As a simple and effective therapeutic system, free of any fear of unwanted side effects, homeopathy has already gained acceptability to a great extent during the by gone two centuries. The principle of ‘Similia Similibus Curenter’ has sufficiently proved its ‘right for existence’ through thousands and thousands of miraculous cures by homeopaths all over the world. But we cannot overlook the fact that we have not yet succeeded in explaining this principle scientifically enough.
Modern life sciences, especially biochemistry, genetics and molecular biology have accumulated a huge wealth of knowledge in recent years, unraveling even the minutest secrets of the phenomenon of life. But we have not yet been able to recreate the fundamental principles of homeopathy scientifically and convincingly enough, by taking advantage of the above mentioned modern scientific achievements.
Homeopathy shall be duly recognized and respected as an advanced branch of modern molecular medicine, only when such a scientific recreation of its basic premises is attained. Until then, homeopathy will remain a dogmatic ‘healing art’, not a ‘scientific medical system’.
According to modern scientific view, life exists through a series of inter-dependant and inter-connected complex chains of biochemical pathways, mediated by a highly organized and diversified class of organic bio-polymers known as proteins, which are considered to be ‘molecular carriers of life’.
Different types of proteins are synthesized according to the requirements from the building blocks known as amino acids, utilizing the genetic blueprint preserved in the DNA. Deficiency or malformation of protein molecules causes derangements in biochemical pathways. Nutritional deficiencies of building materials, errors in genetic blueprint or errors in various stages of genetic expressions may cause such deficiency or malformation of essential protein molecules, which are considered to be molecular errors underlying a broad class of ‘genetic diseases’ and ‘deficiency diseases’.
More over, exogenous or endogenous molecules or ions may bind to the essential protein molecules and lead to ‘molecular inhibitions’ of those proteins, thereby temporarily or permanently deactivating them. Such molecular inhibition and deactivation of essential protein molecules lead to the derangement of concerned biochemical pathways, leading to breakdown of vital processes, which amounts to a state of molecular level pathology. These exogenous and endogenous pathogenic molecules include environmental molecules, drugs, toxins, food articles, metabolic bye-products, infectious agents, antibodies or miasms and various such factors.
Primary basis of any state of pathology is some derangements occurring in the biochemical processes at the molecular level. Endogenous or exogenous foreign molecules or ions having any configurational similarity to certain biochemical ligands can mimic as original ones to attach themselves on the regulatory or the active sites of proteins, effecting changes in their native 3-D configuration, thereby making them unable to discharge their specific biochemical role. This situation is called a molecular inhibition, which leads to pathological molecular errors. It is comparable with the ability of objects having some similarity in shape with that of key, to enter the key hole of a lock and obstructing its function. As a result of this inhibition, the real substrates are prevented from interacting with the appropriate protein molecules, leading to a break in the normal biochemical channels. This type of molecular errors are called competitive inhibitions. It is in this way that many types of drugs, pesticides and poisons interfere in the biochemical processes, creating pathological situations.
Homeopathy has devised its own method of closely following even the minutest deviations in the biochemical processes in the organism, through a special strategy of monitoring and recording the perceivable symptoms caused by such deviations. Obviously, derangement in a particular biochemical pathway resulting from such a nano-level molecular inhibition produces a specific train of subjective and objective symptoms in the organism. In other words, each specific group of symptoms exhibited by the organism indicates a particular error occurred in the molecular level. Homoeopathy chases these trains of symptoms to their minutest level, from periphery to interior, in order to study the exact molecular errors underlying any particular state of pathology. Not even the sophisticated tools of ultra-modern technologies can monitor those molecular errors with such perfection. Then, those pathological molecular inhibitions are removed by applying appropriate therapeutic agents, selected on the basis of ‘law of similars’ or ‘Similia Similibus Curentur’. This fundamental strategy underlying the homeopathic system of therapeutics evidently surpasses even the most scientific methods of modern molecular medicine. It is high time that the scientific world had realized and recognized this truth, and incorporated this wonderful tool into their armamentarium. Obviously, “similia similibus curentur” is the most effective technique of identifying and removing the pathological molecular inhibitions in the organism.
The subjective and objective symptoms presented by the organism are the only reliable indicators to help us correctly understand the minute molecular deviations underlying a state of pathology. Each group or trains of symptoms represent a specific molecular error that had occurred in a particular biochemical pathway. These symptoms invariably indicate the specific type and character of the endogenic or exogenic foreign molecules or ions responsible for the particular molecular inhibition. By studying the train of symptoms carefully and systematically, homoeopaths are really observing these exact molecular inhibitions. This symptomatology-based analytical method of homoeopathy is far more exact and superior to the multitude of expensive complex laboratory chemical tests and imaging technologies we consider to be scientific. Identifying the exact molecular errors in the organism of the patient by observing the expressed symptoms, and identifying the most appropriate therapeutic agents from the similarity of symptoms the drugs could produce in healthy organism- this is the scientific essence of “similia similibus curentur”.
If a drug substance in molecular form is introduced to a healthy living organism, which exists in state of comparatively dynamic equilibrium, constituent molecules of that drug substance are conveyed by the internal transport systems, and bind by their configurational affinity to any of the complex bio-molecules engaged in natural biochemical processes. As a result of such molecular binding, the bio-molecules are subjected to deviations in their three-dimensional configurations, and becomes incapacitated to deliver their natural molecular functions. All the biochemical processes mediated or participated by those bio-molecules are affected, and dependent biological pathways are subsequently blocked. Since different biological pathways are inter-depedent, deviations in one pathway naturally affects the dependent ones also. The cascading of molecular deviations influence the neuro mediator-neuro transmitter systems and endocrine systems and finally manifest in the form of particular groups of subjective and objective symptoms. This is the real molecular kinetics of pathology.
Homeopathy has devised its own peculiar way of experimenting and documenting the properties of medicinal substances in relation with their capability to produce various pathological conditions. This is called drug proving. For proving a particular drug substance, it is introduced into a healthy organism, and, the subjective and objective symptoms and their modalities representing the diverse molecular deviations caused by the drug, are carefully observed and recorded. Each specific group of symptoms that appear as part of diverse pathological conditions are thus artificially created in healthy individuals. These symptoms are compiled as a materia medica of the substance used.
Even though modern biochemistry and molecular medicine has made great strides in the study of diverse molecular inhibitions related with diseases, still there are grave limitations. It is imperative that modern science should strive to find out means to define the exact bio-molecular deviations and inhibitions responsible for each and every one of the multitude of diverse symptoms and modalities expressed in particular disease conditions, in order to evolve a most scientific method of removing such inhibitions. Homeopathy considers “totality of symptoms” as the only clue to the understanding of molecular level pathology, as well as deciding the appropriate therapeutic tools to rectify that molecular errors. Viewing from this perspective, “similia similibus curentur” is a highly scientific principle of therapeutics, deserving to be greatly honored by modern science at least in coming days.
Potentized homeopathic drugs contain ‘molecular imprints’ or ‘hydrosomes’, which can bind to the exogenous and endogenous pathogenic molecules having complementary affinity, thereby relieving the protein molecules from molecular inhibitions. This is the molecular mechanism of homeopathic therapeutics. ‘Hydrosomes’ or ‘Molecular Imprints’ are nanocavities formed in the ‘supra-molecular clusters of water and ethyl alcohol’, by a process of ‘molecular imprinting’ involved in potentization. When introduced into the organism, they act as artificial binding sites for pathogenic molecules having complementary configurational affinity, thereby relieving the biological molecules from pathological molecular inhibitions. This is the most rational and logical explanation of molecular dynamics of homeopathic therapeutics.
’Molecular imprints’ can be compared to ‘antibodies’. Antibodies are native proteins subjected to ‘molecular imprinting’ by ‘antigens’, and acting as binding sites for the specific antigens. ‘Molecular imprints’ in potentized drugs are supra-molecular clusters of water/alcohol, subjected to ‘molecular imprinting’ by constituent molecules of drug substances, and acting as artificial binding sites for pathogenic molecules having configurational similarity to drug molecules used for imprinting.
It is obvious that potentized drugs cannot rectify molecular errors arising from genetic errors and nutritional deficiencies. Scope of homeopathy is limited to the diseases originating from molecular inhibitions of proteins by exogenous or endogenous molecules. Homeopaths should remember these fundamental factors while discussing scope and limitations of homeopathy.
In scientific terms ‘similia similibus curentur’ means, “pathological molecular inhibitions underlying a disease and expressed through specific groups of subjective and objective symptoms can be removed by applying ‘molecular imprints’ of drug molecules, which in crude form could produce similar molecular inhibitions expressed through similar groups of symptoms “.
So far, we understood ‘Similia Similibus Curentur’ as ‘similarity of symptoms produced by drugs as well as diseases’. According to modern scientific understanding, we can explain it as ‘similarity of molecular errors produced by drug molecules and pathogenic molecules’ in the organism. To be more exact, that means ‘similarity of molecular configurations of pathogenic molecules and drug molecules’. Potentized drugs contains ‘molecular imprints’ of constituent molecules of drug used for potentization. ‘Molecular imprints’ are three-dimensional negatives of molecules, and hence they would have a peculiar affinity towards those molecules, due to their complementary configuration. ‘Molecular imprints’ would show this complementary affinity not only towards the molecules used for imprinting, but also towards all molecules that have configurations similar to those molecules. Homeopathy utilizes this phenomenon, and uses molecular imprints of drug molecules to bind and entrap pathogenic molecules having configurations similar to them. Similarity of configurations of drug molecules and pathogenic molecules are identified by evaluating the ‘similarity of symptoms’ they produce in organism during drug proving and disease. This realization is the the basis of scientific understanding of homeopathy I propse.
To be recognized as a scientific medical system, we should explain ‘Similia Similibus Curentur’ before the scientific community in a way fitting to the existing scientific paradigms, and should submit ourselves to be verified in accordance with scientific methods.