MIT Approach To The Treatment Of ‘Polycystic Ovary Syndrome'(PCOS)

Polycystic ovary syndrome (PCOS) is a term used to describe a set of symptoms expressed in a large percentage of women visiting doctors with various gynecological problems, which arise from hormonal imbalances. The name PCOD is used when there is ultrasonographic evidences for ovarian cysts. PCOS is the most common endocrine disorder among women between the ages of 18 and 44. It affects approximately 5% to 10% of this age group. It is one of the leading causes of poor fertility.

Signs and symptoms of PCOS include irregular or no menstrual periods, heavy periods, excess growth of body and facial hair, acne, pelvic pain, infertility due to anovulation, and patches of thick, darker, velvety skin. PCOS commonly appear associated with conditions such as type 2 diabetes, obesity, obstructive sleep apnoea, heart disease, mood disorders, and endometrial cancer.

PCOS is considered to be caused by a combination of genetic as well as environmental factors. Obesity, lack of physical exercise, and a family history of someone with such conditions are major risk factors. Diagnosis is mainly based on two of the following three findings- no ovulation, high androgen levels, and ovarian cysts detectable by ultrasound scanning. Differential diagnosis is required to rule out other conditions that produce similar symptoms, which include adrenal hyperplasia, hypothyroidism, and hyperprolactinemia.They try to alleviate symptoms by  lifestyle changes such as weight loss and exercises, and administration of ‘birth control pills’ to  regularize  menstrual  periods. Anti-androgenic drugs are used in certain cases. Various drugs and techniques are used to treat acne and to control excess hair growth.  Efforts to improve fertility include reducing weight, administering drugs, and in vitro fertilization.

Major signs and symptoms of PCOS include   menstrual disorders such as ooligomenorrhoea (few menstrual periods) or amenorrhea (no menstrual periods) and  infertility resulting from lack of ovulation.  Other common signs are acne and hirsutism (male pattern of hair growth). There may be heavy and prolonged menstrual periods in some cases. Androgenic alopecia with hair thinning or diffuse hair loss may also appear in certain individuals. Levels of androgens or male sex hormones are found to be raised in PCOS patients. There appears as a tendency towards central obesity and other symptoms associated with insulin resistance.  Serum insulin levels, insulin resistance, and homocysteine levels are higher in women with PCOS.

There is strong evidence that PCOS is a genetic disease.  The genetic component appears to be inherited in an autosomal dominant fashion with high genetic penetrance but variable expressivity in females; this means that each child has a 50% chance of inheriting the predisposing genetic variant from a parent, and, if a daughter receives the variant, the daughter will have the disease to some extent. The genetic variants can be inherited from either the father or the mother, and can be passed along to both sons daughters. Sons  may be asymptomatic carriers or may have symptoms such as early baldness.  and daughters show the signs of PCOS. In rare instances, single-gene mutations can give rise to the phenotype of the syndrome. Current  understanding of the pathogenesis of the syndrome suggests, however, that it is a complex multigenic disorder.

Obesity seems to play a big role in determining the severity of PCOS symptoms. PCOS has some aspects of a metabolic disorder, and its symptoms are partly reversible. Even though the name suggests that the ovaries are central to disease pathology, cysts are a symptom instead of the cause of the disease. Some symptoms of PCOS will persist even if both ovaries are removed; the disease can appear even if cysts are absent.. Gynecologists often see it as a gynecological problem, with the ovaries being the primary organ affected. However, recent insights show a multisystem disorder, with the primary problem lying in hormonal regulation in the hypothalamus, with the involvement of many organs. The term PCOS is used since there is a wide spectrum of symptoms possible, and cysts in the ovaries are seen only in 15% of people affected with the syndrome.

PCOS may be related to or worsened by exposures to certain drugs during the prenatal period, epigenetic factors, environmental impacts such as  industrial endocrine disruptors.

History-taking, specifically for menstrual pattern, obesity, hirsutism and acne is very important for diagnosing PCOS. Gynecologic ultrasonography, specifically looking for small ovarian follicles is also important. These ‘cysts’ are believed to be the result of disturbed ovarian function with failed ovulation, reflected by the infrequent or absent menstruation that is typical of the condition. Determining whether an elevation of the serum levels of androgens including androstenedione and testosterone is necessary for diagnosis. The free testosterone level is thought to be the best measure, with more than 60% of PCOS patients demonstrating supranormal levels. Glucose tolerance tests as well as testing fasting insulin levels are also necessary. Other causes of irregular or absent menstruation and hirsutism, such as hypothyroidism, congenital adrenal hyperplasia (21-hydroxylase deficiency), Cushing’s syndrome, hyperprolactinemia, androgen secreting neoplasms, and other pituitary or adrenal disorders, should be investigated and ruled out.

Polycystic ovaries develop when the ovaries are stimulated to produce excessive amounts of male hormones (androgens), in particular testosterone, by either one or a combination of the following (almost certainly combined with genetic susceptibility-  the release of excessive luteinizing hormone (LH) by the anterior pituitary gland, and through high levels of insulin in the blood in women whose ovaries are sensitive to this stimulus.

A majority of people with PCOS have insulin resistance and/or are obese. Their elevated insulin levels contribute to or cause the abnormalities seen in the hypothalamic-pituitary-ovarian axis that lead to PCOS. Hyperinsulinemia increases GnRH pulse frequency, LH over FSH dominance, increased ovarian androgen production, decreased follicular maturation, and decreased SHBG binding; all these steps contribute to the development of PCOS. Insulin resistance is a common finding among women with a normal weight as well as overweight women.

Adipose tissue possesses aromatase, an enzyme that converts androstenedione to estrone and testosterone to estradiol. The excess of adipose tissue in obese women creates the paradox of having both excess androgens which are responsible for hirsutism and virilization, and estrogens which inhibits FSH via negative feedback.

PCOS may be associated with chronic inflammation, with several investigators correlating inflammatory mediators with anovulation and other PCOS symptoms.  Similarly, there seems to be a relation between PCOS and increased level of oxidative stress.

According to MIT perspective, INSULIN 30 is the main homeopathic drug for treating PCOS, as the molecular imprints contained in that drug can reverse the harmful biochemical processes caused by hyperinsulinemia and insulin resistance, which is the starting point of all abnormalities in hypothalamic-pituitary-ovarian axis that lead to PCOS. Drug will have to be repeated twice every day, and continued for a long period.   Since PCOS is a metabolic syndrome involved with abnormalities in diverse hormonal pathways, PITUTRIN 30, ACTH 30, TESTOSTERONE 30 and THYROIDINUM 30 also should be administered in combination or alternation with INSULIN 30.

Better and faster results are produced if we include in this protocol  the homeopathic ‘constitutional’ similimum worked out on the basis of physical generals and mental symptoms expressed by the patient.

Indications of positive response to this highly scientific treatment protocol are observable by three months, as menstrual periods become regular, and male pattern hair growth begins to fade away. All symptoms gradually disappear within 6-12 months of starting medication. Homeopaths can confidently try this method, since there  are absolutely no chances for any kind of adverse effects from using drugs potentized above Avogadro limit.

Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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