Two Important Scientific Studies That Validate the Possibility of Molecular Imprinting in Homeopathic Potentization

As per the scientific explanation of homeopathy proposed by MIT or Molecular Imprints Therapeutics, potentized medicines contain MOLECULAR IMPRINTS or hydrogen bonded supra-molecular clusters of water/ethyl alcohol carrying the conformational imprints of drug molecules, which act artificial binding sites for pathogenic molecules and thereby removing the pathological molecular inhibitions.

One of the important predictions put forward to be verified for proving MIT was that supramolecular structure of potentized drugs will be different from that of unpotentized water-alcohol mixture, even though both contain same chemical molecules, which should be proved by tools and techniques of scientific methods.

I think the two remarkable works discussed below, one by Dr Tanmoy Maity, and the other by by Louis Rey, provide crucial support as very strong scientific proofs for this important prediction, thereby validating the MIT explanation of scientific homeopathy.

First study is one done by Tanmoy Maity (Department of Electrical Engineering, Indian School of Mines, Dhanbad, Jharkhand 826004, India), D. Ghosh & C.R. Mahata (Department of Electrical Engineering, Bengal Engineering and Science University, Shibpur, Howrah 711103, West Bengal, India), regarding effect of dielectric dispersion on potentised homeopathic medicines, which indicates a “rearrangement of vehicle molecules” in potentized drugs.

This report is available on
http://www.sciencedirect.com/science/article/pii/S1475491609001258

Second is one conducted by Louis Rey on thermo-luminescence of ultra-high dilutions of lithium chloride and sodium chloride, and published in December 2002, which is available in its full form at: http://www.janscholten.com/janscholten/Evidence_files/Rey.thermoluminescence.pdf E-mail address: ouis.rey@bluewin.ch (L. Rey).

STUDY I:

SCIENTIFIC EVIDENCE FOR RE-ARRANGEMENT OF VEHICLE MOLECULES DURING POTENTIATION :

This paper reports dielectric dispersion occurring in potentised homeopathic medicines subjected to variable frequency electric field using an instrumentation method developed by the authors. Oscillations occur in the direction of electric field, and are usually termed longitudinal/acoustic-mode vibrations.

The test material was lactose soaked with homeopathic medicine. Multiple resonance frequencies, forming a frequency-set, were observed repeatedly for each medicine.

The team reports experimental results for three potencies of Cuprum metallicum (Cuprum met) in the frequency range of 100 kHz–1 MHz. Each exhibits a set of resonance frequencies, which may be termed as its characteristic set. As the frequency-set of each medicine is different from those of others, each medicine may, therefore, be identified by its characteristic frequency-set. This suggests that potentised homeopathic medicines, which are chemically identical with the vehicle, differ from one another in the arrangement of vehicle molecules.

According to them, these “experiments show that potentised homeopathic medicines, which are chemically identical with the vehicle, differ from one another in the arrangement of vehicle molecules”.

“Difference in arrangement of vehicle molecules” strongly indicates the presence of “supra-molecular clusters of water and ethyl alcohol, into which the three-dimensional configuration of drug molecules are imprinted as nanocavities” as proposed by the hypothesis proposed by MIT.

The observation that “the resonance frequencies frequency-set of each medicine is different from those of others” strongly indicates clusters of water-ethyl alcohol molecules specifically rearranged in accordance with the shapes of constituent molecules of drug substance used for potentization.

Such a re-arrangement of vehicle molecules strongly indicates the process of ‘molecular imprinting’ happening during homeopathic potentization. Present work is a decisive step in the scientific understanding of homeopathy proposed by MIT.

STUDY II:

SCIENTIFIC EVIDENCE FOR SUPRAMOLECULAR STRUCTURAL CHANGES IN POTENTIZING MEDIUM HAPPENING BY THE PROCESS OF POTENTIZATION:

As per the reported work, ultra-high dilutions of lithium chloride and sodium chloride (10−30g cm−3) have been irradiated by X- and gamma rays at 77 K, then progressively re-warmed to room temperature. During that phase, their thermo-luminance has been studied and it was found that, despite their dilution beyond the Avogadro number, the emitted light was specific of the original salts dissolved initially.

This wonderful observation that high dilutions of salts very much above avogadro number retains the specific thermo-luminance patterns reminding of of original salts seems to be very crucial. This phenomenon could be well explained only in terms of supramolecular nanostructures of water carrying the imprints of exact ‘conformations’ of ‘individual’ molecules of salts, as explained by MIT concepts.

Thermo-luminance studies have been developed and utilized so far as a “tool to study the structure of solids, mainly ordered crystals”. In the present study, the researchers successfully utilized it in ultra-high aqueous dilutions, which demonstrates the short range ‘crystalline’ character of water as well as high dilution preparations.

Actually, the researchers took up this work to ‘challenge’ the ‘water memory’ theory, but proved it otherwise. They confess in their report: “we thought that it would be of interest to challenge the theory according which preexistent ‘structures’ in the original liquid, developed around some added chemicals, could survive a great number of successive dilutions when done under vigorous mechanical stirring”.

Another important point to be noted is that the researchers did not use ‘commercial samples’ as most ‘researches’ do, but prepared themselves 15c dilutions of lithium chloride and sodium chloride under the guidance of boiron labs. This fact provides more scientific credence to this study.

The study “showed quite clearly that the initial addition of a solute (NaCl and LiCl) in the original D2O leaves a permanent effect even when, by successive dilutions made under strong vibration, all traces of solute have disappeared.” The results were reproduced in several repeated experiments, “beyond any ambiguity”.

Thermally stimulated luminance—often called thermo-luminance—is a well known phenomenon amongst the thermally stimulated processes (thermally stimulated conductivity—thermally stimulated electron emission—thermogravimetry—differential thermal analysis and differential scanning calorimetry, etc.). Its theory and applications have been fully developed inter alia by McKeever, Chen and Visocekas and it proved to be a most interesting tool to study the structure of solids, mainly ordered crystals. To that end, the studied material is “activated” at low-temperature, usually by radiant energy (UV, X-rays, gamma rays, electron beams, or neutrons) which most generally creates electrons–holes pairs which become separately “trapped” at different energy levels. Then, when the irradiated material is warmed up, the heating serves as a trigger to release the initially accumulated energy and the trapped electrons and holes move and recombine. A characteristic glow is emitted most often under the shape of different successive peaks according to the depths of the initial traps. As a general rule this phenomenon is observed in ordered crystals though it can be equally seen in disordered materials such as glasses. In that mechanism, imperfections in the lattice play a major role and are considered to be the place where luminance centres appear. Thus, thermoluminance is a good tool to study these imperfections and understand how they appear in the crystal.

This is exactly along those lines that the researchers carried our first investigations, starting, this time, from liquids which were turned into stable solids by low-temperature cooling.

Working essentially with water—mainly deuterium oxide—they have shown that the thermoluminance glow of irradiated hexagonal ice consisted in two major peak areas—Peak 1 near 120 K and Peak 2 near 166 K having well-defined emission spectra the D2O samples giving a much higher signal than the H2O ones.

In both cases, un-irradiated samples gave no signals whatsoever. For both D2O and H2O it was shown that the relative intensity of the thermoluminance glow was a function of the irradiation dose and, that at least for Peak 2, it did show a maximum between 1 and 10 kGy .

As a first hypothesis on the nature of the emission itself it has been suggested by Teixeira that Peak 2 could be connected to the hydrogen-bond network within the ice which, in turn, could result from the structure of the original liquid sample, whilst Peak 1 looked to be closely related to the molecule. This strengthens the views on the involvement of hydrogen bonds in this mechanism.

To develop this concept further, the researchers did select to study the effect of lithium chloride on the thermoluminescence of irradiated D2O ice since this particular substance is known to suppress hydrogen bonds. The result, indeed, is spectacular and, at the relatively low concentration of 0:1M, Peak 2 is totally erased whereas the basic emission of Peak 1 remains almost unchanged.

At that point the researchers thought that it would be of interest to challenge the theory according which pre-existent “structures” in the original liquid, developed around some added chemicals, could survive a great number of successive dilutions when done under vigorous mechanical stirring.

To that end they prepared, courtesy of the BOIRON LABORATORIES, ultra-high dilutions of lithium chloride and sodium chloride by successive dilutions to the hundredths, all done under vigorous mechanical stirring (initially 1 g in 100 cm3, then 1 cm3 of this solution in 99 cm3 of pure D2O … and so on) until they reached— theoretically—at the 15th dilution, a “concentration” of10−30 g cm−3. A reference sample of D2O alone was also prepared according to this technique, still keeping vigorous agitation (150 strokes=7:5 s at each successive “dilution” step).

They did proceed, then, to the “activation” of these materials by irradiation according the following experimental protocol.

One cubic centimeter of each solution is placed in aluminium test cavities of 20 mm diameter and 2 mm depth and frozen to −20◦C on a cold metallic block. The frozen systems are kept 24 h at −20◦C to achieve stability into their crystallization patternand they are immersed into liquid nitrogen and kept at −196◦C for 24 h.

In a first set of experiments the frozen ice disks are irradiated at 77 K with 100 kV X-rays to achieve a dose of 0:4 kGy (30 min). Previous determinations were done to check that the disks having identical positions in the field did receive the same dose (dosimetry has been done using Harwell, FWT, and alanine dosimeters).

After irradiation, all the “activated” samples are transferred into a liquid nitrogen container and kept, there, for a week-time, to even out whatever small differences could exist between them.

Finally, all samples are placed in the thermoluminance equipment and their respective glow recorded—with both a photo-multiplier and a CCD camera connected to a spectrograph—in the course of rewarming (3=min) between 77 and 13 K, as has been done in our previous published experiments.

Much to their surprise, the experimental results do show—without any ambiguity— that for an X-ray dose of 0:4 kGy the thermoluminescence glows of the three systems were substantially different. These findings did prove to be reproducible in the course of many different identical experiments.

To compare the curves between them the researchers normalized the emitted light readings taking Peak 1 as the reference. In doing so, we obtain for Peak 2 the different curves presented which show quite clearly that the initial addition of a solute (NaCl and LiCl) in the original D2O leaves a permanent effect even when, by successive dilutions made under strong vibration, all traces of solute have disappeared. More remarkable were the fact that, by far, lithium chloride demonstrates a stronger hydrogen bond suppressing “ghost” effect which could be related to the larger size of the lithium ion.

A second set of experiments done with gamma rays (courtesy of CELESTIN Reactor, COGEMA, Marcoule), at a higher dose (19 kGy) did confirm these findings

It appears, therefore, that the structural state of a solution made in D2O can be modified by the addition of selected solutes like LiCl and NaCl. This modification remains even when the initial molecules have disappeared and the effect is the same at different irradiation doses (0.4 –19 kGy) and for different radiant sources (X-rays, gamma rays). As a working hypothesis, the researchers propose that this phenomenon results from a marked structural change in the hydrogen bond network initiated at the onset by the presence of the dissolved ions and maintained in the course of the dilution process, probably thanks to the successive vigorous mechanical stirrings.

Researchers had no any idea of Molecular Imprinting. They proposes the following hypothesis for explaining their observation:

“As a working hypothesis, we propose that this phenomenon results from a marked structural change in the hydrogen bond network initiated at the onset by the presence of the dissolved ions and maintained in the course of the dilution process, probably thanks to the successive vigorous mechanical stirrings.”

See, this hypothesis comes very close to the concept of Molecular Imprinting!

If we fail to explain the observations of this monumental research in terms of Molecular Imprinting, there remains the danger that it will be hijacked by ‘energy medicine’ theoreticians, by interpreting in terms of ‘essence of drugs’, ‘information’, ‘vibrations’ and the like. Actually, Jan Scholten has already done such an exercise, by saying ‘information’ of drugs imprinted in water are the cause of thermoluminance observed by the researchers. Then he very cleverly fits this thermoluminance into his energy medicine frame work of ‘bioluminance’, vibrations, vital force, resonance and other pseudoscientific theories.

To be specific, precise and fitting to modern scientific knowledge system and its accepted paradigms, it is better to say ‘molecular imprints’ of original drug molecules are the cause of similarity of thermoluminance the researchers could observe. Such an explanation will clearly demonstrate that we are talking about the ‘complementary’ shape of drug molecules imprinted into nanostructures of water, which produce therapeutic effects by acting as ‘artificial binding sites’ for pathogenic molecules.

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