MIT HYPOTHESIS- How To Prove It According To Scientific Methods?

According to MIT HYPOTHESIS, active principles of post-avogadro  potentized drugs are MOLECULAR IMPRINTS of individual chemical molecules contained in the drug substances used for potentization.

As per this hypothesis, ‘molecular imprints’ are hydrogen-bonded supramolecular formations of  water-ethyl alcohol molecules, into which the three-dimensional  spacial conformations of drug molecules are imprinted or engraved as nanocavities, through a process of host-guest interactions or  MOLECULAR IMPRINTING  involved in the process of potentization.

These ‘molecular imprints’ can act as artificial binding sites or key holes for binding to the original drug molecules as well as any pathogenic molecule conformationally similar to the drug molecules.

When applied as therapeutic agent, these molecular imprints specifically bind to the pathogenic molecules having conformational affinity, thereby deactivating them and relieving the biological molecules from pathological molecular inhibitions.

This is the biological mechanism of homeopathic cure as proposed by MIT HYPOTHESIS.

Actually, the biological mechanism of cure proposed in this model is not a new idea. It is well accepted in modern molecular medicine and pharmacology, and is the basis of target-specific drug designing techniques currently very popular in pharmaceutical researches. There remains nothing to be proved on this idea.

Molecular imprinting in polymers (MIP) also is recently a very popular research area, a technique used in developing artificial binding sites in polymer matrices through a process of molecular level ‘host-guest’ interactions. These ‘molecular imprinted polymers’ are currently utilized in various laboratory procedures as molecular binding and filtering agents.

What I have been trying to do by MIT hypothesis is to adapt these well-accepted scientific concepts into the theoretical frame work of homeopathy, so that a scientific model could be developed to explain the biological mechanism of homeopathic  cure. MIT hypothesis explains homeopathic potentization in terms of ‘molecular imprinting in water’, and homeopathic cure in terms of removal of molecular inhibitions.

Only thing remaining to be scientifically proved is that potentized homeopathic drugs contain ‘molecular imprints’. It raises the question whether water-ethyl alcohol mixture can act as a medium for molecular imprinting, similar to polymers. Various studies regarding supra molecular properties of water indicate some ‘polymer-like’ properties of water and formations of hydrogen-bonded nanoclusters in a micro-environment, which obviously opens up possibilities of molecular imprinting in water-ethyl alcohol matrix.


a) high dilution drugs really work as curative agents when applied according to indications,

b) high dilution drugs works not only in living bodies, but also up on ‘in vitro’ biological samples,

c) high dilution drugs cannot interfere or prevent the normal interactions between biological molecules and their natural ligands,

d) high dilution drugs can antidote the biological effects of same drugs used in crude or molecular forms,

e) biological properties of high dilution drugs are different or reverse to those of same drugs in molecular forms,

f) high dilution drugs do not contain original drug molecules,

g) high dilution drugs and unpotentized water-alcohol mixture are similar in their chemical structure and properties,

h) high dilution drugs differ from unpotentized water-alcohol mixture regarding physical properties and various physical parameters,

i) high dilution drugs  differ from unpotentized water-alcohol mixture regarding supra-molecular arrangements by formation of nano-clusters as could be observed by difference in spectroscopic studies,

j) Medicinal properties of high dilution drugs could be destroyed by applying strong heat, electric currents or other forms of electromagnetic energy, which will also change the characteristic physical properties of those potentized drugs,


Author: Chandran Nambiar K C

I am Chandran Nambiar K C Author, REDEFINING HOMEOPATHY Managing Director, Fedarin Mialbs Private Limited Developer. SIMILIMUM ULTRA Homeopathic Software I am not a scientist, academician, scholar, professional homeopath or anybody with 'big credentials', but an old lay man, a retired government servant, who accidentally happened to fall into the deep waters of the great ocean of homeopathic knowledge during his fiery teenage years, and was destined to live a whole life exploring the mysteries of that wonderful world with unending enthusiasm. My interest in homeopathy happened very accidentally when I was only 20 years old UNDERGRADUATE ZOOLOGY student, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy.

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