Here is a list of all the functional groups relevant to the pathology of type 2 diabetes mellitus, along with the substances or chemical molecules that contain these functional groups. A state of diabetic condition arises when endogenous or exogenous pathogenic molecules having similar functional groups competitively bind to the natural targets of these functional groups and produce pathological inhibitions of biological molecules. Potentized forms of these substances will contain the molecular imprints of functional groups, which can act as artificial binding pockets for pathogenic molecules having similar functional groups. As per MIT homeopathy perspective of therapeutics, a combination of potentized forms of all these substances will provide all the molecular imprints required for removing the molecular inhibitions involved in type 2 diabetes mellitus. substances or chemical molecules that that contain.
Functinal group: Hydroxyl Groups (-OH)
Substances: 1. Glucose: A simple sugar with multiple hydroxyl groups, critical in energy metabolism. 2. Glycerol: A component of triglycerides, containing three hydroxyl groups. 3. Insulin: These groups can be found in the side chains of serine and threonine amino acids in insulin. They can be involved in interactions that help stabilize the protein’s structure or interface with receptors. 4. Cortisol: Cortisol, a steroid hormone produced by the adrenal cortex, contains several important functional groups that are crucial for its structure and biological activity.
Functinal group: Carbonyl Groups (C=O)
Substances: 1. Acetone: A simple ketone with a prominent carbonyl group, often elevated in uncontrolled diabetes due to fat metabolism. 2. Glucagon: A peptide hormone which, among other features, includes amide bonds (a type of carbonyl group).
Functional group: Carboxyl Groups (-COOH)
Substances; 1. Palmitic Acid: Palmitic acid, a saturated fatty acid with a terminal carboxyl group. 2. Amino Acids: For example, glutamic acid, which plays roles in metabolism and as a neurotransmitter. 3. Insulin: A crucial peptide hormone for regulating blood glucose levels, has several key functional groups that play vital roles in its structure and function.
Functional group: Phosphate Groups (-PO4)
Substances: 1. ATP (Adenosine Triphosphate): The primary energy carrier in cells, containing high-energy phosphate bonds. 2. Cardiolipin: Critical components of cell membranes, containing phosphate groups.
Functional group: Amine Groups (-NH2)
Substances: 1. Adrenaline: A hormone and neurotransmitter with an amine group, involved in the body’s stress response. 2. Glucosamine: An amino sugar involved in the biosynthesis of glycosaminoglycans. 3. Insulin: A crucial peptide hormone for regulating blood glucose levels, has several key functional groups that play vital roles in its structure and function.
Functional group: Sulfhydryl Groups (-SH) Substances: 1. Glutathione: A tripeptide with an antioxidant role, containing a cysteine residue with a sulfhydryl group. 2. Cysteine: An amino acid with a sulfhydryl group, important for protein structure and function.
Functional group: Ether Groups (C-O-C)
Substances: 1. Anisole: A simple aromatic ether used here to illustrate the structure of an ether linkage. 2. Methyl tert-butyl ether (MTBE): An organic compound used primarily as a fuel additive, representing a non-biological use of ether groups.
These substances are representative of the chemical diversity found in biological and some non-biological contexts, illustrating how each functional group participates in various chemical and metabolic processes relevant to health and disease, including diabetes.
FUNCTIONAL GROUPS MIT COMBINATION FOR TYPE 2 DIABETES:
Insulin 30, Glucose 30, Glycerol: 30, Acetone 30, Glucagon 30, Palmitic acid 30, Linoleic Acid 30, ATP (Adenosine Triphosphate) 30, Cardiolipin 30, Adrenaline 30, Glucosamine 30, Glutathione 30, Cysteine 30, Anisole 30, Methyl tert-butyl ether (MTBE) 30, Cortisol 30.
AN OUTLINE OF MIT HOMEOPATHY APPROACH TO THERAPEUTICS
“Similia Similibus Curentur” is the cornerstone principle of homeopathy, serving as the theoretical foundation upon which the entire practice is constructed. If the functional groups of the pathogenic and drug molecules are similar, they can bind to similar molecular targets and elicit similar symptoms. Homeopathy employs this concept to identify the similarity between pathogenic and drug molecules by observing the symptoms they induce. Through “Similia Similibus Curentur,” Hahnemann sought to harness the principle of competitive inhibitions to develop a novel therapeutic method. If symptoms induced in healthy individuals by a drug taken in its molecular form mirror those in a diseased individual, applying the drug in a molecularly imprinted form could potentially cure the disease.
Symptoms of both the disease and the drug appear similar when the disease-causing and drug substances contain similar chemical molecules with similar functional groups, which bind to similar biological targets, producing similar molecular inhibitions and leading to errors in the same biochemical pathways. These similar chemical molecules can compete to bind to the same molecular targets. Disease molecules produce disease by competitively binding with biological targets, mimicking natural ligands due to their conformational similarity. Drug molecules, by sharing conformational similarities with disease molecules, can displace them through competitive relationships, thereby alleviating the pathological inhibitions they cause.
Molecular imprints of similar chemical molecules can act as artificial binding agents for similar substances, neutralizing them due to their mutually complementary conformations. It is evident that Hahnemann observed this competitive relationship between substances affecting living organisms by producing similar symptoms. Limited by the scientific knowledge of his time, he could not fully explain that two different substances produce similar symptoms only if both contain chemical molecules with functional groups or moieties of similar conformations, enabling them to bind to similar biological targets and induce similar molecular inhibitions, leading to deviations in the same biological pathways.
Understanding the ‘similarity’ between drug-induced symptoms and disease symptoms should extend to the ‘similarity’ in molecular inhibitions caused by drug molecules and disease-causing molecules, stemming from the ‘similarity’ of their functional groups. Samuel Hahnemann, the pioneer of homeopathy, formulated his principles during a time when modern biochemistry had not yet emerged. This historical context explains why Hahnemann was unable to describe his observations using contemporary biochemical concepts. Despite these limitations, his foresight into their therapeutic implications was nothing short of genius.
Homeopathy, or “Similia Similibus Curentur,” is a therapeutic approach grounded in the identification of drug molecules that, due to their similar functional groups, are capable of competing with disease-causing molecules for binding to biological targets. This methodology relies on observing the similarity of symptoms produced by the disease and those the drug can induce in healthy individuals, thereby deactivating the disease-causing molecules through the binding action of molecular imprints derived from the drug. The future recognition of homeopathy as a scientific discipline hinges on our ability to demonstrate to the scientific community that “Similia Similibus Curentur” is based on the naturally occurring phenomenon of competitive relationships between chemically similar molecules, as explained in modern biochemistry. Once this connection is clearly established, homeopathy’s status as a scientific practice will inevitably be recognized.
Only way the medicinal properties of a drug substance could be transmitted to and preserved in a medium of water-ethanol mixture during homeopathic POTENTIZATION without any single drug molecule remaining in it is by preserving the conformational details of its functional groups by a process of MOLECULAR IMPRINTING, since the conformational properties of functional groups of drug molecules play a decisive role in biomolecular interactions.
Active principles of homeopathy drugs potentized above 12 c are molecular imprints of FUNCTIONAL GROUPS of drugs molecules used as templates for potentization process. When introduced into living system as therapeutic agent, these molecular imprints act as artificial binding pockets for the pathogenic molecules having functional groups that are similar to the template molecules used for potentization. As we know, a state of pathology arises when some endogenous or exogenous molecules having functional groups having functional groups similar to those of natural ligands of a biological target competitively bind to that target and produce molecular inhibitions. Removing these molecular inhibitions amounts to cure. Once you understand this biological mechanism, you will realize that molecular imprints of natural ligands also can act as therapeutic agents by binding to pathogenic molecules that compete with the natural ligands.
As per the scientific perspective based on the understanding of functional groups involved in pathology and therapeutics, MIT homeopathy proposes to formulate a comprehensive combination containing potentized forms of selected drug substances, pathogenic agents and biological ligands that can provide all the diverse types of molecular imprints of all functional groups involved in ADHD, that could act as wide spectrum therapeutic agent against this complex disease condition.
REDEFINING HOMEOPATHY 