in binding to their biological targets, thereby inhibiting the essential bio-chemical processes which can take place only with their presence and mediation. Such molecular inhibitions in various bio-chemical pathways result in a condition of pathology, expressed in the form of a train of subjective and objective symptoms, due to the involvement of various neuro-mediator, neuro-transmitter and cellular signalling systems.

From this point of view, drug proving has to be done using molecular forms of drugs, since only they can produce real pathological molecular inhibitions in the organism.

Let us examine what actually happens when potentized drugs are administered into ‘apparently’ healthy individual individuals for drug proving. First point we need to remember is that ‘apparently’ healthy people will not be totally free from pathological molecular inhibitions. There will be diverse types of hidden molecular errors existing in them, arising from diverse types of factors such as nutritional, environmental, miasmatic, genetic, emotional, metabolic, infectious and others. When potentized drugs are introduced into the body, some or other molecular imprints contained in them may act upon these existing molecular inhibitions, which may be reflected as some transient symptoms. Actually, those symptoms are not indicating the ‘disease producing’ properties, but ‘diseases curing’ properties of concerned drugs. As such, symptoms obtained from drug proving using high potencies may confuse our materia medica.

Potentized drugs may act on ‘healthy’ organism by a different mechanism. Molecular imprints may bind to the natural ligands in the body, if they have any configurational affinity. But, such bindings will not lead to a state of pathology since molecular imprints cannot interfere in the interaction between natural ligands and targets which will have stronger affinity to each other. As such, symptoms appearing from such interactions will be very much temporary, and cannot be considered ‘pathological symptoms’.

Drugs potentized above 12c cannot cause pathological molecular inhibitions or produce symptoms. As such ‘drug proving’ with ‘high potencies’ is only a myth- ab false belief that is deep-rooted in the minds of homeopaths.

Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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