MIT Approach To The Homeopathic Management Of Hypertension

Renin or angiotensinogenase, is the key enzyme produced in kidneys that modulates body’s renin-angiotensin-aldosterone system (RAAS) that mediates volume of extracellular fluids such as blood plasma, lymph and interstitial fluid, as well as arterial vasoconstriction. Thus, RENIN regulates the body’s mean arterial blood pressure.

The enzyme renin is secreted by the kidneys from specialized cells called granular cells of the juxtaglomerular apparatus in response to stimuli such as decrease in arterial blood pressure or decrease in blood volume detected by pressure-sensitive cells known as baroceptors, a decrease in sodium chloride levels in the ultrafiltrate of the nephrons, or sympathetic nervous system activity, acting through the beta1 adrenergic receptors.

The renin enzyme produced in kidneys circulates in the blood stream and breaks down angiotensinogen secreted from the liver into angiotensin I.
Angiotensin I is further converted in the lungs by angiotensin-converting enzyme (ACE) into angiotensin II. Angiotensin II is a very potent constrictor of all blood vessels. It acts on the smooth muscle and, therefore, raises the resistance posed by these arteries to the heart. The heart, trying to overcome this increase in its ‘load’, works more vigorously, causing the blood pressure to rise. This is the essential dynamics involved in rise of blood pressure.

Angiotensin II also acts on the adrenal glands and releases Aldosterone, which stimulates the epithelial cells in the nephrotic tubules and collecting ducts of the kidneys to increase re-absorption of sodium and water, leading to raised blood volume and raised blood pressure.

Aldosterone also acts on the CNS to increase water intake by stimulating thirst, as well as conserving blood volume, by reducing urinary loss through the secretion of Vasopressin from the posterior pituitary gland, resulting in increased blood pressure.

In normal physiological conditions, once the reduced blood pressure is raised to the adequate level, production of RENIN in kidneys is stopped by a NEGATIVE FEEDBACK mechanism, where angiotensin II act upon the special ‘angiotensin II receptors’ on the cell membranes of juxtaglomerular apparatus of kidneys. By this process, level of RENIN in blood stream is maintained with in limits, thereby preventing hypertension. Same way, production of catecholamines such as adrenalin which also plays a role in inducing production of RENIN and maintaining blood pressure high, is stopped by negative feedback action of adrenalin upon adrenogenic receptors on cells of adrenal cortex.

A pathological state of RENIN-ANGIOTENSIN AXIS happens once the NEGATIVE FEED BACK mechanism controlling the production of RENIN is disturbed by inhibition of angiotensin II receptors and adrenergic receptors involved in FEEDBACK process. Such inhibitions may be caused by binding of some pathogenic molecules of exogenous or endogenous origin, having functional groups similar to angiotensin II or adrenalin, so that they can competitively bind to the receptors. This leads to elevated state of RENIN in the circulation, resulting in ESSENTIAL HYPERTENSION.

Modern allopathic drugs are targeted either to block the conversion of angiotensin I into angiotensin II by inhibiting the angiotensin converting enzymes, or blocking the angiotensin II receptors using potent drug molecules. Since such molecular inhibitions may necessarily lead to molecular errors in different essential biochemical pathways, modern antihypertension drugs are prone to produce harmful side effects.

According to MIT concepts, maintaining the plasma level of RENIN by controlling its production by facilitating unhindered NEGATIVE FEED BACK mechanism is the ideal way of treating hypertension without any harmful side effects. Inhibition of FEEDBACK mechanism should be removed by using MOLECULAR IMPRINTS of angiotensin II, adrenalin, or drug molecules having similar functional groups. Various drug substances such as RAUWOLFIA contains a number of bioactive chemicals like ajmaline, aricine, corynanthine, deserpidine lankanescine rauwolscine, rescinnamine, reserpine, reserpiline, isoreserpine, isoreserpiline, serpentinine, and yohimbine, which can inhibit the angiotensin and adrenogenic receptors. As such, POTENTIZED FORMS of such drugs will contain MOLECULAR IMPRINTS that can act as artificial binding sites for binding to the endogenous and exogenous pathogenic molecules which are the causative factors of HYPERTENSION.

According to MIT approach, potentized or MOLECULAR IMPRINT forms of ANGIOTENSIN II, ADRENALIN, CATECHOLAMINES and various DRUG SUBSTANCES that can produce hypertension in crude form will be ideal drugs for treating hypertension without any side effects.

Author: Chandran Nambiar K C

I started practicing homeopathy in 1970, when I was 20 years old and studying for final year of BSc (Zoology) course. My interest in homeopathy happened very accidentally, through a constant relationship with a local practitioner who happened to be father of my classmate. I was a regular visitor in his clinic, where from I started reading BOERICKE MATERIA MEDICA and other homeopathic books, which helped me to cure myself my troublesome asthma that have been haunting me since my childhood days. I became a voracious reader of homeopathy. I was also deeply involved in studying marxism and dialectical materialism during my college days, which attracted me to political activities. MARXISM and HOMEOPATHY became two essential parts of my intellectual and practical life, which still continues so. Even though I joined DHMS course in a karnataka homeopathic college, I could not continue it due to my intense involvement in revolutionary political activities that resulted in jail life and a lot of criminal cases. Once that phase was over, I took a diploma in veterinary science and became a livestock inspector in animal husbandry department under govt of kerala. I have been continuing my study and practice of homeopathy all through these years. Since CCH act came into force only in 1976, and it contained provisions allowing existing practitioners to continue, my homeopathic practice went smoothly in parallel with my government job. In 1987, co-operating with some local homeopaths and social activists, I started Kannur District Homeopathic Hospital Sociey, which established a chain of hospitals and homeopathic clinics in different parts of Kannur district. After a few years I had to leave the society for some political reasons, and I established a 100 bedded well equipped homeopathic hospital in Taliparamba, employing a number of prominent homeopaths. That was ended up as a financial disaster for me due to many reasons, including my lack of skills as a money manager, and I was compelled to close down my dream project with in a short period. I lost huge money I invested, lost my reputation, and it pulled me into a debt trap. I learned a lot of valuabl lessons from this failure- about life, human psychology, relationships, and above all, about myself. I realized failure is the greatest teacher, if you are prepared learn from it. I learned how will power and determination to win will help us come back into life as a phoenix from our own ashes. I learned, one does not fail unless he stops fighting and accepts failure. My failure and the hardships that followed has moulded my personality in such a way that I can now withstand any disaster and fight back. I tell you, you will not know what life really is, unless you miserably fail at least once in your life. By this time, I left my government job also, and settled as a full time homeopathic practitioner. By this practice, I could repair my earlier financial losses, and establish well in life. It was during this period that I felt the need of developing a simple and user-friendly homeopathic software, that resulted in the evolution of SIMILIMUM, which was later upgraded into SIMILIMUM ULTRA. Similimum Ultra was well accepted by the profession, and it collected good revenues which continues even today. I stopped my practice a few years back , and concentrated in the study and research activities to evolve scientifically viable explanations to the so-called riddles of homeopathy. This unrelenting study resulted in MIT or Molecular Imprints Therapeutics, which provides a scientific and rational explanation for homeopathy. I started a homeopathic discussion group on facebook called HOMEOPATHY FOR TOTAL CURE, which has more than 35000 homeopaths as members. By this work on facebook, I could establish close relationship with many homeopaths around the world. It goes on. I could successfully convert facebook as my office and work place, from where I propagate my MIT ideas, co-ordinate my works for homeopathic community, and sell my Similimum Ultra Software. My years of hardwork in search of HOW HOMEOPATHY WORKS ultimately resulted in the publication of a book titled REDEFINING HOMEOPATHY (3000 pages, 3 volumes, hard bound, Rs 6000), in which I have compiled my articles regarding my scientific explanations of basic principles of homeopathy. These ideas are called MIT or MOLECULAR IMPRINTS THERAPEUTICS. MIT is now included in the syllabus of MD (HOM) course of prestigious DY PATIL DEEMED UNIVERSITY, PUNE, INDIA. Research department of SARADA KRISHNA HOMEOPATHIC COLLEGE, Kulashekharam, Tamilnadu, India, the only NAC accredited homeopathy college in India, has recently taken up certain reserch projects for proving the scientific explanations proposed by MIT. Based on MIT perspective of homeopathy, I had developed an MIT PROTOCOL for scientific homeopathy, and initiated a project for establishing a chain of MIT NETWORK CLINICS all over India, where MIT PROTOCOL will be practiced. More over, I have developed a whole range of 351 MIT FORMULATIONS, which are disease-specific combinations of post-avogadro diluted homeopathy drugs. NOW I AM IN 71st YEAR OF MY LIFE, AND STILL LOOKING FOR NEW HORRIZONS!

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