Elsewhere im my articles I have discussed about need of developing a new range of Molecular Imprinted Drugs using biological ligands as the templates for imprinting.
Sarcodes used in homeopathy should be understood in terms of biological ligands they contain. When potentizing the sarcodes, we are actually producing Molecular Imprints of their constituent biological ligands.
First of all we have to understand why the molecular imprints of biological ligands are so much important as therapeutic agents.
All normal biological interactions being part of all biological processes actually happen by binding of a biological molecule with its natural ligands. Biological molecules such as cellular and intercellular receptors, Various enzymes, transport molecules etc have bind with different natural ligand molecules to do their work.
These natural ligands have to bind to specific binding sites or active sites of the biological molecules in order to initiate a biochemical interaction between them. Various endogenous or exogenous alien molecules having conformational similarity with natural ligands can compete with natural ligands and produce a molecular inhibition, which amounts to a state of pathology. Since the competing pathogenic molecules and natural ligands have some conformational similarities, molecular imprints of natural ligands can obviously act as artificial binding pockets for those pathogenic molecules also. That is how the molecular imprints of natural ligands or sarcodes work as powerful therapeutic agents.
Two important questions have to be answered regarding sarcodes when considering from MIT perspective:
1. If sarcodes are natural biological ligands having specific functional roles in human organism, how they become pathogenic agents, requiring the intervention of their own potentized forms or ‘molecular imprints’?
2. If the sarcodes are biological ligands being essential parts of living system, will not their physiological functions get negatively affected by the use of their potentized forms, since it is true that potentized form of a drug substance can antidote the biological effects of same drug in crude form?
Let us consider pituitary hormones first. They play a decisive role in the whole metabolism of the organism, and hence called ‘master gland’. Pitutary hormones control many enzyme systems in our body. Then how can they act as pathogenic agents, requiring the use of potentized pituitary extract?
Next question is, when we use potentized pitutrin as a sarcode, will it not act as an antidote towards molecular forms of pituitary hormones and create dangerous
consequences, by disrupting the whole endocrine activities mediated by pituitary hormones?
Pepsinum is very important in digestion of proteins. If pepsinum 30 is given to a person, will it create problems in protein digestion by deactivating pepsin molecules? If they cannot antidote pepsin molecules, how can they act as therapeutic agents?
Thyroid hormones play very important roles in metabolic activities in the living organism. Then how it can be pathogenic agents, requiring the intervention of potentized thyroidinum? Will not potentized thyroidinum hinder the biological processes mediated by thyroid hormones?
These are very pertinent questions we have to answer while trying to explain the science behind using of potentized sarcodes.
We can answer these questions only if we know the dynamics of molecular processes involved in biochemical interactions.
Every biological molecules, especially those belonging to hormones, signaling molecules(cytokines), neuro-chemicals, antibodies and enzymes being circulated in the organism enter into two types of biological interactions:
1. ‘On-target interactions’ 2. ‘Off-target interactions’.
‘On-target’ interactions are those happening between natural ligands and their genuine natural biological targets. Such interactions are essential part of vital processes through which biochemical pathways are carried unhindered.
Natural ligands and their genuine targets interact through two steps:
a). molecular identification and binding, which is effected by complementary conformational affinity between targets and ligands,
b). actual chemical interaction, which is effected by perfect charge affinity between ligands and their natural targets.
Off-target interactions are those accidentally happening between ligands and wrong targets having conformational affinity only. In the absence of exact charge affinity, no chemical changes occur. Such interactions are always ‘inhibitory’, temporarily or permanently deactivating the involved biological molecules. Such ‘inhibitory’ off-target
interactions inevitably lead to derangement in associated biochemical pathways resulting in pathological states.
‘Off-target’ inhibitions caused by biological molecules such as hormones, enzymes, antibodies, signaling molecules(cytokines) and neurochemicals are causative
factors of a wide range of pathological conditions in living beings.
Sarcodes, or potentized preparations of these biological molecules, which contain their ‘molecular imprints’, can effectively remove these molecular inhibitions and thereby act as therapeutic agents. Here lies the importance of sarcodes in homeopathic
Then comes the issue of selective action of the potentized sarcodes. As any other molecular imprints, molecular imprints in potentized sarcodes also cannot interfere in in the interactions between natural ligands and their genuine targets which involves conformational affinity as well as charge affinity. Since molecular imprints act through conformational affinity only, they can interfere in only inhibitory ‘off-target’ interactions.
It is now obvious that thyroidinum 30 cannot interfere in the essential biochemical processes mediated by thyroid hormones, Piturin 30 cannot interfere in the natural actions of pituitary hormones. This principle is applicable to all potentized sarcodes. We can use potentizeds arcodes above 12c without any fear of adverse effects.
Sarcodes or potentized biological ligands can play a very important role in the treatment of diverse types of diseases belonging to metabolic, emotional, psychosomatic, and ontological factors. They can also be part of constitutional prescriptions.
Pathogenic molecules cause diseases by binding to the biological targets and inhibiting their actions by mimicking as their natural ligands, due to the similarity of conformations of their functional groups.
Molecular Imprints of biological ligands can bind and deactivate the pathogenic molecules having functional groups similar to that of the biological ligands used for preparing the particular Molecular Imprints .
It is by this molecular mechanism that the molecular imprints of thyroid hormones contained in potentized THYROIDINUM removes the molecular inhibitions in the cellular receptors of thyroid hormones caused by pathogenic molecules.
We often experience cases where the patient shows symptoms of thyroid deficiency, but thyroid function tests will show normal production of thyroid hormones. It is a very confusing situation for physicians. What actually happens is, cellular receptors of thyroid hormones are blocked by some pathogenic molecules having functional groups similar to those of thyroid hormones binding to the receptors, presenting the interactions between thyroid hormones and their receptors.
If potentized THYROIDINUM.is applied in such cases, molecular imprints contained in the potentized drugs will bind to the pathogenic molecules, there by clearing the pathological inhibitions of receptors. Interactions between thyroid hormones and their biological targets are brought back to normal, and the deficiency symptoms of thyroid hormones are relieved.
It is by this same biological mechanism most of the HORMONE REMEDIES as well as the whole class of SARCODES used in homeopathy actually work. We should study SARCODES in terms of biological ligands they contain.