If ‘molecular imprinting’ is the real mechanism involved in homeopathic potentization, it is obvious that there is no likelihood of any special benefit by higher and higher potentisations above 12C. Logically, potentization need be continued only just beyond the limit of Avagadro number. By that stage, all the drug molecules would be removed from the medium, and the molecular imprinted water–alcohol mixture would have attained sufficient concentration of ‘molecular imprints’, which are the real active principles of potentized medicines. The three-dimensional structure of drug molecules used as ‘guests’ will have already got sufficiently imprinted into the hydration shells or hydrosomes by that time. There is no point in continuing potentization even after that stage.
Even those who believe that potentization is a process by which ‘medicinal energy’ of drug substances are transferred into the medium, would find it difficult to explain what ‘medicinal energy’ could be ‘transferred’ even after the whole drug molecules are removed through serial dilutions.
As per my observation, the medicinal property of any homeopathic drug beyond 12c will be the same. It is only a very rare possibility that there could be any significant difference between various so called higher potencies used by us, with regard to their content or medicinal qualities. Many master prescribers have already put on record that if the selection of similimum is correct, any potency would render the expected therapeutic result.
Since I consider molecular imprints as the active principles of potentized drugs, I do not subscribe to the idea that ‘higher’ potencies are more ‘powerful’, and I see no special benefit by using ‘higher’ potencies.
I think 12c is enough for completing molecular imprinting and removal of all drug molecules from the medium. What happens at molecular level during further potentization is still an open question for me. In supra-molecular chemistry, there is research going on regarding a phenomenon known as ‘induced molecular assembly’. That means, supra-molecular clusters acting as templates and inducing other molecules to form similar clusters. We know, ‘induced molecular assembly’ is involved in crystallization, clathrate formation etc. Even ‘prions’, which are misfolded proteins, multiply by ‘induced misfolding’. Antibodies, which are ‘molecular imprinted proteins’, also multiply by ‘inducing’ other globulin proteins to change configuration. Molecular imprints, which are supra-molecular clusters of water, may also multiply by the process of ‘induced molecular assembly’, where existing ‘molecular imprints’ may act as templates and induce formation of similar molecular imprints. It is only a possibility, which need in-depth study, which may provide us a rational way of resolving the riddle of high potencies.
What actually happens when potentization is continued ‘higher’ even after crossing avogadro limit or 12C?
Actually, large-sized drug molecules disappear from the potentizing medium much before 12c. By crossing 12c, even the smallest molecules will be removed. 12c will contain only molecular imprints. In order to understand what exactly happens when potentization goes higher and higher, we should study the behavior of supra-molecular nano-aggregates. They can act as ‘seeds’ to induce other water-alcohol molecules to form similar nano-structures. This phenomenon is commonly studied and utilized in making of crystals using ‘seeding’. Crystals are nothing but supra-molecular clusters. A few crystals are added to a solution as ‘seeds’ to induce further supra-molecular assembling and crystallization. When 1 drop of 12c is adding to 99 drops of water-ethyl alcohol, we are actually using molecular imprints as ‘seeds’ to induce the formation of similar molecular imprints.
It is obvious that there is no any special benefit by potentizing ‘higher’ above 12c. There is no any increase in power by going higher. Active principles of all potencies above 12c are molecular imprints, which act same way what ever the potency is. Actually, 12c will be ideal, as it contains molecular imprints formed by direct molecular imprinting, where as in higher potencies it is produced by ‘induced molecular assembly’.
Even though ‘molecular imprints’ may be formed in higher potencies through the process of ‘induced molecular assembling’, by no way that makes higher potencies more ‘powerful’ or ‘potent’. By 12c, all drug molecules will be removed from the medium, and medium gets saturated with ‘molecular imprints’. 12c will be ideal homeopathic. therapeutic agent. I see no special benefits by going ‘higher’. But, diluting medicines while administering by mixing with water may be beneficial, by increase the number of molecular imprints.
Based on this observation, for the last five years I use only 30c since all drugs are not available in 12c, and I get expected results in all cases where selection of similimum was correct.
But many homeopaths, even those who were not reluctant to accept my ‘molecular imprint’ concept, invited my attention to their experience that when a drug 30c potency acted for some time, a stage reaches where no further improvement is obtained. In such situations, they could create curative response by going to higher and higher potencies of same drug. My friends said that theor experience does not corroborate my suggestion that a drug in all potencies above 30c will be similar in medicinal properties.
I decided to take up this question seriously, and started working up on it. There were many instance where NUX 30 failed but NUX 200 acted. It was also correct that in some cases NUX 30 acted for some time and then came to a standstill, where repeating same potency did not succeed in evoking any response. Then NUX 30 or NUX 1m acted favorably.
There were another experience reported by some homeopaths, and verified by me. When NUX 1m failed, NUX 30 or NUX 200 acted. In my experiments on that lines, I noticed that when a case comes to standstill after a certain period of improvement after using NUX 1m, administration of NUX 30 or NUX 200 was also beneficial, instead of moving to still higher potencies.
Then I started experimenting on another lines. When NUX 30 failed to provide further improvement after a certain stage, I used NUX 30 from another sample obtained from another manufacturer. The result was wonderful. It acted!. I repeated this experiment with different cases, different drugs, different potencies. Finally I came to the conclusion that it was not a question of going higher or lower, but changing of samples, changing of source of potentized drugs. I can now suggest my friends, if you fail with NUX 30, and your are still convinced that the similimum is NUX, use NUX 30 obtained from another manufacturer. It will work. Always keep maximum samples of same drugs in same potencies obtained from different sources, and try all of them before changing your prescription. I have also seen it beneficial to mix all those different samples together and keep as single drug. For example, you can collect NUX 30 from five different manufacturers and mix them together and keep labeled as NUX. And see the difference!
Logical explanation for this phenomenon is very simple. It is associated with the process of molecular imprinting happening in potentization, and the quality of crude drug sample used for potentization. Simply put, each sample of same drug in same potency may differ in their constituent molecular imprints. One sample may miss some ‘molecular imprints’ that may be present in another sample. Each sample provides only partial curative effect, according to the availability of ‘molecular imprints’ present in them. To get a ‘complete’ therapeutic action of a particular drug, we have to use different samples from different sources, one after other, or mixing together.