Phenomenon Of ‘Hormesis’, And Its Relevance In ‘Ultra-Dilution’ Homeopathic Effects

Attempts have been made by many people to explain the properties of high dilution homeopathic drugs on the basis of the phenomenon known as  ‘hormesis’. This phenomenon was first proposed by Southam and Ehrlich and Stebbing. They proposed that a substance which acts as a toxin in high concentrations, acts as a stimulant in low concentrations. This phenomenon is known as ‘hormesis’. There is a theory known as Arndt-Schulz rule or Schulz’ law to explain this phenomenon. The essence of this theory is “for every substance, small doses stimulate, moderate doses inhibit, and large doses kill”. Hugo Paul Friedrich Schulz and Rudolf Arndt are the exponents of this theory.  According to their view, toxins in their highly diluted form stimulate biological processes, where as in their concentrated forms inhibit or kill the biological processes. But even today nobody succeeded in proving or explaining this phenomenon scientifically.

The scientific experiments conducted at Utrecht University, undertaken by a team under the leadership of Roeland van Wijk and Fred A.C. Wiegant tried to explain homeopathy on the basis of theory of ‘hormesis’. Even though these experiments succeeded in proving the therapeutic properties of potentized drugs to a certain extent, they failed to correlate it with the phenomenon of ‘hormesis’. Actually nobody could so far  uncover the molecular kinetics of what is known as ‘hormesis’.

Not only ‘hormesis’, even the discovery of Hippocrates regarding effects of ‘small doses’, still  remains scientifically unexplained.  What is the exact molecular mechanism by which “small doses of that which caused an ailment would cure” as Hippocrates  theorized? Nobody answered that fundamental question yet.

What hippocrates discovered seems to be the same phenomenon which was later known as ‘hormesis’. Somebody has to explain the molecular mechanism involved in ‘hormesis’. In my opinion, only ‘molecular imprints’ can explain ‘hormesis’ or hippocrates’ discovery in scientific terms. The phenomenon of ‘hormesis’ could have been better explained if people understood the concept of  ‘molecular imprints’ of drug molecules, which are likely to be formed in the highly diluted solution of a toxic substance. Only ‘molecular imprints’ can produce a biological effect that is exactly opposite to that of original molecules.

To get an answer to the question how ‘hormesis’ works or ‘small doses’ work, we have to understand the process of ‘dilution’ in relation with ‘size’ of drug molecules being diluted. Any drug substance of animal or vegetable origin contains diverse types of drug molecules. Some complex molecules will be very ‘big’ in size, and their number in a given quantity of solution will be comparatively very small as per avogadro theory. Smaller molecules will be present in larger numbers. When we start diluting serially, larger molecules will be ‘imprinted’ into the solvent medium, and those molecules get removed from the solution in very early stages of dilution process. Smaller molecules are removed only at later stages of dilution. By reaching 12 c, even the smallest molecules get imprinted and removed from the medium. That is why I say potencies above 12c contain molecular imprints only.

Obviously, lower potencies below 12c will be a mixture of small molecules as well as molecular imprints of larger molecules. From this point of view, we can now explain ‘hormesis’, ‘hippocrates observations’ and ‘homeopathic potency’ in a rational way.

Obviously, the scientifically elusive phenomenon of ‘hormesis’, or the ‘opposite’ biological actions of low dilutions and high dilutions of toxic substances, could be scientifically explained when perceived in the light of the ‘molecular imprints’ ideas proposed by MIT.

Observation that potentized drugs act upon organism in a way exactly opposite to the original drugs indicated a process of generating three-dimensional nanocavities that can act as binding sites for drug molecules and similar pathogenic molecules, which can happen only though ‘molecular imprinting’.

Study of ‘key-lock mechanism’ involved in the dynamics of enzyme inhibitions, ‘ligand-receptor’ interactions and ‘antibody-antigen’ interactions are also found to be fitting well to the concept of ‘molecular imprints’ in potentized drugs.

Through these studies, it becomes clear that ‘similia similibus curentur’ as well as ‘hormesis phenomenon’  could be explained in the light of available scientific knowledge regarding the molecular level processes of pathology and therapeutics, and homeopathy is actually a higher specialized form of modern molecular medicine.

Actually, ‘hormesis’ is all about the biological actions of ‘small’ quantities and ‘large’ quantities of drugs. How could anybody equate ‘ultra-dilution effects’ with ‘hormesis’ knowing well that ‘ultra-dilutions’ do not contain any drug substance? If you equate homeopathy and hormesis, you are obviously discarding the principles of homeopathic potentization. Homeopathy is not small doses- it is NO doses!

Exact molecular mechanism of phenomenon of so called “hormesis” is still unexplained scientifically. Concept of hormesis is applicable only in effects of “small quantities” of toxic substances. It has no any relevance in homeopathic ultra dilution effects, which will not contain any ‘quantity’ of drug substance.


Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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