On Posology of Molecular Imprinted Drugs
Some friends ask me to explain my views on posology of molecular imprinted drugs.
While trying to answer this question, we have to remember that the issue of posology has to consider three aspects:
1. Minimum quantity of drug needed to be given per dose to produce a therapeutic action,
2. Maximum quantity of the drug that could be administered as a dose to ensure that there is no bad effects,
3. Most appropriate frequency of administration or repetition of doses.
Regarding the first question, it is difficult to define exactly what is the minimum quantity of molecular imprinted drug to produce therapeutic effect. To do that, we have to know the exact number of biological molecules affected, as well as the exact number of molecular imprints contained in a given measure molecular imprinted drugs. Both are impossible in the present stage of technology available to us.
Size of a molecular imprint will vary depending upon the size of drug molecule used for molecular imprinting, which in turn determine the number of molecular imprints contained. It is not practical to count these numbers. On the other side, it is also not practical to determine the biological molecules inhibited. Only thing we can do is to determine the minimum dose of drugs through experimenting in real situations.
We should remember, according to avogadro, number of water molecules in 18ml of water will be 6.022140857 × 1023. From this, we can calculate the number of water molecules in 1ml. 1ml contains 15 drops. It is not difficult to understand that the number of water molecules contained in even 1 drop of water so huge for calculation. Same way we can calculate the number of alcohol molecules in 1 drop of alcohol.
Overall, it is obvious that one drop or even a fraction of molecular imprinted drugs will contain millions of molecular imprints. As such, we need not worry much about the minimum quantity of molecular imprinted drugs to be used for therapeutic purpose. It may be as small as we can handle. Normally I prefer one drop for one dose.
Regarding the second question, MIT says that molecular imprints cannot do any harm upon biological system. As such, we need not worry at all about the maximum quantity administered as a dose.
Regarding third question, we have to be aware of the possible changes molecular imprints may undergo once introduced in the body.
Molecular imprints could be antidoted by any chemical molecule having conformations affinity. As such, the drugs we consume may get easily antidoted and deactivated by various chemical molecules entering our body through food, inhalation, drinks and many other ways.
Hence we have to repeat the doses in frequent intervals to ensure adequate quantity of molecular imprints to ensure full and lasting therapeutic effect.
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