A Study of Sepia Biochemistry From MIT Perspective

We all know, our homeopathic drug sepia is prepared from ink of cuttle fish. It contains a number of chemicals in a variety of different concentrations, depending on the species. However, its main constituents are melanin and mucus. It can also contain, among other things, tyrosinase, dopamine and l-dopa, and small amounts of amino acids, including taurine, aspartic acid, glutamic acid, alanine and lysine. Sepia ink also contains large amounts of aquatic minerals such as iodine, sodium, fluorine, iodine etc absorbed from sea water in which they live.

That means, sepia is not a single drug as we are made to believe. it is a compound drug. During drug proving, all these different chemical constituents of sepia act in their individual capacities up on different biological targets during drug proving, produce molecular errors that are expressed through vaious groups of subjective and objective symptoms.

When potentized, these different chemical molecules undergo molecular imprinting as individual molecules. as such, potentized sepia will be a combination of diverse types of molecular imprints that represent different types of constituent chemical molecules. When used as therapeutic agent, these individual molecular imprints bind to specific pathogenic molecules having complementary conformation.

Cuttlefish are marine animals of the order Sepiida. They belong to the class Cephalopoda, which also includes squid, octopuses and nautiluses. Despite their name, cuttlefish are not fish but molluscs.

Cuttlefish are sometimes referred to as the “chameleons of the sea” because of their remarkable ability to rapidly alter their skin color at will. Cuttlefish change color and pattern, including of light polarisation and even texture to communicate to other cuttlefish, to camouflage themselves, and in deimatic display to warn off potential predators.

Sepia ink is a dark pigment released into water by most species of cephalopod, usually as an escape mechanism.

The ink is released from the ink sacs located between the gills, and is dispersed more widely by accompanying its release with a jet of water from the siphon. Its dark color is caused by its main constituent, melanin.

Each species of cephalopod produces slightly differently coloured inks; generally, octopuses produce black ink, squid ink is blue-black and cuttlefish ink is brown.

Sepia ink contains a number of chemicals in a variety of different concentrations, depending on the species. However, its main constituents are melanin and mucus. It can also contain, among other things, tyrosinase, dopamine and l-dopa, and small amounts of amino acids, including taurine, aspartic acid, glutamic acid, alanine and lysine. Sepia ink also contains large amounts of aquatic minerals suchas iodine, sodium, fluorine, iodine etc absorbed from sea water in which they live.

When potentized, sepia contains molecular imprints of all these constituent chemical molecules, which are the active principles of potentized sepia.

In molecular biology, Tyrosinase refers to an oxidase, which is the rate limiting enzyme for controlling the production of melanin. It is mainly involved in two distinct reactions of melanin synthesis; firstly, the hydroxylation of a monophenol and secondly, the conversion of an o-diphenol to the corresponding o-quinone. o-Quinone undergoes several reactions to eventually form melanin. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation, as in the blackening of a peeled or sliced potato exposed to air. It is found inside melanosomes.

A mutation in the tyrosinase gene resulting in impaired tyrosinase production leads to type I oculocutaneous albinism, a hereditary disorder.

Tyrosinase activity is very important. If uncontrolled during melanoma, it results in increased melanin synthesis. Several polyphenols including flavonoids or stilbenoid, substrate analogues, free radical scavengers and copper chelators have been known to inhibit tyrosinase.

Molecular imprints of tyrosinase molecules contained in potentized sepia can remove the molecular errors caused by various types of inhibitors that cause certain types of albinism, leucoderma and hypopigmentations.

Molecular imprints of certain chemical constituents of sepia act homeopathically by binding to the pathogenic molecules that inhibit melanocortin receptors in melanocytes, which are the natural binding sites of melanocyte stimulating hormones that induce production of melanin, the skin pigment of our body

Melanocortin receptors lie within the cell membrane, and is signalled by melanocyte-stimulating hormone (MSH) released by the pituitary gland. When activated by MSH, it initiates a complex signaling cascade that leads to the production of the brown or black pigment eumelanin. In contrast, the receptor can also be antagonized by agouti signalling peptide (ASIP), which reverts the cell back to producing the yellow or red phaeomelanin.

Molecular imprints of melainin, dopamine and l-dopa, taurine, aspartic acid, glutamic acid, alanine and lysine, iodine fluorine, bromine sodium etc contained in potentized sepia decide the diverse types its homeopathic therapeutic actions when used according to similia similibus curentur.

Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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