MIT Approach To Homeopathic Management Of ‘Fibromyalgia’

FIBROMYALGIA is a chronic miasmatic disease syndrome characterized by non-specific generalized body pain and an elevated painful response to tactile pressure stimuli.  Symptoms other than body pain may include extreme tiredness, sleep disturbances, memory disturbances, joint stiffness, dysphagia, numbness, tingling, muscular spasms, twitching, temperomandibular joint dysfunctions, palpitations, symptomatic hypoglycemia, functional bowel/bladder disturbances, cognitive dysfunctions, diminished attention span, depression, anxiety as well as many symptoms of  stress-related disorders such as post-traumatic stress disorders. Not all people with fibromyalgia exhibit all the associated symptoms.

Fibromyalgia is estimated to affect 2-8% of world population, with a female to male incidence ratio of 8:1, which means females are predominantly affected by this disease. The term ‘fibromyalgia’ derives from latin term ‘fibro’(fibrous tissues), combined with greek terms ‘myo’(mucles) and ‘algos’(pain).

The exact eitiology of fibromyalgia is still considered unknown, but is believed to involve multiple factors such as psychological, genetic, neurobiological and environmental. Generalized body pain, the central symptom of fibromyalgia, has been proven to be associated with some neurochemical imbalances and the activation of inflammatory pathways in the brain which results in biochemical abnormalities of pain processing. Fibromyalgia is classed as a ‘neurobiological disorder’, a disorder of pain processing due to abnormalities in how pain signals are processed in the central nervous system. Research evidences suggest that the pain in fibromyalgia results primarily from abnormal functioning of pain processing pathways. Hyper-excitability of pain processing pathways as well as under-activity of inhibitory pain pathways in the central nervous system jointly results in the pain sensation experienced by fibromyalgia patients. Some neurochemical abnormalities happening in fibromyalgia affect the biochemical systems that regulate sleep, mood and energy, which explain the concomitant symptoms of fibromyalgia.

Some references have included fibromyalgia in the list of autoimmune diseases, with cautious ‘qualifiers’ such as “a co-morbidity common among people with autoimmune disease, but with no evidence of being itself caused by autoimmunity”, and “disease is only caused by autoimmunity in only a fraction of those who suffer from it”. Immune-related aspects of fibromyalgia remain still under study.

According to MIT perspective, fibromyalgia has to be considered as a chronic ‘miasmatic’ syndrom. In this context, the concept of ‘miasm’ is used as “chronic disease dispositions caused by ‘off-target’ actions of antibodies generated in the body in response to invasions by endogenous or exogenous ‘alien protiens’ such as infectious agents, vaccines etc”. In the absence of a scientific understanding of miasms as ‘antibody-mediated diseases’, such diseases are presently classified in medical literature along with ‘autoimmune diseases’.

MIT considers fibromyalgia as a chronic disease condition arising from ‘residual effects’ of different kinds of ‘viral fevers’ that were characterized by severe generalized body pains, such as influenza, chikunguniya, chicken pox etc. Of course, vaccinations against these viral infections also would have similar ‘miasmatic’ effects, since vaccinations inevitably result in production of antibodies, which will be similar to the antibodies generated during actual infections. These antibodies remain in the body for long periods, and attack the enzymes associated with the expression of genes involved in the synthesis of various neuro receptors and neuromediators. Inhibition of such enzyme systems lead to faulty or diminished synthesis of neuroreceptors such as ‘dopamine receptors’ that are essential for maintaining healthy neurotransmission and ‘pain processing’ pathways. Breakdown in these pathways ultimately lead to a cascading effects upon various biomolecular pathways in central nervous system and neuroendocrine system, which are expressed through the mind and body symptoms of FIBROMYALGIA. Disruption of neuroendocrine pathways results in abnormalities of hormones under the direct or indirect control of growth hormone(GH), including insulin-like growth factor 1 (IGF-), cortisol, leptin and neuropeptide Y as seen in people with fibromyalgia. This explains the observation that people with fibromyalgia have alterations of normal neuroendocrine function, characterized by mild hypocortisolemia, hyperreactivity of pituitary adrenocorticotropin hormone (ACTH)  release in response to challenge, and glucocorticoid feedback resistance. It also explains  other abnormalities such as reduced responsivity of thyrotropin and thyroid hormones to thyroid-releasing hormone, elevation of prolactin levels with disinhibition of prolactin release in response to challenge and hyposecretion of adrenal androgens.

Kindly remember, functional analysis of the autonomic system in people with fibromyalgia has demonstrated disturbed activity characterized by hyperactivity of the sympathetic nervous system at baseline with reduced sympathoadrenal reactivity in response to a variety of stressors including physical exertion and mental stress. People with fibromyalgia demonstrate lower heart rate variability, an index of sympathetic/parasympathetic balance, indicating sustained sympathetic hyperactivity, especially at night. In addition, plasma levels of neuropeptide Y, which is co-localized with norepinephrine in the sympathetic nervous system, have been reported as low in people with fibromyalgia, while circulating levels of epinephrine and norepinephrine have been variously reported as low, normal and high. Administration of interleukin-6, a cytokine capable of stimulating the release of hypothalamic corticotropin-releasing hormone which in turn stimulates activity within the sympathetic nervous system, results in a dramatic increase in circulating norepinephrine levels and a significantly greater increase in heart rate over baseline in people with fibromyalgia as compared to healthy controls.

One of the most reproduced laboratory finding in people with fibromyalgia is an elevation in cerebrospinal fluid levels of substance P, a putative nociceptive neurotransmitter. Metabolites for the monoamine neurotransmitters serotonin, norepinephrine, and dopamine – all of which play a role in natural analgesia – have been shown to be lower, while concentrations of endogenous opioids such as  endorphins and enkephalins appear to be higher. The mean concentration of nerve growth factor, a substance known to participate in structural and functional plasticity of nociceptive pathways within the dorsal root ganglia and spinal cord, is elevated.  There is also evidence for increased excitatory amino acid release within cerebrospinal fluid, with a correlation demonstrated between levels for metabolites of glutamate and nitric oxide and clinical indices of pain.

Evidence of abnormal brain involvement in fibromyalgia has been provided via functional neuroimaging. Differential activation in response to painful stimulation has also been demonstrated.  People also exhibit neural activation in brain regions associated with pain perception in response to nonpainful stimuli in such areas as the prefrontal, supplemental motor, insular, and cingulate cortices.

Evidence of hippocampal disruption indicated by reduced brain metabolite ratios has been demonstrated by studies. A significant negative correlation was demonstrated between abnormal metabolite ratios and a validated index of the clinical. Correlations between clinical pain severity and concentrations of the excitatory amino acid neurotransmitter glutamate within the insular cortex have also been demonstrated using 1H-MRS.

A significant negative correlation between pain severity and dopamine synthesis was demonstrated within the insular cortex. A subsequent study demonstrated gross disruption of dopaminergic reactivity in response to a tonic pain stimulus within the basal ganglia with a significant positive correlation between the defining feature of the disorder (i.e. tender point index) and dopamine D2 receptor binding potential specifically in the right putamen.

Finally, reduced availability of mu-opioid receptors in the ventral striatum/nucleus accumbens and cingulate cortex has been demonstrated, with a significant negative correlation between affective pain levels and receptor availability in the nucleus accumbens.

 

All these established factors  justify the MIT observation that fibromyalgia is caused by alterations in biomolecular processes in central nervous system and neuroendocrine system, produced by inhibitions of enzyme systems associated with expression of genes involved in synthesis of neuro-transmitters and receptors of neuron synapses.

From MIT perspective, therapeutic management of fibromyalgia essentially involves deactivation of antibodies that are responsible for inhibition of enzymes associated with concerned gene expressions. This could be achieved by administration of ‘molecular imprints’ that can act as ‘artificial binding sites’ for those antibodies, so that they could be deactivated and the biological molecules relieved from inhibitions.

Potentized homeopathic nosodes such as Variolinum 30, Influenzinum 30 etc are found to be very useful for this purpose. Potentized Chikungunia nosode is expected to be a very powerful homeopathic drug for fibromyalgia, as the chronic residual effects of ‘chikungunia’ is found to be symptomatically very similar to fibromyalgia symptoms.

PITUTRIN 30 and ACTH 30 are  very important drugs that should be incorporated into any homeopathic treatment plan for fibromyalgia, as they will antidote the hyper-reactivity of pituitary adrenocorticotropin hormone (ACTH)  release in response to challenge, and glucocorticoid feedback resistance.

All homeopathic drugs that have ‘generalized body pain’ and pain aggravation by pressure’ could be used to alleviate fibromyalgia pains. From my personal experience, I have found ARNICA 30 a very effective drug for this condition. ‘Multiple drug’ approach consisting of homeopathic similimum, potentized hormones and viral nosodes in frequently repeated doses will be a most ideal strategy from MIT point of view.

 

Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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